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Items: 46

1.

High-yield Production of Amyloid-β Peptide Enabled by a Customized Spider Silk Domain.

Abelein A, Chen G, Kitoka K, Aleksis R, Oleskovs F, Sarr M, Landreh M, Pahnke J, Nordling K, Kronqvist N, Jaudzems K, Rising A, Johansson J, Biverstål H.

Sci Rep. 2020 Jan 14;10(1):235. doi: 10.1038/s41598-019-57143-x.

2.

BBE31 from the Lyme disease agent Borrelia burgdorferi, known to play an important role in successful colonization of the mammalian host, shows the ability to bind glutathione.

Brangulis K, Akopjana I, Petrovskis I, Kazaks A, Zelencova D, Jekabsons A, Jaudzems K, Tars K.

Biochim Biophys Acta Gen Subj. 2020 Mar;1864(3):129499. doi: 10.1016/j.bbagen.2019.129499. Epub 2019 Nov 27.

PMID:
31785327
3.

Targeting Bacterial Sortase A with Covalent Inhibitors: 27 New Starting Points for Structure-Based Hit-to-Lead Optimization.

Jaudzems K, Kurbatska V, Je Kabsons A, Bobrovs R, Rudevica Z, Leonchiks A.

ACS Infect Dis. 2019 Nov 18. doi: 10.1021/acsinfecdis.9b00265. [Epub ahead of print]

PMID:
31724850
4.

Biomimetic composites with enhanced toughening using silk-inspired triblock proteins and aligned nanocellulose reinforcements.

Mohammadi P, Aranko AS, Landowski CP, Ikkala O, Jaudzems K, Wagermaier W, Linder MB.

Sci Adv. 2019 Sep 13;5(9):eaaw2541. doi: 10.1126/sciadv.aaw2541. eCollection 2019 Sep.

5.

Structural analysis of Borrelia burgdorferi periplasmic lipoprotein BB0365 involved in Lyme disease infection.

Brangulis K, Akopjana I, Petrovskis I, Kazaks A, Jekabsons A, Jaudzems K, Viksna A, Bertins M, Tars K.

FEBS Lett. 2019 Sep 5. doi: 10.1002/1873-3468.13594. [Epub ahead of print]

PMID:
31486526
6.

Dynamic Nuclear Polarization Magic-Angle Spinning Nuclear Magnetic Resonance Combined with Molecular Dynamics Simulations Permits Detection of Order and Disorder in Viral Assemblies.

Gupta R, Zhang H, Lu M, Hou G, Caporini M, Rosay M, Maas W, Struppe J, Ahn J, Byeon IL, Oschkinat H, Jaudzems K, Barbet-Massin E, Emsley L, Pintacuda G, Lesage A, Gronenborn AM, Polenova T.

J Phys Chem B. 2019 Jun 20;123(24):5048-5058. doi: 10.1021/acs.jpcb.9b02293. Epub 2019 Jun 11.

PMID:
31125232
7.

Exploiting Structural Dynamics To Design Open-Flap Inhibitors of Malarial Aspartic Proteases.

Bobrovs R, Jaudzems K, Jirgensons A.

J Med Chem. 2019 Oct 24;62(20):8931-8950. doi: 10.1021/acs.jmedchem.9b00184. Epub 2019 May 16.

PMID:
31062983
8.

Peptidomimetic plasmepsin inhibitors with potent anti-malarial activity and selectivity against cathepsin D.

Zogota R, Kinena L, Withers-Martinez C, Blackman MJ, Bobrovs R, Pantelejevs T, Kanepe-Lapsa I, Ozola V, Jaudzems K, Suna E, Jirgensons A.

Eur J Med Chem. 2019 Feb 1;163:344-352. doi: 10.1016/j.ejmech.2018.11.068. Epub 2018 Nov 29.

9.

DNP NMR of biomolecular assemblies.

Jaudzems K, Polenova T, Pintacuda G, Oschkinat H, Lesage A.

J Struct Biol. 2019 Apr 1;206(1):90-98. doi: 10.1016/j.jsb.2018.09.011. Epub 2018 Sep 29.

PMID:
30273657
10.

Azole-based non-peptidomimetic plasmepsin inhibitors.

