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Flavonoids enhance rod opsin stability, folding, and self-association by directly binding to ligand-free opsin and modulating its conformation.

Ortega JT, Parmar T, Jastrzebska B.

J Biol Chem. 2019 May 17;294(20):8101-8122. doi: 10.1074/jbc.RA119.007808. Epub 2019 Apr 3.


Specificity of the chromophore-binding site in human cone opsins.

Katayama K, Gulati S, Ortega JT, Alexander NS, Sun W, Shenouda MM, Palczewski K, Jastrzebska B.

J Biol Chem. 2019 Apr 12;294(15):6082-6093. doi: 10.1074/jbc.RA119.007587. Epub 2019 Feb 15.


Contribution of Cotranslational Folding Defects to Membrane Protein Homeostasis.

Roushar FJ, Gruenhagen TC, Penn WD, Li B, Meiler J, Jastrzebska B, Schlebach JP.

J Am Chem Soc. 2019 Jan 9;141(1):204-215. doi: 10.1021/jacs.8b08243. Epub 2018 Dec 26.


Apo-Opsin Exists in Equilibrium Between a Predominant Inactive and a Rare Highly Active State.

Sato S, Jastrzebska B, Engel A, Palczewski K, Kefalov VJ.

J Neurosci. 2019 Jan 9;39(2):212-223. doi: 10.1523/JNEUROSCI.1980-18.2018. Epub 2018 Nov 20.


The Retinitis Pigmentosa-Linked Mutations in Transmembrane Helix 5 of Rhodopsin Disrupt Cellular Trafficking Regardless of Oligomerization State.

Mallory DP, Gutierrez E, Pinkevitch M, Klinginsmith C, Comar WD, Roushar FJ, Schlebach JP, Smith AW, Jastrzebska B.

Biochemistry. 2018 Sep 4;57(35):5188-5201. doi: 10.1021/acs.biochem.8b00403. Epub 2018 Aug 21.


Protective Effect of a Locked Retinal Chromophore Analog against Light-Induced Retinal Degeneration.

Gao S, Parmar T, Palczewska G, Dong Z, Golczak M, Palczewski K, Jastrzebska B.

Mol Pharmacol. 2018 Oct;94(4):1132-1144. doi: 10.1124/mol.118.112581. Epub 2018 Jul 17.


A novel small molecule chaperone of rod opsin and its potential therapy for retinal degeneration.

Chen Y, Chen Y, Jastrzebska B, Golczak M, Gulati S, Tang H, Seibel W, Li X, Jin H, Han Y, Gao S, Zhang J, Liu X, Heidari-Torkabadi H, Stewart PL, Harte WE, Tochtrop GP, Palczewski K.

Nat Commun. 2018 May 17;9(1):1976. doi: 10.1038/s41467-018-04261-1.


Retinal-chitosan Conjugates Effectively Deliver Active Chromophores to Retinal Photoreceptor Cells in Blind Mice and Dogs.

Gao S, Kahremany S, Zhang J, Jastrzebska B, Querubin J, Petersen-Jones SM, Palczewski K.

Mol Pharmacol. 2018 May;93(5):438-452. doi: 10.1124/mol.117.111294. Epub 2018 Feb 16.


Complex binding pathways determine the regeneration of mammalian green cone opsin with a locked retinal analogue.

Alexander NS, Katayama K, Sun W, Salom D, Gulati S, Zhang J, Mogi M, Palczewski K, Jastrzebska B.

J Biol Chem. 2017 Jun 30;292(26):10983-10997. doi: 10.1074/jbc.M117.780478. Epub 2017 May 9.


Photocyclic behavior of rhodopsin induced by an atypical isomerization mechanism.

Gulati S, Jastrzebska B, Banerjee S, Placeres ÁL, Miszta P, Gao S, Gunderson K, Tochtrop GP, Filipek S, Katayama K, Kiser PD, Mogi M, Stewart PL, Palczewski K.

Proc Natl Acad Sci U S A. 2017 Mar 28;114(13):E2608-E2615. doi: 10.1073/pnas.1617446114. Epub 2017 Mar 13.


A G Protein-Coupled Receptor Dimerization Interface in Human Cone Opsins.

Jastrzebska B, Comar WD, Kaliszewski MJ, Skinner KC, Torcasio MH, Esway AS, Jin H, Palczewski K, Smith AW.

