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Items: 1 to 50 of 205

1.

Inter-homologue repair in fertilized human eggs?

Egli D, Zuccaro MV, Kosicki M, Church GM, Bradley A, Jasin M.

Nature. 2018 Aug;560(7717):E5-E7. doi: 10.1038/s41586-018-0379-5. Epub 2018 Aug 8. No abstract available.

PMID:
30089924
2.

ATR is required to complete meiotic recombination in mice.

Pacheco S, Maldonado-Linares A, Marcet-Ortega M, Rojas C, Martínez-Marchal A, Fuentes-Lazaro J, Lange J, Jasin M, Keeney S, Fernández-Capetillo O, Garcia-Caldés M, Roig I.

Nat Commun. 2018 Jul 5;9(1):2622. doi: 10.1038/s41467-018-04851-z.

3.

Control of meiotic double-strand-break formation by ATM: local and global views.

Lukaszewicz A, Lange J, Keeney S, Jasin M.

Cell Cycle. 2018;17(10):1155-1172. doi: 10.1080/15384101.2018.1464847. Epub 2018 Jul 15.

PMID:
29963942
4.
5.

Homologous Recombination and Replication Fork Protection: BRCA2 and More!

Feng W, Jasin M.

Cold Spring Harb Symp Quant Biol. 2017;82:329-338. doi: 10.1101/sqb.2017.82.035006. Epub 2018 Apr 23.

PMID:
29686033
6.

Inhibition of colorectal cancer genomic copy number alterations and chromosomal fragile site tumor suppressor FHIT and WWOX deletions by DNA mismatch repair.

Jahid S, Sun J, Gelincik O, Blecua P, Edelmann W, Kucherlapati R, Zhou K, Jasin M, Gümüş ZH, Lipkin SM.

Oncotarget. 2017 May 10;8(42):71574-71586. doi: 10.18632/oncotarget.17776. eCollection 2017 Sep 22.

7.

BRCA2 suppresses replication stress-induced mitotic and G1 abnormalities through homologous recombination.

Feng W, Jasin M.

Nat Commun. 2017 Sep 13;8(1):525. doi: 10.1038/s41467-017-00634-0.

8.

Genomic and chromatin features shaping meiotic double-strand break formation and repair in mice.

Yamada S, Kim S, Tischfield SE, Jasin M, Lange J, Keeney S.

Cell Cycle. 2017 Oct 18;16(20):1870-1884. doi: 10.1080/15384101.2017.1361065. Epub 2017 Aug 18.

9.

EXO1 suppresses double-strand break induced homologous recombination between diverged sequences in mammalian cells.

Chen CC, Avdievich E, Zhang Y, Zhang Y, Wei K, Lee K, Edelmann W, Jasin M, LaRocque JR.

DNA Repair (Amst). 2017 Sep;57:98-106. doi: 10.1016/j.dnarep.2017.07.003. Epub 2017 Jul 10.

10.

ATM loss leads to synthetic lethality in BRCA1 BRCT mutant mice associated with exacerbated defects in homology-directed repair.

Chen CC, Kass EM, Yen WF, Ludwig T, Moynahan ME, Chaudhuri J, Jasin M.

Proc Natl Acad Sci U S A. 2017 Jul 18;114(29):7665-7670. doi: 10.1073/pnas.1706392114. Epub 2017 Jun 28.

11.

p53 and TAp63 participate in the recombination-dependent pachytene arrest in mouse spermatocytes.

Marcet-Ortega M, Pacheco S, Martínez-Marchal A, Castillo H, Flores E, Jasin M, Keeney S, Roig I.

PLoS Genet. 2017 Jun 15;13(6):e1006845. doi: 10.1371/journal.pgen.1006845. eCollection 2017 Jun.

12.

Secondary Somatic Mutations Restoring RAD51C and RAD51D Associated with Acquired Resistance to the PARP Inhibitor Rucaparib in High-Grade Ovarian Carcinoma.

Kondrashova O, Nguyen M, Shield-Artin K, Tinker AV, Teng NNH, Harrell MI, Kuiper MJ, Ho GY, Barker H, Jasin M, Prakash R, Kass EM, Sullivan MR, Brunette GJ, Bernstein KA, Coleman RL, Floquet A, Friedlander M, Kichenadasse G, O'Malley DM, Oza A, Sun J, Robillard L, Maloney L, Bowtell D, Giordano H, Wakefield MJ, Kaufmann SH, Simmons AD, Harding TC, Raponi M, McNeish IA, Swisher EM, Lin KK, Scott CL; AOCS Study Group.

Cancer Discov. 2017 Sep;7(9):984-998. doi: 10.1158/2159-8290.CD-17-0419. Epub 2017 Jun 6.

