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Comparison of knowledge of HIV status and treatment coverage between non-citizens and citizens: Botswana Combination Prevention Project (BCPP).

Marukutira T, Block L, Alwano MG, Behel S, Jarvis JN, Chakalisa U, Powis K, Novitsky V, Bapati W, Wang H, Ussery F, Lebelonyane R, Mills LA, Moore J, Bachanas P.

PLoS One. 2019 Aug 29;14(8):e0221629. doi: 10.1371/journal.pone.0221629. eCollection 2019.


Using the tools of proteomics to understand the pathogenesis of idiopathic inflammatory myopathies.

Karasawa R, Jarvis JN.

Curr Opin Rheumatol. 2019 Nov;31(6):617-622. doi: 10.1097/BOR.0000000000000643.


HIV-associated cryptococcal meningitis: ongoing challenges and new opportunities.

Tenforde MW, Jarvis JN.

Lancet Infect Dis. 2019 Aug;19(8):793-794. doi: 10.1016/S1473-3099(19)30295-6. No abstract available.


Plasma exosomes from children with juvenile dermatomyositis are taken up by human aortic endothelial cells and are associated with altered gene expression in those cells.

Jiang K, Karasawa R, Hu Z, Chen Y, Holmes L, O'Neil KM, Jarvis JN.

Pediatr Rheumatol Online J. 2019 Jul 12;17(1):41. doi: 10.1186/s12969-019-0347-0.


Recent advances in managing HIV-associated cryptococcal meningitis.

Boyer-Chammard T, Temfack E, Alanio A, Jarvis JN, Harrison TS, Lortholary O.

F1000Res. 2019 May 28;8. pii: F1000 Faculty Rev-743. doi: 10.12688/f1000research.17673.1. eCollection 2019. Review.


Causes of Pediatric Meningitis in Botswana: Results From a 16-Year National Meningitis Audit.

Mitchell HK, Mokomane M, Leeme T, Tlhako N, Tsholo K, Ramodimoosi C, Dube B, Mokobela KO, Tawanana E, Chebani T, Setlhake P, Pilatwe T, Hurt WJ, Molefi M, Mullan PC, Steenhoff AP, Mine M, Jarvis JN, Tenforde MW.

Pediatr Infect Dis J. 2019 Sep;38(9):906-911. doi: 10.1097/INF.0000000000002396.


Low-cerebrospinal fluid white cell counts and mortality in HIV-associated pneumococcal meningitis.

Tenforde MW, Meintjes G, Mokomane M, Harrison TS, Mine M, Jarvis JN.

AIDS. 2019 Jul 15;33(9):1539-1541. doi: 10.1097/QAD.0000000000002241. No abstract available.


Epidemiology of adult meningitis during antiretroviral therapy scale-up in southern Africa: Results from the Botswana national meningitis survey.

Tenforde MW, Mokomane M, Leeme T, Tlhako N, Tsholo K, Ramodimoosi C, Dube B, Mokobela KO, Tawanana E, Chebani T, Pilatwe T, Hurt WJ, Mitchell HK, Molefi M, Mullan PC, Guthrie BL, Farquhar C, Steenhoff AP, Mine M, Jarvis JN.

J Infect. 2019 Sep;79(3):212-219. doi: 10.1016/j.jinf.2019.06.013. Epub 2019 Jun 28.


Mortality in adult patients with culture-positive and culture-negative meningitis in the Botswana national meningitis survey: a prevalent cohort study.

Tenforde MW, Mokomane M, Leeme TB, Tlhako N, Tsholo K, Chebani T, Stephenson A, Hutton J, Mitchell HK, Patel RK, Hurt WJ, Pilatwe T, Masupe T, Molefi M, Guthrie BL, Farquhar C, Mine M, Jarvis JN.

Lancet Infect Dis. 2019 Jul;19(7):740-749. doi: 10.1016/S1473-3099(19)30066-0.