Biochemistry. 2017 Jan 10;56(1):61-72. doi: 10.1021/acs.biochem.6b00877. Epub 2016 Nov 29.


Disruption of Rhodopsin Dimerization with Synthetic Peptides Targeting an Interaction Interface.

Jastrzebska B, Chen Y, Orban T, Jin H, Hofmann L, Palczewski K.

J Biol Chem. 2015 Oct 16;290(42):25728-44. doi: 10.1074/jbc.M115.662684. Epub 2015 Sep 1.


Preface. Rhodopsin.

Jastrzebska B.

Methods Mol Biol. 2015;1271:v-vi. No abstract available.


Oligomeric state of rhodopsin within rhodopsin-transducin complex probed with succinylated concanavalin A.

Jastrzebska B.

Methods Mol Biol. 2015;1271:221-33. doi: 10.1007/978-1-4939-2330-4_15.


Animals deficient in C2Orf71, an autosomal recessive retinitis pigmentosa-associated locus, develop severe early-onset retinal degeneration.

Kevany BM, Zhang N, Jastrzebska B, Palczewski K.

Hum Mol Genet. 2015 May 1;24(9):2627-40. doi: 10.1093/hmg/ddv025. Epub 2015 Jan 23.


Time-resolved fluorescence spectroscopy measures clustering and mobility of a G protein-coupled receptor opsin in live cell membranes.

Comar WD, Schubert SM, Jastrzebska B, Palczewski K, Smith AW.

J Am Chem Soc. 2014 Jun 11;136(23):8342-9. doi: 10.1021/ja501948w. Epub 2014 Jun 2.


Structural approaches to understanding retinal proteins needed for vision.

Orban T, Jastrzebska B, Palczewski K.

Curr Opin Cell Biol. 2014 Apr;27:32-43. doi: 10.1016/ Epub 2013 Nov 28. Review.


Inherent instability of the retinitis pigmentosa P23H mutant opsin.

Chen Y, Jastrzebska B, Cao P, Zhang J, Wang B, Sun W, Yuan Y, Feng Z, Palczewski K.

J Biol Chem. 2014 Mar 28;289(13):9288-303. doi: 10.1074/jbc.M114.551713. Epub 2014 Feb 10.


GPCR: G protein complexes--the fundamental signaling assembly.

Jastrzebska B.

Amino Acids. 2013 Dec;45(6):1303-14. doi: 10.1007/s00726-013-1593-y. Epub 2013 Sep 20. Review.


The rhodopsin-transducin complex houses two distinct rhodopsin molecules.

Jastrzebska B, Ringler P, Palczewski K, Engel A.

J Struct Biol. 2013 May;182(2):164-72. doi: 10.1016/j.jsb.2013.02.014. Epub 2013 Feb 28.


Expression of mammalian G protein-coupled receptors in Caenorhabditis elegans.

Jastrzebska B, Salom D, Jin H, Cao P, Sun W, Palczewski K, Feng Z.

Methods Enzymol. 2013;520:239-56. doi: 10.1016/B978-0-12-391861-1.00011-3.


Asymmetry of the rhodopsin dimer in complex with transducin.

Jastrzebska B, Orban T, Golczak M, Engel A, Palczewski K.

FASEB J. 2013 Apr;27(4):1572-84. doi: 10.1096/fj.12-225383. Epub 2013 Jan 9.


3D imaging and quantitative analysis of small solubilized membrane proteins and their complexes by transmission electron microscopy.

Vahedi-Faridi A, Jastrzebska B, Palczewski K, Engel A.

Microscopy (Oxf). 2013 Feb;62(1):95-107. doi: 10.1093/jmicro/dfs091. Epub 2012 Dec 23.


Autosomal recessive retinitis pigmentosa E150K opsin mice exhibit photoreceptor disorganization.

Zhang N, Kolesnikov AV, Jastrzebska B, Mustafi D, Sawada O, Maeda T, Genoud C, Engel A, Kefalov VJ, Palczewski K.

J Clin Invest. 2013 Jan;123(1):121-37. doi: 10.1172/JCI66176. Epub 2012 Dec 10.


Conformational dynamics of activation for the pentameric complex of dimeric G protein-coupled receptor and heterotrimeric G protein.

