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Items: 40

1.

Synthesis and antiviral activity of novel HCV NS3 protease inhibitors with P4 capping groups.

Li X, Liu Y, Zhang YK, Plattner JJ, Baker SJ, Bu W, Liu L, Zhou Y, Ding CZ, Zhang S, Kazmierski WM, Hamatake R, Duan M, Wright LL, Smith GK, Jarvest RL, Ji JJ, Cooper JP, Tallant MD, Crosby RM, Creech K, Wang A.

Bioorg Med Chem Lett. 2012 Dec 15;22(24):7351-6. doi: 10.1016/j.bmcl.2012.10.075. Epub 2012 Oct 22.

PMID:
23142614
2.

Discovery of novel urea-based hepatitis C protease inhibitors with high potency against protease-inhibitor-resistant mutants.

Kazmierski WM, Hamatake R, Duan M, Wright LL, Smith GK, Jarvest RL, Ji JJ, Cooper JP, Tallant MD, Crosby RM, Creech K, Wang A, Li X, Zhang S, Zhang YK, Liu Y, Ding CZ, Zhou Y, Plattner JJ, Baker SJ, Bu W, Liu L.

J Med Chem. 2012 Apr 12;55(7):3021-6. doi: 10.1021/jm201278q. Epub 2012 Apr 3.

PMID:
22471376
3.

Synthesis and SAR of acyclic HCV NS3 protease inhibitors with novel P4-benzoxaborole moieties.

Li X, Zhang S, Zhang YK, Liu Y, Ding CZ, Zhou Y, Plattner JJ, Baker SJ, Bu W, Liu L, Kazmierski WM, Duan M, Grimes RM, Wright LL, Smith GK, Jarvest RL, Ji JJ, Cooper JP, Tallant MD, Crosby RM, Creech K, Ni ZJ, Zou W, Wright J.

Bioorg Med Chem Lett. 2011 Apr 1;21(7):2048-54. doi: 10.1016/j.bmcl.2011.02.006. Epub 2011 Feb 23.

PMID:
21353550
4.

Synthesis and biological evaluations of P4-benzoxaborole-substituted macrocyclic inhibitors of HCV NS3 protease.

Ding CZ, Zhang YK, Li X, Liu Y, Zhang S, Zhou Y, Plattner JJ, Baker SJ, Liu L, Duan M, Jarvest RL, Ji J, Kazmierski WM, Tallant MD, Wright LL, Smith GK, Crosby RM, Wang AA, Ni ZJ, Zou W, Wright J.

Bioorg Med Chem Lett. 2010 Dec 15;20(24):7317-22. doi: 10.1016/j.bmcl.2010.10.071. Epub 2010 Oct 21.

PMID:
21067923
5.

Synthesis of new acylsulfamoyl benzoxaboroles as potent inhibitors of HCV NS3 protease.

Li X, Zhang YK, Liu Y, Zhang S, Ding CZ, Zhou Y, Plattner JJ, Baker SJ, Liu L, Bu W, Kazmierski WM, Wright LL, Smith GK, Jarvest RL, Duan M, Ji JJ, Cooper JP, Tallant MD, Crosby RM, Creech K, Ni ZJ, Zou W, Wright J.

Bioorg Med Chem Lett. 2010 Dec 15;20(24):7493-7. doi: 10.1016/j.bmcl.2010.10.007. Epub 2010 Oct 30.

PMID:
21041080
6.

Novel macrocyclic HCV NS3 protease inhibitors derived from α-amino cyclic boronates.

Li X, Zhang YK, Liu Y, Ding CZ, Zhou Y, Li Q, Plattner JJ, Baker SJ, Zhang S, Kazmierski WM, Wright LL, Smith GK, Grimes RM, Crosby RM, Creech KL, Carballo LH, Slater MJ, Jarvest RL, Thommes P, Hubbard JA, Convery MA, Nassau PM, McDowell W, Skarzynski TJ, Qian X, Fan D, Liao L, Ni ZJ, Pennicott LE, Zou W, Wright J.

