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Acarbose improved survival for Apc+/Min mice.

Dodds SG, Parihar M, Javors M, Nie J, Musi N, Dave Sharp Z, Hasty P.

Aging Cell. 2020 Feb;19(2):e13088. doi: 10.1111/acel.13088. Epub 2020 Jan 6.


mTOR drives cerebrovascular, synaptic, and cognitive dysfunction in normative aging.

Van Skike CE, Lin AL, Roberts Burbank R, Halloran JJ, Hernandez SF, Cuvillier J, Soto VY, Hussong SA, Jahrling JB, Javors MA, Hart MJ, Fischer KE, Austad SN, Galvan V.

Aging Cell. 2020 Jan;19(1):e13057. doi: 10.1111/acel.13057. Epub 2019 Nov 6.


Evaluation of the pharmacokinetics of metformin and acarbose in the common marmoset.

Fernandez E, Ross C, Liang H, Javors M, Tardif S, Salmon AB.

Pathobiol Aging Age Relat Dis. 2019 Aug 22;9(1):1657756. doi: 10.1080/20010001.2019.1657756. eCollection 2019.


Glycine supplementation extends lifespan of male and female mice.

Miller RA, Harrison DE, Astle CM, Bogue MA, Brind J, Fernandez E, Flurkey K, Javors M, Ladiges W, Leeuwenburgh C, Macchiarini F, Nelson J, Ryazanov AG, Snyder J, Stearns TM, Vaughan DE, Strong R.

Aging Cell. 2019 Jun;18(3):e12953. doi: 10.1111/acel.12953. Epub 2019 Mar 27.


Acarbose improves health and lifespan in aging HET3 mice.

Harrison DE, Strong R, Alavez S, Astle CM, DiGiovanni J, Fernandez E, Flurkey K, Garratt M, Gelfond JAL, Javors MA, Levi M, Lithgow GJ, Macchiarini F, Nelson JF, Sukoff Rizzo SJ, Slaga TJ, Stearns T, Wilkinson JE, Miller RA.

Aging Cell. 2019 Apr;18(2):e12898. doi: 10.1111/acel.12898. Epub 2019 Jan 27.


Rapamycin Prevents Surgery-Induced Immune Dysfunction in Patients with Bladder Cancer.

Svatek RS, Ji N, de Leon E, Mukherjee NZ, Kabra A, Hurez V, Nicolas M, Michalek JE, Javors M, Wheeler K, Sharp ZD, Livi CB, Shu ZJ, Henkes D, Curiel TJ.

Cancer Immunol Res. 2019 Mar;7(3):466-475. doi: 10.1158/2326-6066.CIR-18-0336. Epub 2018 Dec 18.


Effects of intravenous AICAR (5-aminoimidazole-4-carboximide riboside) administration on insulin signaling and resistance in premature baboons, Papio sp.

Blanco CL, Gastaldelli A, Anzueto DG, Winter LA, Seidner SR, McCurnin DC, Liang H, Javors MA, DeFronzo RA, Musi N.

PLoS One. 2018 Dec 12;13(12):e0208757. doi: 10.1371/journal.pone.0208757. eCollection 2018.


Prenatal metformin exposure or organic cation transporter 3 knock-out curbs social interaction preference in male mice.

Garbarino VR, Santos TA, Nelson AR, Zhang WQ, Smolik CM, Javors MA, Daws LC, Gould GG.

Pharmacol Res. 2019 Feb;140:21-32. doi: 10.1016/j.phrs.2018.11.013. Epub 2018 Nov 10.


Differences in pituitary-adrenal reactivity in Black and White men with and without alcohol use disorder.

Price JL, Frazier IR, Lewis B, Walker R, Javors MA, Nixon SJ, Adinoff B.

Psychoneuroendocrinology. 2019 Feb;100:180-189. doi: 10.1016/j.psyneuen.2018.10.004. Epub 2018 Oct 9.


Pharmacokinetics of Phosphatidylethanol 16:0/20:4 in Human Blood After Alcohol Intake.

Lopez-Cruzan M, Roache JD, Hill-Kapturczak N, Karns-Wright TE, Dougherty DM, Sanchez JJ, Koek W, Javors MA.

Alcohol Clin Exp Res. 2018 Nov;42(11):2094-2099. doi: 10.1111/acer.13865. Epub 2018 Aug 26.