Kinena L, Leitis G, Kanepe-Lapsa I, Bobrovs R, Jaudzems K, Ozola V, Suna E, Jirgensons A.

Arch Pharm (Weinheim). 2018 Sep;351(9):e1800151. doi: 10.1002/ardp.201800151. Epub 2018 Jul 31.

PMID:
30063266
11.

2-Aminoquinazolin-4(3H)-one based plasmepsin inhibitors with improved hydrophilicity and selectivity.

Rasina D, Stakanovs G, Borysov OV, Pantelejevs T, Bobrovs R, Kanepe-Lapsa I, Tars K, Jaudzems K, Jirgensons A.

Bioorg Med Chem. 2018 May 15;26(9):2488-2500. doi: 10.1016/j.bmc.2018.04.012. Epub 2018 Apr 5.

PMID:
29636223
12.

A spidroin-derived solubility tag enables controlled aggregation of a designed amyloid protein.

Sarr M, Kronqvist N, Chen G, Aleksis R, Purhonen P, Hebert H, Jaudzems K, Rising A, Johansson J.

FEBS J. 2018 May;285(10):1873-1885. doi: 10.1111/febs.14451. Epub 2018 Apr 14.

13.

Dynamic Nuclear Polarization-Enhanced Biomolecular NMR Spectroscopy at High Magnetic Field with Fast Magic-Angle Spinning.

Jaudzems K, Bertarello A, Chaudhari SR, Pica A, Cala-De Paepe D, Barbet-Massin E, Pell AJ, Akopjana I, Kotelovica S, Gajan D, Ouari O, Tars K, Pintacuda G, Lesage A.

Angew Chem Int Ed Engl. 2018 Jun 18;57(25):7458-7462. doi: 10.1002/anie.201801016. Epub 2018 Apr 27.

PMID:
29566299
14.

N-Leucinyl Benzenesulfonamides as Structurally Simplified Leucyl-tRNA Synthetase Inhibitors.

Charlton MH, Aleksis R, Saint-Leger A, Gupta A, Loza E, Ribas de Pouplana L, Kaula I, Gustina D, Madre M, Lola D, Jaudzems K, Edmund G, Randall CP, Kime L, O'Neill AJ, Goessens W, Jirgensons A, Finn PW.

ACS Med Chem Lett. 2018 Jan 18;9(2):84-88. doi: 10.1021/acsmedchemlett.7b00374. eCollection 2018 Feb 8.

15.

Is protein deuteration beneficial for proton detected solid-state NMR at and above 100 kHz magic-angle spinning?

Cala-De Paepe D, Stanek J, Jaudzems K, Tars K, Andreas LB, Pintacuda G.

Solid State Nucl Magn Reson. 2017 Oct;87:126-136. doi: 10.1016/j.ssnmr.2017.07.004. Epub 2017 Jul 25.

16.

Degree of Biomimicry of Artificial Spider Silk Spinning Assessed by NMR Spectroscopy.

Otikovs M, Andersson M, Jia Q, Nordling K, Meng Q, Andreas LB, Pintacuda G, Johansson J, Rising A, Jaudzems K.

Angew Chem Int Ed Engl. 2017 Oct 2;56(41):12571-12575. doi: 10.1002/anie.201706649. Epub 2017 Aug 30.

PMID:
28791761
17.

Structural studies of amyloid-β peptides: Unlocking the mechanism of aggregation and the associated toxicity.

Aleksis R, Oleskovs F, Jaudzems K, Pahnke J, Biverstål H.

Biochimie. 2017 Sep;140:176-192. doi: 10.1016/j.biochi.2017.07.011. Epub 2017 Jul 25. Review.

PMID:
28751216
18.

Efficient protein production inspired by how spiders make silk.

Kronqvist N, Sarr M, Lindqvist A, Nordling K, Otikovs M, Venturi L, Pioselli B, Purhonen P, Landreh M, Biverstål H, Toleikis Z, Sjöberg L, Robinson CV, Pelizzi N, Jörnvall H, Hebert H, Jaudzems K, Curstedt T, Rising A, Johansson J.

Nat Commun. 2017 May 23;8:15504. doi: 10.1038/ncomms15504.

19.

