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Items: 1 to 50 of 207

1.

Come Fly with Me: an overview of dopamine receptors in Drosophila melanogaster.

Karam CS, Jones SK, Javitch JA.

Basic Clin Pharmacol Toxicol. 2019 Jun 20. doi: 10.1111/bcpt.13277. [Epub ahead of print]

PMID:
31219669
2.

Cannabinoid CB1 and CB2 Receptor-Mediated Arrestin Translocation: Species, Subtype, and Agonist-Dependence.

Ibsen MS, Finlay DB, Patel M, Javitch JA, Glass M, Grimsey NL.

Front Pharmacol. 2019 Apr 10;10:350. doi: 10.3389/fphar.2019.00350. eCollection 2019.

3.

The differential actions of clozapine and other antipsychotic drugs on the translocation of dopamine D2 receptors to the cell surface.

Schrader JM, Irving CM, Octeau JC, Christian JA, Aballo TJ, Kareemo DJ, Conti J, Camberg JL, Lane JR, Javitch JA, Kovoor A.

J Biol Chem. 2019 Apr 5;294(14):5604-5615. doi: 10.1074/jbc.RA118.004682. Epub 2019 Jan 22.

PMID:
30670597
4.

New roles for dopamine D2 and D3 receptors in pancreatic beta cell insulin secretion.

Farino ZJ, Morgenstern TJ, Maffei A, Quick M, De Solis AJ, Wiriyasermkul P, Freyberg RJ, Aslanoglou D, Sorisio D, Inbar BP, Free RB, Donthamsetti P, Mosharov EV, Kellendonk C, Schwartz GJ, Sibley DR, Schmauss C, Zeltser LM, Moore H, Harris PE, Javitch JA, Freyberg Z.

Mol Psychiatry. 2019 Jan 9. doi: 10.1038/s41380-018-0344-6. [Epub ahead of print]

PMID:
30626912
5.

Reply to 'Antipsychotics with similar association kinetics at dopamine D2 receptors differ in extrapyramidal side-effects'.

Sykes DA, Lane JR, Szabo M, Capuano B, Javitch JA, Charlton SJ.

Nat Commun. 2018 Sep 3;9(1):3568. doi: 10.1038/s41467-018-05678-4. No abstract available.

6.

Arrestin recruitment to dopamine D2 receptor mediates locomotion but not incentive motivation.

Donthamsetti P, Gallo EF, Buck DC, Stahl EL, Zhu Y, Lane JR, Bohn LM, Neve KA, Kellendonk C, Javitch JA.

Mol Psychiatry. 2018 Aug 17. doi: 10.1038/s41380-018-0212-4. [Epub ahead of print]

7.

The LeuT-fold neurotransmitter:sodium symporter MhsT has two substrate sites.

Quick M, Abramyan AM, Wiriyasermkul P, Weinstein H, Shi L, Javitch JA.

Proc Natl Acad Sci U S A. 2018 Aug 21;115(34):E7924-E7931. doi: 10.1073/pnas.1717444115. Epub 2018 Aug 6.

8.

Luciferase complementation based-detection of G-protein-coupled receptor activity.

Yano H, Cai NS, Javitch JA, Ferré S.

Biotechniques. 2018 Jul;65(1):9-14. doi: 10.2144/btn-2018-0039.

9.

Exploring Substrate Binding in the Extracellular Vestibule of MhsT by Atomistic Simulations and Markov Models.

Abramyan AM, Quick M, Xue C, Javitch JA, Shi L.

J Chem Inf Model. 2018 Jun 25;58(6):1244-1252. doi: 10.1021/acs.jcim.8b00175. Epub 2018 Jun 11.

10.

Regional Heterogeneity of D2-Receptor Signaling in the Dorsal Striatum and Nucleus Accumbens.

Marcott PF, Gong S, Donthamsetti P, Grinnell SG, Nelson MN, Newman AH, Birnbaumer L, Martemyanov KA, Javitch JA, Ford CP.

Neuron. 2018 May 2;98(3):575-587.e4. doi: 10.1016/j.neuron.2018.03.038. Epub 2018 Apr 12.

11.

Accumbens dopamine D2 receptors increase motivation by decreasing inhibitory transmission to the ventral pallidum.

Gallo EF, Meszaros J, Sherman JD, Chohan MO, Teboul E, Choi CS, Moore H, Javitch JA, Kellendonk C.