Cryptococcal-related mortality despite fluconazole pre-emptive treatment in a cryptococcal antigen (CrAg) screen-and-treat programme.

Wake RM, Govender NP, Omar T, Nel C, Mazanderani AH, Karat AS, Ismail NA, Tiemessen CT, Jarvis JN, Harrison TS.

Clin Infect Dis. 2019 Jun 8. pii: ciz485. doi: 10.1093/cid/ciz485. [Epub ahead of print]


Excess early mortality in HIV/hepatitis B virus co-infected patients initiating antiretroviral therapy in Kenya.

Mbae M, Owen L, Elisha KK, Ndhere A, Mugambi NS, Yogev R, Murphy RL, Jarvis JN.

AIDS. 2019 Jul 1;33(8):1404-1406. doi: 10.1097/QAD.0000000000002216. No abstract available.


AMBIsome Therapy Induction OptimisatioN (AMBITION): High dose AmBisome for cryptococcal meningitis induction therapy in sub-Saharan Africa: economic evaluation protocol for a randomised controlled trial-based equivalence study.

Ponatshego PL, Lawrence DS, Youssouf N, Molloy SF, Alufandika M, Bango F, Boulware DR, Chawinga C, Dziwani E, Gondwe E, Hlupeni A, Hosseinipour MC, Kanyama C, Meya DB, Mosepele M, Muthoga C, Muzoora CK, Mwandumba H, Ndhlovu CE, Rajasingham R, Sayed S, Shamu S, Tsholo K, Tugume L, Williams D, Maheswaran H, Shiri T, Boyer-Chammard T, Loyse A, Chen T, Wang D, Lortholary O, Lalloo DG, Meintjes G, Jaffar S, Harrison TS, Jarvis JN, Niessen LW.

BMJ Open. 2019 Apr 1;9(4):e026288. doi: 10.1136/bmjopen-2018-026288.


Addition of flucytosine to fluconazole for the treatment of cryptococcal meningitis in Africa: a multi-country cost-effectiveness analysis.

Shiri T, Loyse A, Mwenge L, Chen T, Lakhi S, Chanda D, Mwaba P, Molloy SF, Heyderman R, Kanyama C, Hosseinipour MC, Kouanfack C, Temfack E, Mfinanga S, Kivuyo S, Chan AK, Jarvis JN, Lortholary O, Jaffar S, Niessen LW, Harrison TS.

Clin Infect Dis. 2019 Feb 28. pii: ciz163. doi: 10.1093/cid/ciz163. [Epub ahead of print]


Reply to Rajasingham and Boulware.

Jarvis JN, Harrison TS.

Clin Infect Dis. 2019 Jan 29. doi: 10.1093/cid/ciz040. [Epub ahead of print] No abstract available.


Correction to: AMBIsome Therapy Induction OptimisatioN (AMBITION): High Dose AmBisome for Cryptococcal Meningitis Induction Therapy in sub-Saharan Africa: Study Protocol for a Phase 3 Randomised Controlled Non-Inferiority Trial.

Lawrence DS, Youssouf N, Molloy SF, Alanio A, Alufandika M, Boulware DR, Boyer-Chammard T, Chen T, Dromer F, Hlupeni A, Hope W, Hosseinipour MC, Kanyama C, Lortholary O, Loyse A, Meya DB, Mosepele M, Muzoora C, Mwandumba HC, Ndhlovu CE, Niessen L, Schutz C, Stott KE, Wang D, Lalloo DG, Meintjes G, Jaffar S, Harrison TS, Jarvis JN.

Trials. 2019 Jan 14;20(1):48. doi: 10.1186/s13063-018-3155-9.


Using Chromatin Architecture to Understand the Genetics and Transcriptomics of Juvenile Idiopathic Arthritis.

Kessler H, Jiang K, Jarvis JN.

