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Aflatoxin-guanine DNA Adducts and Oxidatively-induced DNA Damage in Aflatoxin-treated Mice in vivo as Measured by Liquid Chromatography-Tandem Mass Spectrometry with Isotope-dilution.

Coskun E, Jaruga P, Vartanian V, Erdem O, Egner PA, Groopman JD, Lloyd RS, Dizdaroglu M.

Chem Res Toxicol. 2018 Dec 11. doi: 10.1021/acs.chemrestox.8b00202. [Epub ahead of print]


Excision release of 5?hydroxycytosine oxidatively induced DNA base lesions from the lung genome by cat dander extract challenge stimulates allergic airway inflammation.

Hosoki K, Jaruga P, Itazawa T, Aguilera-Aguirre L, Coskun E, Hazra TK, Boldogh I, Dizdaroglu M, Sur S.

Clin Exp Allergy. 2018 Dec;48(12):1676-1687. doi: 10.1111/cea.13284. Epub 2018 Nov 5.


Exposure to Engineered Nanomaterials: Impact on DNA Repair Pathways.

Singh N, Nelson BC, Scanlan LD, Coskun E, Jaruga P, Doak SH.

Int J Mol Sci. 2017 Jul 13;18(7). pii: E1515. doi: 10.3390/ijms18071515. Review.


Biomarkers of oxidatively induced DNA damage in dreissenid mussels: A genotoxicity assessment tool for the Laurentian Great Lakes.

Jaruga P, Coskun E, Kimbrough K, Jacob A, Johnson WE, Dizdaroglu M.

Environ Toxicol. 2017 Sep;32(9):2144-2153. doi: 10.1002/tox.22427. Epub 2017 Jun 1.


Repair of oxidatively induced DNA damage by DNA glycosylases: Mechanisms of action, substrate specificities and excision kinetics.

Dizdaroglu M, Coskun E, Jaruga P.

Mutat Res. 2017 Jan - Mar;771:99-127. doi: 10.1016/j.mrrev.2017.02.001. Epub 2017 Feb 16. Review.


Enhanced sensitivity of Neil1-/- mice to chronic UVB exposure.

Calkins MJ, Vartanian V, Owen N, Kirkali G, Jaruga P, Dizdaroglu M, McCullough AK, Lloyd RS.

DNA Repair (Amst). 2016 Dec;48:43-50. doi: 10.1016/j.dnarep.2016.10.010. Epub 2016 Oct 28.


Combined Effects of High-Dose Bisphenol A and Oxidizing Agent (KBrO3) on Cellular Microenvironment, Gene Expression, and Chromatin Structure of Ku70-deficient Mouse Embryonic Fibroblasts.

Gassman NR, Coskun E, Jaruga P, Dizdaroglu M, Wilson SH.

Environ Health Perspect. 2016 Aug;124(8):1241-52. doi: 10.1289/EHP237. Epub 2016 Apr 15.


Production, Purification, and Characterization of ¹⁵N-Labeled DNA Repair Proteins as Internal Standards for Mass Spectrometric Measurements.

Reddy PT, Jaruga P, Nelson BC, Lowenthal MS, Jemth AS, Loseva O, Coskun E, Helleday T, Dizdaroglu M.

Methods Enzymol. 2016;566:305-32. doi: 10.1016/bs.mie.2015.06.044. Epub 2015 Jul 26.


Extreme Expression of DNA Repair Protein Apurinic/Apyrimidinic Endonuclease 1 (APE1) in Human Breast Cancer As Measured by Liquid Chromatography and Isotope Dilution Tandem Mass Spectrometry.

Coskun E, Jaruga P, Reddy PT, Dizdaroglu M.

Biochemistry. 2015 Sep 29;54(38):5787-90. doi: 10.1021/acs.biochem.5b00928. Epub 2015 Sep 15.


Small Molecule Inhibitors of 8-Oxoguanine DNA Glycosylase-1 (OGG1).

Donley N, Jaruga P, Coskun E, Dizdaroglu M, McCullough AK, Lloyd RS.

ACS Chem Biol. 2015 Oct 16;10(10):2334-43. doi: 10.1021/acschembio.5b00452. Epub 2015 Aug 7.


Addiction to MTH1 protein results in intense expression in human breast cancer tissue as measured by liquid chromatography-isotope-dilution tandem mass spectrometry.

Coskun E, Jaruga P, Jemth AS, Loseva O, Scanlan LD, Tona A, Lowenthal MS, Helleday T, Dizdaroglu M.

DNA Repair (Amst). 2015 Sep;33:101-10. doi: 10.1016/j.dnarep.2015.05.008. Epub 2015 Jun 23.


Measurement of oxidatively induced DNA damage and its repair, by mass spectrometric techniques.