Nat Commun. 2018 Mar 14;9(1):1086. doi: 10.1038/s41467-018-03272-2.

12.

Phosphorylation of the Amino Terminus of the Dopamine Transporter: Regulatory Mechanisms and Implications for Amphetamine Action.

Karam CS, Javitch JA.

Adv Pharmacol. 2018;82:205-234. doi: 10.1016/bs.apha.2017.09.002. Epub 2017 Oct 25.

13.

Gs- versus Golf-dependent functional selectivity mediated by the dopamine D1 receptor.

Yano H, Cai NS, Xu M, Verma RK, Rea W, Hoffman AF, Shi L, Javitch JA, Bonci A, Ferré S.

Nat Commun. 2018 Feb 5;9(1):486. doi: 10.1038/s41467-017-02606-w.

14.

The action of a negative allosteric modulator at the dopamine D2 receptor is dependent upon sodium ions.

Draper-Joyce CJ, Verma RK, Michino M, Shonberg J, Kopinathan A, Klein Herenbrink C, Scammells PJ, Capuano B, Abramyan AM, Thal DM, Javitch JA, Christopoulos A, Shi L, Lane JR.

Sci Rep. 2018 Jan 19;8(1):1208. doi: 10.1038/s41598-018-19642-1.

15.

The E2.65A mutation disrupts dynamic binding poses of SB269652 at the dopamine D2 and D3 receptors.

Verma RK, Abramyan AM, Michino M, Free RB, Sibley DR, Javitch JA, Lane JR, Shi L.

PLoS Comput Biol. 2018 Jan 16;14(1):e1005948. doi: 10.1371/journal.pcbi.1005948. eCollection 2018 Jan.

16.

A partially-open inward-facing intermediate conformation of LeuT is associated with Na+ release and substrate transport.

Terry DS, Kolster RA, Quick M, LeVine MV, Khelashvili G, Zhou Z, Weinstein H, Javitch JA, Blanchard SC.

Nat Commun. 2018 Jan 15;9(1):230. doi: 10.1038/s41467-017-02202-y.

17.

The structural determinants of the bitopic binding mode of a negative allosteric modulator of the dopamine D2 receptor.

Draper-Joyce CJ, Michino M, Verma RK, Klein Herenbrink C, Shonberg J, Kopinathan A, Scammells PJ, Capuano B, Thal DM, Javitch JA, Christopoulos A, Shi L, Lane JR.

Biochem Pharmacol. 2018 Feb;148:315-328. doi: 10.1016/j.bcp.2018.01.002. Epub 2018 Jan 9.

18.

Optical Control of Dopamine Receptors Using a Photoswitchable Tethered Inverse Agonist.

Donthamsetti PC, Winter N, Schönberger M, Levitz J, Stanley C, Javitch JA, Isacoff EY, Trauner D.

J Am Chem Soc. 2017 Dec 27;139(51):18522-18535. doi: 10.1021/jacs.7b07659. Epub 2017 Dec 13.

19.

Dopamine D2 Receptors in the Paraventricular Thalamus Attenuate Cocaine Locomotor Sensitization.

Clark AM, Leroy F, Martyniuk KM, Feng W, McManus E, Bailey MR, Javitch JA, Balsam PD, Kellendonk C.

eNeuro. 2017 Oct 24;4(5). pii: ENEURO.0227-17.2017. doi: 10.1523/ENEURO.0227-17.2017. eCollection 2017 Sep-Oct.

20.

Development of novel biosensors to study receptor-mediated activation of the G-protein α subunits Gs and Golf.

Yano H, Provasi D, Cai NS, Filizola M, Ferré S, Javitch JA.

J Biol Chem. 2017 Dec 8;292(49):19989-19998. doi: 10.1074/jbc.M117.800698. Epub 2017 Oct 17.

21.

Extrapyramidal side effects of antipsychotics are linked to their association kinetics at dopamine D2 receptors.

Sykes DA, Moore H, Stott L, Holliday N, Javitch JA, Lane JR, Charlton SJ.

Nat Commun. 2017 Oct 2;8(1):763. doi: 10.1038/s41467-017-00716-z.

22.

Neuronal Depolarization Drives Increased Dopamine Synaptic Vesicle Loading via VGLUT.

