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Exome-Wide Rare Variant Analyses in Sudden Infant Death Syndrome.

Tester DJ, Wong LCH, Chanana P, Gray B, Jaye A, Evans JM, Evans M, Fleming P, Jeffrey I, Cohen M, Tfelt-Hansen J, Simpson MA, Behr ER, Ackerman MJ.

J Pediatr. 2018 Dec;203:423-428.e11. doi: 10.1016/j.jpeds.2018.08.011. Epub 2018 Sep 26.


Noncardiac genetic predisposition in sudden infant death syndrome.

Gray B, Tester DJ, Wong LC, Chanana P, Jaye A, Evans JM, Baruteau AE, Evans M, Fleming P, Jeffrey I, Cohen M, Tfelt-Hansen J, Simpson MA, Ackerman MJ, Behr ER.

Genet Med. 2019 Mar;21(3):641-649. doi: 10.1038/s41436-018-0131-4. Epub 2018 Aug 24.


Parallel regulation of past, present, and future actions during sequencing.

Behmer LP, Jantzen KJ, Martinez S, Walls R, Amir-Brownstein E, Jaye A, Leytze M, Lucier K, Crump MJC.

J Exp Psychol Hum Percept Perform. 2018 Aug;44(8):1147-1152. doi: 10.1037/xhp0000507. Epub 2018 Jul 19.


Dysfunction of NaV1.4, a skeletal muscle voltage-gated sodium channel, in sudden infant death syndrome: a case-control study.

Männikkö R, Wong L, Tester DJ, Thor MG, Sud R, Kullmann DM, Sweeney MG, Leu C, Sisodiya SM, FitzPatrick DR, Evans MJ, Jeffrey IJM, Tfelt-Hansen J, Cohen MC, Fleming PJ, Jaye A, Simpson MA, Ackerman MJ, Hanna MG, Behr ER, Matthews E.

Lancet. 2018 Apr 14;391(10129):1483-1492. doi: 10.1016/S0140-6736(18)30021-7. Epub 2018 Apr 5.


Cardiac Genetic Predisposition in Sudden Infant Death Syndrome.

Tester DJ, Wong LCH, Chanana P, Jaye A, Evans JM, FitzPatrick DR, Evans MJ, Fleming P, Jeffrey I, Cohen MC, Tfelt-Hansen J, Simpson MA, Behr ER, Ackerman MJ.

J Am Coll Cardiol. 2018 Mar 20;71(11):1217-1227. doi: 10.1016/j.jacc.2018.01.030.


HLA-associated polymorphisms in the HIV-2 capsid highlight key differences between HIV-1 and HIV-2 immune adaptation.

de Silva TI, Leligdowicz A, Carlson J, Garcia-Knight M, Onyango C, Miller N, Yindom LM, Hué S, Jaye A, Dong T, Cotten M, Rowland-Jones SL.

AIDS. 2018 Mar 27;32(6):709-714. doi: 10.1097/QAD.0000000000001753.


Does smallpox vaccination modify HIV disease progression among ART-naive people living with HIV in Africa?

Diouf A, Trottier H, Youbong TJ, Ngom-Guéye NF, Ndiaye O, Seck A, Sarr D, Diop S, Seydi M, Mboup S, Nguyen VK, Jaye A.

Epidemiol Infect. 2018 Jan;146(2):218-226. doi: 10.1017/S0950268817002795. Epub 2017 Dec 13.


Pml nuclear body disruption cooperates in APL pathogenesis and impairs DNA damage repair pathways in mice.

Voisset E, Moravcsik E, Stratford EW, Jaye A, Palgrave CJ, Hills RK, Salomoni P, Kogan SC, Solomon E, Grimwade D.

Blood. 2018 Feb 8;131(6):636-648. doi: 10.1182/blood-2017-07-794784. Epub 2017 Nov 30.


Newfound sex differences in axonal structure underlie differential outcomes from in vitro traumatic axonal injury.

Dollé JP, Jaye A, Anderson SA, Ahmadzadeh H, Shenoy VB, Smith DH.

Exp Neurol. 2018 Feb;300:121-134. doi: 10.1016/j.expneurol.2017.11.001. Epub 2017 Nov 22.


The emerging threat of pre-extensively drug-resistant tuberculosis in West Africa: preparing for large-scale tuberculosis research and drug resistance surveillance.