Dizdaroglu M, Coskun E, Jaruga P.

Free Radic Res. 2015 May;49(5):525-48. doi: 10.3109/10715762.2015.1014814. Epub 2015 Mar 27. Review.


Bisphenol a promotes cell survival following oxidative DNA damage in mouse fibroblasts.

Gassman NR, Coskun E, Stefanick DF, Horton JK, Jaruga P, Dizdaroglu M, Wilson SH.

PLoS One. 2015 Feb 18;10(2):e0118819. doi: 10.1371/journal.pone.0118819. eCollection 2015.


Significant disparity in base and sugar damage in DNA resulting from neutron and electron irradiation.

Pang D, Nico JS, Karam L, Timofeeva O, Blakely WF, Dritschilo A, Dizdaroglu M, Jaruga P.

J Radiat Res. 2014 Nov;55(6):1081-8. doi: 10.1093/jrr/rru059. Epub 2014 Jul 17.


Inhibition of DNA glycosylases via small molecule purine analogs.

Jacobs AC, Calkins MJ, Jadhav A, Dorjsuren D, Maloney D, Simeonov A, Jaruga P, Dizdaroglu M, McCullough AK, Lloyd RS.

PLoS One. 2013 Dec 9;8(12):e81667. doi: 10.1371/journal.pone.0081667. eCollection 2013.


Identification and quantification of DNA repair protein apurinic/apyrimidinic endonuclease 1 (APE1) in human cells by liquid chromatography/isotope-dilution tandem mass spectrometry.

Kirkali G, Jaruga P, Reddy PT, Tona A, Nelson BC, Li M, Wilson DM 3rd, Dizdaroglu M.

PLoS One. 2013 Jul 29;8(7):e69894. doi: 10.1371/journal.pone.0069894. Print 2013.


Active transcriptomic and proteomic reprogramming in the C. elegans nucleotide excision repair mutant xpa-1.

Arczewska KD, Tomazella GG, Lindvall JM, Kassahun H, Maglioni S, Torgovnick A, Henriksson J, Matilainen O, Marquis BJ, Nelson BC, Jaruga P, Babaie E, Holmberg CI, Bürglin TR, Ventura N, Thiede B, Nilsen H.

Nucleic Acids Res. 2013 May 1;41(10):5368-81. doi: 10.1093/nar/gkt225. Epub 2013 Apr 10.


Identification and quantification of human DNA repair protein NEIL1 by liquid chromatography/isotope-dilution tandem mass spectrometry.

Reddy PT, Jaruga P, Kirkali G, Tuna G, Nelson BC, Dizdaroglu M.

J Proteome Res. 2013 Feb 1;12(2):1049-61. doi: 10.1021/pr301037t. Epub 2013 Jan 11.


Structural and biochemical studies of a plant formamidopyrimidine-DNA glycosylase reveal why eukaryotic Fpg glycosylases do not excise 8-oxoguanine.

Duclos S, Aller P, Jaruga P, Dizdaroglu M, Wallace SS, Doublié S.

DNA Repair (Amst). 2012 Sep 1;11(9):714-25. doi: 10.1016/j.dnarep.2012.06.004. Epub 2012 Jul 11.


RNA oxidation catalyzed by cytochrome c leads to its depurination and cross-linking, which may facilitate cytochrome c release from mitochondria.

Tanaka M, Jaruga P, Küpfer PA, Leumann CJ, Dizdaroglu M, Sonntag WE, Boon Chock P.

Free Radic Biol Med. 2012 Aug 15;53(4):854-62. doi: 10.1016/j.freeradbiomed.2012.05.044. Epub 2012 Jun 7.


DNA damage products (5'R)- and (5'S)-8,5'-cyclo-2'-deoxyadenosines as potential biomarkers in human urine for atherosclerosis.

Jaruga P, Rozalski R, Jawien A, Migdalski A, Olinski R, Dizdaroglu M.

Biochemistry. 2012 Mar 6;51(9):1822-4. doi: 10.1021/bi201912c. Epub 2012 Feb 23.


Mechanisms of free radical-induced damage to DNA.

Dizdaroglu M, Jaruga P.

Free Radic Res. 2012 Apr;46(4):382-419. doi: 10.3109/10715762.2011.653969. Review.


Copper oxide nanoparticle mediated DNA damage in terrestrial plant models.

Atha DH, Wang H, Petersen EJ, Cleveland D, Holbrook RD, Jaruga P, Dizdaroglu M, Xing B, Nelson BC.

Environ Sci Technol. 2012 Feb 7;46(3):1819-27. doi: 10.1021/es202660k. Epub 2012 Jan 20. Erratum in: Environ Sci Technol. 2014 Oct 21;48(20):12473.