Bioorg Med Chem Lett. 2010 Oct 1;20(19):5695-700. doi: 10.1016/j.bmcl.2010.08.022. Epub 2010 Aug 10.

PMID:
20801653
7.

6-Alkylquinolone-3-carboxylic acid tethered to macrolides synthesis and antimicrobial profile.

Kapić S, Cipcić Paljetak H, Alihodzić S, Antolović R, Eraković Haber V, Jarvest RL, Holmes DJ, Broskey JP, Hunt E.

Bioorg Med Chem. 2010 Sep 1;18(17):6569-77. doi: 10.1016/j.bmc.2010.06.048. Epub 2010 Jul 3.

PMID:
20673633
8.

Synthesis and evaluation of novel alpha-amino cyclic boronates as inhibitors of HCV NS3 protease.

Li X, Zhang YK, Liu Y, Ding CZ, Li Q, Zhou Y, Plattner JJ, Baker SJ, Qian X, Fan D, Liao L, Ni ZJ, White GV, Mordaunt JE, Lazarides LX, Slater MJ, Jarvest RL, Thommes P, Ellis M, Edge CM, Hubbard JA, Somers D, Rowland P, Nassau P, McDowell B, Skarzynski TJ, Kazmierski WM, Grimes RM, Wright LL, Smith GK, Zou W, Wright J, Pennicott LE.

Bioorg Med Chem Lett. 2010 Jun 15;20(12):3550-6. doi: 10.1016/j.bmcl.2010.04.129. Epub 2010 May 20.

PMID:
20493689
9.

Optimization of novel acyl pyrrolidine inhibitors of hepatitis C virus RNA-dependent RNA polymerase leading to a development candidate.

Slater MJ, Amphlett EM, Andrews DM, Bravi G, Burton G, Cheasty AG, Corfield JA, Ellis MR, Fenwick RH, Fernandes S, Guidetti R, Haigh D, Hartley CD, Howes PD, Jackson DL, Jarvest RL, Lovegrove VL, Medhurst KJ, Parry NR, Price H, Shah P, Singh OM, Stocker R, Thommes P, Wilkinson C, Wonacott A.

J Med Chem. 2007 Mar 8;50(5):897-900. Epub 2007 Feb 2.

PMID:
17269759
10.

Discovery and optimisation of potent, selective, ethanolamine inhibitors of bacterial phenylalanyl tRNA synthetase.

Jarvest RL, Erskine SG, Forrest AK, Fosberry AP, Hibbs MJ, Jones JJ, O'Hanlon PJ, Sheppard RJ, Worby A.

Bioorg Med Chem Lett. 2005 May 2;15(9):2305-9.

PMID:
15837314
11.

Definition of the heterocyclic pharmacophore of bacterial methionyl tRNA synthetase inhibitors: potent antibacterially active non-quinolone analogues.

Jarvest RL, Armstrong SA, Berge JM, Brown P, Elder JS, Brown MJ, Copley RC, Forrest AK, Hamprecht DW, O'Hanlon PJ, Mitchell DJ, Rittenhouse S, Witty DR.

Bioorg Med Chem Lett. 2004 Aug 2;14(15):3937-41.

PMID:
15225702
12.
13.

Variable sensitivity to bacterial methionyl-tRNA synthetase inhibitors reveals subpopulations of Streptococcus pneumoniae with two distinct methionyl-tRNA synthetase genes.

Gentry DR, Ingraham KA, Stanhope MJ, Rittenhouse S, Jarvest RL, O'Hanlon PJ, Brown JR, Holmes DJ.

Antimicrob Agents Chemother. 2003 Jun;47(6):1784-9.

14.

Conformational restriction of methionyl tRNA synthetase inhibitors leading to analogues with potent inhibition and excellent gram-positive antibacterial activity.