Gehre F, Otu J, Kendall L, Forson A, Kwara A, Kudzawu S, Kehinde AO, Adebiyi O, Salako K, Baldeh I, Jallow A, Jallow M, Dagnra A, Dissé K, Kadanga EA, Idigbe EO, Onubogu C, Onyejepu N, Gaye-Diallo A, Ba-Diallo A, Rabna P, Mane M, Sanogo M, Diarra B, Dezemon Z, Sanou A, Senghore M, Kwambana-Adams BA, Demba E, Faal-Jawara T, Kumar S, Tientcheu LD, Jallow A, Ceesay S, Adetifa I, Jaye A, Pallen MJ, D'Alessandro U, Kampmann B, Adegbola RA, Mboup S, Corrah T, de Jong BC, Antonio M.

BMC Med. 2016 Nov 3;14(1):160.


Seasonal variation in haematological and biochemical reference values for healthy young children in The Gambia.

Okebe J, Mwesigwa J, Agbla SC, Sanya-Isijola F, Abubakar I, D'Alessandro U, Jaye A, Bojang K.

BMC Pediatr. 2016 Jan 11;16:5. doi: 10.1186/s12887-016-0545-6.


Elevated Hepcidin Is Part of a Complex Relation That Links Mortality with Iron Homeostasis and Anemia in Men and Women with HIV Infection.

Minchella PA, Armitage AE, Darboe B, Jallow MW, Drakesmith H, Jaye A, Prentice AM, McDermid JM.

J Nutr. 2015 Jun;145(6):1194-201. doi: 10.3945/jn.114.203158. Epub 2015 Apr 22.


Elevated hepcidin at HIV diagnosis is associated with incident tuberculosis in a retrospective cohort study.

Minchella PA, Armitage AE, Darboe B, Jallow MW, Drakesmith H, Jaye A, Prentice AM, McDermid JM.

Int J Tuberc Lung Dis. 2014 Nov;18(11):1337-9. doi: 10.5588/ijtld.14.0143.


Protection versus pathology in aviremic and high viral load HIV-2 infection-the pivotal role of immune activation and T-cell kinetics.

Hegedus A, Nyamweya S, Zhang Y, Govind S, Aspinall R, Mashanova A, Jansen VA, Whittle H, Jaye A, Flanagan KL, Macallan DC.

J Infect Dis. 2014 Sep 1;210(5):752-61. doi: 10.1093/infdis/jiu165. Epub 2014 May 5.


Use of Self-Reported Adherence and Keeping Clinic Appointments as Predictors of Viremia in Routine HIV Care in the Gambia.

Peterson K, Menten J, Peterson I, Togun T, Okomo U, Oko F, Corrah T, Jaye A, Colebunders R.

J Int Assoc Provid AIDS Care. 2015 Jul-Aug;14(4):343-7. doi: 10.1177/2325957413500344. Epub 2013 Aug 30.


Skewing of the CD4(+) T-cell pool toward monofunctional antigen-specific responses in patients with immune reconstitution inflammatory syndrome in The Gambia.

Wilson H, de Jong BC, Peterson K, Jaye A, Kampmann B, Ota MO, Sutherland JS.

Clin Infect Dis. 2013 Aug;57(4):594-603. doi: 10.1093/cid/cit285. Epub 2013 May 3.


Correlates of T-cell-mediated viral control and phenotype of CD8(+) T cells in HIV-2, a naturally contained human retroviral infection.

de Silva TI, Peng Y, Leligdowicz A, Zaidi I, Li L, Griffin H, Blais ME, Vincent T, Saraiva M, Yindom LM, van Tienen C, Easterbrook P, Jaye A, Whittle H, Dong T, Rowland-Jones SL.

Blood. 2013 May 23;121(21):4330-9. doi: 10.1182/blood-2012-12-472787. Epub 2013 Apr 4.


Comparing HIV-1 and HIV-2 infection: Lessons for viral immunopathogenesis.

Nyamweya S, Hegedus A, Jaye A, Rowland-Jones S, Flanagan KL, Macallan DC.

Rev Med Virol. 2013 Jul;23(4):221-40. doi: 10.1002/rmv.1739. Epub 2013 Feb 26. Review.


Host iron redistribution as a risk factor for incident tuberculosis in HIV infection: an 11-year retrospective cohort study.

McDermid JM, Hennig BJ, van der Sande M, Hill AV, Whittle HC, Jaye A, Prentice AM.

BMC Infect Dis. 2013 Jan 29;13:48. doi: 10.1186/1471-2334-13-48.


Effect of HIV-2 infection on HIV-1 disease progression.