Intensive prolonged exposure therapy for combat-related posttraumatic stress disorder: Design and methodology of a randomized clinical trial.

Peterson AL, Foa EB, Blount TH, McLean CP, Shah DV, Young-McCaughan S, Litz BT, Schobitz RP, Castillo DT, Rentz TO, Yarvis JS, Dondanville KA, Fina BA, Hall-Clark BN, Brown LA, DeBeer BR, Jacoby VM, Hancock AK, Williamson DE, Evans WR, Synett S, Straud C, Hansen HR, Meyer EC, Javors MA, Sharrieff AM, Lara-Ruiz J, Koch LM, Roache JD, Mintz J, Keane TM; Consortium to Alleviate PTSD.

Contemp Clin Trials. 2018 Sep;72:126-136. doi: 10.1016/j.cct.2018.07.016. Epub 2018 Jul 25.


The long-term effect of maternal dietary protein restriction on 5-HT1A receptor function and behavioral responses to stress in adulthood.

Ye W, Pitlock MD, Javors MA, Thompson BJ, Lechleiter JD, Hensler JG.

Behav Brain Res. 2018 Sep 3;349:116-124. doi: 10.1016/j.bbr.2018.03.038. Epub 2018 Apr 13.


Differences in the Synthesis and Elimination of Phosphatidylethanol 16:0/18:1 and 16:0/18:2 After Acute Doses of Alcohol.

Hill-Kapturczak N, Dougherty DM, Roache JD, Karns-Wright TE, Javors MA.

Alcohol Clin Exp Res. 2018 May;42(5):851-860. doi: 10.1111/acer.13620. Epub 2018 Mar 30.


A randomized control trial to establish the feasibility and safety of rapamycin treatment in an older human cohort: Immunological, physical performance, and cognitive effects.

Kraig E, Linehan LA, Liang H, Romo TQ, Liu Q, Wu Y, Benavides AD, Curiel TJ, Javors MA, Musi N, Chiodo L, Koek W, Gelfond JAL, Kellogg DL Jr.

Exp Gerontol. 2018 May;105:53-69. doi: 10.1016/j.exger.2017.12.026. Epub 2018 Feb 3.


Effects of rapamycin on growth hormone receptor knockout mice.

Fang Y, Hill CM, Darcy J, Reyes-Ordoñez A, Arauz E, McFadden S, Zhang C, Osland J, Gao J, Zhang T, Frank SJ, Javors MA, Yuan R, Kopchick JJ, Sun LY, Chen J, Bartke A.

Proc Natl Acad Sci U S A. 2018 Feb 13;115(7):E1495-E1503. doi: 10.1073/pnas.1717065115. Epub 2018 Jan 29.


Low-dose rapamycin extends lifespan in a mouse model of mtDNA depletion syndrome.

Siegmund SE, Yang H, Sharma R, Javors M, Skinner O, Mootha V, Hirano M, Schon EA.

Hum Mol Genet. 2017 Dec 1;26(23):4588-4605. doi: 10.1093/hmg/ddx341.


Pilot investigation of a phosphatidylethanol-based contingency management intervention targeting alcohol use.

McDonell MG, Skalisky J, Leickly E, Orr MF, McPherson S, Roll J, Hill-Kapturczak N, Javors M.

Psychol Addict Behav. 2017 Aug;31(5):608-613. doi: 10.1037/adb0000293. Epub 2017 Jul 17.


mTOR drives cerebral blood flow and memory deficits in LDLR-/- mice modeling atherosclerosis and vascular cognitive impairment.

Jahrling JB, Lin AL, DeRosa N, Hussong SA, Van Skike CE, Girotti M, Javors M, Zhao Q, Maslin LA, Asmis R, Galvan V.

J Cereb Blood Flow Metab. 2018 Jan;38(1):58-74. doi: 10.1177/0271678X17705973. Epub 2017 May 17.


The discriminative stimulus effects of i.v. nicotine in rhesus monkeys: Pharmacokinetics and apparent pA2 analysis with dihydro-β-erythroidine.

Moerke MJ, Zhu AZ, Tyndale RF, Javors MA, McMahon LR.

Neuropharmacology. 2017 Apr;116:9-17. doi: 10.1016/j.neuropharm.2016.12.003. Epub 2016 Dec 8.


