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Recombinant human PRG4 (rhPRG4) suppresses breast cancer cell invasion by inhibiting TGFβ-Hyaluronan-CD44 signalling pathway.

Sarkar A, Chanda A, Regmi SC, Karve K, Deng L, Jay GD, Jirik FR, Schmidt TA, Bonni S.

PLoS One. 2019 Jul 30;14(7):e0219697. doi: 10.1371/journal.pone.0219697. eCollection 2019.


Absence of Proteoglycan 4 (Prg4) Leads to Increased Subchondral Bone Porosity Which Can be Mitigated Through Intra-Articular Injection of PRG4.

Abubacker S, Premnath P, Shonak A, Leonard C, Shah S, Zhu Y, Jay GD, Schmidt TA, Boyd S, Krawetz R.

J Orthop Res. 2019 May 23. doi: 10.1002/jor.24378. [Epub ahead of print]


Interactions between Lubricin and Hyaluronic Acid Synergistically Enhance Antiadhesive Properties.

Ye H, Han M, Huang R, Schmidt TA, Qi W, He Z, Martin LL, Jay GD, Su R, Greene GW.

ACS Appl Mater Interfaces. 2019 May 22;11(20):18090-18102. doi: 10.1021/acsami.9b01493. Epub 2019 May 13.


The Restrictive IV Fluid Trial in Severe Sepsis and Septic Shock (RIFTS): A Randomized Pilot Study.

Corl KA, Prodromou M, Merchant RC, Gareen I, Marks S, Banerjee D, Amass T, Abbasi A, Delcompare C, Palmisciano A, Aliotta J, Jay G, Levy MM.

Crit Care Med. 2019 Jul;47(7):951-959. doi: 10.1097/CCM.0000000000003779.


When the Best of Intentions Leads to Bad Outcomes.

Jay GW, Heit HA, Gourlay DL.

Pain Ther. 2019 Jun;8(1):1-4. doi: 10.1007/s40122-019-0120-6. Epub 2019 Apr 2.


Probing the Molecular Interactions and Lubrication Mechanisms of Purified Full-Length Recombinant Human Proteoglycan 4 (rhPRG4) and Hyaluronic Acid (HA).

Huang J, Qiu X, Xie L, Jay GD, Schmidt TA, Zeng H.

Biomacromolecules. 2019 Feb 11;20(2):1056-1067. doi: 10.1021/acs.biomac.8b01678. Epub 2019 Jan 16.


Two compartment pharmacokinetic model describes the intra-articular delivery and retention of rhprg4 following ACL transection in the Yucatan mini pig.

Hurtig M, Zaghoul I, Sheardown H, Schmidt TA, Liu L, Zhang L, Elsaid KA, Jay GD.

J Orthop Res. 2019 Feb;37(2):386-396. doi: 10.1002/jor.24191. Epub 2018 Dec 17.


Comparative Analysis of Emergency Medical Service Provider Workload During Simulated Out-of-Hospital Cardiac Arrest Resuscitation Using Standard Versus Experimental Protocols and Equipment.

Asselin N, Choi B, Pettit CC, Dannecker M, Machan JT, Merck DL, Merck LH, Suner S, Williams KA, Baird J, Jay GD, Kobayashi L.

Simul Healthc. 2018 Dec;13(6):376-386. doi: 10.1097/SIH.0000000000000339.


Perspectives on the opioid crisis from pain medicine clinicians.

Jay GW, Barkin RL.

Dis Mon. 2018 Oct;64(10):451-466. doi: 10.1016/j.disamonth.2018.07.002. Epub 2018 Sep 18. Review.


Headache attributed to TMD Is Associated With the Presence of Comorbid Bodily Pain: A Case-Control Study.

Vivaldi D, Di Giosia M, Tchivileva IE, Jay GW, Slade GD, Lim PF.

Headache. 2018 Nov;58(10):1593-1600. doi: 10.1111/head.13404. Epub 2018 Sep 4.


