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Editor's Note: Epidermal Growth Factor Receptor (EGFR) Is Overexpressed in Anaplastic Thyroid Cancer, and the EGFR Inhibitor Gefitinib Inhibits the Growth of Anaplastic Thyroid Cancer.

Schiff BA, McMurphy AB, Jasser SA, Younes MN, Doan D, Yigitbasi OG, Kim S, Zhou G, Mandal M, Bekele BN, Holsinger FC, Sherman SI, Yeung SC, El-Naggar AK, Myers JN.

Clin Cancer Res. 2019 Aug 1;25(15):4862. doi: 10.1158/1078-0432.CCR-19-2052. No abstract available.


High-Risk TP53 Mutations Are Associated with Extranodal Extension in Oral Cavity Squamous Cell Carcinoma.

Sandulache VC, Michikawa C, Kataria P, Gleber-Netto FO, Bell D, Trivedi S, Rao X, Wang J, Zhao M, Jasser S, Myers JN, Pickering CR.

Clin Cancer Res. 2018 Apr 1;24(7):1727-1733. doi: 10.1158/1078-0432.CCR-17-0721. Epub 2018 Jan 12.


Distinct pattern of TP53 mutations in human immunodeficiency virus-related head and neck squamous cell carcinoma.

Gleber-Netto FO, Zhao M, Trivedi S, Wang J, Jasser S, McDowell C, Kadara H, Zhang J, Wang J, William WN Jr, Lee JJ, Nguyen ML, Pai SI, Walline HM, Shin DM, Ferris RL, Carey TE, Myers JN, Pickering CR; Head and Neck Cancer Specialized Program of Research Excellence (SPORE) Human Immunodeficiency Virus (HIV) Supplement Consortium.

Cancer. 2018 Jan 1;124(1):84-94. doi: 10.1002/cncr.31063. Epub 2017 Oct 20.


Squamous cell carcinoma of the oral tongue in young non-smokers is genomically similar to tumors in older smokers.

Pickering CR, Zhang J, Neskey DM, Zhao M, Jasser SA, Wang J, Ward A, Tsai CJ, Ortega Alves MV, Zhou JH, Drummond J, El-Naggar AK, Gibbs R, Weinstein JN, Wheeler DA, Wang J, Frederick MJ, Myers JN.

Clin Cancer Res. 2014 Jul 15;20(14):3842-8. doi: 10.1158/1078-0432.CCR-14-0565. Epub 2014 May 29.


Gain-of-function mutant p53 promotes cell growth and cancer cell metabolism via inhibition of AMPK activation.

Zhou G, Wang J, Zhao M, Xie TX, Tanaka N, Sano D, Patel AA, Ward AM, Sandulache VC, Jasser SA, Skinner HD, Fitzgerald AL, Osman AA, Wei Y, Xia X, Songyang Z, Mills GB, Hung MC, Caulin C, Liang J, Myers JN.

Mol Cell. 2014 Jun 19;54(6):960-74. doi: 10.1016/j.molcel.2014.04.024. Epub 2014 May 22.


HRAS mutations and resistance to the epidermal growth factor receptor tyrosine kinase inhibitor erlotinib in head and neck squamous cell carcinoma cells.

Hah JH, Zhao M, Pickering CR, Frederick MJ, Andrews GA, Jasser SA, Fooshee DR, Milas ZL, Galer C, Sano D, William WN Jr, Kim E, Heymach J, Byers LA, Papadimitrakopoulou V, Myers JN.

Head Neck. 2014 Nov;36(11):1547-54. doi: 10.1002/hed.23499. Epub 2014 Mar 20.


Serine substitution of proline at codon 151 of TP53 confers gain of function activity leading to anoikis resistance and tumor progression of head and neck cancer cells.

Xie TX, Zhou G, Zhao M, Sano D, Jasser SA, Brennan RG, Myers JN.

Laryngoscope. 2013 Jun;123(6):1416-23. doi: 10.1002/lary.23846. Epub 2013 Apr 26.


Assembly and initial characterization of a panel of 85 genomically validated cell lines from diverse head and neck tumor sites.

Zhao M, Sano D, Pickering CR, Jasser SA, Henderson YC, Clayman GL, Sturgis EM, Ow TJ, Lotan R, Carey TE, Sacks PG, Grandis JR, Sidransky D, Heldin NE, Myers JN.

Clin Cancer Res. 2011 Dec 1;17(23):7248-64. doi: 10.1158/1078-0432.CCR-11-0690. Epub 2011 Aug 25.


Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1.

Agrawal N, Frederick MJ, Pickering CR, Bettegowda C, Chang K, Li RJ, Fakhry C, Xie TX, Zhang J, Wang J, Zhang N, El-Naggar AK, Jasser SA, Weinstein JN, TreviƱo L, Drummond JA, Muzny DM, Wu Y, Wood LD, Hruban RH, Westra WH, Koch WM, Califano JA, Gibbs RA, Sidransky D, Vogelstein B, Velculescu VE, Papadopoulos N, Wheeler DA, Kinzler KW, Myers JN.