Front Immunol. 2018 Dec 14;9:2964. doi: 10.3389/fimmu.2018.02964. eCollection 2018. Review.


Biomarkers from circulating neutrophil transcriptomes have potential to detect unruptured intracranial aneurysms.

Tutino VM, Poppenberg KE, Li L, Shallwani H, Jiang K, Jarvis JN, Sun Y, Snyder KV, Levy EI, Siddiqui AH, Kolega J, Meng H.

J Transl Med. 2018 Dec 28;16(1):373. doi: 10.1186/s12967-018-1749-3.


Transcriptional Profiling of Patient Isolates Identifies a Novel TOR/Starvation Regulatory Pathway in Cryptococcal Virulence.

Park YD, Jarvis JN, Hu G, Davis SE, Qiu J, Zhang N, Hollingsworth C, Loyse A, Gardina PJ, Valyi-Nagy T, Myers TG, Harrison TS, Bicanic T, Williamson PR.

MBio. 2018 Dec 18;9(6). pii: e02353-18. doi: 10.1128/mBio.02353-18.


Emerging concepts in HIV-associated cryptococcal meningitis.

Lawrence DS, Boyer-Chammard T, Jarvis JN.

Curr Opin Infect Dis. 2019 Feb;32(1):16-23. doi: 10.1097/QCO.0000000000000514.


High Mortality in HIV-Associated Cryptococcal Meningitis Patients Treated With Amphotericin B-Based Therapy Under Routine Care Conditions in Africa.

Patel RKK, Leeme T, Azzo C, Tlhako N, Tsholo K, Tawanana EO, Molefi M, Mosepele M, Lawrence DS, Mokomane M, Tenforde MW, Jarvis JN.

Open Forum Infect Dis. 2018 Oct 23;5(11):ofy267. doi: 10.1093/ofid/ofy267. eCollection 2018 Nov.


AMBIsome Therapy Induction OptimisatioN (AMBITION): High Dose AmBisome for Cryptococcal Meningitis Induction Therapy in sub-Saharan Africa: Study Protocol for a Phase 3 Randomised Controlled Non-Inferiority Trial.

Lawrence DS, Youssouf N, Molloy SF, Alanio A, Alufandika M, Boulware DR, Boyer-Chammard T, Chen T, Dromer F, Hlupeni A, Hope W, Hosseinipour MC, Kanyama C, Lortholary O, Loyse A, Meya DB, Mosepele M, Muzoora C, Mwandumba HC, Ndhlovu CE, Niessen L, Schutz C, Stott KE, Wang D, Lalloo DG, Meintjes G, Jaffar S, Harrison TS, Jarvis JN.

Trials. 2018 Nov 23;19(1):649. doi: 10.1186/s13063-018-3026-4. Erratum in: Trials. 2019 Jan 14;20(1):48.


Leave no one behind: response to new evidence and guidelines for the management of cryptococcal meningitis in low-income and middle-income countries.

Loyse A, Burry J, Cohn J, Ford N, Chiller T, Ribeiro I, Koulla-Shiro S, Mghamba J, Ramadhani A, Nyirenda R, Aliyu SH, Wilson D, Le T, Oladele R, Lesikari S, Muzoora C, Kalata N, Temfack E, Mapoure Y, Sini V, Chanda D, Shimwela M, Lakhi S, Ngoma J, Gondwe-Chunda L, Perfect C, Shroufi A, Andrieux-Meyer I, Chan A, Schutz C, Hosseinipour M, Van der Horst C, Klausner JD, Boulware DR, Heyderman R, Lalloo D, Day J, Jarvis JN, Rodrigues M, Jaffar S, Denning D, Migone C, Doherty M, Lortholary O, Dromer F, Stack M, Molloy SF, Bicanic T, van Oosterhout J, Mwaba P, Kanyama C, Kouanfack C, Mfinanga S, Govender N, Harrison TS.