Orban T, Jastrzebska B, Gupta S, Wang B, Miyagi M, Chance MR, Palczewski K.

Structure. 2012 May 9;20(5):826-40. doi: 10.1016/j.str.2012.03.017.


Substrate-induced changes in the dynamics of rhodopsin kinase (G protein-coupled receptor kinase 1).

Orban T, Huang CC, Homan KT, Jastrzebska B, Tesmer JJ, Palczewski K.

Biochemistry. 2012 Apr 24;51(16):3404-11. doi: 10.1021/bi300295y. Epub 2012 Apr 11.


Heterologous expression of functional G-protein-coupled receptors in Caenorhabditis elegans.

Salom D, Cao P, Sun W, Kramp K, Jastrzebska B, Jin H, Feng Z, Palczewski K.

FASEB J. 2012 Feb;26(2):492-502. doi: 10.1096/fj.11-197780. Epub 2011 Nov 16.


Light-sensitive coupling of rhodopsin and melanopsin to G(i/o) and G(q) signal transduction in Caenorhabditis elegans.

Cao P, Sun W, Kramp K, Zheng M, Salom D, Jastrzebska B, Jin H, Palczewski K, Feng Z.

FASEB J. 2012 Feb;26(2):480-91. doi: 10.1096/fj.11-197798. Epub 2011 Nov 16.


Rhodopsin-transducin heteropentamer: three-dimensional structure and biochemical characterization.

Jastrzebska B, Ringler P, Lodowski DT, Moiseenkova-Bell V, Golczak M, Müller SA, Palczewski K, Engel A.

J Struct Biol. 2011 Dec;176(3):387-94. doi: 10.1016/j.jsb.2011.08.016. Epub 2011 Sep 6.


Role of bulk water in hydrolysis of the rhodopsin chromophore.

Jastrzebska B, Palczewski K, Golczak M.

J Biol Chem. 2011 May 27;286(21):18930-7. doi: 10.1074/jbc.M111.234583. Epub 2011 Apr 1.


Role of membrane integrity on G protein-coupled receptors: Rhodopsin stability and function.

Jastrzebska B, Debinski A, Filipek S, Palczewski K.

Prog Lipid Res. 2011 Jul;50(3):267-77. doi: 10.1016/j.plipres.2011.03.002. Epub 2011 Mar 22. Review.


Activation of G protein-coupled receptor kinase 1 involves interactions between its N-terminal region and its kinase domain.

Huang CC, Orban T, Jastrzebska B, Palczewski K, Tesmer JJ.

Biochemistry. 2011 Mar 22;50(11):1940-9. doi: 10.1021/bi101606e. Epub 2011 Feb 22.


Complexes between photoactivated rhodopsin and transducin: progress and questions.

Jastrzebska B, Tsybovsky Y, Palczewski K.

Biochem J. 2010 Apr 28;428(1):1-10. doi: 10.1042/BJ20100270. Review.


Structural waters define a functional channel mediating activation of the GPCR, rhodopsin.

Angel TE, Gupta S, Jastrzebska B, Palczewski K, Chance MR.

Proc Natl Acad Sci U S A. 2009 Aug 25;106(34):14367-72. doi: 10.1073/pnas.0901074106. Epub 2009 Aug 13.


Phospholipids are needed for the proper formation, stability, and function of the photoactivated rhodopsin-transducin complex.

Jastrzebska B, Goc A, Golczak M, Palczewski K.

Biochemistry. 2009 Jun 16;48(23):5159-70. doi: 10.1021/bi900284x.


Monitoring of MMPs activity in vivo, non-invasively, using solubility switchable MRI contrast agent.

Jastrzebska B, Lebel R, McIntyre OJ, Paquette B, Neugebauer W, Escher E, Lepage M.

Adv Exp Med Biol. 2009;611:453-4. No abstract available.


Modulation of molecular interactions and function by rhodopsin palmitylation.

Park PS, Sapra KT, Jastrzebska B, Maeda T, Maeda A, Pulawski W, Kono M, Lem J, Crouch RK, Filipek S, Müller DJ, Palczewski K.

Biochemistry. 2009 May 26;48(20):4294-304. doi: 10.1021/bi900417b.