Aguilar JI, Dunn M, Mingote S, Karam CS, Farino ZJ, Sonders MS, Choi SJ, Grygoruk A, Zhang Y, Cela C, Choi BJ, Flores J, Freyberg RJ, McCabe BD, Mosharov EV, Krantz DE, Javitch JA, Sulzer D, Sames D, Rayport S, Freyberg Z.

Neuron. 2017 Aug 30;95(5):1074-1088.e7. doi: 10.1016/j.neuron.2017.07.038. Epub 2017 Aug 17.

23.

Single-molecule analysis of ligand efficacy in β2AR-G-protein activation.

Gregorio GG, Masureel M, Hilger D, Terry DS, Juette M, Zhao H, Zhou Z, Perez-Aguilar JM, Hauge M, Mathiasen S, Javitch JA, Weinstein H, Kobilka BK, Blanchard SC.

Nature. 2017 Jul 6;547(7661):68-73. doi: 10.1038/nature22354. Epub 2017 Jun 7.

24.

Phospho-specific antibodies targeting the amino terminus of the human dopamine transporter.

Karam CS, Sen N, Javitch JA.

J Chem Neuroanat. 2017 Oct;83-84:91-98. doi: 10.1016/j.jchemneu.2017.05.003. Epub 2017 May 30.

25.

Electronic tuning of self-healing fluorophores for live-cell and single-molecule imaging.

Zheng Q, Jockusch S, Zhou Z, Altman RB, Zhao H, Asher W, Holsey M, Mathiasen S, Geggier P, Javitch JA, Blanchard SC.

Chem Sci. 2017 Jan 1;8(1):755-762. doi: 10.1039/C6SC02976K. Epub 2016 Sep 7.

26.

The role of transmembrane segment 5 (TM5) in Na2 release and the conformational transition of neurotransmitter:sodium symporters toward the inward-open state.

Stolzenberg S, Li Z, Quick M, Malinauskaite L, Nissen P, Weinstein H, Javitch JA, Shi L.

J Biol Chem. 2017 May 5;292(18):7372-7384. doi: 10.1074/jbc.M116.757153. Epub 2017 Mar 20.

27.

The Behavioral Effects of the Antidepressant Tianeptine Require the Mu-Opioid Receptor.

Samuels BA, Nautiyal KM, Kruegel AC, Levinstein MR, Magalong VM, Gassaway MM, Grinnell SG, Han J, Ansonoff MA, Pintar JE, Javitch JA, Sames D, Hen R.

Neuropsychopharmacology. 2017 Sep;42(10):2052-2063. doi: 10.1038/npp.2017.60. Epub 2017 Mar 17.

28.

Potentiating SLC transporter activity: Emerging drug discovery opportunities.

Rives ML, Javitch JA, Wickenden AD.

Biochem Pharmacol. 2017 Jul 1;135:1-11. doi: 10.1016/j.bcp.2017.02.010. Epub 2017 Feb 16. Review.

PMID:
28214518
29.

Toward Understanding the Structural Basis of Partial Agonism at the Dopamine D3 Receptor.

Michino M, Boateng CA, Donthamsetti P, Yano H, Bakare OM, Bonifazi A, Ellenberger MP, Keck TM, Kumar V, Zhu C, Verma R, Deschamps JR, Javitch JA, Newman AH, Shi L.

J Med Chem. 2017 Jan 26;60(2):580-593. doi: 10.1021/acs.jmedchem.6b01148. Epub 2017 Jan 5.

30.

In vivo variation in same-day estimates of metabotropic glutamate receptor subtype 5 binding using [11C]ABP688 and [18F]FPEB.

DeLorenzo C, Gallezot JD, Gardus J, Yang J, Planeta B, Nabulsi N, Ogden RT, Labaree DC, Huang YH, Mann JJ, Gasparini F, Lin X, Javitch JA, Parsey RV, Carson RE, Esterlis I.

J Cereb Blood Flow Metab. 2017 Aug;37(8):2716-2727. doi: 10.1177/0271678X16673646. Epub 2016 Jan 1.

31.

Conformational Dynamics on the Extracellular Side of LeuT Controlled by Na+ and K+ Ions and the Protonation State of Glu290.

Khelashvili G, Schmidt SG, Shi L, Javitch JA, Gether U, Loland CJ, Weinstein H.

