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Items: 29


Mesenchymal transition and increased therapy resistance of glioblastoma cells is related to astrocyte reactivity.

Niklasson M, Bergström T, Jarvius M, Sundström A, Nyberg F, Haglund C, Larsson R, Westermark B, Segerman B, Segerman A.

J Pathol. 2019 Nov;249(3):295-307. doi: 10.1002/path.5317. Epub 2019 Aug 31.


COMBImage2: a parallel computational framework for higher-order drug combination analysis that includes automated plate design, matched filter based object counting and temporal data mining.

Chantzi E, Jarvius M, Niklasson M, Segerman A, Gustafsson MG.

BMC Bioinformatics. 2019 Jun 4;20(1):304. doi: 10.1186/s12859-019-2908-0.


Mebendazole-induced M1 polarisation of THP-1 macrophages may involve DYRK1B inhibition.

Blom K, Rubin J, Berglund M, Jarvius M, Lenhammar L, Parrow V, Andersson C, Loskog A, Fryknäs M, Nygren P, Larsson R.

BMC Res Notes. 2019 Apr 22;12(1):234. doi: 10.1186/s13104-019-4273-5.


COMBImage: a modular parallel processing framework for pairwise drug combination analysis that quantifies temporal changes in label-free video microscopy movies.

Chantzi E, Jarvius M, Niklasson M, Segerman A, Gustafsson MG.

BMC Bioinformatics. 2018 Nov 26;19(1):453. doi: 10.1186/s12859-018-2458-x.


LGR5 promotes tumorigenicity and invasion of glioblastoma stem-like cells and is a potential therapeutic target for a subset of glioblastoma patients.

Xie Y, Sundström A, Maturi NP, Tan EJ, Marinescu VD, Jarvius M, Tirfing M, Jin C, Chen L, Essand M, Swartling FJ, Nelander S, Jiang Y, Uhrbom L.

J Pathol. 2019 Feb;247(2):228-240. doi: 10.1002/path.5186. Epub 2019 Jan 10.


Targeting tumor cells based on Phosphodiesterase 3A expression.

Nazir M, Senkowski W, Nyberg F, Blom K, Edqvist PH, Jarvius M, Andersson C, Gustafsson MG, Nygren P, Larsson R, Fryknäs M.

Exp Cell Res. 2017 Dec 15;361(2):308-315. doi: 10.1016/j.yexcr.2017.10.032. Epub 2017 Oct 26.


The anticancer effect of mebendazole may be due to M1 monocyte/macrophage activation via ERK1/2 and TLR8-dependent inflammasome activation.

Blom K, Senkowski W, Jarvius M, Berglund M, Rubin J, Lenhammar L, Parrow V, Andersson C, Loskog A, Fryknäs M, Nygren P, Larsson R.

Immunopharmacol Immunotoxicol. 2017 Aug;39(4):199-210. doi: 10.1080/08923973.2017.1320671. Epub 2017 May 4.


Glioblastoma Cell Malignancy and Drug Sensitivity Are Affected by the Cell of Origin.

Jiang Y, Marinescu VD, Xie Y, Jarvius M, Maturi NP, Haglund C, Olofsson S, Lindberg N, Olofsson T, Leijonmarck C, Hesselager G, Alafuzoff I, Fryknäs M, Larsson R, Nelander S, Uhrbom L.

Cell Rep. 2017 May 2;19(5):1080-1081. doi: 10.1016/j.celrep.2017.04.053. No abstract available.


Glioblastoma Cell Malignancy and Drug Sensitivity Are Affected by the Cell of Origin.

Jiang Y, Marinescu VD, Xie Y, Jarvius M, Maturi NP, Haglund C, Olofsson S, Lindberg N, Olofsson T, Leijonmarck C, Hesselager G, Alafuzoff I, Fryknäs M, Larsson R, Nelander S, Uhrbom L.

Cell Rep. 2017 Jan 24;18(4):977-990. doi: 10.1016/j.celrep.2017.01.003. Erratum in: Cell Rep. 2017 May 2;19(5):1080-1081.


Mouse Models of Pediatric Supratentorial High-grade Glioma Reveal How Cell-of-Origin Influences Tumor Development and Phenotype.

