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Items: 1 to 50 of 57

1.

RNA sequencing of transplant-stage idiopathic pulmonary fibrosis lung reveals unique pathway regulation.

Sivakumar P, Thompson JR, Ammar R, Porteous M, McCoubrey C, Cantu E 3rd, Ravi K, Zhang Y, Luo Y, Streltsov D, Beers MF, Jarai G, Christie JD.

ERJ Open Res. 2019 Aug 12;5(3). pii: 00117-2019. doi: 10.1183/23120541.00117-2019. eCollection 2019 Jul.

2.

A robust data-driven genomic signature for idiopathic pulmonary fibrosis with applications for translational model selection.

Ammar R, Sivakumar P, Jarai G, Thompson JR.

PLoS One. 2019 Apr 18;14(4):e0215565. doi: 10.1371/journal.pone.0215565. eCollection 2019.

3.

Development and validation of an in vitro 3D model of NASH with severe fibrotic phenotype.

Mukherjee S, Zhelnin L, Sanfiz A, Pan J, Li Z, Yarde M, McCarty J, Jarai G.

Am J Transl Res. 2019 Mar 15;11(3):1531-1540. eCollection 2019.

4.

Molecular characterization of a precision-cut rat liver slice model for the evaluation of antifibrotic compounds.

Huang X, Cai H, Ammar R, Zhang Y, Wang Y, Ravi K, Thompson J, Jarai G.

Am J Physiol Gastrointest Liver Physiol. 2019 Jan 1;316(1):G15-G24. doi: 10.1152/ajpgi.00281.2018. Epub 2018 Nov 8.

PMID:
30561231
5.

Molecular characterization of a precision-cut rat lung slice model for the evaluation of antifibrotic drugs.

Huang X, Li L, Ammar R, Zhang Y, Wang Y, Ravi K, Thompson J, Jarai G.

Am J Physiol Lung Cell Mol Physiol. 2019 Feb 1;316(2):L348-L357. doi: 10.1152/ajplung.00339.2018. Epub 2018 Nov 29.

PMID:
30489156
6.

Molecular characterization of a precision-cut rat liver slice model for the evaluation of antifibrotic compounds.

Huang X, Cai H, Ammar R, Zhang Y, Wang Y, Ravi K, Thompson J, Jarai G.

Am J Physiol Gastrointest Liver Physiol. 2019 Jan 1;316(1):G15-G24. doi: 10.1152/ajpgi.00281.2018. Epub 2018 Nov 8.

PMID:
30406699
7.

An Evaluation of the Collagen Fragments Related to Fibrogenesis and Fibrolysis in Nonalcoholic Steatohepatitis.

Luo Y, Oseini A, Gagnon R, Charles ED, Sidik K, Vincent R, Collen R, Idowu M, Contos MJ, Mirshahi F, Daita K, Asgharpour A, Siddiqui MS, Jarai G, Rosen G, Christian R, Sanyal AJ.

Sci Rep. 2018 Aug 17;8(1):12414. doi: 10.1038/s41598-018-30457-y.

8.

Modeling and measuring extracellular matrix alterations in fibrosis: challenges and perspectives for antifibrotic drug discovery.

Sivakumar P, Kitson C, Jarai G.

Connect Tissue Res. 2019 Jan;60(1):62-70. doi: 10.1080/03008207.2018.1500557. Epub 2018 Aug 3.

PMID:
30071759
9.

Association Between Inflammatory Markers and Progression to Kidney Dysfunction: Examining Different Assessment Windows in Patients With Type 1 Diabetes.

Baker NL, Hunt KJ, Stevens DR, Jarai G, Rosen GD, Klein RL, Virella G, Lopes-Virella MF; DCCT/EDIC Research Group.

Diabetes Care. 2018 Jan;41(1):128-135. doi: 10.2337/dc17-0867. Epub 2017 Nov 8.

10.

Identification of a Novel Allosteric Inhibitory Site on Tryptophan Hydroxylase 1 Enabling Unprecedented Selectivity Over all Related Hydroxylases.

Petrassi M, Barber R, Be C, Beach S, Cox B, D'Souza AM, Duggan N, Hussey M, Fox R, Hunt P, Jarai G, Kosaka T, Oakley P, Patel V, Press N, Rowlands D, Scheufler C, Schmidt O, Srinivas H, Turner M, Turner R, Westwick J, Wolfreys A, Pathan N, Watson S, Thomas M.

Front Pharmacol. 2017 May 5;8:240. doi: 10.3389/fphar.2017.00240. eCollection 2017.