NMR Spectroscopic Assignment of Backbone and Side-Chain Protons in Fully Protonated Proteins: Microcrystals, Sedimented Assemblies, and Amyloid Fibrils.

Stanek J, Andreas LB, Jaudzems K, Cala D, Lalli D, Bertarello A, Schubeis T, Akopjana I, Kotelovica S, Tars K, Pica A, Leone S, Picone D, Xu ZQ, Dixon NE, Martinez D, Berbon M, El Mammeri N, Noubhani A, Saupe S, Habenstein B, Loquet A, Pintacuda G.

Angew Chem Int Ed Engl. 2016 Dec 12;55(50):15504-15509. doi: 10.1002/anie.201607084. Epub 2016 Nov 16.

PMID:
27865050
20.

Lunasin is a redox sensitive intrinsically disordered peptide with two transiently populated α-helical regions.

Aleksis R, Jaudzems K, Muceniece R, Liepinsh E.

Peptides. 2016 Nov;85:56-62. doi: 10.1016/j.peptides.2016.09.006. Epub 2016 Sep 14.

PMID:
27639324
21.

Crystal structure of Plasmodium falciparum proplasmepsin IV: the plasticity of proplasmepsins.

Recacha R, Jaudzems K, Akopjana I, Jirgensons A, Tars K.

Acta Crystallogr F Struct Biol Commun. 2016 Sep;72(Pt 9):659-66. doi: 10.1107/S2053230X16011663. Epub 2016 Aug 9.

22.

Structure of AP205 Coat Protein Reveals Circular Permutation in ssRNA Bacteriophages.

Shishovs M, Rumnieks J, Diebolder C, Jaudzems K, Andreas LB, Stanek J, Kazaks A, Kotelovica S, Akopjana I, Pintacuda G, Koning RI, Tars K.

J Mol Biol. 2016 Oct 23;428(21):4267-4279. doi: 10.1016/j.jmb.2016.08.025. Epub 2016 Aug 31.

PMID:
27591890
23.

Structure of fully protonated proteins by proton-detected magic-angle spinning NMR.

Andreas LB, Jaudzems K, Stanek J, Lalli D, Bertarello A, Le Marchand T, Cala-De Paepe D, Kotelovica S, Akopjana I, Knott B, Wegner S, Engelke F, Lesage A, Emsley L, Tars K, Herrmann T, Pintacuda G.

Proc Natl Acad Sci U S A. 2016 Aug 16;113(33):9187-92. doi: 10.1073/pnas.1602248113. Epub 2016 Aug 3.

24.

Transmissible amyloid.

Tjernberg LO, Rising A, Johansson J, Jaudzems K, Westermark P.

J Intern Med. 2016 Aug;280(2):153-63. doi: 10.1111/joim.12499. Epub 2016 Mar 22. Review.

25.

Fragment-Based Discovery of 2-Aminoquinazolin-4(3H)-ones As Novel Class Nonpeptidomimetic Inhibitors of the Plasmepsins I, II, and IV.

Rasina D, Otikovs M, Leitans J, Recacha R, Borysov OV, Kanepe-Lapsa I, Domraceva I, Pantelejevs T, Tars K, Blackman MJ, Jaudzems K, Jirgensons A.

J Med Chem. 2016 Jan 14;59(1):374-87. doi: 10.1021/acs.jmedchem.5b01558. Epub 2015 Dec 23.

PMID:
26670264
26.

Structures of plasmepsin II from Plasmodium falciparum in complex with two hydroxyethylamine-based inhibitors.

Recacha R, Leitans J, Akopjana I, Aprupe L, Trapencieris P, Jaudzems K, Jirgensons A, Tars K.

Acta Crystallogr F Struct Biol Commun. 2015 Dec;71(Pt 12):1531-9. doi: 10.1107/S2053230X15022049. Epub 2015 Nov 27.

27.

Structural and functional analysis of BB0689 from Borrelia burgdorferi, a member of the bacterial CAP superfamily.

Brangulis K, Jaudzems K, Petrovskis I, Akopjana I, Kazaks A, Tars K.

J Struct Biol. 2015 Dec;192(3):320-330. doi: 10.1016/j.jsb.2015.09.007. Epub 2015 Sep 25.