J Biol Chem. 2016 Sep 16;291(38):19786-99. doi: 10.1074/jbc.M116.731455. Epub 2016 Jul 29.

32.

Development and Antiparkinsonian Activity of VU0418506, a Selective Positive Allosteric Modulator of Metabotropic Glutamate Receptor 4 Homomers without Activity at mGlu2/4 Heteromers.

Niswender CM, Jones CK, Lin X, Bubser M, Thompson Gray A, Blobaum AL, Engers DW, Rodriguez AL, Loch MT, Daniels JS, Lindsley CW, Hopkins CR, Javitch JA, Conn PJ.

ACS Chem Neurosci. 2016 Sep 21;7(9):1201-11. doi: 10.1021/acschemneuro.6b00036. Epub 2016 Aug 5.

33.

Synthetic and Receptor Signaling Explorations of the Mitragyna Alkaloids: Mitragynine as an Atypical Molecular Framework for Opioid Receptor Modulators.

Kruegel AC, Gassaway MM, Kapoor A, Váradi A, Majumdar S, Filizola M, Javitch JA, Sames D.

J Am Chem Soc. 2016 Jun 1;138(21):6754-64. doi: 10.1021/jacs.6b00360. Epub 2016 May 18.

34.

Novel Analogues of (R)-5-(Methylamino)-5,6-dihydro-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (Sumanirole) Provide Clues to Dopamine D2/D3 Receptor Agonist Selectivity.

Zou MF, Keck TM, Kumar V, Donthamsetti P, Michino M, Burzynski C, Schweppe C, Bonifazi A, Free RB, Sibley DR, Janowsky A, Shi L, Javitch JA, Newman AH.

J Med Chem. 2016 Apr 14;59(7):2973-88. doi: 10.1021/acs.jmedchem.5b01612. Epub 2016 Apr 1.

35.

The role of kinetic context in apparent biased agonism at GPCRs.

Klein Herenbrink C, Sykes DA, Donthamsetti P, Canals M, Coudrat T, Shonberg J, Scammells PJ, Capuano B, Sexton PM, Charlton SJ, Javitch JA, Christopoulos A, Lane JR.

Nat Commun. 2016 Feb 24;7:10842. doi: 10.1038/ncomms10842.

36.

Mechanisms of amphetamine action illuminated through optical monitoring of dopamine synaptic vesicles in Drosophila brain.

Freyberg Z, Sonders MS, Aguilar JI, Hiranita T, Karam CS, Flores J, Pizzo AB, Zhang Y, Farino ZJ, Chen A, Martin CA, Kopajtic TA, Fei H, Hu G, Lin YY, Mosharov EV, McCabe BD, Freyberg R, Wimalasena K, Hsin LW, Sames D, Krantz DE, Katz JL, Sulzer D, Javitch JA.

Nat Commun. 2016 Feb 16;7:10652. doi: 10.1038/ncomms10652.

37.

Development of a Rapid Insulin Assay by Homogenous Time-Resolved Fluorescence.

Farino ZJ, Morgenstern TJ, Vallaghe J, Gregor N, Donthamsetti P, Harris PE, Pierre N, Freyberg R, Charrier-Savournin F, Javitch JA, Freyberg Z.

PLoS One. 2016 Feb 5;11(2):e0148684. doi: 10.1371/journal.pone.0148684. eCollection 2016.

38.

Role of Annular Lipids in the Functional Properties of Leucine Transporter LeuT Proteomicelles.

LeVine MV, Khelashvili G, Shi L, Quick M, Javitch JA, Weinstein H.

Biochemistry. 2016 Feb 16;55(6):850-9. doi: 10.1021/acs.biochem.5b01268. Epub 2016 Feb 5.

39.

Substrate-induced unlocking of the inner gate determines the catalytic efficiency of a neurotransmitter:sodium symporter.

Billesbølle CB, Krüger MB, Shi L, Quick M, Li Z, Stolzenberg S, Kniazeff J, Gotfryd K, Mortensen JS, Javitch JA, Weinstein H, Loland CJ, Gether U.

J Biol Chem. 2015 Oct 30;290(44):26725-38. doi: 10.1074/jbc.M115.677658. Epub 2015 Sep 11.

40.

Using Bioluminescence Resonance Energy Transfer (BRET) to Characterize Agonist-Induced Arrestin Recruitment to Modified and Unmodified G Protein-Coupled Receptors.

