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Items: 39

1.

Identification and Optimization of Mechanism-Based Fluoroallylamine Inhibitors of Lysyl Oxidase-like 2/3.

Findlay AD, Foot JS, Buson A, Deodhar M, Jarnicki AG, Hansbro PM, Liu G, Schilter H, Turner CI, Zhou W, Jarolimek W.

J Med Chem. 2019 Oct 16. doi: 10.1021/acs.jmedchem.9b01283. [Epub ahead of print]

PMID:
31580073
2.

Fibulin-1c regulates transforming growth factor-β activation in pulmonary tissue fibrosis.

Liu G, Cooley MA, Jarnicki AG, Borghuis T, Nair PM, Tjin G, Hsu AC, Haw TJ, Fricker M, Harrison CL, Jones B, Hansbro NG, Wark PA, Horvat JC, Argraves WS, Oliver BG, Knight DA, Burgess JK, Hansbro PM.

JCI Insight. 2019 Jul 25;5. pii: 124529. doi: 10.1172/jci.insight.124529.

3.

Chronic cigarette smoke exposure induces systemic hypoxia that drives intestinal dysfunction.

Fricker M, Goggins BJ, Mateer S, Jones B, Kim RY, Gellatly SL, Jarnicki AG, Powell N, Oliver BG, Radford-Smith G, Talley NJ, Walker MM, Keely S, Hansbro PM.

JCI Insight. 2018 Feb 8;3(3). pii: 94040. doi: 10.1172/jci.insight.94040. eCollection 2018 Feb 8.

4.

Airway remodelling and inflammation in asthma are dependent on the extracellular matrix protein fibulin-1c.

Liu G, Cooley MA, Nair PM, Donovan C, Hsu AC, Jarnicki AG, Haw TJ, Hansbro NG, Ge Q, Brown AC, Tay H, Foster PS, Wark PA, Horvat JC, Bourke JE, Grainge CL, Argraves WS, Oliver BG, Knight DA, Burgess JK, Hansbro PM.

J Pathol. 2017 Dec;243(4):510-523. doi: 10.1002/path.4979.

PMID:
28862768
5.

Grandmaternal smoke exposure reduces female fertility in a murine model, with great-grandmaternal smoke exposure unlikely to have an effect.

Camlin NJ, Jarnicki AG, Vanders RL, Walters KA, Hansbro PM, McLaughlin EA, Holt JE.

Hum Reprod. 2017 Jun 1;32(6):1270-1281. doi: 10.1093/humrep/dex073.

PMID:
28402417
6.

The inhibitor of semicarbazide-sensitive amine oxidase, PXS-4728A, ameliorates key features of chronic obstructive pulmonary disease in a mouse model.

Jarnicki AG, Schilter H, Liu G, Wheeldon K, Essilfie AT, Foot JS, Yow TT, Jarolimek W, Hansbro PM.

Br J Pharmacol. 2016 Nov;173(22):3161-3175. doi: 10.1111/bph.13573. Epub 2016 Oct 12.

7.

MicroRNA-21 drives severe, steroid-insensitive experimental asthma by amplifying phosphoinositide 3-kinase-mediated suppression of histone deacetylase 2.

Kim RY, Horvat JC, Pinkerton JW, Starkey MR, Essilfie AT, Mayall JR, Nair PM, Hansbro NG, Jones B, Haw TJ, Sunkara KP, Nguyen TH, Jarnicki AG, Keely S, Mattes J, Adcock IM, Foster PS, Hansbro PM.

J Allergy Clin Immunol. 2017 Feb;139(2):519-532. doi: 10.1016/j.jaci.2016.04.038. Epub 2016 Jun 10.

8.

Fibulin-1 regulates the pathogenesis of tissue remodeling in respiratory diseases.

