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Items: 1 to 50 of 156

1.

Evidence Favoring a Positive Feedback Loop for Physiologic Auto Upregulation of hnRNP-E1 during Prolonged Folate Deficiency in Human Placental Cells.

Tang YS, Khan RA, Xiao S, Hansen DK, Stabler SP, Kusumanchi P, Jayaram HN, Antony AC.

J Nutr. 2017 Apr;147(4):482-498. doi: 10.3945/jn.116.241364. Epub 2017 Mar 1.

2.

From the covalent linkage of drugs to novel inhibitors of ribonucleotide reductase: synthesis and biological evaluation of valproic esters of 3'-C-methyladenosine.

Petrelli R, Meli M, Vita P, Torquati I, Ferro A, Vodnala M, D'Alessandro N, Tolomeo M, Del Bello F, Kusumanchi P, Franchetti P, Grifantini M, Jayaram HN, Hofer A, Cappellacci L.

Bioorg Med Chem Lett. 2014 Nov 15;24(22):5304-9. doi: 10.1016/j.bmcl.2014.09.046. Epub 2014 Sep 28.

PMID:
25304896
3.

Serum one-carbon metabolites and risk of cervical cancer.

Pathak S, Bajpai D, Banerjee A, Bhatla N, Jain SK, Jayaram HN, Singh N.

Nutr Cancer. 2014;66(5):818-24. doi: 10.1080/01635581.2014.916318. Epub 2014 May 21.

PMID:
24848140
4.

Nicotinamide mononucleotide adenylyltransferase2 overexpression enhances colorectal cancer cell-kill by Tiazofurin.

Kusumanchi P, Zhang Y, Jani MB, Jayaram NH, Khan RA, Tang Y, Antony AC, Jayaram HN.

Cancer Gene Ther. 2013 Jul;20(7):403-12. doi: 10.1038/cgt.2013.33. Epub 2013 Jun 14.

PMID:
23764899
5.

Variability of apoptosis and response in N1-S1 rodent hepatomas to benzamide riboside and correlation to early changes in water apparent diffusion coefficient and sodium MR imaging.

Faramarzalian A, McLennan G, Bennett SL, Babsky A, Bansal N, Lieber M, Bonnac L, Pankiewicz K, Jayaram HN.

J Vasc Interv Radiol. 2013 Jun;24(6):894-900. doi: 10.1016/j.jvir.2013.02.011. Epub 2013 Apr 6.

PMID:
23566523
6.

Influence of physiologic folate deficiency on human papillomavirus type 16 (HPV16)-harboring human keratinocytes in vitro and in vivo.

Xiao S, Tang YS, Khan RA, Zhang Y, Kusumanchi P, Stabler SP, Jayaram HN, Antony AC.

J Biol Chem. 2012 Apr 6;287(15):12559-77. doi: 10.1074/jbc.M111.317040. Epub 2012 Feb 17.

7.

Cloning, expression and characterization of mouse (Mus musculus) nicotinamide 5'-mononucleotide adenylyltransferase-2.

Raches DW, Xiao S, Kusumanchi P, Yalowitz J, Sanghani P, Long EC, Antony AC, Jayaram HN.

Med Chem. 2011 Nov;7(6):718-26.

PMID:
22313312
8.

Incrimination of heterogeneous nuclear ribonucleoprotein E1 (hnRNP-E1) as a candidate sensor of physiological folate deficiency.

Tang YS, Khan RA, Zhang Y, Xiao S, Wang M, Hansen DK, Jayaram HN, Antony A.

J Biol Chem. 2011 Nov 11;286(45):39100-15. doi: 10.1074/jbc.M111.230938. Epub 2011 Sep 19.

9.

Predicting response to benzamide riboside chemotherapy in hepatocellular carcinoma using apparent diffusion coefficient of water.

Babsky AM, Ju S, George B, Bennett S, Huang M, Jayaram HN, McLennan G, Bansal N.

Anticancer Res. 2011 Jun;31(6):2045-51.

PMID:
21737621
10.

NMNAT expression and its relation to NAD metabolism.

Jayaram HN, Kusumanchi P, Yalowitz JA.

Curr Med Chem. 2011;18(13):1962-72. Review.

PMID:
21517776
11.

Tumor response and apoptosis of N1-S1 rodent hepatomas in response to intra-arterial and intravenous benzamide riboside.

McLennan G, Bennett SL, Ju S, Babsky A, Bansal N, Shorten ML, Levitin S, Bonnac L, Panciewicz KW, Jayaram HN.

Cardiovasc Intervent Radiol. 2012 Jun;35(3):645-52. doi: 10.1007/s00270-011-0140-z. Epub 2011 Mar 24.

