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IPSE, a parasite-derived host immunomodulatory protein, is a potential therapeutic for hemorrhagic cystitis.

Zee RS, Mbanefo EC, Le LH, Pennington LF, Odegaard JI, Jardetzky TS, Alouffi A, Akinwale J, Falcone FH, Hsieh MH.

Am J Physiol Renal Physiol. 2019 Jun 1;316(6):F1133-F1140. doi: 10.1152/ajprenal.00468.2018. Epub 2019 Feb 20.


Ephrin Receptor A4 is a New Kaposi's Sarcoma-Associated Herpesvirus Virus Entry Receptor.

Chen J, Zhang X, Schaller S, Jardetzky TS, Longnecker R.

MBio. 2019 Feb 19;10(1). pii: e02892-18. doi: 10.1128/mBio.02892-18.


IPSE, a urogenital parasite-derived immunomodulatory protein, ameliorates ifosfamide-induced hemorrhagic cystitis through downregulation of pro-inflammatory pathways.

Mbanefo EC, Le L, Zee R, Banskota N, Ishida K, Pennington LF, Odegaard JI, Jardetzky TS, Alouffi A, Falcone FH, Hsieh MH.

Sci Rep. 2019 Feb 7;9(1):1586. doi: 10.1038/s41598-018-38274-z.


HCMV trimer- and pentamer-specific antibodies synergize for virus neutralization but do not correlate with congenital transmission.

Vanarsdall AL, Chin AL, Liu J, Jardetzky TS, Mudd JO, Orloff SL, Streblow D, Mussi-Pinhata MM, Yamamoto AY, Duarte G, Britt WJ, Johnson DC.

Proc Natl Acad Sci U S A. 2019 Feb 26;116(9):3728-3733. doi: 10.1073/pnas.1814835116. Epub 2019 Feb 7.


Pillars Article: Three-Dimensional Structure of a Human Class II Histocompatibility Molecule Complexed with Superantigen. Nature. 1994. 368: 711-718.

Jardetzky TS, Brown JH, Gorga JC, Stern LJ, Urban RG, Chi YI, Stauffacher C, Strominger JL, Wiley DC.

J Immunol. 2018 Oct 1;201(7):1819-1826. No abstract available.


The Human Cytomegalovirus Trimer and Pentamer Promote Sequential Steps in Entry into Epithelial and Endothelial Cells at Cell Surfaces and Endosomes.

Liu J, Jardetzky TS, Chin AL, Johnson DC, Vanarsdall AL.

J Virol. 2018 Oct 12;92(21). pii: e01336-18. doi: 10.1128/JVI.01336-18. Print 2018 Nov 1.


CD147 Promotes Entry of Pentamer-Expressing Human Cytomegalovirus into Epithelial and Endothelial Cells.

Vanarsdall AL, Pritchard SR, Wisner TW, Liu J, Jardetzky TS, Johnson DC.

MBio. 2018 May 8;9(3). pii: e00781-18. doi: 10.1128/mBio.00781-18.


Therapeutic exploitation of IPSE, a urogenital parasite-derived host modulatory protein, for chemotherapy-induced hemorrhagic cystitis.

Mbanefo EC, Le L, Pennington LF, Odegaard JI, Jardetzky TS, Alouffi A, Falcone FH, Hsieh MH.

FASEB J. 2018 Aug;32(8):4408-4419. doi: 10.1096/fj.201701415R. Epub 2018 Apr 3.


Ephrin receptor A2 is a functional entry receptor for Epstein-Barr virus.

Chen J, Sathiyamoorthy K, Zhang X, Schaller S, Perez White BE, Jardetzky TS, Longnecker R.

Nat Microbiol. 2018 Feb;3(2):172-180. doi: 10.1038/s41564-017-0081-7. Epub 2018 Jan 1.


Monomeric ephrinB2 binding induces allosteric changes in Nipah virus G that precede its full activation.

Wong JJW, Young TA, Zhang J, Liu S, Leser GP, Komives EA, Lamb RA, Zhou ZH, Salafsky J, Jardetzky TS.

Nat Commun. 2017 Oct 3;8(1):781. doi: 10.1038/s41467-017-00863-3.


Epstein-Barr Virus Fusion with Epithelial Cells Triggered by gB Is Restricted by a gL Glycosylation Site.

Möhl BS, Chen J, Park SJ, Jardetzky TS, Longnecker R.

J Virol. 2017 Nov 14;91(23). pii: e01255-17. doi: 10.1128/JVI.01255-17. Print 2017 Dec 1.


Inhibition of EBV-mediated membrane fusion by anti-gHgL antibodies.