Liu G, Cooley MA, Jarnicki AG, Hsu AC, Nair PM, Haw TJ, Fricker M, Gellatly SL, Kim RY, Inman MD, Tjin G, Wark PA, Walker MM, Horvat JC, Oliver BG, Argraves WS, Knight DA, Burgess JK, Hansbro PM.

JCI Insight. 2016 Jun 16;1(9). pii: e86380.

9.

TLR2, TLR4 AND MyD88 Mediate Allergic Airway Disease (AAD) and Streptococcus pneumoniae-Induced Suppression of AAD.

Thorburn AN, Tseng HY, Donovan C, Hansbro NG, Jarnicki AG, Foster PS, Gibson PG, Hansbro PM.

PLoS One. 2016 Jun 16;11(6):e0156402. doi: 10.1371/journal.pone.0156402. eCollection 2016.

10.

Maternal Smoke Exposure Impairs the Long-Term Fertility of Female Offspring in a Murine Model.

Camlin NJ, Sobinoff AP, Sutherland JM, Beckett EL, Jarnicki AG, Vanders RL, Hansbro PM, McLaughlin EA, Holt JE.

Biol Reprod. 2016 Feb;94(2):39. doi: 10.1095/biolreprod.115.135848. Epub 2016 Jan 13.

PMID:
26764348
11.

Programming of formalin-induced nociception by neonatal LPS exposure: Maintenance by peripheral and central neuroimmune activity.

Zouikr I, Ahmed AF, Horvat JC, Beagley KW, Clifton VL, Ray A, Thorne RF, Jarnicki AG, Hansbro PM, Hodgson DM.

Brain Behav Immun. 2015 Feb;44:235-46. doi: 10.1016/j.bbi.2014.10.014. Epub 2014 Oct 31.

PMID:
25449583
12.

Damaging legacy: maternal cigarette smoking has long-term consequences for male offspring fertility.

Sobinoff AP, Sutherland JM, Beckett EL, Stanger SJ, Johnson R, Jarnicki AG, McCluskey A, St John JC, Hansbro PM, McLaughlin EA.

Hum Reprod. 2014 Dec;29(12):2719-35. doi: 10.1093/humrep/deu235. Epub 2014 Sep 30.

PMID:
25269568
13.

Mitochondrial DNA neutrophil extracellular traps are formed after trauma and subsequent surgery.

McIlroy DJ, Jarnicki AG, Au GG, Lott N, Smith DW, Hansbro PM, Balogh ZJ.

J Crit Care. 2014 Dec;29(6):1133.e1-5. doi: 10.1016/j.jcrc.2014.07.013. Epub 2014 Jul 22. Review.

14.

The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation.

Franklin BS, Bossaller L, De Nardo D, Ratter JM, Stutz A, Engels G, Brenker C, Nordhoff M, Mirandola SR, Al-Amoudi A, Mangan MS, Zimmer S, Monks BG, Fricke M, Schmidt RE, Espevik T, Jones B, Jarnicki AG, Hansbro PM, Busto P, Marshak-Rothstein A, Hornemann S, Aguzzi A, Kastenmüller W, Latz E.

Nat Immunol. 2014 Aug;15(8):727-37. doi: 10.1038/ni.2913. Epub 2014 Jun 22.

15.

Importance of mast cell Prss31/transmembrane tryptase/tryptase-γ in lung function and experimental chronic obstructive pulmonary disease and colitis.

Hansbro PM, Hamilton MJ, Fricker M, Gellatly SL, Jarnicki AG, Zheng D, Frei SM, Wong GW, Hamadi S, Zhou S, Foster PS, Krilis SA, Stevens RL.

J Biol Chem. 2014 Jun 27;289(26):18214-27. doi: 10.1074/jbc.M114.548594. Epub 2014 May 12.

16.

Scrambled and fried: cigarette smoke exposure causes antral follicle destruction and oocyte dysfunction through oxidative stress.

Sobinoff AP, Beckett EL, Jarnicki AG, Sutherland JM, McCluskey A, Hansbro PM, McLaughlin EA.

