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Items: 28


Rab46 integrates Ca2+ and histamine signaling to regulate selective cargo release from Weibel-Palade bodies.

Miteva KT, Pedicini L, Wilson LA, Jayasinghe I, Slip RG, Marszalek K, Gaunt HJ, Bartoli F, Deivasigamani S, Sobradillo D, Beech DJ, McKeown L.

J Cell Biol. 2019 May 15. pii: jcb.201810118. doi: 10.1083/jcb.201810118. [Epub ahead of print]


Three-Dimensional and Chemical Mapping of Intracellular Signaling Nanodomains in Health and Disease with Enhanced Expansion Microscopy.

Sheard TMD, Hurley ME, Colyer J, White E, Norman R, Pervolaraki E, Narayanasamy KK, Hou Y, Kirton HM, Yang Z, Hunter L, Shim JU, Clowsley AH, Smith AJ, Baddeley D, Soeller C, Colman MA, Jayasinghe I.

ACS Nano. 2019 Feb 26;13(2):2143-2157. doi: 10.1021/acsnano.8b08742. Epub 2019 Feb 8.


Shining New Light on the Structural Determinants of Cardiac Couplon Function: Insights From Ten Years of Nanoscale Microscopy.

Jayasinghe I, Clowsley AH, de Langen O, Sali SS, Crossman DJ, Soeller C.

Front Physiol. 2018 Oct 22;9:1472. doi: 10.3389/fphys.2018.01472. eCollection 2018. Review.


Many pitfalls in diagnosis of acute intermittent porphyria: a case report.

Indika NLR, Kesavan T, Dilanthi HW, Jayasena KLSPKM, Chandrasiri NDPD, Jayasinghe IN, Piumika UMT, Vidanapathirana DM, Gunarathne KDAV, Dissanayake M, Jasinge E, Arachchi WK, Doheny D, Desnick RJ.

BMC Res Notes. 2018 Aug 2;11(1):552. doi: 10.1186/s13104-018-3615-z.


True Molecular Scale Visualization of Variable Clustering Properties of Ryanodine Receptors.

Jayasinghe I, Clowsley AH, Lin R, Lutz T, Harrison C, Green E, Baddeley D, Di Michele L, Soeller C.

Cell Rep. 2018 Jan 9;22(2):557-567. doi: 10.1016/j.celrep.2017.12.045.


Correlative Single-Molecule Localization Microscopy and Confocal Microscopy.

Soeller C, Hou Y, Jayasinghe ID, Baddeley D, Crossman D.

Methods Mol Biol. 2017;1663:205-217. doi: 10.1007/978-1-4939-7265-4_17.


Sweet rebellion: a campaign for a sugar-sweetened beverage tax in New Zealand.

Parmenter T, Jordan C, Jayasinghe I.

N Z Med J. 2017 Sep 1;130(1461):78-80. No abstract available.


Algorithmic corrections for localization microscopy with sCMOS cameras - characterisation of a computationally efficient localization approach.

Lin R, Clowsley AH, Jayasinghe ID, Baddeley D, Soeller C.

Opt Express. 2017 May 15;25(10):11701-11716. doi: 10.1364/OE.25.011701.


Transverse tubule remodelling: a cellular pathology driven by both sides of the plasmalemma?

Crossman DJ, Jayasinghe ID, Soeller C.

Biophys Rev. 2017 Dec;9(6):919-929. doi: 10.1007/s12551-017-0273-7. Epub 2017 Jul 10. Review.


Human skeletal muscle plasmalemma alters its structure to change its Ca2+-handling following heavy-load resistance exercise.

Cully TR, Murphy RM, Roberts L, Raastad T, Fassett RG, Coombes JS, Jayasinghe ID, Launikonis BS.

Nat Commun. 2017 Feb 13;8:14266. doi: 10.1038/ncomms14266.


Junctophilin-2 in the nanoscale organisation and functional signalling of ryanodine receptor clusters in cardiomyocytes.

Munro ML, Jayasinghe ID, Wang Q, Quick A, Wang W, Baddeley D, Wehrens XH, Soeller C.

J Cell Sci. 2016 Dec 1;129(23):4388-4398. Epub 2016 Oct 21.


Revealing T-Tubules in Striated Muscle with New Optical Super-Resolution Microscopy Techniquess.

Jayasinghe ID, Clowsley AH, Munro M, Hou Y, Crossman DJ, Soeller C.

Eur J Transl Myol. 2014 Dec 24;25(1):4747. doi: 10.4081/ejtm.2015.4747. eCollection 2015 Jan 7. Review.


Combining confocal and single molecule localisation microscopy: A correlative approach to multi-scale tissue imaging.

Crossman DJ, Hou Y, Jayasinghe I, Baddeley D, Soeller C.

Methods. 2015 Oct 15;88:98-108. doi: 10.1016/j.ymeth.2015.03.011. Epub 2015 Mar 24.


Nanoscale analysis of ryanodine receptor clusters in dyadic couplings of rat cardiac myocytes.