Adrenocortical sensitivity, moderated by ongoing stress, predicts drinking intensity in alcohol-dependent men.

Adinoff B, Leonard D, Price J, Javors MA, Walker R, Brown ES, Xiao H, Rao U.

Psychoneuroendocrinology. 2017 Feb;76:67-76. doi: 10.1016/j.psyneuen.2016.10.011. Epub 2016 Nov 5.


Phosphatidylethanol in Postmortem Brain and Serum Ethanol at Time of Death.

Thompson PM, Hill-Kapturczak N, Lopez-Cruzan M, Alvarado LA, Dwivedi AK, Javors MA.

Alcohol Clin Exp Res. 2016 Dec;40(12):2557-2562. doi: 10.1111/acer.13254. Epub 2016 Nov 3.


The Formation, Elimination, Interpretation, and Future Research Needs of Phosphatidylethanol for Research Studies and Clinical Practice.

Hahn JA, Anton RF, Javors MA.

Alcohol Clin Exp Res. 2016 Nov;40(11):2292-2295. doi: 10.1111/acer.13213. Epub 2016 Sep 26. No abstract available.


Attenuated nicotine-like effects of varenicline but not other nicotinic ACh receptor agonists in monkeys receiving nicotine daily.

Cunningham CS, Moerke MJ, Javors MA, Carroll FI, McMahon LR.

Br J Pharmacol. 2016 Dec;173(24):3454-3466. doi: 10.1111/bph.13635. Epub 2016 Nov 6.


Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an α-glucosidase inhibitor or a Nrf2-inducer.

Strong R, Miller RA, Antebi A, Astle CM, Bogue M, Denzel MS, Fernandez E, Flurkey K, Hamilton KL, Lamming DW, Javors MA, de Magalhães JP, Martinez PA, McCord JM, Miller BF, Müller M, Nelson JF, Ndukum J, Rainger GE, Richardson A, Sabatini DM, Salmon AB, Simpkins JW, Steegenga WT, Nadon NL, Harrison DE.

Aging Cell. 2016 Oct;15(5):872-84. doi: 10.1111/acel.12496. Epub 2016 Jun 16.


Adaptations to chronic rapamycin in mice.

Dodds SG, Livi CB, Parihar M, Hsu HK, Benavides AD, Morris J, Javors M, Strong R, Christy B, Hasty P, Sharp ZD.

Pathobiol Aging Age Relat Dis. 2016 May 27;6:31688. doi: 10.3402/pba.v6.31688. eCollection 2016.


Characterization of the Pharmacokinetics of Phosphatidylethanol 16:0/18:1 and 16:0/18:2 in Human Whole Blood After Alcohol Consumption in a Clinical Laboratory Study.

Javors MA, Hill-Kapturczak N, Roache JD, Karns-Wright TE, Dougherty DM.

Alcohol Clin Exp Res. 2016 Jun;40(6):1228-34. doi: 10.1111/acer.13062. Epub 2016 Apr 30.


Metabolic consequences of long-term rapamycin exposure on common marmoset monkeys (Callithrix jacchus).

Ross C, Salmon A, Strong R, Fernandez E, Javors M, Richardson A, Tardif S.

Aging (Albany NY). 2015 Nov;7(11):964-73.


Lorcaserin Reduces the Discriminative Stimulus and Reinforcing Effects of Cocaine in Rhesus Monkeys.

Collins GT, Gerak LR, Javors MA, France CP.

J Pharmacol Exp Ther. 2016 Jan;356(1):85-95. doi: 10.1124/jpet.115.228833. Epub 2015 Nov 3.


Rapamycin Increases Mortality in db/db Mice, a Mouse Model of Type 2 Diabetes.

Sataranatarajan K, Ikeno Y, Bokov A, Feliers D, Yalamanchili H, Lee HJ, Mariappan MM, Tabatabai-Mir H, Diaz V, Prasad S, Javors MA, Ghosh Choudhury G, Hubbard GB, Barnes JL, Richardson A, Kasinath BS.

J Gerontol A Biol Sci Med Sci. 2016 Jul;71(7):850-7. doi: 10.1093/gerona/glv170. Epub 2015 Oct 5.


MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation.