Science. 2011 Aug 26;333(6046):1154-7. doi: 10.1126/science.1206923. Epub 2011 Jul 28.


Targeted therapy of VEGFR2 and EGFR significantly inhibits growth of anaplastic thyroid cancer in an orthotopic murine model.

Gule MK, Chen Y, Sano D, Frederick MJ, Zhou G, Zhao M, Milas ZL, Galer CE, Henderson YC, Jasser SA, Schwartz DL, Bankson JA, Myers JN, Lai SY.

Clin Cancer Res. 2011 Apr 15;17(8):2281-91. doi: 10.1158/1078-0432.CCR-10-2762. Epub 2011 Jan 10.


Dual inhibition of epidermal growth factor receptor and insulin-like growth factor receptor I: reduction of angiogenesis and tumor growth in cutaneous squamous cell carcinoma.

Galer CE, Corey CL, Wang Z, Younes MN, Gomez-Rivera F, Jasser SA, Ludwig DL, El-Naggar AK, Weber RS, Myers JN.

Head Neck. 2011 Feb;33(2):189-98. doi: 10.1002/hed.21419.


Mindfulness-based stress reduction for chronic pain conditions: variation in treatment outcomes and role of home meditation practice.

Rosenzweig S, Greeson JM, Reibel DK, Green JS, Jasser SA, Beasley D.

J Psychosom Res. 2010 Jan;68(1):29-36. doi: 10.1016/j.jpsychores.2009.03.010.


Phosphorylated insulin like growth factor-I receptor expression and its clinico-pathological significance in histologic subtypes of human thyroid cancer.

Chakravarty G, Santillan AA, Galer C, Adams HP, El-Naggar AK, Jasser SA, Mohsin S, Mondal D, Clayman GL, Myers JN.

Exp Biol Med (Maywood). 2009 Apr;234(4):372-86. doi: 10.3181/0809-RM-284. Epub 2009 Jan 28.


Therapeutic suppression of constitutive and inducible JAK\STAT activation in head and neck squamous cell carcinoma.

Kupferman ME, Jayakumar A, Zhou G, Xie T, Dakak-Yazici Y, Zhao M, Ju J, Mandal M, Jasser S, Madden T, Myers JN, Priebe W.

J Exp Ther Oncol. 2009;8(2):117-27.


An orthotopic murine model of sinonasal malignancy.

Gelbard A, Kupferman ME, Jasser SA, Chen W, El-Naggar AK, Myers JN, Hanna EY.

Clin Cancer Res. 2008 Nov 15;14(22):7348-57. doi: 10.1158/1078-0432.CCR-08-0977.


Sensitivity of the human circadian system to short-wavelength (420-nm) light.

Brainard GC, Sliney D, Hanifin JP, Glickman G, Byrne B, Greeson JM, Jasser S, Gerner E, Rollag MD.

J Biol Rhythms. 2008 Oct;23(5):379-86. doi: 10.1177/0748730408323089.


Vandetanib inhibits growth of adenoid cystic carcinoma in an orthotopic nude mouse model.

Choi S, Sano D, Cheung M, Zhao M, Jasser SA, Ryan AJ, Mao L, Chen WT, El-Naggar AK, Myers JN.

Clin Cancer Res. 2008 Aug 15;14(16):5081-9. doi: 10.1158/1078-0432.CCR-08-0245. Erratum in: Clin Cancer Res. 2009 Jan 1;15(1):416.


Use of coded and administrative data to identify mental health conditions: impediments and implications in a chronic pain study.

Jasser SA, Garvin JH, Wiedemer N, Roche D, Gallagher RM.

AMIA Annu Symp Proc. 2007 Oct 11:991.


Reciprocal negative regulation between S100A7/psoriasin and beta-catenin signaling plays an important role in tumor progression of squamous cell carcinoma of oral cavity.

Zhou G, Xie TX, Zhao M, Jasser SA, Younes MN, Sano D, Lin J, Kupferman ME, Santillan AA, Patel V, Gutkind JS, Ei-Naggar AK, Emberley ED, Watson PH, Matsuzawa SI, Reed JC, Myers JN.

Oncogene. 2008 Jun 5;27(25):3527-38. doi: 10.1038/sj.onc.1211015. Epub 2008 Jan 28.


Mindfulness-based stress reduction is associated with improved glycemic control in type 2 diabetes mellitus: a pilot study.

Rosenzweig S, Reibel DK, Greeson JM, Edman JS, Jasser SA, McMearty KD, Goldstein BJ.

Altern Ther Health Med. 2007 Sep-Oct;13(5):36-8.