PMID:
21431971
12.

Synthesis and biological activity of novel N6-substituted and 2,N6-disubstituted adenine ribo- and 3'-C-methyl-ribonucleosides as antitumor agents.

Cappellacci L, Petrelli R, Franchetti P, Vita P, Kusumanchi P, Kumar M, Jayaram HN, Zhou B, Yen Y, Grifantini M.

Eur J Med Chem. 2011 May;46(5):1499-504. doi: 10.1016/j.ejmech.2011.01.055. Epub 2011 Feb 3.

PMID:
21349610
13.

Cofactor-type inhibitors of inosine monophosphate dehydrogenase via modular approach: targeting the pyrophosphate binding sub-domain.

Felczak K, Chen L, Wilson D, Williams J, Vince R, Petrelli R, Jayaram HN, Kusumanchi P, Kumar M, Pankiewicz KW.

Bioorg Med Chem. 2011 Mar 1;19(5):1594-605. doi: 10.1016/j.bmc.2011.01.042. Epub 2011 Jan 27.

PMID:
21324702
14.

Dual inhibitors of inosine monophosphate dehydrogenase and histone deacetylase based on a cinnamic hydroxamic acid core structure.

Chen L, Petrelli R, Gao G, Wilson DJ, McLean GT, Jayaram HN, Sham YY, Pankiewicz KW.

Bioorg Med Chem. 2010 Aug 15;18(16):5950-64. doi: 10.1016/j.bmc.2010.06.081. Epub 2010 Jul 1.

PMID:
20650640
15.

Apoptotic signaling induced by benzamide riboside: an in vitro study.

Pathak S, Sharma C, Jayaram HN, Singh N.

Mol Cell Biochem. 2009 Aug;328(1-2):67-73. doi: 10.1007/s11010-009-0075-8. Epub 2009 Mar 5.

PMID:
19262994
16.

Effects of WY-14,643 on the phosphorylation and activation of AMP-dependent protein kinase.

Liangpunsakul S, Wou SE, Wineinger KD, Zeng Y, Cyganek I, Jayaram HN, Crabb DW.

Arch Biochem Biophys. 2009 May 1;485(1):10-5. doi: 10.1016/j.abb.2009.02.006. Epub 2009 Feb 21.

17.

Technical aspects of imaging and transfemoral arterial treatment of N1-S1 tumors in rats: an appropriate model to test the biology and therapeutic response to transarterial treatments of liver cancers.

Ju S, McLennan G, Bennett SL, Liang Y, Bonnac L, Pankiewicz KW, Jayaram HN.

J Vasc Interv Radiol. 2009 Mar;20(3):410-4. doi: 10.1016/j.jvir.2008.12.408. Epub 2009 Jan 23.

PMID:
19167243
18.

Can targeting organic anion transporter polypeptide (OATP) genes play a key role in drug therapy?

Jayaram HN, Kusumanchi P.

Cancer Biol Ther. 2008 Sep;7(9):1456-9. Epub 2008 Sep 3. No abstract available.

PMID:
18836293
19.

Effect of ethanol on hydrogen peroxide-induced AMPK phosphorylation.

Liangpunsakul S, Wou SE, Zeng Y, Ross RA, Jayaram HN, Crabb DW.

Am J Physiol Gastrointest Liver Physiol. 2008 Dec;295(6):G1173-81. doi: 10.1152/ajpgi.90349.2008. Epub 2008 Oct 2.

20.

Mycophenolic acid analogs with a modified metabolic profile.

Chen L, Wilson DJ, Labello NP, Jayaram HN, Pankiewicz KW.

Bioorg Med Chem. 2008 Oct 15;16(20):9340-5. doi: 10.1016/j.bmc.2008.08.062. Epub 2008 Aug 29.

PMID:
18809333
21.

Ribose-modified purine nucleosides as ribonucleotide reductase inhibitors. Synthesis, antitumor activity, and molecular modeling of N6-substituted 3'-C-methyladenosine derivatives.

Cappellacci L, Franchetti P, Vita P, Petrelli R, Lavecchia A, Jayaram HN, Saiko P, Graser G, Szekeres T, Grifantini M.

J Med Chem. 2008 Jul 24;51(14):4260-9. doi: 10.1021/jm800205c. Epub 2008 Jun 28.

PMID:
18588281
22.

Efficient synthesis of benzamide riboside, a potential anticancer agent.

Bonnac LF, Gao GY, Chen L, Patterson SE, Jayaram HN, Pankiewicz KW.

Nucleosides Nucleotides Nucleic Acids. 2007;26(10-12):1249-53.

PMID:
18066762
23.