Sathiyamoorthy K, Jiang J, Möhl BS, Chen J, Zhou ZH, Longnecker R, Jardetzky TS.

Proc Natl Acad Sci U S A. 2017 Oct 10;114(41):E8703-E8710. doi: 10.1073/pnas.1704661114. Epub 2017 Sep 22.


H-IPSE Is a Pathogen-Secreted Host Nucleus-Infiltrating Protein (Infiltrin) Expressed Exclusively by the Schistosoma haematobium Egg Stage.

Pennington LF, Alouffi A, Mbanefo EC, Ray D, Heery DM, Jardetzky TS, Hsieh MH, Falcone FH.

Infect Immun. 2017 Nov 17;85(12). pii: e00301-17. doi: 10.1128/IAI.00301-17. Print 2017 Dec.


The COMPLEXity in herpesvirus entry.

Sathiyamoorthy K, Chen J, Longnecker R, Jardetzky TS.

Curr Opin Virol. 2017 Jun;24:97-104. doi: 10.1016/j.coviro.2017.04.006. Epub 2017 May 21. Review.


Structural basis for antibody cross-neutralization of respiratory syncytial virus and human metapneumovirus.

Wen X, Mousa JJ, Bates JT, Lamb RA, Crowe JE Jr, Jardetzky TS.

Nat Microbiol. 2017 Jan 30;2:16272. doi: 10.1038/nmicrobiol.2016.272.


Structural basis for Epstein-Barr virus host cell tropism mediated by gp42 and gHgL entry glycoproteins.

Sathiyamoorthy K, Hu YX, Möhl BS, Chen J, Longnecker R, Jardetzky TS.

Nat Commun. 2016 Dec 8;7:13557. doi: 10.1038/ncomms13557.


Structural basis for nonneutralizing antibody competition at antigenic site II of the respiratory syncytial virus fusion protein.

Mousa JJ, Sauer MF, Sevy AM, Finn JA, Bates JT, Alvarado G, King HG, Loerinc LB, Fong RH, Doranz BJ, Correia BE, Kalyuzhniy O, Wen X, Jardetzky TS, Schief WR, Ohi MD, Meiler J, Crowe JE Jr.

Proc Natl Acad Sci U S A. 2016 Nov 1;113(44):E6849-E6858. Epub 2016 Oct 17.


Flexibility of the Head-Stalk Linker Domain of Paramyxovirus HN Glycoprotein Is Essential for Triggering Virus Fusion.

Adu-Gyamfi E, Kim LS, Jardetzky TS, Lamb RA.

J Virol. 2016 Sep 29;90(20):9172-81. doi: 10.1128/JVI.01187-16. Print 2016 Oct 15.


Immobilization of the N-terminal helix stabilizes prefusion paramyxovirus fusion proteins.

Song AS, Poor TA, Abriata LA, Jardetzky TS, Dal Peraro M, Lamb RA.

Proc Natl Acad Sci U S A. 2016 Jul 5;113(27):E3844-51. doi: 10.1073/pnas.1608349113. Epub 2016 Jun 22.


Mutagenesis of Paramyxovirus Hemagglutinin-Neuraminidase Membrane-Proximal Stalk Region Influences Stability, Receptor Binding, and Neuraminidase Activity.

Adu-Gyamfi E, Kim LS, Jardetzky TS, Lamb RA.

J Virol. 2016 Aug 12;90(17):7778-88. doi: 10.1128/JVI.00896-16. Print 2016 Sep 1.


A Chimeric Pneumovirus Fusion Protein Carrying Neutralizing Epitopes of Both MPV and RSV.

Wen X, Pickens J, Mousa JJ, Leser GP, Lamb RA, Crowe JE Jr, Jardetzky TS.

PLoS One. 2016 May 25;11(5):e0155917. doi: 10.1371/journal.pone.0155917. eCollection 2016.


Structural basis of omalizumab therapy and omalizumab-mediated IgE exchange.

Pennington LF, Tarchevskaya S, Brigger D, Sathiyamoorthy K, Graham MT, Nadeau KC, Eggel A, Jardetzky TS.

Nat Commun. 2016 May 19;7:11610. doi: 10.1038/ncomms11610.


Structural and Mechanistic Insights into the Tropism of Epstein-Barr Virus.

Möhl BS, Chen J, Sathiyamoorthy K, Jardetzky TS, Longnecker R.

Mol Cells. 2016 Apr 30;39(4):286-91. doi: 10.14348/molcells.2016.0066. Epub 2016 Apr 6. Review.


