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Items: 18


Identifying Drugs that Bind Selectively to Intersubunit General Anesthetic Sites in the α1β3γ2 GABAAR Transmembrane Domain.

Jayakar SS, Zhou X, Chiara DC, Jarava-Barrera C, Savechenkov PY, Bruzik KS, Tortosa M, Miller KW, Cohen JB.

Mol Pharmacol. 2019 Jun;95(6):615-628. doi: 10.1124/mol.118.114975. Epub 2019 Apr 5.


Inhibitable photolabeling by neurosteroid diazirine analog in the β3-Subunit of human hetereopentameric type A GABA receptors.

Wu B, Jayakar SS, Zhou X, Titterton K, Chiara DC, Szabo AL, Savechenkov PY, Kent DE, Cohen JB, Forman SA, Miller KW, Bruzik KS.

Eur J Med Chem. 2019 Jan 15;162:810-824. doi: 10.1016/j.ejmech.2018.11.019. Epub 2018 Nov 19.


Etomidate and Etomidate Analog Binding and Positive Modulation of γ-Aminobutyric Acid Type A Receptors: Evidence for a State-dependent Cutoff Effect.

McGrath M, Yu Z, Jayakar SS, Ma C, Tolia M, Zhou X, Miller KW, Cohen JB, Raines DE.

Anesthesiology. 2018 Nov;129(5):959-969. doi: 10.1097/ALN.0000000000002356.


Competitive Antagonism of Anesthetic Action at the γ-Aminobutyric Acid Type A Receptor by a Novel Etomidate Analog with Low Intrinsic Efficacy.

Ma C, Pejo E, McGrath M, Jayakar SS, Zhou X, Miller KW, Cohen JB, Raines DE.

Anesthesiology. 2017 Nov;127(5):824-837. doi: 10.1097/ALN.0000000000001840.


Photoaffinity Labeling of Pentameric Ligand-Gated Ion Channels: A Proteomic Approach to Identify Allosteric Modulator Binding Sites.

Jayakar SS, Ang G, Chiara DC, Hamouda AK.

Methods Mol Biol. 2017;1598:157-197. doi: 10.1007/978-1-4939-6952-4_7.


Orthosteric and Allosteric Ligands of Nicotinic Acetylcholine Receptors for Smoking Cessation.

Mohamed TS, Jayakar SS, Hamouda AK.

Front Mol Neurosci. 2015 Nov 25;8:71. doi: 10.3389/fnmol.2015.00071. eCollection 2015. Review.


Positive and Negative Allosteric Modulation of an α1β3γ2 γ-Aminobutyric Acid Type A (GABAA) Receptor by Binding to a Site in the Transmembrane Domain at the γ+-β- Interface.

Jayakar SS, Zhou X, Savechenkov PY, Chiara DC, Desai R, Bruzik KS, Miller KW, Cohen JB.

J Biol Chem. 2015 Sep 18;290(38):23432-46. doi: 10.1074/jbc.M115.672006. Epub 2015 Jul 30.


PACAP induces plasticity at autonomic synapses by nAChR-dependent NOS1 activation and AKAP-mediated PKA targeting.

Jayakar SS, Pugh PC, Dale Z, Starr ER, Cole S, Margiotta JF.

Mol Cell Neurosci. 2014 Nov;63:1-12. doi: 10.1016/j.mcn.2014.08.007. Epub 2014 Aug 25.


Multiple propofol-binding sites in a γ-aminobutyric acid type A receptor (GABAAR) identified using a photoreactive propofol analog.

Jayakar SS, Zhou X, Chiara DC, Dostalova Z, Savechenkov PY, Bruzik KS, Dailey WP, Miller KW, Eckenhoff RG, Cohen JB.

J Biol Chem. 2014 Oct 3;289(40):27456-68. doi: 10.1074/jbc.M114.581728. Epub 2014 Aug 1.


Photoaffinity labeling of nicotinic receptors: diversity of drug binding sites!

Hamouda AK, Jayakar SS, Chiara DC, Cohen JB.

J Mol Neurosci. 2014 Jul;53(3):480-6. doi: 10.1007/s12031-013-0150-1. Epub 2013 Oct 26. Review.


Specificity of intersubunit general anesthetic-binding sites in the transmembrane domain of the human α1β3γ2 γ-aminobutyric acid type A (GABAA) receptor.

Chiara DC, Jayakar SS, Zhou X, Zhang X, Savechenkov PY, Bruzik KS, Miller KW, Cohen JB.

J Biol Chem. 2013 Jul 5;288(27):19343-57. doi: 10.1074/jbc.M113.479725. Epub 2013 May 15.


Identification of propofol binding sites in a nicotinic acetylcholine receptor with a photoreactive propofol analog.

Jayakar SS, Dailey WP, Eckenhoff RG, Cohen JB.

J Biol Chem. 2013 Mar 1;288(9):6178-89. doi: 10.1074/jbc.M112.435909. Epub 2013 Jan 8.


Kinetic modeling and scale up of lipoic acid (LA) production from Saccharomyces cerevisiae in a stirred tank bioreactor.

Jayakar SS, Singhal RS.

Bioprocess Biosyst Eng. 2013 Aug;36(8):1063-70. doi: 10.1007/s00449-012-0859-1. Epub 2012 Nov 24.


Mapping general anesthetic binding site(s) in human α1β3 γ-aminobutyric acid type A receptors with [³H]TDBzl-etomidate, a photoreactive etomidate analogue.

Chiara DC, Dostalova Z, Jayakar SS, Zhou X, Miller KW, Cohen JB.

Biochemistry. 2012 Jan 31;51(4):836-47. doi: 10.1021/bi201772m. Epub 2012 Jan 23.


Abelson family tyrosine kinases regulate the function of nicotinic acetylcholine receptors and nicotinic synapses on autonomic neurons.

Jayakar SS, Margiotta JF.

Mol Pharmacol. 2011 Jul;80(1):97-109. doi: 10.1124/mol.111.071308. Epub 2011 Apr 18.


PACAP/PAC1R signaling modulates acetylcholine release at neuronal nicotinic synapses.

Pugh PC, Jayakar SS, Margiotta JF.

Mol Cell Neurosci. 2010 Feb;43(2):244-57. doi: 10.1016/j.mcn.2009.11.007. Epub 2009 Dec 1.


Depolarization promotes survival of ciliary ganglion neurons by BDNF-dependent and -independent mechanisms.

Pugh PC, Zhou X, Jayakar SS, Margiotta JF.

Dev Biol. 2006 Mar 1;291(1):182-91. Epub 2006 Jan 19.


AMPA receptor regulation mechanisms: future target for safer neuroprotective drugs.

Jayakar SS, Dikshit M.

Int J Neurosci. 2004 Jun;114(6):695-734. Review.


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