The tyrosine kinase inhibitor, AZD2171, inhibits vascular endothelial growth factor receptor signaling and growth of anaplastic thyroid cancer in an orthotopic nude mouse model.

Gomez-Rivera F, Santillan-Gomez AA, Younes MN, Kim S, Fooshee D, Zhao M, Jasser SA, Myers JN.

Clin Cancer Res. 2007 Aug 1;13(15 Pt 1):4519-27.


Development of a macromolecular dual-modality MR-optical imaging for sentinel lymph node mapping.

Melancon MP, Wang Y, Wen X, Bankson JA, Stephens LC, Jasser S, Gelovani JG, Myers JN, Li C.

Invest Radiol. 2007 Aug;42(8):569-78.


Sorafenib inhibits the angiogenesis and growth of orthotopic anaplastic thyroid carcinoma xenografts in nude mice.

Kim S, Yazici YD, Calzada G, Wang ZY, Younes MN, Jasser SA, El-Naggar AK, Myers JN.

Mol Cancer Ther. 2007 Jun;6(6):1785-92.


Concurrent cetuximab and bevacizumab therapy in a murine orthotopic model of anaplastic thyroid carcinoma.

Prichard CN, Kim S, Yazici YD, Doan DD, Jasser SA, Mandal M, Myers JN.

Laryngoscope. 2007 Apr;117(4):674-9.


Effects of the integrin-linked kinase inhibitor QLT0267 on squamous cell carcinoma of the head and neck.

Younes MN, Yigitbasi OG, Yazici YD, Jasser SA, Bucana CD, El-Naggar AK, Mills GB, Myers JN.

Arch Otolaryngol Head Neck Surg. 2007 Jan;133(1):15-23.


Dim light adaptation attenuates acute melatonin suppression in humans.

Jasser SA, Hanifin JP, Rollag MD, Brainard GC.

J Biol Rhythms. 2006 Oct;21(5):394-404.


Molecular analysis of anoikis resistance in oral cavity squamous cell carcinoma.

Kupferman ME, Patel V, Sriuranpong V, Amornphimoltham P, Jasser SA, Mandal M, Zhou G, Wang J, Coombes K, Multani A, Pathak S, Silvio Gutkind J, Myers JN.

Oral Oncol. 2007 May;43(5):440-54. Epub 2006 Sep 15.


Growth-inhibitory effects of human anti-insulin-like growth factor-I receptor antibody (A12) in an orthotopic nude mouse model of anaplastic thyroid carcinoma.

Wang Z, Chakravarty G, Kim S, Yazici YD, Younes MN, Jasser SA, Santillan AA, Bucana CD, El-Naggar AK, Myers JN.

Clin Cancer Res. 2006 Aug 1;12(15):4755-65.


Light during darkness and cancer: relationships in circadian photoreception and tumor biology.

Jasser SA, Blask DE, Brainard GC.

Cancer Causes Control. 2006 May;17(4):515-23. Review.


The Akt inhibitor KP372-1 inhibits proliferation and induces apoptosis and anoikis in squamous cell carcinoma of the head and neck.

Mandal M, Younes M, Swan EA, Jasser SA, Doan D, Yigitbasi O, McMurphey A, Ludwick J, El-Naggar AK, Bucana C, Mills GB, Myers JN.

Oral Oncol. 2006 Apr;42(4):430-9. Epub 2006 Jan 27.


Cetuximab and irinotecan interact synergistically to inhibit the growth of orthotopic anaplastic thyroid carcinoma xenografts in nude mice.

Kim S, Prichard CN, Younes MN, Yazici YD, Jasser SA, Bekele BN, Myers JN.

Clin Cancer Res. 2006 Jan 15;12(2):600-7.


Growth inhibition of orthotopic anaplastic thyroid carcinoma xenografts in nude mice by PTK787/ZK222584 and CPT-11.

Kim S, Yazici YD, Barber SE, Jasser SA, Mandal M, Bekele BN, Myers JN.

Head Neck. 2006 May;28(5):389-99.


Antivascular therapy of oral tongue squamous cell carcinoma with PTK787.

Yazici YD, Kim S, Jasser SA, Wang Z, Carter KB Jr, Bucana CD, Myers JN.

Laryngoscope. 2005 Dec;115(12):2249-55.


Melatonin-depleted blood from premenopausal women exposed to light at night stimulates growth of human breast cancer xenografts in nude rats.

Blask DE, Brainard GC, Dauchy RT, Hanifin JP, Davidson LK, Krause JA, Sauer LA, Rivera-Bermudez MA, Dubocovich ML, Jasser SA, Lynch DT, Rollag MD, Zalatan F.

Cancer Res. 2005 Dec 1;65(23):11174-84.


Integrin-linked kinase is a potential therapeutic target for anaplastic thyroid cancer.