Laberge RM, Sun Y, Orjalo AV, Patil CK, Freund A, Zhou L, Curran SC, Davalos AR, Wilson-Edell KA, Liu S, Limbad C, Demaria M, Li P, Hubbard GB, Ikeno Y, Javors M, Desprez PY, Benz CC, Kapahi P, Nelson PS, Campisi J.

Nat Cell Biol. 2015 Aug;17(8):1049-61. doi: 10.1038/ncb3195. Epub 2015 Jul 6.


Physiological and behavioral effects of amphetamine in BACE1(-/-) mice.

Paredes RM, Piccart E, Navaira E, Cruz D, Javors MA, Koek W, Beckstead MJ, Walss-Bass C.

Genes Brain Behav. 2015 Jun;14(5):411-8. doi: 10.1111/gbb.12222. Epub 2015 May 21.


Acute dietary tryptophan manipulation differentially alters social behavior, brain serotonin and plasma corticosterone in three inbred mouse strains.

Zhang WQ, Smolik CM, Barba-Escobedo PA, Gamez M, Sanchez JJ, Javors MA, Daws LC, Gould GG.

Neuropharmacology. 2015 Mar;90:1-8. doi: 10.1016/j.neuropharm.2014.10.024. Epub 2014 Nov 4.


Testing efficacy of administration of the antiaging drug rapamycin in a nonhuman primate, the common marmoset.

Tardif S, Ross C, Bergman P, Fernandez E, Javors M, Salmon A, Spross J, Strong R, Richardson A.

J Gerontol A Biol Sci Med Sci. 2015 May;70(5):577-87. doi: 10.1093/gerona/glu101. Epub 2014 Jul 19.


Blood levels do not predict behavioral or physiological effects of Δ⁹-tetrahydrocannabinol in rhesus monkeys with different patterns of exposure.

Ginsburg BC, Hruba L, Zaki A, Javors MA, McMahon LR.

Drug Alcohol Depend. 2014 Jun 1;139:1-8. doi: 10.1016/j.drugalcdep.2014.02.696. Epub 2014 Mar 19.


Development of a lozenge for oral transmucosal delivery of trans-resveratrol in humans: proof of concept.

Blanchard OL, Friesenhahn G, Javors MA, Smoliga JM.

PLoS One. 2014 Feb 26;9(2):e90131. doi: 10.1371/journal.pone.0090131. eCollection 2014.


Distribution of venlafaxine, O-desmethylvenlafaxine, and O-desmethylvenlafaxine to venlafaxine ratio in postmortem human brain tissue.

Murrell MD, Cruz DA, Javors MA, Thompson PM.

J Forensic Sci. 2014 May;59(3):683-9. doi: 10.1111/1556-4029.12393. Epub 2014 Feb 6.


Mice fed rapamycin have an increase in lifespan associated with major changes in the liver transcriptome.

Fok WC, Chen Y, Bokov A, Zhang Y, Salmon AB, Diaz V, Javors M, Wood WH 3rd, Zhang Y, Becker KG, Pérez VI, Richardson A.

PLoS One. 2014 Jan 7;9(1):e83988. doi: 10.1371/journal.pone.0083988. eCollection 2014. Erratum in: PLoS One. 2014;9(4):e92346.


Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction.

Miller RA, Harrison DE, Astle CM, Fernandez E, Flurkey K, Han M, Javors MA, Li X, Nadon NL, Nelson JF, Pletcher S, Salmon AB, Sharp ZD, Van Roekel S, Winkleman L, Strong R.

Aging Cell. 2014 Jun;13(3):468-77. doi: 10.1111/acel.12194. Epub 2014 Feb 9.


Combined treatment of rapamycin and dietary restriction has a larger effect on the transcriptome and metabolome of liver.

Fok WC, Bokov A, Gelfond J, Yu Z, Zhang Y, Doderer M, Chen Y, Javors M, Wood WH 3rd, Zhang Y, Becker KG, Richardson A, Pérez VI.

Aging Cell. 2014 Apr;13(2):311-9. doi: 10.1111/acel.12175. Epub 2013 Dec 5.


eRapa restores a normal life span in a FAP mouse model.

Hasty P, Livi CB, Dodds SG, Jones D, Strong R, Javors M, Fischer KE, Sloane L, Murthy K, Hubbard G, Sun L, Hurez V, Curiel TJ, Sharp ZD.