13.

Generation of chromosomal translocations that lead to conditional fusion protein expression using CRISPR-Cas9 and homology-directed repair.

Vanoli F, Jasin M.

Methods. 2017 May 15;121-122:138-145. doi: 10.1016/j.ymeth.2017.05.006. Epub 2017 May 15.

14.

CRISPR-Cas9-guided oncogenic chromosomal translocations with conditional fusion protein expression in human mesenchymal cells.

Vanoli F, Tomishima M, Feng W, Lamribet K, Babin L, Brunet E, Jasin M.

Proc Natl Acad Sci U S A. 2017 Apr 4;114(14):3696-3701. doi: 10.1073/pnas.1700622114. Epub 2017 Mar 21.

15.

53BP1 ablation rescues genomic instability in mice expressing 'RING-less' BRCA1.

Li M, Cole F, Patel DS, Misenko SM, Her J, Malhowski A, Alhamza A, Zheng H, Baer R, Ludwig T, Jasin M, Nussenzweig A, Serrano L, Bunting SF.

EMBO Rep. 2016 Nov;17(11):1532-1541. Epub 2016 Sep 26.

16.

Meiotic DNA break formation requires the unsynapsed chromosome axis-binding protein IHO1 (CCDC36) in mice.

Stanzione M, Baumann M, Papanikos F, Dereli I, Lange J, Ramlal A, Tränkner D, Shibuya H, de Massy B, Watanabe Y, Jasin M, Keeney S, Tóth A.

Nat Cell Biol. 2016 Nov;18(11):1208-1220. doi: 10.1038/ncb3417. Epub 2016 Oct 10.

17.

Robust homology-directed repair within mouse mammary tissue is not specifically affected by Brca2 mutation.

Kass EM, Lim PX, Helgadottir HR, Moynahan ME, Jasin M.

Nat Commun. 2016 Oct 25;7:13241. doi: 10.1038/ncomms13241.

18.

The Landscape of Mouse Meiotic Double-Strand Break Formation, Processing, and Repair.

Lange J, Yamada S, Tischfield SE, Pan J, Kim S, Zhu X, Socci ND, Jasin M, Keeney S.

Cell. 2016 Oct 20;167(3):695-708.e16. doi: 10.1016/j.cell.2016.09.035. Epub 2016 Oct 13.

19.

Prolonged Particulate Hexavalent Chromium Exposure Suppresses Homologous Recombination Repair in Human Lung Cells.

Browning CL, Qin Q, Kelly DF, Prakash R, Vanoli F, Jasin M, Wise JP Sr.

Toxicol Sci. 2016 Sep;153(1):70-8. doi: 10.1093/toxsci/kfw103. Epub 2016 Jul 22.

20.

PARP Inhibitors in Clinical Use Induce Genomic Instability in Normal Human Cells.

Ito S, Murphy CG, Doubrovina E, Jasin M, Moynahan ME.

PLoS One. 2016 Jul 18;11(7):e0159341. doi: 10.1371/journal.pone.0159341. eCollection 2016.

21.

The democratization of gene editing: Insights from site-specific cleavage and double-strand break repair.

Jasin M, Haber JE.

DNA Repair (Amst). 2016 Aug;44:6-16. doi: 10.1016/j.dnarep.2016.05.001. Epub 2016 May 12. Review.

22.

When Genome Maintenance Goes Badly Awry.

Kass EM, Moynahan ME, Jasin M.

Mol Cell. 2016 Jun 2;62(5):777-87. doi: 10.1016/j.molcel.2016.05.021. Review.

23.

Distinct genetic control of homologous recombination repair of Cas9-induced double-strand breaks, nicks and paired nicks.

Vriend LE, Prakash R, Chen CC, Vanoli F, Cavallo F, Zhang Y, Jasin M, Krawczyk PM.

Nucleic Acids Res. 2016 Jun 20;44(11):5204-17. doi: 10.1093/nar/gkw179. Epub 2016 Mar 21.

24.

Mechanisms of germ line genome instability.

Kim S, Peterson SE, Jasin M, Keeney S.

Semin Cell Dev Biol. 2016 Jun;54:177-87. doi: 10.1016/j.semcdb.2016.02.019. Epub 2016 Feb 12. Review.

PMID:
26880205
25.

Accolades for the DNA Damage Response.

Jasin M.

N Engl J Med. 2015 Oct 15;373(16):1492-5. doi: 10.1056/NEJMp1509698. Epub 2015 Sep 8. No abstract available.

PMID:
26348215
26.

Local and sex-specific biases in crossover vs. noncrossover outcomes at meiotic recombination hot spots in mice.

de Boer E, Jasin M, Keeney S.