Donthamsetti P, Quejada JR, Javitch JA, Gurevich VV, Lambert NA.

Curr Protoc Pharmacol. 2015 Sep 1;70:2.14.1-14. doi: 10.1002/0471141755.ph0214s70.

41.

High Affinity Dopamine D3 Receptor (D3R)-Selective Antagonists Attenuate Heroin Self-Administration in Wild-Type but not D3R Knockout Mice.

Boateng CA, Bakare OM, Zhan J, Banala AK, Burzynski C, Pommier E, Keck TM, Donthamsetti P, Javitch JA, Rais R, Slusher BS, Xi ZX, Newman AH.

J Med Chem. 2015 Aug 13;58(15):6195-213. doi: 10.1021/acs.jmedchem.5b00776. Epub 2015 Jul 23.

42.

Mechanism of the Association between Na+ Binding and Conformations at the Intracellular Gate in Neurotransmitter:Sodium Symporters.

Stolzenberg S, Quick M, Zhao C, Gotfryd K, Khelashvili G, Gether U, Loland CJ, Javitch JA, Noskov S, Weinstein H, Shi L.

J Biol Chem. 2015 May 29;290(22):13992-4003. doi: 10.1074/jbc.M114.625343. Epub 2015 Apr 13.

43.

Upregulation of dopamine D2 receptors in the nucleus accumbens indirect pathway increases locomotion but does not reduce alcohol consumption.

Gallo EF, Salling MC, Feng B, Morón JA, Harrison NL, Javitch JA, Kellendonk C.

Neuropsychopharmacology. 2015 Jun;40(7):1609-18. doi: 10.1038/npp.2015.11. Epub 2015 Jan 12.

44.

Evidence against dopamine D1/D2 receptor heteromers.

Frederick AL, Yano H, Trifilieff P, Vishwasrao HD, Biezonski D, Mészáros J, Urizar E, Sibley DR, Kellendonk C, Sonntag KC, Graham DL, Colbran RJ, Stanwood GD, Javitch JA.

Mol Psychiatry. 2015 Nov;20(11):1373-85. doi: 10.1038/mp.2014.166. Epub 2015 Jan 6.

45.

Evidence for limited D1 and D2 receptor coexpression and colocalization within the dorsal striatum of the neonatal mouse.

Biezonski DK, Trifilieff P, Meszaros J, Javitch JA, Kellendonk C.

J Comp Neurol. 2015 Jun 1;523(8):1175-89. doi: 10.1002/cne.23730. Epub 2015 Feb 17.

46.

What can crystal structures of aminergic receptors tell us about designing subtype-selective ligands?

Michino M, Beuming T, Donthamsetti P, Newman AH, Javitch JA, Shi L.

Pharmacol Rev. 2015;67(1):198-213. doi: 10.1124/pr.114.009944. Review.

47.

Mutation of three residues in the third intracellular loop of the dopamine D2 receptor creates an internalization-defective receptor.

Clayton CC, Donthamsetti P, Lambert NA, Javitch JA, Neve KA.

J Biol Chem. 2014 Nov 28;289(48):33663-75. doi: 10.1074/jbc.M114.605378. Epub 2014 Oct 21.

48.

A mechanism for intracellular release of Na+ by neurotransmitter/sodium symporters.

Malinauskaite L, Quick M, Reinhard L, Lyons JA, Yano H, Javitch JA, Nissen P.

Nat Struct Mol Biol. 2014 Nov;21(11):1006-12. doi: 10.1038/nsmb.2894. Epub 2014 Oct 5.

49.

Dopamine receptor activation increases HIV entry into primary human macrophages.

Gaskill PJ, Yano HH, Kalpana GV, Javitch JA, Berman JW.

PLoS One. 2014 Sep 30;9(9):e108232. doi: 10.1371/journal.pone.0108232. eCollection 2014.

50.

A new mechanism of allostery in a G protein-coupled receptor dimer.

Lane JR, Donthamsetti P, Shonberg J, Draper-Joyce CJ, Dentry S, Michino M, Shi L, López L, Scammells PJ, Capuano B, Sexton PM, Javitch JA, Christopoulos A.

Nat Chem Biol. 2014 Sep;10(9):745-52. doi: 10.1038/nchembio.1593. Epub 2014 Aug 10.

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