Lancet Infect Dis. 2019 Apr;19(4):e143-e147. doi: 10.1016/S1473-3099(18)30493-6. Epub 2018 Oct 18. Review.


Treatment for HIV-associated cryptococcal meningitis.

Tenforde MW, Shapiro AE, Rouse B, Jarvis JN, Li T, Eshun-Wilson I, Ford N.

Cochrane Database Syst Rev. 2018 Jul 25;7:CD005647. doi: 10.1002/14651858.CD005647.pub3. Review.


Impact of Routine Cryptococcal Antigen Screening and Targeted Preemptive Fluconazole Therapy in Antiretroviral-naive Human Immunodeficiency Virus-infected Adults With CD4 Cell Counts <100/μL: A Systematic Review and Meta-analysis.

Temfack E, Bigna JJ, Luma HN, Spijker R, Meintjes G, Jarvis JN, Dromer F, Harrison T, Cohen JF, Lortholary O.

Clin Infect Dis. 2019 Feb 1;68(4):688-698. doi: 10.1093/cid/ciy567.


Understanding Causal Pathways in Cryptococcal Meningitis Immune Reconstitution Inflammatory Syndrome.

Jarvis JN, Harrison TS.

J Infect Dis. 2019 Jan 9;219(3):344-346. doi: 10.1093/infdis/jiy448. No abstract available.


Short-course High-dose Liposomal Amphotericin B for Human Immunodeficiency Virus-associated Cryptococcal Meningitis: A Phase 2 Randomized Controlled Trial.

Jarvis JN, Leeme TB, Molefi M, Chofle AA, Bidwell G, Tsholo K, Tlhako N, Mawoko N, Patel RKK, Tenforde MW, Muthoga C, Bisson GP, Kidola J, Changalucha J, Lawrence D, Jaffar S, Hope W, Molloy SLF, Harrison TS.

Clin Infect Dis. 2019 Jan 18;68(3):393-401. doi: 10.1093/cid/ciy515.


RNA sequencing data from neutrophils of patients with cystic fibrosis reveals potential for developing biomarkers for pulmonary exacerbations.

Jiang K, Poppenberg KE, Wong L, Chen Y, Borowitz D, Goetz D, Sheehan D, Frederick C, Tutino VM, Meng H, Jarvis JN.

J Cyst Fibros. 2019 Mar;18(2):194-202. doi: 10.1016/j.jcf.2018.05.014. Epub 2018 Jun 23.


Four-class drug-resistant HIV-1 subtype C in a treatment experienced individual on dolutegravir-based antiretroviral therapy in Botswana.

Seatla KK, Avalos A, Moyo S, Mine M, Diphoko T, Mosepele M, Gaolatlhe T, Rowley CF, Ramaabya D, Jarvis JN, Kasvosve I, Gaseitsiwe S.

AIDS. 2018 Aug 24;32(13):1899-1902. doi: 10.1097/QAD.0000000000001920.


Soluble inflammatory mediators induce transcriptional re-organization that is independent of dna methylation changes in cultured human chorionic villous trophoblasts.

Jiang K, Wong L, Chen Y, Xing X, Li D, Wang T, Jarvis JN.

J Reprod Immunol. 2018 Aug;128:2-8. doi: 10.1016/j.jri.2018.05.005. Epub 2018 May 23.


Modeling Transcriptional Rewiring in Neutrophils Through the Course of Treated Juvenile Idiopathic Arthritis.

Hu Z, Jiang K, Frank MB, Chen Y, Jarvis JN.

Sci Rep. 2018 May 17;8(1):7805. doi: 10.1038/s41598-018-26163-4.


Brief Report: Point of Care Cryptococcal Antigen Screening: Pipetting Finger-Prick Blood Improves Performance of Immunomycologics Lateral Flow Assay.

Wake RM, Jarvis JN, Harrison TS, Govender NP.