11.

TGFβ upregulates PAR-1 expression and signalling responses in A549 lung adenocarcinoma cells.

Smoktunowicz N, Platé M, Stern AO, D'Antongiovanni V, Robinson E, Chudasama V, Caddick S, Scotton CJ, Jarai G, Chambers RC.

Oncotarget. 2016 Oct 4;7(40):65471-65484. doi: 10.18632/oncotarget.11472.

12.

Integrated pharmacokinetic, pharmacodynamic and immunogenicity profiling of an anti-CCL21 monoclonal antibody in cynomolgus monkeys.

Dudal S, Subramanian K, Flandre T, Law WS, Lowe PJ, Skerjanec A, Genin JC, Duval M, Piequet A, Cordier A, Jarai G, Van Heeke G, Taplin S, Krantz C, Jones S, Warren AP, Brennan FR, Sims J, Lloyd P.

MAbs. 2015;7(5):829-37. doi: 10.1080/19420862.2015.1060384.

13.

The anti-fibrotic effect of inhibition of TGFβ-ALK5 signalling in experimental pulmonary fibrosis in mice is attenuated in the presence of concurrent γ-herpesvirus infection.

Smoktunowicz N, Alexander RE, Franklin L, Williams AE, Holman B, Mercer PF, Jarai G, Scotton CJ, Chambers RC.

Dis Model Mech. 2015 Sep;8(9):1129-39. doi: 10.1242/dmm.019984. Epub 2015 Jul 2.

14.

Sustained activation of toll-like receptor 9 induces an invasive phenotype in lung fibroblasts: possible implications in idiopathic pulmonary fibrosis.

Kirillov V, Siler JT, Ramadass M, Ge L, Davis J, Grant G, Nathan SD, Jarai G, Trujillo G.

Am J Pathol. 2015 Apr;185(4):943-57. doi: 10.1016/j.ajpath.2014.12.011. Epub 2015 Feb 7.

PMID:
25660181
15.

A functional analysis of Wnt inducible signalling pathway protein -1 (WISP-1/CCN4).

Stephens S, Palmer J, Konstantinova I, Pearce A, Jarai G, Day E.

J Cell Commun Signal. 2015 Mar;9(1):63-72. doi: 10.1007/s12079-015-0267-9. Epub 2015 Feb 6.

16.

A translational preclinical model of interstitial pulmonary fibrosis and pulmonary hypertension: mechanistic pathways driving disease pathophysiology.

Jarman ER, Khambata VS, Yun Ye L, Cheung K, Thomas M, Duggan N, Jarai G.

Physiol Rep. 2014 Sep 11;2(9). pii: e12133. doi: 10.14814/phy2.12133. Print 2014 Sep 1.

17.

Deficient repair response of IPF fibroblasts in a co-culture model of epithelial injury and repair.

Prasad S, Hogaboam CM, Jarai G.

Fibrogenesis Tissue Repair. 2014 Apr 29;7:7. doi: 10.1186/1755-1536-7-7. eCollection 2014.

18.

Lung volume quantified by MRI reflects extracellular-matrix deposition and altered pulmonary function in bleomycin models of fibrosis: effects of SOM230.

Egger C, Gérard C, Vidotto N, Accart N, Cannet C, Dunbar A, Tigani B, Piaia A, Jarai G, Jarman E, Schmid HA, Beckmann N.

Am J Physiol Lung Cell Mol Physiol. 2014 Jun 15;306(12):L1064-77. doi: 10.1152/ajplung.00027.2014. Epub 2014 Apr 11.

19.

Cytokine induced phenotypic and epigenetic signatures are key to establishing specific macrophage phenotypes.

Kittan NA, Allen RM, Dhaliwal A, Cavassani KA, Schaller M, Gallagher KA, Carson WF 4th, Mukherjee S, Grembecka J, Cierpicki T, Jarai G, Westwick J, Kunkel SL, Hogaboam CM.

PLoS One. 2013 Oct 21;8(10):e78045. doi: 10.1371/journal.pone.0078045. eCollection 2013.

20.

Treatment with anti-gremlin 1 antibody ameliorates chronic hypoxia/SU5416-induced pulmonary arterial hypertension in mice.

Ciuclan L, Sheppard K, Dong L, Sutton D, Duggan N, Hussey M, Simmons J, Morrell NW, Jarai G, Edwards M, Dubois G, Thomas M, Van Heeke G, England K.