Recombinant human proteoglycan-4 reduces phagocytosis of urate crystals and downstream nuclear factor kappa B and inflammasome activation and production of cytokines and chemokines in human and murine macrophages.

Qadri M, Jay GD, Zhang LX, Wong W, Reginato AM, Sun C, Schmidt TA, Elsaid KA.

Arthritis Res Ther. 2018 Aug 29;20(1):192. doi: 10.1186/s13075-018-1693-x.


cAMP attenuates TGF-β's profibrotic responses in osteoarthritic synoviocytes: involvement of hyaluronan and PRG4.

Qadri MM, Jay GD, Ostrom RS, Zhang LX, Elsaid KA.

Am J Physiol Cell Physiol. 2018 Sep 1;315(3):C432-C443. doi: 10.1152/ajpcell.00041.2018. Epub 2018 Jun 13.


Comparison of Autograft and Allograft with Surface Modification for Flexor Tendon Reconstruction: A Canine in Vivo Model.

Wei Z, Reisdorf RL, Thoreson AR, Jay GD, Moran SL, An KN, Amadio PC, Zhao C.

J Bone Joint Surg Am. 2018 Apr 4;100(7):e42. doi: 10.2106/JBJS.17.00925.


Preclinical Animal Studies of Intravesical Recombinant Human Proteoglycan 4 as a Novel Potential Therapy for Diseases Resulting From Increased Bladder Permeability.

Greenwood-Van Meerveld B, Mohammadi E, Latorre R, Truitt ER 3rd, Jay GD, Sullivan BD, Schmidt TA, Smith N, Saunders D, Ziegler J, Lerner M, Hurst R, Towner RA.

Urology. 2018 Jun;116:230.e1-230.e7. doi: 10.1016/j.urology.2018.02.034. Epub 2018 Mar 12.


Role of CD44 in Regulating TLR2 Activation of Human Macrophages and Downstream Expression of Proinflammatory Cytokines.

Qadri M, Almadani S, Jay GD, Elsaid KA.

J Immunol. 2018 Jan 15;200(2):758-767. doi: 10.4049/jimmunol.1700713. Epub 2017 Dec 1.


Primary Headache Disorders- Part 2: Tension-type headache and medication overuse headache.

Jay GW, Barkin RL.

Dis Mon. 2017 Dec;63(12):342-367. doi: 10.1016/j.disamonth.2017.05.001. Epub 2017 Sep 6. Review.


Primary Headache Disorders Part I- Migraine and the Trigeminal Autonomic Cephalalgias.

Jay GW, Barkin RL.

Dis Mon. 2017 Nov;63(11):308-338. doi: 10.1016/j.disamonth.2017.04.001. Epub 2017 Sep 6.


Friction-Induced Mitochondrial Dysregulation Contributes to Joint Deterioration in Prg4 Knockout Mice.

Waller KA, Zhang LX, Jay GD.

Int J Mol Sci. 2017 Jun 11;18(6). pii: E1252. doi: 10.3390/ijms18061252.


Early genetic restoration of lubricin expression in transgenic mice mitigates chondrocyte peroxynitrite release and caspase-3 activation.

Larson KM, Zhang L, Badger GJ, Jay GD.

Osteoarthritis Cartilage. 2017 Sep;25(9):1488-1495. doi: 10.1016/j.joca.2017.05.012. Epub 2017 Jun 1.


Degradation of proteoglycan 4/lubricin by cathepsin S: Potential mechanism for diminished ocular surface lubrication in Sjögren's syndrome.

Regmi SC, Samsom ML, Heynen ML, Jay GD, Sullivan BD, Srinivasan S, Caffery B, Jones L, Schmidt TA.

Exp Eye Res. 2017 Aug;161:1-9. doi: 10.1016/j.exer.2017.05.006. Epub 2017 May 23.


The autocrine role of proteoglycan-4 (PRG4) in modulating osteoarthritic synoviocyte proliferation and expression of matrix degrading enzymes.

Alquraini A, Jamal M, Zhang L, Schmidt T, Jay GD, Elsaid KA.