J Acquir Immune Defic Syndr. 2018 Aug 15;78(5):574-578. doi: 10.1097/QAI.0000000000001721.


Fully 3D printed integrated reactor array for point-of-care molecular diagnostics.

Kadimisetty K, Song J, Doto AM, Hwang Y, Peng J, Mauk MG, Bushman FD, Gross R, Jarvis JN, Liu C.

Biosens Bioelectron. 2018 Jun 30;109:156-163. doi: 10.1016/j.bios.2018.03.009. Epub 2018 Mar 10.


Unique clinical characteristics, autoantibodies and medication use in Native American patients with systemic lupus erythematosus.

Kheir JM, Guthridge CJ, Johnston JR, Adams LJ, Rasmussen A, Gross TF, Munroe ME, Bourn RL, Sivils KL, Guthridge JM, Weisman MH, Wallace DJ, Anaya JM, Rojas Villarraga A, Jarvis JN, Harley JB, James JA.

Lupus Sci Med. 2018 Feb 27;5(1):e000247. doi: 10.1136/lupus-2017-000247. eCollection 2018.


CD4 Cell Count Threshold for Cryptococcal Antigen Screening of HIV-Infected Individuals: A Systematic Review and Meta-analysis.

Ford N, Shubber Z, Jarvis JN, Chiller T, Greene G, Migone C, Vitoria M, Doherty M, Meintjes G.

Clin Infect Dis. 2018 Mar 4;66(suppl_2):S152-S159. doi: 10.1093/cid/cix1143.


A tale of two countries: progress towards UNAIDS 90-90-90 targets in Botswana and Australia.

Marukutira T, Stoové M, Lockman S, Mills LA, Gaolathe T, Lebelonyane R, Jarvis JN, Kelly SL, Wilson DP, Luchters S, Crowe SM, Hellard M.

J Int AIDS Soc. 2018 Mar;21(3). doi: 10.1002/jia2.25090.


Multiple target autoantigens on endothelial cells identified in juvenile dermatomyositis using proteomics.

Karasawa R, Tamaki M, Sato T, Tanaka M, Nawa M, Yudoh K, Jarvis JN.

Rheumatology (Oxford). 2018 Apr 1;57(4):671-676. doi: 10.1093/rheumatology/kex468.


Circulating neutrophil transcriptome may reveal intracranial aneurysm signature.

Tutino VM, Poppenberg KE, Jiang K, Jarvis JN, Sun Y, Sonig A, Siddiqui AH, Snyder KV, Levy EI, Kolega J, Meng H.

PLoS One. 2018 Jan 17;13(1):e0191407. doi: 10.1371/journal.pone.0191407. eCollection 2018.


Neurological Sequelae of Adult Meningitis in Africa: A Systematic Literature Review.

Goldberg DW, Tenforde MW, Mitchell HK, Jarvis JN.

Open Forum Infect Dis. 2017 Nov 11;5(1):ofx246. doi: 10.1093/ofid/ofx246. eCollection 2018 Jan. Review.


Modulating host immune responses to fight invasive fungal infections.

Scriven JE, Tenforde MW, Levitz SM, Jarvis JN.

Curr Opin Microbiol. 2017 Dec;40:95-103. doi: 10.1016/j.mib.2017.10.018. Epub 2017 Nov 15. Review.


High Cryptococcal Antigen Titers in Blood Are Predictive of Subclinical Cryptococcal Meningitis Among Human Immunodeficiency Virus-Infected Patients.

Wake RM, Britz E, Sriruttan C, Rukasha I, Omar T, Spencer DC, Nel JS, Mashamaite S, Adelekan A, Chiller TM, Jarvis JN, Harrison TS, Govender NP.

Clin Infect Dis. 2018 Feb 10;66(5):686-692. doi: 10.1093/cid/cix872.


Neurosyphilis in Africa: A systematic review.

Marks M, Jarvis JN, Howlett W, Mabey DCW.