Younes MN, Kim S, Yigitbasi OG, Mandal M, Jasser SA, Dakak Yazici Y, Schiff BA, El-Naggar A, Bekele BN, Mills GB, Myers JN.

Mol Cancer Ther. 2005 Aug;4(8):1146-56.


Antivascular therapy of human follicular thyroid cancer experimental bone metastasis by blockade of epidermal growth factor receptor and vascular growth factor receptor phosphorylation.

Younes MN, Yigitbasi OG, Park YW, Kim SJ, Jasser SA, Hawthorne VS, Yazici YD, Mandal M, Bekele BN, Bucana CD, Fidler IJ, Myers JN.

Cancer Res. 2005 Jun 1;65(11):4716-27.


The Akt inhibitor KP372-1 suppresses Akt activity and cell proliferation and induces apoptosis in thyroid cancer cells.

Mandal M, Kim S, Younes MN, Jasser SA, El-Naggar AK, Mills GB, Myers JN.

Br J Cancer. 2005 May 23;92(10):1899-905.


Toward optimizing lighting as a countermeasure to sleep and circadian disruption in space flight.

Fucci RL, Gardner J, Hanifin JP, Jasser S, Byrne B, Gerner E, Rollag M, Brainard GC.

Acta Astronaut. 2005 May-Jun;56(9-12):1017-24.


Targeted molecular therapy of anaplastic thyroid carcinoma with AEE788.

Kim S, Schiff BA, Yigitbasi OG, Doan D, Jasser SA, Bekele BN, Mandal M, Myers JN.

Mol Cancer Ther. 2005 Apr;4(4):632-40.


AEE788, a dual tyrosine kinase receptor inhibitor, induces endothelial cell apoptosis in human cutaneous squamous cell carcinoma xenografts in nude mice.

Park YW, Younes MN, Jasser SA, Yigitbasi OG, Zhou G, Bucana CD, Bekele BN, Myers JN.

Clin Cancer Res. 2005 Mar 1;11(5):1963-73.


An orthotopic model of anaplastic thyroid carcinoma in athymic nude mice.

Kim S, Park YW, Schiff BA, Doan DD, Yazici Y, Jasser SA, Younes M, Mandal M, Bekele BN, Myers JN.

Clin Cancer Res. 2005 Mar 1;11(5):1713-21.


Epidermal growth factor receptor (EGFR) is overexpressed in anaplastic thyroid cancer, and the EGFR inhibitor gefitinib inhibits the growth of anaplastic thyroid cancer.

Schiff BA, McMurphy AB, Jasser SA, Younes MN, Doan D, Yigitbasi OG, Kim S, Zhou G, Mandal M, Bekele BN, Holsinger FC, Sherman SI, Yeung SC, El-Naggar AK, Myers JN.

Clin Cancer Res. 2004 Dec 15;10(24):8594-602. Erratum in: Clin Cancer Res. 2019 Aug 1;25(15):4862.


Tumor cell and endothelial cell therapy of oral cancer by dual tyrosine kinase receptor blockade.

Yigitbasi OG, Younes MN, Doan D, Jasser SA, Schiff BA, Bucana CD, Bekele BN, Fidler IJ, Myers JN.

Cancer Res. 2004 Nov 1;64(21):7977-84.


Epidermal growth factor receptor blockade potentiates apoptosis mediated by Paclitaxel and leads to prolonged survival in a murine model of oral cancer.

Holsinger FC, Doan DD, Jasser SA, Swan EA, Greenberg JS, Schiff BA, Bekele BN, Younes MN, Bucana CD, Fidler IJ, Myers JN.

Clin Cancer Res. 2003 Aug 1;9(8):3183-9.


Acquisition of anoikis resistance is a critical step in the progression of oral tongue cancer.

Swan EA, Jasser SA, Holsinger FC, Doan D, Bucana C, Myers JN.

Oral Oncol. 2003 Oct;39(7):648-55.


Ethical perspectives: opioid treatment of chronic pain in the context of addiction.

Cohen MJ, Jasser S, Herron PD, Margolis CG.

Clin J Pain. 2002 Jul-Aug;18(4 Suppl):S99-107.


Targeted molecular therapy for oral cancer with epidermal growth factor receptor blockade: a preliminary report.

Myers JN, Holsinger FC, Bekele BN, Li E, Jasser SA, Killion JJ, Fidler IJ.

Arch Otolaryngol Head Neck Surg. 2002 Aug;128(8):875-9.


Motif analysis of the tumor suppressor gene MMAC/PTEN identifies tyrosines critical for tumor suppression and lipid phosphatase activity.

Koul D, Jasser SA, Lu Y, Davies MA, Shen R, Shi Y, Mills GB, Yung WK.

Oncogene. 2002 Apr 4;21(15):2357-64.

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