Arthritis Res Ther. 2017 May 8;19(1):89. doi: 10.1186/s13075-017-1301-5.


Intra-articular Recombinant Human Proteoglycan 4 Mitigates Cartilage Damage After Destabilization of the Medial Meniscus in the Yucatan Minipig.

Waller KA, Chin KE, Jay GD, Zhang LX, Teeple E, McAllister S, Badger GJ, Schmidt TA, Fleming BC.

Am J Sports Med. 2017 Jun;45(7):1512-1521. doi: 10.1177/0363546516686965. Epub 2017 Jan 27.


Recombinant human lubricin for prevention of postoperative intra-abdominal adhesions in a rat model.

Oh J, Kuan KG, Tiong LU, Trochsler MI, Jay G, Schmidt TA, Barnett H, Maddern GJ.

J Surg Res. 2017 Feb;208:20-25. doi: 10.1016/j.jss.2016.08.092. Epub 2016 Sep 4.


Interdisciplinary Development of an Improved Emergency Department Procedural Work Surface Through Iterative Design and Use Testing in Simulated and Clinical Environments.

Zhang XC, Bermudez AM, Reddy PM, Sarpatwari RR, Chheng DB, Mezoian TJ, Schwartz VR, Simmons QJ, Jay GD, Kobayashi L.

Ann Emerg Med. 2017 Mar;69(3):275-283. doi: 10.1016/j.annemergmed.2016.08.436. Epub 2016 Nov 14.


A Two-Week, Randomized, Double-masked Study to Evaluate Safety and Efficacy of Lubricin (150 μg/mL) Eye Drops Versus Sodium Hyaluronate (HA) 0.18% Eye Drops (Vismed®) in Patients with Moderate Dry Eye Disease.

Lambiase A, Sullivan BD, Schmidt TA, Sullivan DA, Jay GD, Truitt ER 3rd, Bruscolini A, Sacchetti M, Mantelli F.

Ocul Surf. 2017 Jan;15(1):77-87. doi: 10.1016/j.jtos.2016.08.004. Epub 2016 Sep 8.


Arthroscopic irrigation of the bovine stifle joint increases cartilage surface friction and decreases superficial zone lubricin.

Teeple E, Karamchedu NP, Larson KM, Zhang L, Badger GJ, Fleming BC, Jay GD.

J Biomech. 2016 Sep 6;49(13):3106-3110. doi: 10.1016/j.jbiomech.2016.07.024. Epub 2016 Jul 27.


Simulation-based Randomized Comparative Assessment of Out-of-Hospital Cardiac Arrest Resuscitation Bundle Completion by Emergency Medical Service Teams Using Standard Life Support or an Experimental Automation-assisted Approach.

Choi B, Asselin N, Pettit CC, Dannecker M, Machan JT, Merck DL, Merck LH, Suner S, Williams KA, Jay GD, Kobayashi L.

Simul Healthc. 2016 Dec;11(6):365-375.


Lubricin/proteoglycan 4 increases in both experimental and naturally occurring equine osteoarthritis.

Reesink HL, Watts AE, Mohammed HO, Jay GD, Nixon AJ.

Osteoarthritis Cartilage. 2017 Jan;25(1):128-137. doi: 10.1016/j.joca.2016.07.021. Epub 2016 Aug 4.


Induced superficial chondrocyte death reduces catabolic cartilage damage in murine posttraumatic osteoarthritis.

Zhang M, Mani SB, He Y, Hall AM, Xu L, Li Y, Zurakowski D, Jay GD, Warman ML.

J Clin Invest. 2016 Aug 1;126(8):2893-902. doi: 10.1172/JCI83676. Epub 2016 Jul 18.


Reduction of friction by recombinant human proteoglycan 4 in IL-1α stimulated bovine cartilage explants.

Larson KM, Zhang L, Elsaid KA, Schmidt TA, Fleming BC, Badger GJ, Jay GD.

J Orthop Res. 2017 Mar;35(3):580-589. doi: 10.1002/jor.23367. Epub 2017 Mar 2.