Dual inhibitors of inosine monophosphate dehydrogenase and histone deacetylases for cancer treatment.

Chen L, Wilson D, Jayaram HN, Pankiewicz KW.

J Med Chem. 2007 Dec 27;50(26):6685-91. Epub 2007 Nov 27.

PMID:
18038969
24.

Probing binding requirements of type I and type II isoforms of inosine monophosphate dehydrogenase with adenine-modified nicotinamide adenine dinucleotide analogues.

Chen L, Gao G, Felczak K, Bonnac L, Patterson SE, Wilson D, Bennett EM, Jayaram HN, Hedstrom L, Pankiewicz KW.

J Med Chem. 2007 Nov 15;50(23):5743-51. Epub 2007 Oct 24.

PMID:
17958343
25.

Methylenebis(sulfonamide) linked nicotinamide adenine dinucleotide analogue as an inosine monophosphate dehydrogenase inhibitor.

Chen L, Gao G, Bonnac L, Wilson DJ, Bennett EM, Jayaram HN, Pankiewicz KW.

Bioorg Med Chem Lett. 2007 Jun 1;17(11):3152-5. Epub 2007 Mar 15.

PMID:
17395461
26.

Novel methylenephosphophosphonate analogues of mycophenolic adenine dinucleotide. Inhibition of inosine monophosphate dehydrogenase.

Rejman D, Olesiak M, Chen L, Patterson SE, Wilson D, Jayaram HN, Hedstrom L, Pankiewicz KW.

J Med Chem. 2006 Aug 10;49(16):5018-22.

PMID:
16884314
27.

The effect of benzamide riboside on the VX2 model of liver cancer in rabbits.

McLennan G, Cressman EN, Xu Y, Zhang D, Jagtap MR, Jayaram HN.

J Vasc Interv Radiol. 2005 Nov;16(11):1499-504.

PMID:
16319157
28.

Antitumor activity of C-methyl-beta-D-ribofuranosyladenine nucleoside ribonucleotide reductase inhibitors.

Franchetti P, Cappellacci L, Pasqualini M, Petrelli R, Vita P, Jayaram HN, Horvath Z, Szekeres T, Grifantini M.

J Med Chem. 2005 Jul 28;48(15):4983-9.

PMID:
16033277
29.

Synthesis, conformational analysis, and biological activity of new analogues of thiazole-4-carboxamide adenine dinucleotide (TAD) as IMP dehydrogenase inhibitors.

Franchetti P, Cappellacci L, Pasqualini M, Petrelli R, Jayaprakasan V, Jayaram HN, Boyd DB, Jain MD, Grifantini M.

Bioorg Med Chem. 2005 Mar 15;13(6):2045-53.

PMID:
15727858
30.

Maternal folate deficiency results in selective upregulation of folate receptors and heterogeneous nuclear ribonucleoprotein-E1 associated with multiple subtle aberrations in fetal tissues.

Xiao S, Hansen DK, Horsley ET, Tang YS, Khan RA, Stabler SP, Jayaram HN, Antony AC.

Birth Defects Res A Clin Mol Teratol. 2005 Jan;73(1):6-28.

PMID:
15641086
31.

Role of human nucleoside transporters in the cellular uptake of two inhibitors of IMP dehydrogenase, tiazofurin and benzamide riboside.

Damaraju VL, Visser F, Zhang J, Mowles D, Ng AM, Young JD, Jayaram HN, Cass CE.

Mol Pharmacol. 2005 Jan;67(1):273-9. Epub 2004 Oct 14.

PMID:
15486050
32.
33.

Benzamide riboside induced mitochondrial mediated apoptosis in human lung cancer H520 cells.

Khanna N, Jayaram HN, Singh N.

Life Sci. 2004 May 28;75(2):179-90.

PMID:
15120570
34.

Cofactor mimics as selective inhibitors of NAD-dependent inosine monophosphate dehydrogenase (IMPDH)--the major therapeutic target.

Pankiewicz KW, Patterson SE, Black PL, Jayaram HN, Risal D, Goldstein BM, Stuyver LJ, Schinazi RF.

Curr Med Chem. 2004 Apr;11(7):887-900. Review.

PMID:
15083807
35.

Translational upregulation of folate receptors is mediated by homocysteine via RNA-heterogeneous nuclear ribonucleoprotein E1 interactions.

Antony A, Tang YS, Khan RA, Biju MP, Xiao X, Li QJ, Sun XL, Jayaram HN, Stabler SP.

J Clin Invest. 2004 Jan;113(2):285-301.

36.

A new tiazofurin pronucleotide: synthesis and biological evaluation of cyclosaligenyl-tiazofurin monophosphate.

Cappellacci L, Barboni G, Franchetti P, Martini C, Jayaram HN, Grifantini M.

Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):869-72.

PMID:
14565299
37.

Characterization of human brain nicotinamide 5'-mononucleotide adenylyltransferase-2 and expression in human pancreas.

Yalowitz JA, Xiao S, Biju MP, Antony AC, Cummings OW, Deeg MA, Jayaram HN.

Biochem J. 2004 Jan 15;377(Pt 2):317-26.

38.
39.

Cytotoxicity and cellular differentiation activity of methylenebis(phosphonate) analogs of tiazofurin and mycophenolic acid adenine dinucleotide in human cancer cell lines.

Yalowitz JA, Pankiewicz K, Patterson SE, Jayaram HN.

Cancer Lett. 2002 Jul 8;181(1):31-8. Erratum in: Cancer Lett. 2003 Sep 10;199(1):107-8.

PMID:
12430176
40.

Toxicity and efficacy of benzamide riboside in cancer chemotherapy models.

Jayaram HN, Yalowitz JA, Arguello F, Greene JF Jr.

Curr Med Chem. 2002 Apr;9(7):787-92. Review.

PMID:
11966443
41.

Modulation of cytotoxicity of benzamide riboside by expression of NMN adenylyltransferase.

Yalowitz JA, Jayaram HN.

Curr Med Chem. 2002 Apr;9(7):749-58. Review.

PMID:
11966438
42.

Studies on the mechanism of action of benzamide riboside: a novel inhibitor of IMP dehydrogenase.

Gharehbaghi K, Grünberger W, Jayaram HN.

Curr Med Chem. 2002 Apr;9(7):743-8.

PMID:
11966437
43.

The chemistry of nicotinamide adenine dinucleotide (NAD) analogues containing C-nucleosides related to nicotinamide riboside.

Pankiewicz KW, Watanabe KA, Lesiak-Watanabe K, Goldstein BM, Jayaram HN.

Curr Med Chem. 2002 Apr;9(7):733-41.

PMID:
11966436
44.

Maintenance of ATP favours apoptosis over necrosis triggered by benzamide riboside.

Grusch M, Polgar D, Gfatter S, Leuhuber K, Huettenbrenner S, Leisser C, Fuhrmann G, Kassie F, Steinkellner H, Smid K, Peters GJ, Jayaram HN, Klepal W, Szekeres T, Knasmüller S, Krupitza G.

Cell Death Differ. 2002 Feb;9(2):169-78.

45.

Novel mycophenolic adenine bis(phosphonate) analogues as potential differentiation agents against human leukemia.

Pankiewicz KW, Lesiak-Watanabe KB, Watanabe KA, Patterson SE, Jayaram HN, Yalowitz JA, Miller MD, Seidman M, Majumdar A, Prehna G, Goldstein BM.

J Med Chem. 2002 Jan 31;45(3):703-12.

PMID:
11806722
46.

Metabolism and disposition of the novel antileukaemic drug, benzamide riboside, in the isolated perfused rat liver.

Salamon A, Hagenauer B, Thalhammer T, Szekeres T, Krohn K, Jayaram HN, Jäger W.

Life Sci. 2001 Oct 12;69(21):2489-502.

PMID:
11693257
47.

Isolation and characterization of a folate receptor mRNA-binding trans-factor from human placenta. Evidence favoring identity with heterogeneous nuclear ribonucleoprotein E1.

Xiao X, Tang YS, Mackins JY, Sun XL, Jayaram HN, Hansen DK, Antony AC.

J Biol Chem. 2001 Nov 2;276(44):41510-7. Epub 2001 Aug 29.

48.

Antitumor activity of benzamide riboside and its combination with cisplatin and staurosporine.

Rauko P, Novotny L, Dovinova I, Hunakova L, Szekeres T, Jayaram HN.

Eur J Pharm Sci. 2001 Feb;12(4):387-94.

PMID:
11231105
49.

Synthesis, conformational analysis, and biological activity of C-thioribonucleosides related to tiazofurin.

Franchetti P, Marchetti S, Cappellacci L, Jayaram HN, Yalowitz JA, Goldstein BM, Barascut JL, Dukhan D, Imbach JL, Grifantini M.

J Med Chem. 2000 Apr 6;43(7):1264-70.

PMID:
10753464
50.

A new C-nucleoside analogue of tiazofurin: synthesis and biological evaluation of 2-beta-D-ribofuranosylimidazole-4-carboxamide (imidazofurin).

Franchetti P, Marchetti S, Cappellacci L, Yalowitz JA, Jayaram HN, Goldstein BM, Grifantini M.

Bioorg Med Chem Lett. 2001 Jan 8;11(1):67-9.

PMID:
11140736

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