Hou Y, Jayasinghe I, Crossman DJ, Baddeley D, Soeller C.

J Mol Cell Cardiol. 2015 Mar;80:45-55. doi: 10.1016/j.yjmcc.2014.12.013. Epub 2014 Dec 20.


Observation of the molecular organization of calcium release sites in fast- and slow-twitch skeletal muscle with nanoscale imaging.

Jayasinghe ID, Munro M, Baddeley D, Launikonis BS, Soeller C.

J R Soc Interface. 2014 Oct 6;11(99). pii: 20140570. doi: 10.1098/rsif.2014.0570.


Super-resolution fluorescence imaging to study cardiac biophysics: α-actinin distribution and Z-disk topologies in optically thick cardiac tissue slices.

Hou Y, Crossman DJ, Rajagopal V, Baddeley D, Jayasinghe I, Soeller C.

Prog Biophys Mol Biol. 2014 Aug;115(2-3):328-39. doi: 10.1016/j.pbiomolbio.2014.07.003. Epub 2014 Jul 18.


Three-dimensional reconstruction and analysis of the tubular system of vertebrate skeletal muscle.

Jayasinghe ID, Launikonis BS.

J Cell Sci. 2013 Sep 1;126(Pt 17):4048-58. doi: 10.1242/jcs.131565. Epub 2013 Jun 26.


Examination of the subsarcolemmal tubular system of mammalian skeletal muscle fibers.

Jayasinghe ID, Lo HP, Morgan GP, Baddeley D, Parton RG, Soeller C, Launikonis BS.

Biophys J. 2013 Jun 4;104(11):L19-21. doi: 10.1016/j.bpj.2013.04.029.


Nanoscale organization of junctophilin-2 and ryanodine receptors within peripheral couplings of rat ventricular cardiomyocytes.

Jayasinghe ID, Baddeley D, Kong CH, Wehrens XH, Cannell MB, Soeller C.

Biophys J. 2012 Mar 7;102(5):L19-21. doi: 10.1016/j.bpj.2012.01.034. Epub 2012 Mar 6.


Comparison of the organization of T-tubules, sarcoplasmic reticulum and ryanodine receptors in rat and human ventricular myocardium.

Jayasinghe I, Crossman Dj, Soeller C, Cannell M.

Clin Exp Pharmacol Physiol. 2012 May;39(5):469-76. doi: 10.1111/j.1440-1681.2011.05578.x.


4D super-resolution microscopy with conventional fluorophores and single wavelength excitation in optically thick cells and tissues.

Baddeley D, Crossman D, Rossberger S, Cheyne JE, Montgomery JM, Jayasinghe ID, Cremer C, Cannell MB, Soeller C.

PLoS One. 2011;6(5):e20645. doi: 10.1371/journal.pone.0020645. Epub 2011 May 31.


A new twist in cardiac muscle: dislocated and helicoid arrangements of myofibrillar z-disks in mammalian ventricular myocytes.

Jayasinghe ID, Crossman DJ, Soeller C, Cannell MB.

J Mol Cell Cardiol. 2010 May;48(5):964-71. doi: 10.1016/j.yjmcc.2009.12.012. Epub 2010 Jan 4.


Optical single-channel resolution imaging of the ryanodine receptor distribution in rat cardiac myocytes.

Baddeley D, Jayasinghe ID, Lam L, Rossberger S, Cannell MB, Soeller C.

Proc Natl Acad Sci U S A. 2009 Dec 29;106(52):22275-80. doi: 10.1073/pnas.0908971106. Epub 2009 Dec 15.


Organization of ryanodine receptors, transverse tubules, and sodium-calcium exchanger in rat myocytes.

Jayasinghe ID, Cannell MB, Soeller C.

Biophys J. 2009 Nov 18;97(10):2664-73. doi: 10.1016/j.bpj.2009.08.036.


Light-induced dark states of organic fluochromes enable 30 nm resolution imaging in standard media.

Baddeley D, Jayasinghe ID, Cremer C, Cannell MB, Soeller C.

Biophys J. 2009 Jan;96(2):L22-4. doi: 10.1016/j.bpj.2008.11.002.


Three-dimensional high-resolution imaging of cardiac proteins to construct models of intracellular Ca2+ signalling in rat ventricular myocytes.

Soeller C, Jayasinghe ID, Li P, Holden AV, Cannell MB.

Exp Physiol. 2009 May;94(5):496-508. doi: 10.1113/expphysiol.2008.043976. Epub 2009 Jan 12.


Deployable laboratory response to emergence of melioidosis in central Sri Lanka.

Inglis TJ, Merritt A, Montgomery J, Jayasinghe I, Thevanesam V, McInnes R.

J Clin Microbiol. 2008 Oct;46(10):3479-81. doi: 10.1128/JCM.01254-08. Epub 2008 Aug 20.


Clinical case study: pediatric residents' discussions of and interventions for children's behavioral and emotional problems.

Applegate H, Kelley ML, Applegate BW, Jayasinghe IK, Venters CL.

J Pediatr Psychol. 2003 Jul-Aug;28(5):315-21.


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