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Items: 20


Sensitive and adaptable pharmacological control of CAR T cells through extracellular receptor dimerization.

Leung WH, Gay J, Martin U, Garrett TE, Horton HM, Certo MT, Blazar BR, Morgan RA, Gregory PD, Jarjour J, Astrakhan A.

JCI Insight. 2019 Apr 30;5. pii: 124430. doi: 10.1172/jci.insight.124430.


Recurrent Biatrial Myxoma in a 41-Year-Old Woman after Left Atrial Myxoma Resection.

Jia X, Kohli A, Jarjour J, Chen CJ, Gilmore B, Tabbaa R, Poythress EL.

Tex Heart Inst J. 2017 Dec 19;44(6):402-404. doi: 10.14503/THIJ-16-6017. eCollection 2017 Dec.


Crystallographic analyses illustrate significant plasticity and efficient recoding of meganuclease target specificity.

Werther R, Hallinan JP, Lambert AR, Havens K, Pogson M, Jarjour J, Galizi R, Windbichler N, Crisanti A, Nolan T, Stoddard BL.

Nucleic Acids Res. 2017 Aug 21;45(14):8621-8634. doi: 10.1093/nar/gkx544.


Efficient Modification of the CCR5 Locus in Primary Human T Cells With megaTAL Nuclease Establishes HIV-1 Resistance.

Romano Ibarra GS, Paul B, Sather BD, Younan PM, Sommer K, Kowalski JP, Hale M, Stoddard B, Jarjour J, Astrakhan A, Kiem HP, Rawlings DJ.

Mol Ther Nucleic Acids. 2016 Aug 23;5(8):e352. doi: 10.1038/mtna.2016.56.


Indirect DNA Sequence Recognition and Its Impact on Nuclease Cleavage Activity.

Lambert AR, Hallinan JP, Shen BW, Chik JK, Bolduc JM, Kulshina N, Robins LI, Kaiser BK, Jarjour J, Havens K, Scharenberg AM, Stoddard BL.

Structure. 2016 Jun 7;24(6):862-73. doi: 10.1016/j.str.2016.03.024. Epub 2016 Apr 28.


Efficient modification of CCR5 in primary human hematopoietic cells using a megaTAL nuclease and AAV donor template.

Sather BD, Romano Ibarra GS, Sommer K, Curinga G, Hale M, Khan IF, Singh S, Song Y, Gwiazda K, Sahni J, Jarjour J, Astrakhan A, Wagner TA, Scharenberg AM, Rawlings DJ.

Sci Transl Med. 2015 Sep 30;7(307):307ra156. doi: 10.1126/scitranslmed.aac5530.


A Novel Approach to Improving Fat Delivery in Neonatal Enteral Feeding.

Jarjour J, Juarez AM, Kocak DK, Liu NJ, Tabata MM, Hawthorne KM, Ramos RF, Abrams SA.

Nutrients. 2015 Jun 23;7(6):5051-64. doi: 10.3390/nu7065051.


Fanconi anemia gene editing by the CRISPR/Cas9 system.

Osborn MJ, Gabriel R, Webber BR, DeFeo AP, McElroy AN, Jarjour J, Starker CG, Wagner JE, Joung JK, Voytas DF, von Kalle C, Schmidt M, Blazar BR, Tolar J.

Hum Gene Ther. 2015 Feb;26(2):114-26. doi: 10.1089/hum.2014.111.


Progressive engineering of a homing endonuclease genome editing reagent for the murine X-linked immunodeficiency locus.

Wang Y, Khan IF, Boissel S, Jarjour J, Pangallo J, Thyme S, Baker D, Scharenberg AM, Rawlings DJ.

Nucleic Acids Res. 2014 Jun;42(10):6463-75. doi: 10.1093/nar/gku224. Epub 2014 Mar 25.


megaTALs: a rare-cleaving nuclease architecture for therapeutic genome engineering.