Evidence for upregulated repair of oxidatively induced DNA damage in human colorectal cancer.

Kirkali G, Keles D, Canda AE, Terzi C, Reddy PT, Jaruga P, Dizdaroglu M, Oktay G.

DNA Repair (Amst). 2011 Nov 10;10(11):1114-20. doi: 10.1016/j.dnarep.2011.08.008. Epub 2011 Sep 15.


Stable isotope-labeling of DNA repair proteins, and their purification and characterization.

Reddy PT, Jaruga P, Nelson BC, Lowenthal M, Dizdaroglu M.

Protein Expr Purif. 2011 Jul;78(1):94-101. doi: 10.1016/j.pep.2011.02.011. Epub 2011 Feb 26.


A major role for nonenzymatic antioxidant processes in the radioresistance of Halobacterium salinarum.

Robinson CK, Webb K, Kaur A, Jaruga P, Dizdaroglu M, Baliga NS, Place A, Diruggiero J.

J Bacteriol. 2011 Apr;193(7):1653-62. doi: 10.1128/JB.01310-10. Epub 2011 Jan 28.


Identification and quantification of (5'R)- and (5'S)-8,5'-cyclo-2'-deoxyadenosines in human urine as putative biomarkers of oxidatively induced damage to DNA.

Jaruga P, Dizdaroglu M.

Biochem Biophys Res Commun. 2010 Jun 18;397(1):48-52. doi: 10.1016/j.bbrc.2010.05.050. Epub 2010 May 13.


The mouse ortholog of NEIL3 is a functional DNA glycosylase in vitro and in vivo.

Liu M, Bandaru V, Bond JP, Jaruga P, Zhao X, Christov PP, Burrows CJ, Rizzo CJ, Dizdaroglu M, Wallace SS.

Proc Natl Acad Sci U S A. 2010 Mar 16;107(11):4925-30. doi: 10.1073/pnas.0908307107. Epub 2010 Feb 25.


Evidence for the involvement of DNA repair enzyme NEIL1 in nucleotide excision repair of (5'R)- and (5'S)-8,5'-cyclo-2'-deoxyadenosines.

Jaruga P, Xiao Y, Vartanian V, Lloyd RS, Dizdaroglu M.

Biochemistry. 2010 Feb 16;49(6):1053-5. doi: 10.1021/bi902161f.


The oxidative DNA glycosylases of Mycobacterium tuberculosis exhibit different substrate preferences from their Escherichia coli counterparts.

Guo Y, Bandaru V, Jaruga P, Zhao X, Burrows CJ, Iwai S, Dizdaroglu M, Bond JP, Wallace SS.

DNA Repair (Amst). 2010 Feb 4;9(2):177-90. doi: 10.1016/j.dnarep.2009.11.008. Epub 2009 Dec 23.


Substrate specificity and excision kinetics of natural polymorphic variants and phosphomimetic mutants of human 8-oxoguanine-DNA glycosylase.

Sidorenko VS, Grollman AP, Jaruga P, Dizdaroglu M, Zharkov DO.

FEBS J. 2009 Sep;276(18):5149-62. doi: 10.1111/j.1742-4658.2009.07212.x. Epub 2009 Aug 7.


Measurement of (5'R)- and (5'S)-8,5'-cyclo-2'-deoxyadenosines in DNA in vivo by liquid chromatography/isotope-dilution tandem mass spectrometry.

Jaruga P, Xiao Y, Nelson BC, Dizdaroglu M.

Biochem Biophys Res Commun. 2009 Sep 4;386(4):656-60. doi: 10.1016/j.bbrc.2009.06.107. Epub 2009 Jun 23.


Salt shield: intracellular salts provide cellular protection against ionizing radiation in the halophilic archaeon, Halobacterium salinarum NRC-1.

Kish A, Kirkali G, Robinson C, Rosenblatt R, Jaruga P, Dizdaroglu M, DiRuggiero J.

Environ Microbiol. 2009 May;11(5):1066-78.


Glutathione depletion by buthionine sulfoximine induces oxidative damage to DNA in organs of rabbits in vivo.

Gokce G, Ozsarlak-Sozer G, Oktay G, Kirkali G, Jaruga P, Dizdaroglu M, Kerry Z.

Biochemistry. 2009 Jun 9;48(22):4980-7. doi: 10.1021/bi900030z.


Targeted deletion of the genes encoding NTH1 and NEIL1 DNA N-glycosylases reveals the existence of novel carcinogenic oxidative damage to DNA.

Chan MK, Ocampo-Hafalla MT, Vartanian V, Jaruga P, Kirkali G, Koenig KL, Brown S, Lloyd RS, Dizdaroglu M, Teebor GW.