Jarvest RL, Berge JM, Brown P, Houge-Frydrych CS, O'Hanlon PJ, McNair DJ, Pope AJ, Rittenhouse S.

Bioorg Med Chem Lett. 2003 Apr 7;13(7):1265-8.

PMID:
12657260
15.

Optimisation of aryl substitution leading to potent methionyl tRNA synthetase inhibitors with excellent gram-positive antibacterial activity.

Jarvest RL, Berge JM, Brown MJ, Brown P, Elder JS, Forrest AK, Houge-Frydrych CS, O'Hanlon PJ, McNair DJ, Rittenhouse S, Sheppard RJ.

Bioorg Med Chem Lett. 2003 Feb 24;13(4):665-8.

PMID:
12639554
16.

The antimicrobial natural product chuangxinmycin and some synthetic analogues are potent and selective inhibitors of bacterial tryptophanyl tRNA synthetase.

Brown MJ, Carter PS, Fenwick AS, Fosberry AP, Hamprecht DW, Hibbs MJ, Jarvest RL, Mensah L, Milner PH, O'Hanlon PJ, Pope AJ, Richardson CM, West A, Witty DR.

Bioorg Med Chem Lett. 2002 Nov 4;12(21):3171-4.

PMID:
12372526
17.

Nanomolar inhibitors of Staphylococcus aureus methionyl tRNA synthetase with potent antibacterial activity against gram-positive pathogens.

Jarvest RL, Berge JM, Berry V, Boyd HF, Brown MJ, Elder JS, Forrest AK, Fosberry AP, Gentry DR, Hibbs MJ, Jaworski DD, O'Hanlon PJ, Pope AJ, Rittenhouse S, Sheppard RJ, Slater-Radosti C, Worby A.

J Med Chem. 2002 May 9;45(10):1959-62.

PMID:
11985462
18.

Crystal structure of Staphylococcus aureus tyrosyl-tRNA synthetase in complex with a class of potent and specific inhibitors.

Qiu X, Janson CA, Smith WW, Green SM, McDevitt P, Johanson K, Carter P, Hibbs M, Lewis C, Chalker A, Fosberry A, Lalonde J, Berge J, Brown P, Houge-Frydrych CS, Jarvest RL.

Protein Sci. 2001 Oct;10(10):2008-16.

19.

Inhibitors of bacterial tyrosyl tRNA synthetase: synthesis of carbocyclic analogues of the natural product SB-219383.

Jarvest RL, Berge JM, Houge-Frydrych CS, Mensah LM, O'Hanlon PJ, Pope AJ.

Bioorg Med Chem Lett. 2001 Sep 17;11(18):2499-502.

PMID:
11549455
20.

Potent synthetic inhibitors of tyrosyl tRNA synthetase derived from C-pyranosyl analogues of SB-219383.

Jarvest RL, Berge JM, Brown P, Hamprecht DW, McNair DJ, Mensah L, O'Hanlon PJ, Pope AJ.

Bioorg Med Chem Lett. 2001 Mar 12;11(5):715-8.

PMID:
11266176
21.

Synthetic analogues of SB-219383. Novel C-glycosyl peptides as inhibitors of tyrosyl tRNA synthetase.

Brown P, Eggleston DS, Haltiwanger RC, Jarvest RL, Mensah L, O'Hanlon PJ, Pope AJ.

Bioorg Med Chem Lett. 2001 Mar 12;11(5):711-4.

PMID:
11266175
22.

Synthesis and activity of analogues of SB-219383: novel potent inhibitors of bacterial tyrosyl tRNA synthetase.

Berge JM, Broom NJ, Houge-Frydrych CS, Jarvest RL, Mensah L, McNair DJ, O'Hanlon PJ, Pope AJ, Rittenhouse S.

J Antibiot (Tokyo). 2000 Nov;53(11):1282-92.

23.