Sreedharan S, Maturi NP, Xie Y, Sundström A, Jarvius M, Libard S, Alafuzoff I, Weishaupt H, Fryknäs M, Larsson R, Swartling FJ, Uhrbom L.

Cancer Res. 2017 Feb 1;77(3):802-812. doi: 10.1158/0008-5472.CAN-16-2482. Epub 2016 Nov 15.


Large-Scale Gene Expression Profiling Platform for Identification of Context-Dependent Drug Responses in Multicellular Tumor Spheroids.

Senkowski W, Jarvius M, Rubin J, Lengqvist J, Gustafsson MG, Nygren P, Kultima K, Larsson R, Fryknäs M.

Cell Chem Biol. 2016 Nov 17;23(11):1428-1438. doi: 10.1016/j.chembiol.2016.09.013. Epub 2016 Oct 27.


Clonal Variation in Drug and Radiation Response among Glioma-Initiating Cells Is Linked to Proneural-Mesenchymal Transition.

Segerman A, Niklasson M, Haglund C, Bergström T, Jarvius M, Xie Y, Westermark A, Sönmez D, Hermansson A, Kastemar M, Naimaie-Ali Z, Nyberg F, Berglund M, Sundström M, Hesselager G, Uhrbom L, Gustafsson M, Larsson R, Fryknäs M, Segerman B, Westermark B.

Cell Rep. 2016 Dec 13;17(11):2994-3009. doi: 10.1016/j.celrep.2016.11.056.


Evaluation of Intracellular Signaling Downstream Chimeric Antigen Receptors.

Karlsson H, Svensson E, Gigg C, Jarvius M, Olsson-Strömberg U, Savoldo B, Dotti G, Loskog A.

PLoS One. 2015 Dec 23;10(12):e0144787. doi: 10.1371/journal.pone.0144787. eCollection 2015.


Drug screen in patient cells suggests quinacrine to be repositioned for treatment of acute myeloid leukemia.

Eriksson A, Österroos A, Hassan S, Gullbo J, Rickardson L, Jarvius M, Nygren P, Fryknäs M, Höglund M, Larsson R.

Blood Cancer J. 2015 Apr 17;5:e307. doi: 10.1038/bcj.2015.31.


AKN-028 induces cell cycle arrest, downregulation of Myc associated genes and dose dependent reduction of tyrosine kinase activity in acute myeloid leukemia.

Eriksson A, Kalushkova A, Jarvius M, Hilhorst R, Rickardson L, Kultima HG, de Wijn R, Hovestad L, Fryknäs M, Öberg F, Larsson R, Parrow V, Höglund M.

Biochem Pharmacol. 2014 Jan 15;87(2):284-91. doi: 10.1016/j.bcp.2013.10.022. Epub 2013 Nov 4.


Screening for phenotype selective activity in multidrug resistant cells identifies a novel tubulin active agent insensitive to common forms of cancer drug resistance.

Fryknäs M, Gullbo J, Wang X, Rickardson L, Jarvius M, Wickström M, Hassan S, Andersson C, Gustafsson M, Westman G, Nygren P, Linder S, Larsson R.

BMC Cancer. 2013 Aug 6;13:374. doi: 10.1186/1471-2407-13-374.


Piperlongumine induces inhibition of the ubiquitin-proteasome system in cancer cells.

Jarvius M, Fryknäs M, D'Arcy P, Sun C, Rickardson L, Gullbo J, Haglund C, Nygren P, Linder S, Larsson R.

Biochem Biophys Res Commun. 2013 Feb 8;431(2):117-23. doi: 10.1016/j.bbrc.2013.01.017. Epub 2013 Jan 11.


Prognostic but not predictive role of platelet-derived growth factor receptors in patients with recurrent glioblastoma.

Paulsson J, Lindh MB, Jarvius M, Puputti M, Nistér M, Nupponen NN, Paulus W, Söderberg O, Dresemann G, von Deimling A, Joensuu H, Ostman A, Hasselblatt M.

Int J Cancer. 2011 Apr 15;128(8):1981-8. doi: 10.1002/ijc.25528.