Toxicol Appl Pharmacol. 2013 Sep 1;271(2):156-67. doi: 10.1016/j.taap.2013.05.009. Epub 2013 May 18.

PMID:
23693141
17.

Murine models of infectious exacerbations of airway inflammation.

Starkey MR, Jarnicki AG, Essilfie AT, Gellatly SL, Kim RY, Brown AC, Foster PS, Horvat JC, Hansbro PM.

Curr Opin Pharmacol. 2013 Jun;13(3):337-44. doi: 10.1016/j.coph.2013.03.005. Epub 2013 Apr 6. Review.

PMID:
23566696
18.

A new short-term mouse model of chronic obstructive pulmonary disease identifies a role for mast cell tryptase in pathogenesis.

Beckett EL, Stevens RL, Jarnicki AG, Kim RY, Hanish I, Hansbro NG, Deane A, Keely S, Horvat JC, Yang M, Oliver BG, van Rooijen N, Inman MD, Adachi R, Soberman RJ, Hamadi S, Wark PA, Foster PS, Hansbro PM.

J Allergy Clin Immunol. 2013 Mar;131(3):752-62. doi: 10.1016/j.jaci.2012.11.053. Epub 2013 Feb 4.

19.

Genetic partitioning of interleukin-6 signalling in mice dissociates Stat3 from Smad3-mediated lung fibrosis.

O'Donoghue RJ, Knight DA, Richards CD, Prêle CM, Lau HL, Jarnicki AG, Jones J, Bozinovski S, Vlahos R, Thiem S, McKenzie BS, Wang B, Stumbles P, Laurent GJ, McAnulty RJ, Rose-John S, Zhu HJ, Anderson GP, Ernst MR, Mutsaers SE.

EMBO Mol Med. 2012 Sep;4(9):939-51. doi: 10.1002/emmm.201100604. Epub 2012 Jun 8.

20.

Macrolides for macrophages in chronic obstructive pulmonary disease.

Hansbro PM, Jarnicki AG.

Respirology. 2012 Jul;17(5):739-40. doi: 10.1111/j.1440-1843.2012.02186.x. No abstract available.

PMID:
22563902
21.

Sensitizing and Th2 adjuvant activity of cysteine protease allergens.

Cunningham PT, Elliot CE, Lenzo JC, Jarnicki AG, Larcombe AN, Zosky GR, Holt PG, Thomas WR.

Int Arch Allergy Immunol. 2012;158(4):347-58. doi: 10.1159/000334280. Epub 2012 Apr 3.

PMID:
22472801
22.

Genetic dissection of differential signaling threshold requirements for the Wnt/beta-catenin pathway in vivo.

Buchert M, Athineos D, Abud HE, Burke ZD, Faux MC, Samuel MS, Jarnicki AG, Winbanks CE, Newton IP, Meniel VS, Suzuki H, Stacker SA, Näthke IS, Tosh D, Huelsken J, Clarke AR, Heath JK, Sansom OJ, Ernst M.

PLoS Genet. 2010 Jan 15;6(1):e1000816. doi: 10.1371/journal.pgen.1000816.

23.

Therapeutic vaccination with dendritic cells pulsed with tumor-derived Hsp70 and a COX-2 inhibitor induces protective immunity against B16 melanoma.

Toomey D, Conroy H, Jarnicki AG, Higgins SC, Sutton C, Mills KH.

Vaccine. 2008 Jun 25;26(27-28):3540-9. doi: 10.1016/j.vaccine.2008.04.005. Epub 2008 Apr 24.

PMID:
18479787
24.

Attenuating regulatory T cell induction by TLR agonists through inhibition of p38 MAPK signaling in dendritic cells enhances their efficacy as vaccine adjuvants and cancer immunotherapeutics.