DNA Repair (Amst). 2009 Jul 4;8(7):786-94. doi: 10.1016/j.dnarep.2009.03.001. Epub 2009 Apr 5.


Plant and fungal Fpg homologs are formamidopyrimidine DNA glycosylases but not 8-oxoguanine DNA glycosylases.

Kathe SD, Barrantes-Reynolds R, Jaruga P, Newton MR, Burrows CJ, Bandaru V, Dizdaroglu M, Bond JP, Wallace SS.

DNA Repair (Amst). 2009 May 1;8(5):643-53. doi: 10.1016/j.dnarep.2008.12.013. Epub 2009 Feb 12.


Accumulation of (5'S)-8,5'-cyclo-2'-deoxyadenosine in organs of Cockayne syndrome complementation group B gene knockout mice.

Kirkali G, de Souza-Pinto NC, Jaruga P, Bohr VA, Dizdaroglu M.

DNA Repair (Amst). 2009 Feb 1;8(2):274-8. doi: 10.1016/j.dnarep.2008.09.009. Epub 2008 Nov 18.


Measurement of formamidopyrimidines in DNA.

Jaruga P, Kirkali G, Dizdaroglu M.

Free Radic Biol Med. 2008 Dec 15;45(12):1601-9. doi: 10.1016/j.freeradbiomed.2008.09.019. Epub 2008 Sep 27.


Formamidopyrimidines in DNA: mechanisms of formation, repair, and biological effects.

Dizdaroglu M, Kirkali G, Jaruga P.

Free Radic Biol Med. 2008 Dec 15;45(12):1610-21. doi: 10.1016/j.freeradbiomed.2008.07.004. Epub 2008 Jul 17. Review.


8,5'-Cyclopurine-2'-deoxynucleosides in DNA: mechanisms of formation, measurement, repair and biological effects.

Jaruga P, Dizdaroglu M.

DNA Repair (Amst). 2008 Sep 1;7(9):1413-25. doi: 10.1016/j.dnarep.2008.06.005. Epub 2008 Jul 17. Review.


Oxidative DNA damage in polymorphonuclear leukocytes of patients with familial Mediterranean fever.

Kirkali G, Tunca M, Genc S, Jaruga P, Dizdaroglu M.

Free Radic Biol Med. 2008 Feb 1;44(3):386-93. Epub 2007 Oct 10.


Accumulation of oxidatively induced DNA damage in human breast cancer cell lines following treatment with hydrogen peroxide.

Nyaga SG, Jaruga P, Lohani A, Dizdaroglu M, Evans MK.

Cell Cycle. 2007 Jun 15;6(12):1472-8. Epub 2007 Apr 13.


Human polymorphic variants of the NEIL1 DNA glycosylase.

Roy LM, Jaruga P, Wood TG, McCullough AK, Dizdaroglu M, Lloyd RS.

J Biol Chem. 2007 May 25;282(21):15790-8. Epub 2007 Mar 26.


The role of CSA in the response to oxidative DNA damage in human cells.

D'Errico M, Parlanti E, Teson M, Degan P, Lemma T, Calcagnile A, Iavarone I, Jaruga P, Ropolo M, Pedrini AM, Orioli D, Frosina G, Zambruno G, Dizdaroglu M, Stefanini M, Dogliotti E.

Oncogene. 2007 Jun 28;26(30):4336-43. Epub 2007 Feb 12.


Lymphoblasts of women with BRCA1 mutations are deficient in cellular repair of 8,5'-Cyclopurine-2'-deoxynucleosides and 8-hydroxy-2'-deoxyguanosine.

Rodriguez H, Jaruga P, Leber D, Nyaga SG, Evans MK, Dizdaroglu M.

Biochemistry. 2007 Mar 6;46(9):2488-96. Epub 2007 Feb 9.


Reduced repair of 8-hydroxyguanine in the human breast cancer cell line, HCC1937.

Nyaga SG, Lohani A, Jaruga P, Trzeciak AR, Dizdaroglu M, Evans MK.

BMC Cancer. 2006 Dec 27;6:297.


Molecular analysis of base damage clustering associated with a site-specific radiation-induced DNA double-strand break.

Datta K, Jaruga P, Dizdaroglu M, Neumann RD, Winters TA.

Radiat Res. 2006 Nov;166(5):767-81.


New functions of XPC in the protection of human skin cells from oxidative damage.

D'Errico M, Parlanti E, Teson M, de Jesus BM, Degan P, Calcagnile A, Jaruga P, Bjørås M, Crescenzi M, Pedrini AM, Egly JM, Zambruno G, Stefanini M, Dizdaroglu M, Dogliotti E.

EMBO J. 2006 Sep 20;25(18):4305-15. Epub 2006 Sep 7.

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