PMID:
26407658
28.

Diversified Structural Basis of a Conserved Molecular Mechanism for pH-Dependent Dimerization in Spider Silk N-Terminal Domains.

Otikovs M, Chen G, Nordling K, Landreh M, Meng Q, Jörnvall H, Kronqvist N, Rising A, Johansson J, Jaudzems K.

Chembiochem. 2015 Aug 17;16(12):1720-4. doi: 10.1002/cbic.201500263. Epub 2015 Jul 1.

PMID:
26033527
29.

High-resolution proton-detected NMR of proteins at very fast MAS.

Andreas LB, Le Marchand T, Jaudzems K, Pintacuda G.

J Magn Reson. 2015 Apr;253:36-49. doi: 10.1016/j.jmr.2015.01.003. Review.

PMID:
25797003
30.

O-tert-Butyltyrosine, an NMR tag for high-molecular-weight systems and measurements of submicromolar ligand binding affinities.

Chen WN, Kuppan KV, Lee MD, Jaudzems K, Huber T, Otting G.

J Am Chem Soc. 2015 Apr 8;137(13):4581-6. doi: 10.1021/jacs.5b01918. Epub 2015 Mar 27.

PMID:
25789794
31.

J-UNIO protocol used for NMR structure determination of the 206-residue protein NP_346487.1 from Streptococcus pneumoniae TIGR4.

Jaudzems K, Pedrini B, Geralt M, Serrano P, Wüthrich K.

J Biomol NMR. 2015 Jan;61(1):65-72. doi: 10.1007/s10858-014-9886-3. Epub 2014 Nov 27.

32.

Discovery and structure-activity relationship studies of irreversible benzisothiazolinone-based inhibitors against Staphylococcus aureus sortase A transpeptidase.

Zhulenkovs D, Rudevica Z, Jaudzems K, Turks M, Leonchiks A.

Bioorg Med Chem. 2014 Nov 1;22(21):5988-6003. doi: 10.1016/j.bmc.2014.09.011. Epub 2014 Sep 16.

PMID:
25282649
33.

Rapid proton-detected NMR assignment for proteins with fast magic angle spinning.

Barbet-Massin E, Pell AJ, Retel JS, Andreas LB, Jaudzems K, Franks WT, Nieuwkoop AJ, Hiller M, Higman V, Guerry P, Bertarello A, Knight MJ, Felletti M, Le Marchand T, Kotelovica S, Akopjana I, Tars K, Stoppini M, Bellotti V, Bolognesi M, Ricagno S, Chou JJ, Griffin RG, Oschkinat H, Lesage A, Emsley L, Herrmann T, Pintacuda G.

J Am Chem Soc. 2014 Sep 3;136(35):12489-97. doi: 10.1021/ja507382j. Epub 2014 Aug 18.

34.

Carbonic anhydrase generates CO2 and H+ that drive spider silk formation via opposite effects on the terminal domains.

Andersson M, Chen G, Otikovs M, Landreh M, Nordling K, Kronqvist N, Westermark P, Jörnvall H, Knight S, Ridderstråle Y, Holm L, Meng Q, Jaudzems K, Chesler M, Johansson J, Rising A.

PLoS Biol. 2014 Aug 5;12(8):e1001921. doi: 10.1371/journal.pbio.1001921. eCollection 2014 Aug.

35.

Plasmepsin inhibitory activity and structure-guided optimization of a potent hydroxyethylamine-based antimalarial hit.

Jaudzems K, Tars K, Maurops G, Ivdra N, Otikovs M, Leitans J, Kanepe-Lapsa I, Domraceva I, Mutule I, Trapencieris P, Blackman MJ, Jirgensons A.

ACS Med Chem Lett. 2014 Jan 13;5(4):373-7. doi: 10.1021/ml4004952. eCollection 2014 Apr 10.

36.

Structural characterization of CspZ, a complement regulator factor H and FHL-1 binding protein from Borrelia burgdorferi.

Brangulis K, Petrovskis I, Kazaks A, Bogans J, Otikovs M, Jaudzems K, Ranka R, Tars K.

FEBS J. 2014 Jun;281(11):2613-22. doi: 10.1111/febs.12808. Epub 2014 Apr 28.

