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Items: 31


Adenovirus E4-ORF1 Dysregulates Epidermal Growth Factor and Insulin/Insulin-Like Growth Factor Receptors To Mediate Constitutive Myc Expression.

Kong K, Kumar M, Taruishi M, Javier RT.

J Virol. 2015 Nov;89(21):10774-85. doi: 10.1128/JVI.01463-15. Epub 2015 Aug 12.


The human adenovirus E4-ORF1 protein subverts discs large 1 to mediate membrane recruitment and dysregulation of phosphatidylinositol 3-kinase.

Kong K, Kumar M, Taruishi M, Javier RT.

PLoS Pathog. 2014 May 1;10(5):e1004102. doi: 10.1371/journal.ppat.1004102. eCollection 2014 May.


High throughput method to quantify anterior-posterior polarity of T-cells and epithelial cells.

Irvin-Wilson CV, Newberg JY, Kong K, Javier RT, Marriott SJ.

Viruses. 2011 Dec;3(12):2396-411. doi: 10.3390/v3122396. Epub 2011 Nov 28.


The avian influenza virus NS1 ESEV PDZ binding motif associates with Dlg1 and Scribble to disrupt cellular tight junctions.

Golebiewski L, Liu H, Javier RT, Rice AP.

J Virol. 2011 Oct;85(20):10639-48. doi: 10.1128/JVI.05070-11. Epub 2011 Aug 17.


Emerging theme: cellular PDZ proteins as common targets of pathogenic viruses.

Javier RT, Rice AP.

J Virol. 2011 Nov;85(22):11544-56. doi: 10.1128/JVI.05410-11. Epub 2011 Jul 20. Review.


The ESEV PDZ-binding motif of the avian influenza A virus NS1 protein protects infected cells from apoptosis by directly targeting Scribble.

Liu H, Golebiewski L, Dow EC, Krug RM, Javier RT, Rice AP.

J Virol. 2010 Nov;84(21):11164-74. doi: 10.1128/JVI.01278-10. Epub 2010 Aug 11.


Cell polarity proteins: common targets for tumorigenic human viruses.

Javier RT.

Oncogene. 2008 Nov 24;27(55):7031-46. doi: 10.1038/onc.2008.352. Review.


The history of tumor virology.

Javier RT, Butel JS.

Cancer Res. 2008 Oct 1;68(19):7693-706. doi: 10.1158/0008-5472.CAN-08-3301. Review.


Functionally distinct monomers and trimers produced by a viral oncoprotein.

Chung SH, Weiss RS, Frese KK, Prasad BV, Javier RT.

Oncogene. 2008 Feb 28;27(10):1412-20. Epub 2007 Sep 10.


A new crucial protein interaction element that targets the adenovirus E4-ORF1 oncoprotein to membrane vesicles.

Chung SH, Frese KK, Weiss RS, Prasad BV, Javier RT.

J Virol. 2007 May;81(9):4787-97. Epub 2007 Feb 21.


Oncogenic function for the Dlg1 mammalian homolog of the Drosophila discs-large tumor suppressor.

Frese KK, Latorre IJ, Chung SH, Caruana G, Bernstein A, Jones SN, Donehower LA, Justice MJ, Garner CC, Javier RT.

EMBO J. 2006 Mar 22;25(6):1406-17. Epub 2006 Mar 2.


Viral oncoprotein-induced mislocalization of select PDZ proteins disrupts tight junctions and causes polarity defects in epithelial cells.

Latorre IJ, Roh MH, Frese KK, Weiss RS, Margolis B, Javier RT.

J Cell Sci. 2005 Sep 15;118(Pt 18):4283-93. Epub 2005 Sep 1.


Discs-Large and Strabismus are functionally linked to plasma membrane formation.

Lee OK, Frese KK, James JS, Chadda D, Chen ZH, Javier RT, Cho KO.

Nat Cell Biol. 2003 Nov;5(11):987-93. Epub 2003 Oct 19.


Selective PDZ protein-dependent stimulation of phosphatidylinositol 3-kinase by the adenovirus E4-ORF1 oncoprotein.

Frese KK, Lee SS, Thomas DL, Latorre IJ, Weiss RS, Glaunsinger BA, Javier RT.

Oncogene. 2003 Feb 6;22(5):710-21.


Evidence that the tandem-pleckstrin-homology-domain-containing protein TAPP1 interacts with Ptd(3,4)P2 and the multi-PDZ-domain-containing protein MUPP1 in vivo.

Kimber WA, Trinkle-Mulcahy L, Cheung PC, Deak M, Marsden LJ, Kieloch A, Watt S, Javier RT, Gray A, Downes CP, Lucocq JM, Alessi DR.

Biochem J. 2002 Feb 1;361(Pt 3):525-36.


The multi-PDZ domain protein MUPP1 is a cytoplasmic ligand for the membrane-spanning proteoglycan NG2.

Barritt DS, Pearn MT, Zisch AH, Lee SS, Javier RT, Pasquale EB, Stallcup WB.

J Cell Biochem. 2000 Aug 2;79(2):213-24.


Early region 1 transforming functions are dispensable for mammary tumorigenesis by human adenovirus type 9.

Thomas DL, Shin S, Jiang BH, Vogel H, Ross MA, Kaplitt M, Shenk TE, Javier RT.

J Virol. 1999 Apr;73(4):3071-9.


Herpes simplex virus latent phase transcription facilitates in vivo reactivation.

Hill JM, Sedarati F, Javier RT, Wagner EK, Stevens JG.

Virology. 1990 Jan;174(1):117-25.


Two avirulent herpes simplex viruses generate lethal recombinants in vivo.

Javier RT, Sedarati F, Stevens JG.

Science. 1986 Nov 7;234(4777):746-8.


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