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Items: 33


Generation of homogeneous midbrain organoids with in vivo-like cellular composition facilitates neurotoxin-based Parkinson's disease modeling.

Kwak TH, Kang JH, Hali S, Kim J, Kim KP, Park C, Lee JH, Ryu HK, Na JE, Jo J, Je HS, Ng HH, Kwon J, Kim NH, Hong KH, Sun W, Chung CH, Rhyu IJ, Han DW.

Stem Cells. 2020 Feb 21. doi: 10.1002/stem.3163. [Epub ahead of print]


Potassium channel dysfunction in human neuronal models of Angelman syndrome.

Sun AX, Yuan Q, Fukuda M, Yu W, Yan H, Lim GGY, Nai MH, D'Agostino GA, Tran HD, Itahana Y, Wang D, Lokman H, Itahana K, Lim SWL, Tang J, Chang YY, Zhang M, Cook SA, Rackham OJL, Lim CT, Tan EK, Ng HH, Lim KL, Jiang YH, Je HS.

Science. 2019 Dec 20;366(6472):1486-1492. doi: 10.1126/science.aav5386.


Visualizing Microglia with a Fluorescence Turn-On Ugt1a7c Substrate.

Kim B, Fukuda M, Lee JY, Su D, Sanu S, Silvin A, Khoo ATT, Kwon T, Liu X, Chi W, Liu X, Choi S, Wan DSY, Park SJ, Kim JS, Ginhoux F, Je HS, Chang YT.

Angew Chem Int Ed Engl. 2019 Jun 11;58(24):7972-7976. doi: 10.1002/anie.201903058. Epub 2019 Apr 30.


Prenatal selective serotonin reuptake inhibitor (SSRI) exposure induces working memory and social recognition deficits by disrupting inhibitory synaptic networks in male mice.

Yu W, Yen YC, Lee YH, Tan S, Xiao Y, Lokman H, Ting AKT, Ganegala H, Kwon T, Ho WK, Je HS.

Mol Brain. 2019 Apr 1;12(1):29. doi: 10.1186/s13041-019-0452-5.


Postnatal TrkB ablation in corticolimbic interneurons induces social dominance in male mice.

Tan S, Xiao Y, Yin HH, Chen AI, Soong TW, Je HS.

Proc Natl Acad Sci U S A. 2018 Oct 16;115(42):E9909-E9915. doi: 10.1073/pnas.1812083115. Epub 2018 Oct 3.


Ca2+-dependent demethylation of phosphatase PP2Ac promotes glucose deprivation-induced cell death independently of inhibiting glycolysis.

Lee HY, Itahana Y, Schuechner S, Fukuda M, Je HS, Ogris E, Virshup DM, Itahana K.

Sci Signal. 2018 Jan 9;11(512). pii: eaam7893. doi: 10.1126/scisignal.aam7893.


Maternal Separation Does Not Produce a Significant Behavioral Change in Mice.

Tan S, Ho HS, Song AY, Low J, Je HS.

Exp Neurobiol. 2017 Dec;26(6):390-398. doi: 10.5607/en.2017.26.6.390. Epub 2017 Dec 18.


Direct Induction and Functional Maturation of Forebrain GABAergic Neurons from Human Pluripotent Stem Cells.

Sun AX, Yuan Q, Tan S, Xiao Y, Wang D, Khoo AT, Sani L, Tran HD, Kim P, Chiew YS, Lee KJ, Yen YC, Ng HH, Lim B, Je HS.

Cell Rep. 2016 Aug 16;16(7):1942-53. doi: 10.1016/j.celrep.2016.07.035. Epub 2016 Aug 4.


Midbrain-like Organoids from Human Pluripotent Stem Cells Contain Functional Dopaminergic and Neuromelanin-Producing Neurons.

Jo J, Xiao Y, Sun AX, Cukuroglu E, Tran HD, Göke J, Tan ZY, Saw TY, Tan CP, Lokman H, Lee Y, Kim D, Ko HS, Kim SO, Park JH, Cho NJ, Hyde TM, Kleinman JE, Shin JH, Weinberger DR, Tan EK, Je HS, Ng HH.