Jarnicki AG, Conroy H, Brereton C, Donnelly G, Toomey D, Walsh K, Sweeney C, Leavy O, Fletcher J, Lavelle EC, Dunne P, Mills KH.

J Immunol. 2008 Mar 15;180(6):3797-806.

25.

Reciprocal effects of Th1 and Treg cell inducing pathogen-associated immunomodulatory molecules on anti-tumor immunity.

Lysaght J, Jarnicki AG, Mills KH.

Cancer Immunol Immunother. 2007 Sep;56(9):1367-79. Epub 2007 Feb 6.

PMID:
17279412
26.

TLR4 mediates vaccine-induced protective cellular immunity to Bordetella pertussis: role of IL-17-producing T cells.

Higgins SC, Jarnicki AG, Lavelle EC, Mills KH.

J Immunol. 2006 Dec 1;177(11):7980-9.

28.

T helper type-2 cytokine responses: potential therapeutic targets.

Jarnicki AG, Fallon PG.

Curr Opin Pharmacol. 2003 Aug;3(4):449-55. Review.

PMID:
12901956
29.

Hypersensitivity reactions after respiratory sensitization: effect of intranasal peptides containing T-cell epitopes.

Jarnicki AG, Tsuji T, Thomas WR.

J Allergy Clin Immunol. 2002 Oct;110(4):610-6.

PMID:
12373270
30.

Stimulatory and inhibitory epitopes in the T cell responses of mice to Der p 1.

Jarnicki AG, Thomas WR.

Clin Exp Allergy. 2002 Jun;32(6):942-50.

PMID:
12047443
32.

Allergens of wild house dust mites: environmental Der p 1 and Der p 2 sequence polymorphisms.

Smith WA, Hales BJ, Jarnicki AG, Thomas WR.

J Allergy Clin Immunol. 2001 Jun;107(6):985-92.

PMID:
11398075
34.

Altered CD3 chain and cytokine gene expression in tumor infiltrating T lymphocytes during the development of mesothelioma.

Jarnicki AG, Fitzpatrick DR, Robinson BW, Bielefeldt-Ohmann H.

Cancer Lett. 1996 May 15;103(1):1-9.

PMID:
8616801
35.

Molecular pathobiology and immunology of malignant mesothelioma.

Bielefeldt-Ohmann H, Jarnicki AG, Fitzpatrick DR.

J Pathol. 1996 Apr;178(4):369-78. Review. No abstract available.

PMID:
8691313
36.

Interleukin-6 involvement in mesothelioma pathobiology: inhibition by interferon alpha immunotherapy.

Bielefeldt-Ohmann H, Marzo AL, Himbeck RP, Jarnicki AG, Robinson BW, Fitzpatrick DR.

Cancer Immunol Immunother. 1995 Apr;40(4):241-50.

PMID:
7750122
37.

Potential for interferon-alpha-based therapy in mesothelioma: assessment in a murine model.

Bielefeldt-Ohmann H, Fitzpatrick DR, Marzo AL, Jarnicki AG, Musk AW, Robinson BW.

J Interferon Cytokine Res. 1995 Mar;15(3):213-23.

PMID:
7584666
38.

Patho- and immunobiology of malignant mesothelioma: characterisation of tumour infiltrating leucocytes and cytokine production in a murine model.

Bielefeldt-Ohmann H, Fitzpatrick DR, Marzo AL, Jarnicki AG, Himbeck RP, Davis MR, Manning LS, Robinson BW.

Cancer Immunol Immunother. 1994 Dec;39(6):347-59.

PMID:
8001022
39.

Transforming growth factor-beta: antisense RNA-mediated inhibition affects anchorage-independent growth, tumorigenicity and tumor-infiltrating T-cells in malignant mesothelioma.

Fitzpatrick DR, Bielefeldt-Ohmann H, Himbeck RP, Jarnicki AG, Marzo AL, Robinson BW.

Growth Factors. 1994;11(1):29-44.

PMID:
7833058

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