Adhesion in hydrogel contacts.

Torres JR, Jay GD, Kim KS, Bothun GD.

Proc Math Phys Eng Sci. 2016 May;472(2189):20150892.


Lubricin/Proteoglycan 4 binds to and regulates the activity of Toll-Like Receptors In Vitro.

Iqbal SM, Leonard C, Regmi SC, De Rantere D, Tailor P, Ren G, Ishida H, Hsu C, Abubacker S, Pang DS, Salo PT, Vogel HJ, Hart DA, Waterhouse CC, Jay GD, Schmidt TA, Krawetz RJ.

Sci Rep. 2016 Jan 11;6:18910. doi: 10.1038/srep18910.


Research design considerations for single-dose analgesic clinical trials in acute pain: IMMPACT recommendations.

Cooper SA, Desjardins PJ, Turk DC, Dworkin RH, Katz NP, Kehlet H, Ballantyne JC, Burke LB, Carragee E, Cowan P, Croll S, Dionne RA, Farrar JT, Gilron I, Gordon DB, Iyengar S, Jay GW, Kalso EA, Kerns RD, McDermott MP, Raja SN, Rappaport BA, Rauschkolb C, Royal MA, Segerdahl M, Stauffer JW, Todd KH, Vanhove GF, Wallace MS, West C, White RE, Wu C.

Pain. 2016 Feb;157(2):288-301. doi: 10.1097/j.pain.0000000000000375. Review.


The interaction of lubricin/proteoglycan 4 (PRG4) with toll-like receptors 2 and 4: an anti-inflammatory role of PRG4 in synovial fluid.

Alquraini A, Garguilo S, D'Souza G, Zhang LX, Schmidt TA, Jay GD, Elsaid KA.

Arthritis Res Ther. 2015 Dec 4;17:353. doi: 10.1186/s13075-015-0877-x.


Objective Assessment and Thematic Categorization of Patient-audible Information in an Emergency Department.

Zhang XC, Kobayashi L, Berger M, Reddy PM, Chheng DB, Gorham SA, Pathania S, Stern SP, Icaza Milson E, Jay GD, Baruch JM.

Acad Emerg Med. 2015 Oct;22(10):1222-5. doi: 10.1111/acem.12762. Epub 2015 Oct 1.


Lubricin restoration in a mouse model of congenital deficiency.

Hill A, Waller KA, Cui Y, Allen JM, Smits P, Zhang LX, Ayturk UM, Hann S, Lessard SG, Zurakowski D, Warman ML, Jay GD.

Arthritis Rheumatol. 2015 Nov;67(11):3070-81. doi: 10.1002/art.39276.


Full-Length Recombinant Human Proteoglycan 4 Interacts with Hyaluronan to Provide Cartilage Boundary Lubrication.

Abubacker S, Dorosz SG, Ponjevic D, Jay GD, Matyas JR, Schmidt TA.

Ann Biomed Eng. 2016 Apr;44(4):1128-37. doi: 10.1007/s10439-015-1390-8. Epub 2015 Jul 21.


Effects of lubricant and autologous bone marrow stromal cell augmentation on immobilized flexor tendon repairs.

Zhao C, Ozasa Y, Shimura H, Reisdorf RL, Thoreson AR, Jay G, Moran SL, An KN, Amadio PC.

J Orthop Res. 2016 Jan;34(1):154-60. doi: 10.1002/jor.22980. Epub 2015 Jul 31.


Detection and Measurement of Unhealthy, Environment-Derived Aerosol Materials in an Emergency Department.

Choi BY, Kobayashi L, Pathania S, Miller CB, Locke ER, Stearns BC, Hudepohl NJ, Patefield SS, Suner S, Williams KA, Machan JT, Jay GD.

HERD. 2015 Fall;9(1):34-53. doi: 10.1177/1937586715592634. Epub 2015 Jul 10.


An Electrical Burn.

Gemme S, Jay G, Binder W.

R I Med J (2013). 2015 Jul 1;98(7):42-4. No abstract available.