Aminoalkyl adenylate and aminoacyl sulfamate intermediate analogues differing greatly in affinity for their cognate Staphylococcus aureus aminoacyl tRNA synthetases.

Forrest AK, Jarvest RL, Mensah LM, O'Hanlon PJ, Pope AJ, Sheppard RJ.

Bioorg Med Chem Lett. 2000 Aug 21;10(16):1871-4.

PMID:
10969988
24.

Inhibitors of bacterial tyrosyl tRNA synthetase: synthesis of four stereoisomeric analogues of the natural product SB-219383.

Berge JM, Copley RC, Eggleston DS, Hamprecht DW, Jarvest RL, Mensah LM, O'Hanlon PJ, Pope AJ.

Bioorg Med Chem Lett. 2000 Aug 21;10(16):1811-4.

PMID:
10969974
25.

Interaction of tyrosyl aryl dipeptides with S. aureus tyrosyl tRNA synthetase: inhibition and crystal structure of a complex.

Jarvest RL, Berge JM, Houge-Frydrych CS, Janson C, Mensah LM, O'Hanlon PJ, Pope A, Saldanha A, Qiu X.

Bioorg Med Chem Lett. 1999 Oct 4;9(19):2859-62.

PMID:
10522706
26.

Inhibition of human cytomegalovirus protease by enedione derivatives of thieno[2,3-d]oxazinones through a novel dual acylation/alkylation mechanism.

Pinto IL, Jarvest RL, Clarke B, Dabrowski CE, Fenwick A, Gorczyca MM, Jennings LJ, Lavery P, Sternberg EJ, Tew DG, West A.

Bioorg Med Chem Lett. 1999 Feb 8;9(3):449-52.

PMID:
10091700
27.

Inhibition of herpes proteases and antiviral activity of 2-substituted thieno[2,3-d]oxazinones.

Jarvest RL, Pinto IL, Ashman SM, Dabrowski CE, Fernandez AV, Jennings LJ, Lavery P, Tew DG.

Bioorg Med Chem Lett. 1999 Feb 8;9(3):443-8.

PMID:
10091699
28.

Famciclovir. Discovery and development of a novel antiherpesvirus agent.

Jarvest RL, Sutton D, Vere Hodge RA.

Pharm Biotechnol. 1998;11:313-43. Review. No abstract available.

PMID:
9760686
29.

Exploring the active site of herpes simplex virus type-1 thymidine kinase by X-ray crystallography of complexes with aciclovir and other ligands.

Champness JN, Bennett MS, Wien F, Visse R, Summers WC, Herdewijn P, de Clerq E, Ostrowski T, Jarvest RL, Sanderson MR.

Proteins. 1998 Aug 15;32(3):350-61.

PMID:
9715911
31.
32.

Selection of an oral prodrug (BRL 42810; famciclovir) for the antiherpesvirus agent BRL 39123 [9-(4-hydroxy-3-hydroxymethylbut-l-yl)guanine; penciclovir].

Vere Hodge RA, Sutton D, Boyd MR, Harnden MR, Jarvest RL.

Antimicrob Agents Chemother. 1989 Oct;33(10):1765-73.

33.
34.

Synthesis and antiviral activity of 9-[4-hydroxy-3-(hydroxymethyl)but-1-yl]purines.

Harnden MR, Jarvest RL, Bacon TH, Boyd MR.

J Med Chem. 1987 Sep;30(9):1636-42.

PMID:
3040998
35.

The stereochemical course of nucleotidyl transfer catalyzed by ATP sulfurylase.

Bicknell R, Cullis PM, Jarvest RL, Lowe G.

J Biol Chem. 1982 Aug 10;257(15):8922-7.

38.
40.

Stereochemistry of phosphoryl transfer.

Lowe G, Cullis PM, Jarvest RL, Potter BV, Sproat BS.

Philos Trans R Soc Lond B Biol Sci. 1981 Jun 26;293(1063):75-92. Review.

PMID:
6115426

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