Vannberg FO, McDermid JM, Jaye A; MRC Gambia HIV Clinical Cohort Study; Wellcome Trust Case Control Consortium 3.

N Engl J Med. 2012 Nov 15;367(20):1962; author reply 1962-3. doi: 10.1056/NEJMc1210334. No abstract available.


Population dynamics of HIV-2 in rural West Africa: comparison with HIV-1 and ongoing transmission at the heart of the epidemic.

de Silva TI, van Tienen C, Onyango C, Jabang A, Vincent T, Loeff MF, Coutinho RA, Jaye A, Rowland-Jones S, Whittle H, Cotten M, Hué S.

AIDS. 2013 Jan 2;27(1):125-34. doi: 10.1097/QAD.0b013e32835ab12c.


Mortality and loss to programme before antiretroviral therapy among HIV-infected children eligible for treatment in The Gambia, West Africa.

Okomo U, Togun T, Oko F, Peterson K, Jaye A.

AIDS Res Ther. 2012 Oct 2;9(1):28. doi: 10.1186/1742-6405-9-28.


Are plasma biomarkers of immune activation predictive of HIV progression: a longitudinal comparison and analyses in HIV-1 and HIV-2 infections?

Nyamweya S, Townend J, Zaman A, Steele SJ, Jeffries D, Rowland-Jones S, Whittle H, Flanagan KL, Jaye A.

PLoS One. 2012;7(9):e44411. doi: 10.1371/journal.pone.0044411. Epub 2012 Sep 10.


Epitope mapping of broadly neutralizing HIV-2 human monoclonal antibodies.

Kong R, Li H, Georgiev I, Changela A, Bibollet-Ruche F, Decker JM, Rowland-Jones SL, Jaye A, Guan Y, Lewis GK, Langedijk JP, Hahn BH, Kwong PD, Robinson JE, Shaw GM.

J Virol. 2012 Nov;86(22):12115-28. doi: 10.1128/JVI.01632-12. Epub 2012 Aug 29.


Treatment outcomes among HIV-1 and HIV-2 infected children initiating antiretroviral therapy in a concentrated low prevalence setting in West Africa.

Okomo U, Togun T, Oko F, Peterson K, Townend J, Peterson I, Jaye A.

BMC Pediatr. 2012 Jul 8;12:95. doi: 10.1186/1471-2431-12-95.


Immune reconstitution inflammatory syndrome and the influence of T regulatory cells: a cohort study in The Gambia.

Zaidi I, Peterson K, Jeffries D, Whittle H, de Silva T, Rowland-Jones S, Jaye A, de Jong BC.

PLoS One. 2012;7(6):e39213. doi: 10.1371/journal.pone.0039213. Epub 2012 Jun 20.


Immunological impact of an additional early measles vaccine in Gambian children: responses to a boost at 3 years.

Njie-Jobe J, Nyamweya S, Miles DJ, van der Sande M, Zaman S, Touray E, Hossin S, Adetifa J, Palmero M, Burl S, Jeffries D, Rowland-Jones S, Flanagan K, Jaye A, Whittle H.

Vaccine. 2012 Mar 28;30(15):2543-50. doi: 10.1016/j.vaccine.2012.01.083. Epub 2012 Feb 5.


Emergence of HBV resistance to lamivudine (3TC) in HIV/HBV co-infected patients in The Gambia, West Africa.

Stewart B, Jobarteh ML, Sarge-Njie R, Alabi A, de Silva T, Peterson K, Peterson I, Whittle H, Rowland-Jones S, Jaye A, Cotten M, Mendy M.

BMC Res Notes. 2011 Dec 23;4:561. doi: 10.1186/1756-0500-4-561.


Potent autologous and heterologous neutralizing antibody responses occur in HIV-2 infection across a broad range of infection outcomes.

de Silva TI, Aasa-Chapman M, Cotten M, Hué S, Robinson J, Bibollet-Ruche F, Sarge-Njie R, Berry N, Jaye A, Aaby P, Whittle H, Rowland-Jones S, Weiss R.

J Virol. 2012 Jan;86(2):930-46. doi: 10.1128/JVI.06126-11. Epub 2011 Nov 9.


Maternal proviral load and vertical transmission of human T cell lymphotropic virus type 1 in Guinea-Bissau.

van Tienen C, McConkey SJ, de Silva TI, Cotten M, Kaye S, Sarge-Njie R, da Costa C, Gonçalves N, Parker J, Vincent T, Jaye A, Aaby P, Whittle H, Schim van der Loeff M.