New enzyme-activated solubility-switchable contrast agent for magnetic resonance imaging: from synthesis to in vivo imaging.

Jastrzebska B, Lebel R, Therriault H, McIntyre JO, Escher E, Guérin B, Paquette B, Neugebauer WA, Lepage M.

J Med Chem. 2009 Mar 26;52(6):1576-81. doi: 10.1021/jm801411h.


CacyBP/SIP binds ERK1/2 and affects transcriptional activity of Elk-1.

Kilanczyk E, Filipek S, Jastrzebska B, Filipek A.

Biochem Biophys Res Commun. 2009 Feb 27;380(1):54-9. doi: 10.1016/j.bbrc.2009.01.026. Epub 2009 Jan 21.


Different properties of the native and reconstituted heterotrimeric G protein transducin.

Goc A, Angel TE, Jastrzebska B, Wang B, Wintrode PL, Palczewski K.

Biochemistry. 2008 Nov 25;47(47):12409-19. doi: 10.1021/bi8015444.


Novel solubility-switchable MRI agent allows the noninvasive detection of matrix metalloproteinase-2 activity in vivo in a mouse model.

Lebel R, Jastrzebska B, Therriault H, Cournoyer MM, McIntyre JO, Escher E, Neugebauer W, Paquette B, Lepage M.

Magn Reson Med. 2008 Nov;60(5):1056-65. doi: 10.1002/mrm.21741.


Isolation and functional characterization of a stable complex between photoactivated rhodopsin and the G protein, transducin.

Jastrzebska B, Golczak M, Fotiadis D, Engel A, Palczewski K.

FASEB J. 2009 Feb;23(2):371-81. doi: 10.1096/fj.07-114835. Epub 2008 Sep 30.


Efficient coupling of transducin to monomeric rhodopsin in a phospholipid bilayer.

Whorton MR, Jastrzebska B, Park PS, Fotiadis D, Engel A, Palczewski K, Sunahara RK.

J Biol Chem. 2008 Feb 15;283(7):4387-94. Epub 2007 Nov 22.


Heterologous expression of the adenosine A1 receptor in transgenic mouse retina.

Li N, Salom D, Zhang L, Harris T, Ballesteros JA, Golczak M, Jastrzebska B, Palczewski K, Kurahara C, Juan T, Jordan S, Salon JA.

Biochemistry. 2007 Jul 17;46(28):8350-9. Epub 2007 Jun 20.


Crystal structure of a photoactivated deprotonated intermediate of rhodopsin.

Salom D, Lodowski DT, Stenkamp RE, Le Trong I, Golczak M, Jastrzebska B, Harris T, Ballesteros JA, Palczewski K.

Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16123-8. Epub 2006 Oct 23.


Retinol dehydrogenase (RDH12) protects photoreceptors from light-induced degeneration in mice.

Maeda A, Maeda T, Imanishi Y, Sun W, Jastrzebska B, Hatala DA, Winkens HJ, Hofmann KP, Janssen JJ, Baehr W, Driessen CA, Palczewski K.

J Biol Chem. 2006 Dec 8;281(49):37697-704. Epub 2006 Oct 10.


Autosomal recessive retinitis pigmentosa and E150K mutation in the opsin gene.

Zhu L, Imanishi Y, Filipek S, Alekseev A, Jastrzebska B, Sun W, Saperstein DA, Palczewski K.

J Biol Chem. 2006 Aug 4;281(31):22289-98. Epub 2006 May 31.


Structure of the rhodopsin dimer: a working model for G-protein-coupled receptors.

Fotiadis D, Jastrzebska B, Philippsen A, Müller DJ, Palczewski K, Engel A.

Curr Opin Struct Biol. 2006 Apr;16(2):252-9. Epub 2006 Mar 29. Review.


Functional and structural characterization of rhodopsin oligomers.

Jastrzebska B, Fotiadis D, Jang GF, Stenkamp RE, Engel A, Palczewski K.

J Biol Chem. 2006 Apr 28;281(17):11917-22. Epub 2006 Feb 22.


The modular structure of SIP facilitates its role in stabilizing multiprotein assemblies.

Bhattacharya S, Lee YT, Michowski W, Jastrzebska B, Filipek A, Kuznicki J, Chazin WJ.

Biochemistry. 2005 Jul 12;44(27):9462-71.


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