Structure and stabilization of the Hendra virus F glycoprotein in its prefusion form.

Wong JJ, Paterson RG, Lamb RA, Jardetzky TS.

Proc Natl Acad Sci U S A. 2016 Jan 26;113(4):1056-61. doi: 10.1073/pnas.1523303113. Epub 2015 Dec 28.


Comparative Mutagenesis of Pseudorabies Virus and Epstein-Barr Virus gH Identifies a Structural Determinant within Domain III of gH Required for Surface Expression and Entry Function.

Möhl BS, Schröter C, Klupp BG, Fuchs W, Mettenleiter TC, Jardetzky TS, Longnecker R.

J Virol. 2015 Dec 9;90(5):2285-93. doi: 10.1128/JVI.03032-15.


Timing is everything: Fine-tuned molecular machines orchestrate paramyxovirus entry.

Bose S, Jardetzky TS, Lamb RA.

Virology. 2015 May;479-480:518-31. doi: 10.1016/j.virol.2015.02.037. Epub 2015 Mar 12. Review.


On the stability of parainfluenza virus 5 F proteins.

Poor TA, Song AS, Welch BD, Kors CA, Jardetzky TS, Lamb RA.

J Virol. 2015 Mar;89(6):3438-41. doi: 10.1128/JVI.03221-14. Epub 2015 Jan 14.


Membrane anchoring of Epstein-Barr virus gp42 inhibits fusion with B cells even with increased flexibility allowed by engineered spacers.

Rowe CL, Chen J, Jardetzky TS, Longnecker R.

MBio. 2015 Jan 6;6(1). pii: e02285-14. doi: 10.1128/mBio.02285-14.


Pillars article: three-dimensional structure of the human class II histocompatibility antigen HLA-DR1. Nature. 1993. 364: 33-39.

Brown JH, Jardetzky TS, Gorga JC, Stern LJ, Urban RG, Strominger JL, Wiley DC.

J Immunol. 2015 Jan 1;194(1):5-11. No abstract available.


The conserved disulfide bond within domain II of Epstein-Barr virus gH has divergent roles in membrane fusion with epithelial cells and B cells.

Möhl BS, Sathiyamoorthy K, Jardetzky TS, Longnecker R.

J Virol. 2014 Dec;88(23):13570-9. doi: 10.1128/JVI.02272-14. Epub 2014 Sep 17.


Assembly and architecture of the EBV B cell entry triggering complex.

Sathiyamoorthy K, Jiang J, Hu YX, Rowe CL, Möhl BS, Chen J, Jiang W, Mellins ED, Longnecker R, Zhou ZH, Jardetzky TS.

PLoS Pathog. 2014 Aug 21;10(8):e1004309. doi: 10.1371/journal.ppat.1004309. eCollection 2014 Aug.


Probing the functions of the paramyxovirus glycoproteins F and HN with a panel of synthetic antibodies.

Welch BD, Paduch M, Leser GP, Bergman Z, Kors CA, Paterson RG, Jardetzky TS, Kossiakoff AA, Lamb RA.

J Virol. 2014 Oct;88(20):11713-25. doi: 10.1128/JVI.01707-14. Epub 2014 Aug 13.


The Epstein-Barr virus (EBV) glycoprotein B cytoplasmic C-terminal tail domain regulates the energy requirement for EBV-induced membrane fusion.

Chen J, Zhang X, Jardetzky TS, Longnecker R.

J Virol. 2014 Oct;88(20):11686-95. doi: 10.1128/JVI.01349-14. Epub 2014 Aug 6.


Probing the paramyxovirus fusion (F) protein-refolding event from pre- to postfusion by oxidative footprinting.

Poor TA, Jones LM, Sood A, Leser GP, Plasencia MD, Rempel DL, Jardetzky TS, Woods RJ, Gross ML, Lamb RA.

Proc Natl Acad Sci U S A. 2014 Jun 24;111(25):E2596-605. doi: 10.1073/pnas.1408983111. Epub 2014 Jun 9.


Accelerated dissociation of IgE-FcεRI complexes by disruptive inhibitors actively desensitizes allergic effector cells.

Eggel A, Baravalle G, Hobi G, Kim B, Buschor P, Forrer P, Shin JS, Vogel M, Stadler BM, Dahinden CA, Jardetzky TS.

J Allergy Clin Immunol. 2014 Jun;133(6):1709-19.e8. doi: 10.1016/j.jaci.2014.02.005. Epub 2014 Mar 15.


Activation of paramyxovirus membrane fusion and virus entry.

Jardetzky TS, Lamb RA.