Boissel S, Jarjour J, Astrakhan A, Adey A, Gouble A, Duchateau P, Shendure J, Stoddard BL, Certo MT, Baker D, Scharenberg AM.

Nucleic Acids Res. 2014 Feb;42(4):2591-601. doi: 10.1093/nar/gkt1224. Epub 2013 Nov 26.


The design and in vivo evaluation of engineered I-OnuI-based enzymes for HEG gene drive.

Chan YS, Takeuchi R, Jarjour J, Huen DS, Stoddard BL, Russell S.

PLoS One. 2013 Sep 10;8(9):e74254. doi: 10.1371/journal.pone.0074254. eCollection 2013.


Flow cytometric assays for interrogating LAGLIDADG homing endonuclease DNA-binding and cleavage properties.

Baxter SK, Lambert AR, Scharenberg AM, Jarjour J.

Methods Mol Biol. 2013;978:45-61. doi: 10.1007/978-1-62703-293-3_4.


Design of poly(ethylene glycol)-functionalized hydrophilic carbon clusters for targeted therapy of cerebrovascular dysfunction in mild traumatic brain injury.

Marcano DC, Bitner BR, Berlin JM, Jarjour J, Lee JM, Jacob A, Fabian RH, Kent TA, Tour JM.

J Neurotrauma. 2013 May 1;30(9):789-96. doi: 10.1089/neu.2011.2301. Epub 2012 Nov 5.


Engineering domain fusion chimeras from I-OnuI family LAGLIDADG homing endonucleases.

Baxter S, Lambert AR, Kuhar R, Jarjour J, Kulshina N, Parmeggiani F, Danaher P, Gano J, Baker D, Stoddard BL, Scharenberg AM.

Nucleic Acids Res. 2012 Sep;40(16):7985-8000. doi: 10.1093/nar/gks502. Epub 2012 Jun 7.


LAHEDES: the LAGLIDADG homing endonuclease database and engineering server.

Taylor GK, Petrucci LH, Lambert AR, Baxter SK, Jarjour J, Stoddard BL.

Nucleic Acids Res. 2012 Jul;40(Web Server issue):W110-6. doi: 10.1093/nar/gks365. Epub 2012 May 8.


Expanding LAGLIDADG endonuclease scaffold diversity by rapidly surveying evolutionary sequence space.

Jacoby K, Metzger M, Shen BW, Certo MT, Jarjour J, Stoddard BL, Scharenberg AM.

Nucleic Acids Res. 2012 Jun;40(11):4954-64. doi: 10.1093/nar/gkr1303. Epub 2012 Feb 14.


Tracking genome engineering outcome at individual DNA breakpoints.

Certo MT, Ryu BY, Annis JE, Garibov M, Jarjour J, Rawlings DJ, Scharenberg AM.

Nat Methods. 2011 Jul 10;8(8):671-6. doi: 10.1038/nmeth.1648.


Exploitation of binding energy for catalysis and design.

Thyme SB, Jarjour J, Takeuchi R, Havranek JJ, Ashworth J, Scharenberg AM, Stoddard BL, Baker D.

Nature. 2009 Oct 29;461(7268):1300-4. doi: 10.1038/nature08508.


High-resolution profiling of homing endonuclease binding and catalytic specificity using yeast surface display.

Jarjour J, West-Foyle H, Certo MT, Hubert CG, Doyle L, Getz MM, Stoddard BL, Scharenberg AM.

Nucleic Acids Res. 2009 Nov;37(20):6871-80. doi: 10.1093/nar/gkp726. Epub 2009 Sep 8.


Flow cytometric analysis of DNA binding and cleavage by cell surface-displayed homing endonucleases.

Volná P, Jarjour J, Baxter S, Roffler SR, Monnat RJ Jr, Stoddard BL, Scharenberg AM.

Nucleic Acids Res. 2007;35(8):2748-58. Epub 2007 Apr 10.

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