Genes Dev. 2015 Aug 15;29(16):1721-33. doi: 10.1101/gad.265561.115. Epub 2015 Aug 6.

27.

Homologous recombination and human health: the roles of BRCA1, BRCA2, and associated proteins.

Prakash R, Zhang Y, Feng W, Jasin M.

Cold Spring Harb Perspect Biol. 2015 Apr 1;7(4):a016600. doi: 10.1101/cshperspect.a016600. Review.

28.

Genomic Complexity Profiling Reveals That HORMAD1 Overexpression Contributes to Homologous Recombination Deficiency in Triple-Negative Breast Cancers.

Watkins J, Weekes D, Shah V, Gazinska P, Joshi S, Sidhu B, Gillett C, Pinder S, Vanoli F, Jasin M, Mayrhofer M, Isaksson A, Cheang MC, Mirza H, Frankum J, Lord CJ, Ashworth A, Vinayak S, Ford JM, Telli ML, Grigoriadis A, Tutt AN.

Cancer Discov. 2015 May;5(5):488-505. doi: 10.1158/2159-8290.CD-14-1092. Epub 2015 Mar 13.

29.

The ATM signaling cascade promotes recombination-dependent pachytene arrest in mouse spermatocytes.

Pacheco S, Marcet-Ortega M, Lange J, Jasin M, Keeney S, Roig I.

PLoS Genet. 2015 Mar 13;11(3):e1005017. doi: 10.1371/journal.pgen.1005017. eCollection 2015 Mar.

30.

Polycomb protein SCML2 associates with USP7 and counteracts histone H2A ubiquitination in the XY chromatin during male meiosis.

Luo M, Zhou J, Leu NA, Abreu CM, Wang J, Anguera MC, de Rooij DG, Jasin M, Wang PJ.

PLoS Genet. 2015 Jan 29;11(1):e1004954. doi: 10.1371/journal.pgen.1004954. eCollection 2015 Jan.

31.

Identification of novel radiosensitizers in a high-throughput, cell-based screen for DSB repair inhibitors.

Goglia AG, Delsite R, Luz AN, Shahbazian D, Salem AF, Sundaram RK, Chiaravalli J, Hendrikx PJ, Wilshire JA, Jasin M, Kluger HM, Glickman JF, Powell SN, Bindra RS.

Mol Cancer Ther. 2015 Feb;14(2):326-42. doi: 10.1158/1535-7163.MCT-14-0765. Epub 2014 Dec 15.

32.

Creating cancer translocations in human cells using Cas9 DSBs and nCas9 paired nicks.

Renouf B, Piganeau M, Ghezraoui H, Jasin M, Brunet E.

Methods Enzymol. 2014;546:251-71. doi: 10.1016/B978-0-12-801185-0.00012-X.

33.

Assaying break and nick-induced homologous recombination in mammalian cells using the DR-GFP reporter and Cas9 nucleases.

Vriend LE, Jasin M, Krawczyk PM.

Methods Enzymol. 2014;546:175-91. doi: 10.1016/B978-0-12-801185-0.00009-X.

34.

RAD51B Activity and Cell Cycle Regulation in Response to DNA Damage in Breast Cancer Cell Lines.

Lee PS, Fang J, Jessop L, Myers T, Raj P, Hu N, Wang C, Taylor PR, Wang J, Khan J, Jasin M, Chanock SJ.

Breast Cancer (Auckl). 2014 Oct 12;8:135-44. doi: 10.4137/BCBCR.S17766. eCollection 2014.

35.

Chromosomal translocations in human cells are generated by canonical nonhomologous end-joining.

Ghezraoui H, Piganeau M, Renouf B, Renaud JB, Sallmyr A, Ruis B, Oh S, Tomkinson AE, Hendrickson EA, Giovannangeli C, Jasin M, Brunet E.

Mol Cell. 2014 Sep 18;55(6):829-842. doi: 10.1016/j.molcel.2014.08.002. Epub 2014 Sep 4.

36.

Mouse tetrad analysis provides insights into recombination mechanisms and hotspot evolutionary dynamics.

Cole F, Baudat F, Grey C, Keeney S, de Massy B, Jasin M.

Nat Genet. 2014 Oct;46(10):1072-80. doi: 10.1038/ng.3068. Epub 2014 Aug 24.

37.

Male fertility defect associated with disrupted BRCA1-PALB2 interaction in mice.

Simhadri S, Peterson S, Patel DS, Huo Y, Cai H, Bowman-Colin C, Miller S, Ludwig T, Ganesan S, Bhaumik M, Bunting SF, Jasin M, Xia B.

J Biol Chem. 2014 Aug 29;289(35):24617-29. doi: 10.1074/jbc.M114.566141. Epub 2014 Jul 11.

38.