Curr Opin Virol. 2014 Apr;5:24-33. doi: 10.1016/j.coviro.2014.01.005. Epub 2014 Feb 16. Review.


Fusion activation through attachment protein stalk domains indicates a conserved core mechanism of paramyxovirus entry into cells.

Bose S, Song AS, Jardetzky TS, Lamb RA.

J Virol. 2014 Apr;88(8):3925-41. doi: 10.1128/JVI.03741-13. Epub 2014 Jan 22.


Mutations in the parainfluenza virus 5 fusion protein reveal domains important for fusion triggering and metastability.

Bose S, Heath CM, Shah PA, Alayyoubi M, Jardetzky TS, Lamb RA.

J Virol. 2013 Dec;87(24):13520-31. doi: 10.1128/JVI.02123-13. Epub 2013 Oct 2.


Structure of the parainfluenza virus 5 (PIV5) hemagglutinin-neuraminidase (HN) ectodomain.

Welch BD, Yuan P, Bose S, Kors CA, Lamb RA, Jardetzky TS.

PLoS Pathog. 2013;9(8):e1003534. doi: 10.1371/journal.ppat.1003534. Epub 2013 Aug 8.


A readily applicable strategy to convert peptides to peptoid-based therapeutics.

Park M, Wetzler M, Jardetzky TS, Barron AE.

PLoS One. 2013;8(3):e58874. doi: 10.1371/journal.pone.0058874. Epub 2013 Mar 21.


The large groove found in the gH/gL structure is an important functional domain for Epstein-Barr virus fusion.

Chen J, Jardetzky TS, Longnecker R.

J Virol. 2013 Apr;87(7):3620-7. doi: 10.1128/JVI.03245-12. Epub 2013 Jan 16.


A soluble form of Epstein-Barr virus gH/gL inhibits EBV-induced membrane fusion and does not function in fusion.

Rowe CL, Connolly SA, Chen J, Jardetzky TS, Longnecker R.

Virology. 2013 Feb 5;436(1):118-26. doi: 10.1016/j.virol.2012.10.039. Epub 2012 Nov 29.


Accelerated disassembly of IgE-receptor complexes by a disruptive macromolecular inhibitor.

Kim B, Eggel A, Tarchevskaya SS, Vogel M, Prinz H, Jardetzky TS.

Nature. 2012 Nov 22;491(7425):613-7. doi: 10.1038/nature11546. Epub 2012 Oct 28.


Structure of the cleavage-activated prefusion form of the parainfluenza virus 5 fusion protein.

Welch BD, Liu Y, Kors CA, Leser GP, Jardetzky TS, Lamb RA.

Proc Natl Acad Sci U S A. 2012 Oct 9;109(41):16672-7. doi: 10.1073/pnas.1213802109. Epub 2012 Sep 10.


A time-resolved fluorescence resonance energy transfer assay suitable for high-throughput screening for inhibitors of immunoglobulin E-receptor interactions.

Kim B, Tarchevskaya SS, Eggel A, Vogel M, Jardetzky TS.

Anal Biochem. 2012 Dec 15;431(2):84-9. doi: 10.1016/j.ab.2012.09.010. Epub 2012 Sep 18.


Reversible inhibition of fusion activity of a paramyxovirus fusion protein by an engineered disulfide bond in the membrane-proximal external region.

Zokarkar A, Connolly SA, Jardetzky TS, Lamb RA.

J Virol. 2012 Nov;86(22):12397-401. doi: 10.1128/JVI.02006-12. Epub 2012 Sep 5.


Fusion activation by a headless parainfluenza virus 5 hemagglutinin-neuraminidase stalk suggests a modular mechanism for triggering.

Bose S, Zokarkar A, Welch BD, Leser GP, Jardetzky TS, Lamb RA.

Proc Natl Acad Sci U S A. 2012 Sep 25;109(39):E2625-34. Epub 2012 Sep 4.


An engineered disulfide bond reversibly traps the IgE-Fc3-4 in a closed, nonreceptor binding conformation.

Wurzburg BA, Kim B, Tarchevskaya SS, Eggel A, Vogel M, Jardetzky TS.

J Biol Chem. 2012 Oct 19;287(43):36251-7. doi: 10.1074/jbc.M112.407502. Epub 2012 Sep 4.


Structure of the ulster strain newcastle disease virus hemagglutinin-neuraminidase reveals auto-inhibitory interactions associated with low virulence.

Yuan P, Paterson RG, Leser GP, Lamb RA, Jardetzky TS.

PLoS Pathog. 2012;8(8):e1002855. doi: 10.1371/journal.ppat.1002855. Epub 2012 Aug 9.

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