AIDS Res Hum Retroviruses. 2012 Jun;28(6):584-90. doi: 10.1089/AID.2011.0219. Epub 2012 Mar 9.


Mortality and immunovirological outcomes on antiretroviral therapy in HIV-1 and HIV-2-infected individuals in the Gambia.

Peterson I, Togun O, de Silva T, Oko F, Rowland-Jones S, Jaye A, Peterson K.

AIDS. 2011 Nov 13;25(17):2167-75. doi: 10.1097/QAD.0b013e32834c4adb.


Pre-treatment mortality and loss-to-follow-up in HIV-1, HIV-2 and HIV-1/HIV-2 dually infected patients eligible for antiretroviral therapy in The Gambia, West Africa.

Togun T, Peterson I, Jaffar S, Oko F, Okomo U, Peterson K, Jaye A.

AIDS Res Ther. 2011 Jul 20;8(1):24. doi: 10.1186/1742-6405-8-24.


Age-dependent maturation of Toll-like receptor-mediated cytokine responses in Gambian infants.

Burl S, Townend J, Njie-Jobe J, Cox M, Adetifa UJ, Touray E, Philbin VJ, Mancuso C, Kampmann B, Whittle H, Jaye A, Flanagan KL, Levy O.

PLoS One. 2011 Apr 13;6(4):e18185. doi: 10.1371/journal.pone.0018185.


Neurologic manifestations of human immunodeficiency virus-2: dementia, myelopathy, and neuropathy in West Africa.

Choi Y, Townend J, Vincent T, Zaidi I, Sarge-Njie R, Jaye A, Clifford DB.

J Neurovirol. 2011 Apr;17(2):166-75. doi: 10.1007/s13365-011-0022-9. Epub 2011 Mar 22.


Transmission of Armillifer armillatus ova at snake farm, The Gambia, West Africa.

Tappe D, Meyer M, Oesterlein A, Jaye A, Frosch M, Schoen C, Pantchev N.

Emerg Infect Dis. 2011 Feb;17(2):251-4. doi: 10.3201/eid1702.101118.


HIV-1 subtype distribution in the Gambia and the significant presence of CRF49_cpx, a novel circulating recombinant form.

de Silva TI, Turner R, Hué S, Trikha R, van Tienen C, Onyango C, Jaye A, Foley B, Whittle H, Rowland-Jones SL, Cotten M.

Retrovirology. 2010 Oct 9;7:82. doi: 10.1186/1742-4690-7-82.


CD4 intragenic SNPs associate with HIV-2 plasma viral load and CD4 count in a community-based study from Guinea-Bissau, West Africa.

Hennig BJ, Velez-Edwards DR, Schim van der Loeff MF, Bisseye C, Edwards TL, Tacconelli A, Novelli G, Aaby P, Kaye S, Scott WK, Jaye A, Whittle HC, Williams SM, Hill AV, Sirugo G.

J Acquir Immune Defic Syndr. 2011 Jan 1;56(1):1-8. doi: 10.1097/QAI.0b013e3181f638ed.


Seroprevalence of hepatitis B and C virus in HIV-1 and HIV-2 infected Gambians.

Jobarteh M, Malfroy M, Peterson I, Jeng A, Sarge-Njie R, Alabi A, Peterson K, Cotten M, Hall A, Rowland-Jones S, Whittle H, Tedder R, Jaye A, Mendy M.

Virol J. 2010 Sep 15;7:230. doi: 10.1186/1743-422X-7-230.


HTLV-1 in rural Guinea-Bissau: prevalence, incidence and a continued association with HIV between 1990 and 2007.

van Tienen C, van der Loeff MF, Peterson I, Cotten M, Holmgren B, Andersson S, Vincent T, Sarge-Njie R, Rowland-Jones S, Jaye A, Aaby P, Whittle H.

Retrovirology. 2010 Jun 4;7:50. doi: 10.1186/1742-4690-7-50.


Influence of HLA class I and HLA-KIR compound genotypes on HIV-2 infection and markers of disease progression in a Manjako community in West Africa.

Yindom LM, Leligdowicz A, Martin MP, Gao X, Qi Y, Zaman SM, van der Loeff MS, van Tienen C, Jaye A, Aveika A, Worwui A, Diatta M, Vincent T, Whittle HC, Rowland-Jones SL, Walton R, Carrington M.

J Virol. 2010 Aug;84(16):8202-8. doi: 10.1128/JVI.00116-10. Epub 2010 Jun 2.