37.

Sequential pH-driven dimerization and stabilization of the N-terminal domain enables rapid spider silk formation.

Kronqvist N, Otikovs M, Chmyrov V, Chen G, Andersson M, Nordling K, Landreh M, Sarr M, Jörnvall H, Wennmalm S, Widengren J, Meng Q, Rising A, Otzen D, Knight SD, Jaudzems K, Johansson J.

Nat Commun. 2014;5:3254. doi: 10.1038/ncomms4254.

PMID:
24510122
38.

Out-and-back 13C-13C scalar transfers in protein resonance assignment by proton-detected solid-state NMR under ultra-fast MAS.

Barbet-Massin E, Pell AJ, Jaudzems K, Franks WT, Retel JS, Kotelovica S, Akopjana I, Tars K, Emsley L, Oschkinat H, Lesage A, Pintacuda G.

J Biomol NMR. 2013 Aug;56(4):379-86. doi: 10.1007/s10858-013-9757-3. Epub 2013 Jun 29.

PMID:
23812971
39.

Structural basis for 5'-end-specific recognition of single-stranded DNA by the R3H domain from human Sμbp-2.

Jaudzems K, Jia X, Yagi H, Zhulenkovs D, Graham B, Otting G, Liepinsh E.

J Mol Biol. 2012 Nov 23;424(1-2):42-53. doi: 10.1016/j.jmb.2012.09.010. Epub 2012 Sep 18.

PMID:
22999958
40.

pH-dependent dimerization of spider silk N-terminal domain requires relocation of a wedged tryptophan side chain.

Jaudzems K, Askarieh G, Landreh M, Nordling K, Hedhammar M, Jörnvall H, Rising A, Knight SD, Johansson J.

J Mol Biol. 2012 Sep 28;422(4):477-87. doi: 10.1016/j.jmb.2012.06.004. Epub 2012 Jun 15.

PMID:
22706024
41.

Comparison of NMR and crystal structures highlights conformational isomerism in protein active sites.

Serrano P, Pedrini B, Geralt M, Jaudzems K, Mohanty B, Horst R, Herrmann T, Elsliger MA, Wilson IA, Wüthrich K.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Oct 1;66(Pt 10):1393-405. doi: 10.1107/S1744309110033658. Epub 2010 Sep 30.

42.

Comparison of NMR and crystal structures for the proteins TM1112 and TM1367.

Mohanty B, Serrano P, Pedrini B, Jaudzems K, Geralt M, Horst R, Herrmann T, Elsliger MA, Wilson IA, Wüthrich K.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Oct 1;66(Pt 10):1381-92. doi: 10.1107/S1744309110020956. Epub 2010 Aug 7.

43.

NMR structure of the protein NP_247299.1: comparison with the crystal structure.

Jaudzems K, Geralt M, Serrano P, Mohanty B, Horst R, Pedrini B, Elsliger MA, Wilson IA, Wüthrich K.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Oct 1;66(Pt 10):1367-80. doi: 10.1107/S1744309110005890. Epub 2010 Jul 6.

44.

NMR Structure of the SARS-CoV Nonstructural Protein 7 in Solution at pH 6.5.

Johnson MA, Jaudzems K, Wüthrich K.

J Mol Biol. 2010 Oct 1;402(4):619-28. doi: 10.1016/j.jmb.2010.07.043. Epub 2010 Aug 13.

45.

Inhibition of carnitine acetyltransferase by mildronate, a regulator of energy metabolism.

Jaudzems K, Kuka J, Gutsaits A, Zinovjevs K, Kalvinsh I, Liepinsh E, Liepinsh E, Dambrova M.

J Enzyme Inhib Med Chem. 2009 Dec;24(6):1269-75. doi: 10.3109/14756360902829527.

PMID:
19912061
46.

A novel zinc-binding fold in the helicase interaction domain of the Bacillus subtilis DnaI helicase loader.

Loscha KV, Jaudzems K, Ioannou C, Su XC, Hill FR, Otting G, Dixon NE, Liepinsh E.

Nucleic Acids Res. 2009 Apr;37(7):2395-404. doi: 10.1093/nar/gkp092. Epub 2009 Mar 2.

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