PLoS Negl Trop Dis. 2017 Aug 31;11(8):e0005880. doi: 10.1371/journal.pntd.0005880. eCollection 2017 Aug. Review.


Cryptococcal meningitis: A neglected NTD?

Molloy SF, Chiller T, Greene GS, Burry J, Govender NP, Kanyama C, Mfinanga S, Lesikari S, Mapoure YN, Kouanfack C, Sini V, Temfack E, Boulware DR, Dromer F, Denning DW, Day J, Stone NRH, Bicanic T, Jarvis JN, Lortholary O, Harrison TS, Jaffar S, Loyse A.

PLoS Negl Trop Dis. 2017 Jun 29;11(6):e0005575. doi: 10.1371/journal.pntd.0005575. eCollection 2017 Jun. No abstract available.


Genetic insights into juvenile idiopathic arthritis derived from deep whole genome sequencing.

Wong L, Jiang K, Chen Y, Jarvis JN.

Sci Rep. 2017 Jun 1;7(1):2657. doi: 10.1038/s41598-017-02966-9.


Advanced Human Immunodeficiency Virus Disease in Botswana Following Successful Antiretroviral Therapy Rollout: Incidence of and Temporal Trends in Cryptococcal Meningitis.

Tenforde MW, Mokomane M, Leeme T, Patel RKK, Lekwape N, Ramodimoosi C, Dube B, Williams EA, Mokobela KO, Tawanana E, Pilatwe T, Hurt WJ, Mitchell H, Banda DL, Stone H, Molefi M, Mokgacha K, Phillips H, Mullan PC, Steenhoff AP, Mashalla Y, Mine M, Jarvis JN.

Clin Infect Dis. 2017 Sep 1;65(5):779-786. doi: 10.1093/cid/cix430.


Global burden of disease of HIV-associated cryptococcal meningitis: an updated analysis.

Rajasingham R, Smith RM, Park BJ, Jarvis JN, Govender NP, Chiller TM, Denning DW, Loyse A, Boulware DR.

Lancet Infect Dis. 2017 Aug;17(8):873-881. doi: 10.1016/S1473-3099(17)30243-8. Epub 2017 May 5.


Immune correlates of HIV-associated cryptococcal meningitis.

Tenforde MW, Scriven JE, Harrison TS, Jarvis JN.

PLoS Pathog. 2017 Mar 23;13(3):e1006207. doi: 10.1371/journal.ppat.1006207. eCollection 2017 Mar. Review. No abstract available.


Chromatin landscapes and genetic risk for juvenile idiopathic arthritis.

Zhu L, Jiang K, Webber K, Wong L, Liu T, Chen Y, Jarvis JN.

Arthritis Res Ther. 2017 Mar 14;19(1):57. doi: 10.1186/s13075-017-1260-x.


A Population Genomics Approach to Assessing the Genetic Basis of Within-Host Microevolution Underlying Recurrent Cryptococcal Meningitis Infection.

Rhodes J, Beale MA, Vanhove M, Jarvis JN, Kannambath S, Simpson JA, Ryan A, Meintjes G, Harrison TS, Fisher MC, Bicanic T.

G3 (Bethesda). 2017 Apr 3;7(4):1165-1176. doi: 10.1534/g3.116.037499.


Chromatin landscapes and genetic risk in systemic lupus.

Hui-Yuen JS, Zhu L, Wong LP, Jiang K, Chen Y, Liu T, Jarvis JN.

Arthritis Res Ther. 2016 Dec 1;18(1):281.


Cryptococcal meningitis: epidemiology, immunology, diagnosis and therapy.

Williamson PR, Jarvis JN, Panackal AA, Fisher MC, Molloy SF, Loyse A, Harrison TS.

Nat Rev Neurol. 2017 Jan;13(1):13-24. doi: 10.1038/nrneurol.2016.167. Epub 2016 Nov 25. Review.


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