Surface Modification with Chemically Modified Synovial Fluid for Flexor Tendon Reconstruction in a Canine Model in Vivo.

Ji X, Reisdorf RL, Thoreson AR, Berglund LR, Moran SL, Jay GD, An KN, Amadio PC, Zhao C.

J Bone Joint Surg Am. 2015 Jun 17;97(12):972-8. doi: 10.2106/JBJS.N.01100.


Lacosamide cardiac safety: clinical trials in patients with partial-onset seizures.

Rudd GD, Haverkamp W, Mason JW, Wenger T, Jay G, Hebert D, Doty P, Horstmann R.

Acta Neurol Scand. 2015 Nov;132(5):355-63. doi: 10.1111/ane.12414. Epub 2015 Apr 30.


Lubricin deficiency in the murine lumbar intervertebral disc results in elevated torsional apparent modulus.

Teeple E, Aslani K, Shalvoy MR, Medrano JE, Zhang L, Machan JT, Fleming BC, Jay GD.

J Biomech. 2015 Jul 16;48(10):2210-3. doi: 10.1016/j.jbiomech.2015.03.029. Epub 2015 Apr 3.


Research design considerations for chronic pain prevention clinical trials: IMMPACT recommendations.

Gewandter JS, Dworkin RH, Turk DC, Farrar JT, Fillingim RB, Gilron I, Markman JD, Oaklander AL, Polydefkis MJ, Raja SN, Robinson JP, Woolf CJ, Ziegler D, Ashburn MA, Burke LB, Cowan P, George SZ, Goli V, Graff OX, Iyengar S, Jay GW, Katz J, Kehlet H, Kitt RA, Kopecky EA, Malamut R, McDermott MP, Palmer P, Rappaport BA, Rauschkolb C, Steigerwald I, Tobias J, Walco GA.

Pain. 2015 Jul;156(7):1184-97. doi: 10.1097/j.pain.0000000000000191. Review.


Lubricin in human achilles tendon: The evidence of intratendinous sliding motion and shear force in achilles tendon.

Sun YL, Wei Z, Zhao C, Jay GD, Schmid TM, Amadio PC, An KN.

J Orthop Res. 2015 Jun;33(6):932-7. doi: 10.1002/jor.22897.


In situ medical simulation investigation of emergency department procedural sedation with randomized trial of experimental bedside clinical process guidance intervention.

Siegel NA, Kobayashi L, Dunbar-Viveiros JA, Devine J, Al-Rasheed RS, Gardiner FG, Olsson K, Lai S, Jones MS, Dannecker M, Overly FL, Gosbee JW, Portelli DC, Jay GD.

Simul Healthc. 2015 Jun;10(3):146-53. doi: 10.1097/SIH.0000000000000083.


Effects of concentration and structure on proteoglycan 4 rheology and interaction with hyaluronan.

Ludwig TE, Cowman MK, Jay GD, Schmidt TA.

Biorheology. 2014;51(6):409-22. doi: 10.3233/BIR-14037.



Jay GW, Barkin RL.

Dis Mon. 2015 Mar;61(3):66-111. doi: 10.1016/j.disamonth.2015.01.002. Review. No abstract available.


Lubricin/Proteoglycan 4 Binding to CD44 Receptor: A Mechanism of the Suppression of Proinflammatory Cytokine-Induced Synoviocyte Proliferation by Lubricin.

Al-Sharif A, Jamal M, Zhang LX, Larson K, Schmidt TA, Jay GD, Elsaid KA.

Arthritis Rheumatol. 2015 Jun;67(6):1503-13. doi: 10.1002/art.39087.


Anti-lubricin monoclonal antibodies created using lubricin-knockout mice immunodetect lubricin in several species and in patients with healthy and diseased joints.

Ai M, Cui Y, Sy MS, Lee DM, Zhang LX, Larson KM, Kurek KC, Jay GD, Warman ML.

PLoS One. 2015 Feb 2;10(2):e0116237. doi: 10.1371/journal.pone.0116237. eCollection 2015.

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