Proximity ligation assays: a recent addition to the proteomics toolbox.

Weibrecht I, Leuchowius KJ, Clausson CM, Conze T, Jarvius M, Howell WM, Kamali-Moghaddam M, Söderberg O.

Expert Rev Proteomics. 2010 Jun;7(3):401-9. doi: 10.1586/epr.10.10. Review.


VEGF receptor 2/-3 heterodimers detected in situ by proximity ligation on angiogenic sprouts.

Nilsson I, Bahram F, Li X, Gualandi L, Koch S, Jarvius M, Söderberg O, Anisimov A, Kholová I, Pytowski B, Baldwin M, Ylä-Herttuala S, Alitalo K, Kreuger J, Claesson-Welsh L.

EMBO J. 2010 Apr 21;29(8):1377-88. doi: 10.1038/emboj.2010.30. Epub 2010 Mar 11.


High content screening for inhibitors of protein interactions and post-translational modifications in primary cells by proximity ligation.

Leuchowius KJ, Jarvius M, Wickström M, Rickardson L, Landegren U, Larsson R, Söderberg O, Fryknäs M, Jarvius J.

Mol Cell Proteomics. 2010 Jan;9(1):178-83. doi: 10.1074/mcp.M900331-MCP200. Epub 2009 Oct 27.


Platelet-derived growth factor receptor expression and activation in choroid plexus tumors.

Koos B, Paulsson J, Jarvius M, Sanchez BC, Wrede B, Mertsch S, Jeibmann A, Kruse A, Peters O, Wolff JE, Galla HJ, Söderberg O, Paulus W, Ostman A, Hasselblatt M.

Am J Pathol. 2009 Oct;175(4):1631-7. doi: 10.2353/ajpath.2009.081022. Epub 2009 Aug 28.


Characterizing proteins and their interactions in cells and tissues using the in situ proximity ligation assay.

Söderberg O, Leuchowius KJ, Gullberg M, Jarvius M, Weibrecht I, Larsson LG, Landegren U.

Methods. 2008 Jul;45(3):227-32. doi: 10.1016/j.ymeth.2008.06.014. Epub 2008 Jul 11.


In situ detection of phosphorylated platelet-derived growth factor receptor beta using a generalized proximity ligation method.

Jarvius M, Paulsson J, Weibrecht I, Leuchowius KJ, Andersson AC, Wählby C, Gullberg M, Botling J, Sjöblom T, Markova B, Ostman A, Landegren U, Söderberg O.

Mol Cell Proteomics. 2007 Sep;6(9):1500-9. Epub 2007 Jun 12.


Proximity ligation: a specific and versatile tool for the proteomic era.

Söderberg O, Leuchowius KJ, Kamali-Moghaddam M, Jarvius M, Gustafsdottir S, Schallmeiner E, Gullberg M, Jarvius J, Landegren U.

Genet Eng (N Y). 2007;28:85-93. Review.


Direct observation of individual endogenous protein complexes in situ by proximity ligation.

Söderberg O, Gullberg M, Jarvius M, Ridderstråle K, Leuchowius KJ, Jarvius J, Wester K, Hydbring P, Bahram F, Larsson LG, Landegren U.

Nat Methods. 2006 Dec;3(12):995-1000. Epub 2006 Oct 29.


Proximity ligation assays for sensitive and specific protein analyses.

Gustafsdottir SM, Schallmeiner E, Fredriksson S, Gullberg M, Söderberg O, Jarvius M, Jarvius J, Howell M, Landegren U.

Anal Biochem. 2005 Oct 1;345(1):2-9. Epub 2005 Feb 7. Review. No abstract available.


Triptans induce vasoconstriction of human arteries and veins from the thoracic wall.

Wackenfors A, Jarvius M, Ingemansson R, Edvinsson L, Malmsjö M.

J Cardiovasc Pharmacol. 2005 May;45(5):476-84.


Prospects for in situ analyses of individual and complexes of DNA, RNA, and protein molecules with padlock and proximity probes.

Landegren U, Nilsson M, Gullberg M, Söderberg O, Jarvius M, Larsson C, Jarvius J.

Methods Cell Biol. 2004;75:787-97. No abstract available.


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