Cancer Prev Res (Phila). 2014 Jan;7(1):169-78. doi: 10.1158/1940-6207.CAPR-13-0299. Epub 2013 Nov 26.


Acarbose, 17-α-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males.

Harrison DE, Strong R, Allison DB, Ames BN, Astle CM, Atamna H, Fernandez E, Flurkey K, Javors MA, Nadon NL, Nelson JF, Pletcher S, Simpkins JW, Smith D, Wilkinson JE, Miller RA.

Aging Cell. 2014 Apr;13(2):273-82. doi: 10.1111/acel.12170. Epub 2013 Nov 19.


Topiramate for the treatment of cocaine addiction: a randomized clinical trial.

Johnson BA, Ait-Daoud N, Wang XQ, Penberthy JK, Javors MA, Seneviratne C, Liu L.

JAMA Psychiatry. 2013 Dec;70(12):1338-46. doi: 10.1001/jamapsychiatry.2013.2295.


Chronic rapamycin restores brain vascular integrity and function through NO synthase activation and improves memory in symptomatic mice modeling Alzheimer's disease.

Lin AL, Zheng W, Halloran JJ, Burbank RR, Hussong SA, Hart MJ, Javors M, Shih YY, Muir E, Solano Fonseca R, Strong R, Richardson AG, Lechleiter JD, Fox PT, Galvan V.

J Cereb Blood Flow Metab. 2013 Sep;33(9):1412-21. doi: 10.1038/jcbfm.2013.82. Epub 2013 Jun 26.


Rapamycin extends life and health in C57BL/6 mice.

Zhang Y, Bokov A, Gelfond J, Soto V, Ikeno Y, Hubbard G, Diaz V, Sloane L, Maslin K, Treaster S, Réndon S, van Remmen H, Ward W, Javors M, Richardson A, Austad SN, Fischer K.

J Gerontol A Biol Sci Med Sci. 2014 Feb;69(2):119-30. doi: 10.1093/gerona/glt056. Epub 2013 May 16.


Duration of rapamycin treatment has differential effects on metabolism in mice.

Fang Y, Westbrook R, Hill C, Boparai RK, Arum O, Spong A, Wang F, Javors MA, Chen J, Sun LY, Bartke A.

Cell Metab. 2013 Mar 5;17(3):456-62. doi: 10.1016/j.cmet.2013.02.008.


Rapamycin extends life span of Rb1+/- mice by inhibiting neuroendocrine tumors.

Livi CB, Hardman RL, Christy BA, Dodds SG, Jones D, Williams C, Strong R, Bokov A, Javors MA, Ikeno Y, Hubbard G, Hasty P, Sharp ZD.

Aging (Albany NY). 2013 Feb;5(2):100-10.


Seizure susceptibility and epileptogenesis in a rat model of epilepsy and depression co-morbidity.

Epps SA, Tabb KD, Lin SJ, Kahn AB, Javors MA, Boss-Williams KA, Weiss JM, Weinshenker D.

Neuropsychopharmacology. 2012 Dec;37(13):2756-63. doi: 10.1038/npp.2012.141. Epub 2012 Aug 8.


Evaluation of resveratrol, green tea extract, curcumin, oxaloacetic acid, and medium-chain triglyceride oil on life span of genetically heterogeneous mice.

Strong R, Miller RA, Astle CM, Baur JA, de Cabo R, Fernandez E, Guo W, Javors M, Kirkland JL, Nelson JF, Sinclair DA, Teter B, Williams D, Zaveri N, Nadon NL, Harrison DE.

J Gerontol A Biol Sci Med Sci. 2013 Jan;68(1):6-16. doi: 10.1093/gerona/gls070. Epub 2012 Mar 26.


Pharmacologic characterization of a nicotine-discriminative stimulus in rhesus monkeys.

Cunningham CS, Javors MA, McMahon LR.

J Pharmacol Exp Ther. 2012 Jun;341(3):840-9. doi: 10.1124/jpet.112.193078. Epub 2012 Mar 21.


Purity of synthetic cannabinoids sold online for recreational use.

Ginsburg BC, McMahon LR, Sanchez JJ, Javors MA.

J Anal Toxicol. 2012 Jan-Feb;36(1):66-8. doi: 10.1093/jat/bkr018.

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