HIV-2 capsids distinguish high and low virus load patients in a West African community cohort.

Onyango CO, Leligdowicz A, Yokoyama M, Sato H, Song H, Nakayama EE, Shioda T, de Silva T, Townend J, Jaye A, Whittle H, Rowland-Jones S, Cotten M.

Vaccine. 2010 May 26;28 Suppl 2:B60-7. doi: 10.1016/j.vaccine.2009.08.060.


NeuroAIDS in Africa.

Robertson K, Liner J, Hakim J, Sankalé JL, Grant I, Letendre S, Clifford D, Diop AG, Jaye A, Kanmogne G, Njamnshi A, Langford TD, Weyessa TG, Wood C, Banda M, Hosseinipour M, Sacktor N, Nakasuja N, Bangirana P, Paul R, Joska J, Wong J, Boivin M, Holding P, Kammerer B, Van Rie A, Ive P, Nath A, Lawler K, Adebamowo C, Royal W 3rd, Joseph J; NeuroAIDS in Africa Conference Participants.

J Neurovirol. 2010 May;16(3):189-202. doi: 10.3109/13550284.2010.489597. Review.


Undetectable plasma viral load predicts normal survival in HIV-2-infected people in a West African village.

van der Loeff MF, Larke N, Kaye S, Berry N, Ariyoshi K, Alabi A, van Tienen C, Leligdowicz A, Sarge-Njie R, da Silva Z, Jaye A, Ricard D, Vincent T, Jones SR, Aaby P, Jaffar S, Whittle H.

Retrovirology. 2010 May 19;7:46. doi: 10.1186/1742-4690-7-46.


Polyfunctional CD4(+) and CD8(+) T cell responses to tuberculosis antigens in HIV-1-infected patients before and after anti-retroviral treatment.

Sutherland JS, Young JM, Peterson KL, Sanneh B, Whittle HC, Rowland-Jones SL, Adegbola RA, Jaye A, Ota MO.

J Immunol. 2010 Jun 1;184(11):6537-44. doi: 10.4049/jimmunol.1000399. Epub 2010 Apr 30.


Highly avid, oligoclonal, early-differentiated antigen-specific CD8+ T cells in chronic HIV-2 infection.

Leligdowicz A, Onyango C, Yindom LM, Peng Y, Cotten M, Jaye A, McMichael A, Whittle H, Dong T, Rowland-Jones S.

Eur J Immunol. 2010 Jul;40(7):1963-72. doi: 10.1002/eji.200940295.


Direct relationship between virus load and systemic immune activation in HIV-2 infection.

Leligdowicz A, Feldmann J, Jaye A, Cotten M, Dong T, McMichael A, Whittle H, Rowland-Jones S.

J Infect Dis. 2010 Jan 1;201(1):114-22. doi: 10.1086/648733.


Two distinct epidemics: the rise of HIV-1 and decline of HIV-2 infection between 1990 and 2007 in rural Guinea-Bissau.

Tienen Cv, van der Loeff MS, Zaman SM, Vincent T, Sarge-Njie R, Peterson I, Leligdowicz A, Jaye A, Rowland-Jones S, Aaby P, Whittle H.

J Acquir Immune Defic Syndr. 2010 Apr;53(5):640-7. doi: 10.1097/QAI.0b013e3181bf1a25.


Downregulation of the T-cell receptor by human immunodeficiency virus type 2 Nef does not protect against disease progression.

Feldmann J, Leligdowicz A, Jaye A, Dong T, Whittle H, Rowland-Jones SL.

J Virol. 2009 Dec;83(24):12968-72. doi: 10.1128/JVI.01252-09. Epub 2009 Oct 7.


Ultrafast Electronic and Vibrational Dynamics of Stabilized A State Mutants of the Green Fluorescent Protein (GFP): Snipping the Proton Wire.

Stoner-Ma D, Jaye AA, Ronayne KL, Nappa J, Tonge PJ, Meech SR.

Chem Phys. 2008 Jun 23;350(1-3):193-200.


Mortality in HIV infection is independently predicted by host iron status and SLC11A1 and HP genotypes, with new evidence of a gene-nutrient interaction.

McDermid JM, van der Loeff MF, Jaye A, Hennig BJ, Bates C, Todd J, Sirugo G, Hill AV, Whittle HC, Prentice AM.

Am J Clin Nutr. 2009 Jul;90(1):225-33. doi: 10.3945/ajcn.2009.27709. Epub 2009 May 27.


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