Cell Stem Cell. 2016 Aug 4;19(2):248-257. doi: 10.1016/j.stem.2016.07.005. Epub 2016 Jul 28.


Polarizing the Neuron through Sustained Co-expression of Alternatively Spliced Isoforms.

Yap K, Xiao Y, Friedman BA, Je HS, Makeyev EV.

Cell Rep. 2016 May 10;15(6):1316-28. doi: 10.1016/j.celrep.2016.04.012. Epub 2016 Apr 28.


Erratum: Hepatic circadian clock oscillators and nuclear receptors integrate microbiome-derived signals.

Montagner A, Korecka A, Polizzi A, Lippi Y, Blum Y, Canlet C, Tremblay-Franco M, Gautier-Stein A, Burcelin R, Yen YC, Je HS, Al-Asmakh M, Mithieux G, Arulampalam V, Lagarrigue S, Guillou H, Pettersson S, Wahli W.

Sci Rep. 2016 Apr 20;6:23951. doi: 10.1038/srep23951. No abstract available.


MiRNA-128 regulates the proliferation and neurogenesis of neural precursors by targeting PCM1 in the developing cortex.

Zhang W, Kim PJ, Chen Z, Lokman H, Qiu L, Zhang K, Rozen SG, Tan EK, Je HS, Zeng L.

Elife. 2016 Feb 17;5. pii: e11324. doi: 10.7554/eLife.11324.


Hepatic circadian clock oscillators and nuclear receptors integrate microbiome-derived signals.

Montagner A, Korecka A, Polizzi A, Lippi Y, Blum Y, Canlet C, Tremblay-Franco M, Gautier-Stein A, Burcelin R, Yen YC, Je HS, Al-Asmakh M, Mithieux G, Arulampalam V, Lagarrigue S, Guillou H, Pettersson S, Wahli W.

Sci Rep. 2016 Feb 16;6:20127. doi: 10.1038/srep20127. Erratum in: Sci Rep. 2016;6:23951. Maha, Al-Asmakh [corrected to Al-Asmakh, Maha].


Regulation of Brain-Derived Neurotrophic Factor Exocytosis and Gamma-Aminobutyric Acidergic Interneuron Synapse by the Schizophrenia Susceptibility Gene Dysbindin-1.

Yuan Q, Yang F, Xiao Y, Tan S, Husain N, Ren M, Hu Z, Martinowich K, Ng JS, Kim PJ, Han W, Nagata KI, Weinberger DR, Je HS.

Biol Psychiatry. 2016 Aug 15;80(4):312-322. doi: 10.1016/j.biopsych.2015.08.019. Epub 2015 Aug 28.


Triad3A regulates synaptic strength by ubiquitination of Arc.

Mabb AM, Je HS, Wall MJ, Robinson CG, Larsen RS, Qiang Y, Corrêa SA, Ehlers MD.

Neuron. 2014 Jun 18;82(6):1299-316. doi: 10.1016/j.neuron.2014.05.016.


Amyloid precursor protein regulates neurogenesis by antagonizing miR-574-5p in the developing cerebral cortex.

Zhang W, Thevapriya S, Kim PJ, Yu WP, Je HS, Tan EK, Zeng L.

Nat Commun. 2014 Mar 3;5:3330. doi: 10.1038/ncomms4330.


ProBDNF and mature BDNF as punishment and reward signals for synapse elimination at mouse neuromuscular junctions.

Je HS, Yang F, Ji Y, Potluri S, Fu XQ, Luo ZG, Nagappan G, Chan JP, Hempstead B, Son YJ, Lu B.

J Neurosci. 2013 Jun 12;33(24):9957-62. doi: 10.1523/JNEUROSCI.0163-13.2013.


MDGAs interact selectively with neuroligin-2 but not other neuroligins to regulate inhibitory synapse development.

Lee K, Kim Y, Lee SJ, Qiang Y, Lee D, Lee HW, Kim H, Je HS, Südhof TC, Ko J.

Proc Natl Acad Sci U S A. 2013 Jan 2;110(1):336-41. doi: 10.1073/pnas.1219987110. Epub 2012 Dec 17.