Biallelic targeting of expressed genes in mouse embryonic stem cells using the Cas9 system.

Zhang Y, Vanoli F, LaRocque JR, Krawczyk PM, Jasin M.

Methods. 2014 Sep;69(2):171-178. doi: 10.1016/j.ymeth.2014.05.003. Epub 2014 Jun 12.

39.

Measuring recombination proficiency in mouse embryonic stem cells.

Pierce AJ, Jasin M.

Methods Mol Biol. 2014;1105:481-95. doi: 10.1007/978-1-62703-739-6_34.

PMID:
24623248
40.

Mouse BAZ1A (ACF1) is dispensable for double-strand break repair but is essential for averting improper gene expression during spermatogenesis.

Dowdle JA, Mehta M, Kass EM, Vuong BQ, Inagaki A, Egli D, Jasin M, Keeney S.

PLoS Genet. 2013 Nov;9(11):e1003945. doi: 10.1371/journal.pgen.1003945. Epub 2013 Nov 7.

41.

Repair of strand breaks by homologous recombination.

Jasin M, Rothstein R.

Cold Spring Harb Perspect Biol. 2013 Nov 1;5(11):a012740. doi: 10.1101/cshperspect.a012740. Review.

42.

Androgen receptor signaling regulates DNA repair in prostate cancers.

Polkinghorn WR, Parker JS, Lee MX, Kass EM, Spratt DE, Iaquinta PJ, Arora VK, Yen WF, Cai L, Zheng D, Carver BS, Chen Y, Watson PA, Shah NP, Fujisawa S, Goglia AG, Gopalan A, Hieronymus H, Wongvipat J, Scardino PT, Zelefsky MJ, Jasin M, Chaudhuri J, Powell SN, Sawyers CL.

Cancer Discov. 2013 Nov;3(11):1245-53. doi: 10.1158/2159-8290.CD-13-0172. Epub 2013 Sep 11.

43.

How much is enough? Control of DNA double-strand break numbers in mouse meiosis.

Kauppi L, Jasin M, Keeney S.

Cell Cycle. 2013 Sep 1;12(17):2719-20. doi: 10.4161/cc.26079. Epub 2013 Aug 19. No abstract available.

44.

Nonsurgical rhinoplasty using dermal fillers.

Jasin ME.

Facial Plast Surg Clin North Am. 2013 May;21(2):241-52. doi: 10.1016/j.fsc.2013.02.004. Review.

PMID:
23731585
45.

Numerical constraints and feedback control of double-strand breaks in mouse meiosis.

Kauppi L, Barchi M, Lange J, Baudat F, Jasin M, Keeney S.

Genes Dev. 2013 Apr 15;27(8):873-86. doi: 10.1101/gad.213652.113. Epub 2013 Apr 18.

46.

Attenuating homologous recombination stimulates an AID-induced antileukemic effect.

Lamont KR, Hasham MG, Donghia NM, Branca J, Chavaree M, Chase B, Breggia A, Hedlund J, Emery I, Cavallo F, Jasin M, Rüter J, Mills KD.

J Exp Med. 2013 May 6;210(5):1021-33.

47.

Development of an assay to measure mutagenic non-homologous end-joining repair activity in mammalian cells.

Bindra RS, Goglia AG, Jasin M, Powell SN.

Nucleic Acids Res. 2013 Jun;41(11):e115. doi: 10.1093/nar/gkt255. Epub 2013 Apr 12.

48.

Cancer translocations in human cells induced by zinc finger and TALE nucleases.

Piganeau M, Ghezraoui H, De Cian A, Guittat L, Tomishima M, Perrouault L, René O, Katibah GE, Zhang L, Holmes MC, Doyon Y, Concordet JP, Giovannangeli C, Jasin M, Brunet E.

Genome Res. 2013 Jul;23(7):1182-93. doi: 10.1101/gr.147314.112. Epub 2013 Apr 8.

49.

Double-strand break repair by homologous recombination in primary mouse somatic cells requires BRCA1 but not the ATM kinase.

Kass EM, Helgadottir HR, Chen CC, Barbera M, Wang R, Westermark UK, Ludwig T, Moynahan ME, Jasin M.

Proc Natl Acad Sci U S A. 2013 Apr 2;110(14):5564-9. doi: 10.1073/pnas.1216824110. Epub 2013 Mar 18.

50.

Homologous recombination DNA repair genes play a critical role in reprogramming to a pluripotent state.

González F, Georgieva D, Vanoli F, Shi ZD, Stadtfeld M, Ludwig T, Jasin M, Huangfu D.

Cell Rep. 2013 Mar 28;3(3):651-60. doi: 10.1016/j.celrep.2013.02.005. Epub 2013 Mar 7.

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