Role of pro-brain-derived neurotrophic factor (proBDNF) to mature BDNF conversion in activity-dependent competition at developing neuromuscular synapses.

Je HS, Yang F, Ji Y, Nagappan G, Hempstead BL, Lu B.

Proc Natl Acad Sci U S A. 2012 Sep 25;109(39):15924-9. Epub 2012 Sep 10.


Prefrontal cortical mechanisms underlying delayed alternation in mice.

Rossi MA, Hayrapetyan VY, Maimon B, Mak K, Je HS, Yin HH.

J Neurophysiol. 2012 Aug;108(4):1211-22. doi: 10.1152/jn.01060.2011. Epub 2012 Apr 25.


Synaptic dysfunction and abnormal behaviors in mice lacking major isoforms of Shank3.

Wang X, McCoy PA, Rodriguiz RM, Pan Y, Je HS, Roberts AC, Kim CJ, Berrios J, Colvin JS, Bousquet-Moore D, Lorenzo I, Wu G, Weinberg RJ, Ehlers MD, Philpot BD, Beaudet AL, Wetsel WC, Jiang YH.

Hum Mol Genet. 2011 Aug 1;20(15):3093-108. doi: 10.1093/hmg/ddr212. Epub 2011 May 10.


Presynaptic protein synthesis required for NT-3-induced long-term synaptic modulation.

Je HS, Ji Y, Wang Y, Yang F, Wu W, Lu B.

Mol Brain. 2011 Jan 7;4:1. doi: 10.1186/1756-6606-4-1.


eIF2alpha Phosphorylation-dependent translation in CA1 pyramidal cells impairs hippocampal memory consolidation without affecting general translation.

Jiang Z, Belforte JE, Lu Y, Yabe Y, Pickel J, Smith CB, Je HS, Lu B, Nakazawa K.

J Neurosci. 2010 Feb 17;30(7):2582-94. doi: 10.1523/JNEUROSCI.3971-09.2010.


Chemically inducible inactivation of protein synthesis in genetically targeted neurons.

Je HS, Lu Y, Yang F, Nagappan G, Zhou J, Jiang Z, Nakazawa K, Lu B.

J Neurosci. 2009 May 27;29(21):6761-6. doi: 10.1523/JNEUROSCI.1280-09.2009. No abstract available.


Pro-BDNF-induced synaptic depression and retraction at developing neuromuscular synapses.

Yang F, Je HS, Ji Y, Nagappan G, Hempstead B, Lu B.

J Cell Biol. 2009 May 18;185(4):727-41. doi: 10.1083/jcb.200811147.


Distinct mechanisms for neurotrophin-3-induced acute and long-term synaptic potentiation.

Je HS, Zhou J, Yang F, Lu B.

J Neurosci. 2005 Dec 14;25(50):11719-29.


Neurotrophic regulation of the development and function of the neuromuscular synapses.

Lu B, Je HS.

J Neurocytol. 2003 Jun-Sep;32(5-8):931-41. Review.


Implication of geranylgeranyltransferase I in synapse formation.

Luo ZG, Je HS, Wang Q, Yang F, Dobbins GC, Yang ZH, Xiong WC, Lu B, Mei L.

Neuron. 2003 Nov 13;40(4):703-17.


Regulation of TrkB receptor tyrosine kinase and its internalization by neuronal activity and Ca2+ influx.

Du J, Feng L, Zaitsev E, Je HS, Liu XW, Lu B.

J Cell Biol. 2003 Oct 27;163(2):385-95.


Neural induction, neural fate stabilization, and neural stem cells.

Moody SA, Je HS.

ScientificWorldJournal. 2002 Apr 28;2:1147-66. Review.


Regulation of neuromuscular synapse development by glial cell line-derived neurotrophic factor and neurturin.

Wang CY, Yang F, He XP, Je HS, Zhou JZ, Eckermann K, Kawamura D, Feng L, Shen L, Lu B.

J Biol Chem. 2002 Mar 22;277(12):10614-25. Epub 2002 Jan 14.

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