Am J Pathol. 2013 Nov;183(5):1461-73. doi: 10.1016/j.ajpath.2013.07.017.

21.

An inhibitor of NADPH oxidase-4 attenuates established pulmonary fibrosis in a rodent disease model.

Jarman ER, Khambata VS, Cope C, Jones P, Roger J, Ye LY, Duggan N, Head D, Pearce A, Press NJ, Bellenie B, Sohal B, Jarai G.

Am J Respir Cell Mol Biol. 2014 Jan;50(1):158-69. doi: 10.1165/rcmb.2013-0174OC.

PMID:
23977848
22.

Administration of bleomycin via the oropharyngeal aspiration route leads to sustained lung fibrosis in mice and rats as quantified by UTE-MRI and histology.

Egger C, Cannet C, Gérard C, Jarman E, Jarai G, Feige A, Suply T, Micard A, Dunbar A, Tigani B, Beckmann N.

PLoS One. 2013 May 7;8(5):e63432. doi: 10.1371/journal.pone.0063432. Print 2013.

23.

Imatinib attenuates hypoxia-induced pulmonary arterial hypertension pathology via reduction in 5-hydroxytryptamine through inhibition of tryptophan hydroxylase 1 expression.

Ciuclan L, Hussey MJ, Burton V, Good R, Duggan N, Beach S, Jones P, Fox R, Clay I, Bonneau O, Konstantinova I, Pearce A, Rowlands DJ, Jarai G, Westwick J, MacLean MR, Thomas M.

Am J Respir Crit Care Med. 2013 Jan 1;187(1):78-89. doi: 10.1164/rccm.201206-1028OC. Epub 2012 Oct 18.

PMID:
23087024
24.

Discoidin domain receptors regulate the migration of primary human lung fibroblasts through collagen matrices.

Ruiz PA, Jarai G.

Fibrogenesis Tissue Repair. 2012 Feb 15;5:3. doi: 10.1186/1755-1536-5-3.

25.

Notch signaling mediates TGF-β1-induced epithelial-mesenchymal transition through the induction of Snai1.

Matsuno Y, Coelho AL, Jarai G, Westwick J, Hogaboam CM.

Int J Biochem Cell Biol. 2012 May;44(5):776-89. doi: 10.1016/j.biocel.2012.01.021. Epub 2012 Feb 7.

PMID:
22330899
26.

Attenuation of leukocyte recruitment via CXCR1/2 inhibition stops the progression of PAH in mice with genetic ablation of endothelial BMPR-II.

Burton VJ, Holmes AM, Ciuclan LI, Robinson A, Roger JS, Jarai G, Pearce AC, Budd DC.

Blood. 2011 Oct 27;118(17):4750-8. doi: 10.1182/blood-2011-05-347393. Epub 2011 Sep 7.

27.

A novel murine model of severe pulmonary arterial hypertension.

Ciuclan L, Bonneau O, Hussey M, Duggan N, Holmes AM, Good R, Stringer R, Jones P, Morrell NW, Jarai G, Walker C, Westwick J, Thomas M.

Am J Respir Crit Care Med. 2011 Nov 15;184(10):1171-82. doi: 10.1164/rccm.201103-0412OC. Epub 2011 Aug 25.

PMID:
21868504
28.

Collagen I induces discoidin domain receptor (DDR) 1 expression through DDR2 and a JAK2-ERK1/2-mediated mechanism in primary human lung fibroblasts.

Ruiz PA, Jarai G.

J Biol Chem. 2011 Apr 15;286(15):12912-23. doi: 10.1074/jbc.M110.143693. Epub 2011 Feb 18.

29.

TLR9 differentiates rapidly from slowly progressing forms of idiopathic pulmonary fibrosis.

Trujillo G, Meneghin A, Flaherty KR, Sholl LM, Myers JL, Kazerooni EA, Gross BH, Oak SR, Coelho AL, Evanoff H, Day E, Toews GB, Joshi AD, Schaller MA, Waters B, Jarai G, Westwick J, Kunkel SL, Martinez FJ, Hogaboam CM.

Sci Transl Med. 2010 Nov 10;2(57):57ra82. doi: 10.1126/scitranslmed.3001510.

30.
31.

Expression of transient receptor potential C6 channels in human lung macrophages.

Finney-Hayward TK, Popa MO, Bahra P, Li S, Poll CT, Gosling M, Nicholson AG, Russell RE, Kon OM, Jarai G, Westwick J, Barnes PJ, Donnelly LE.

Am J Respir Cell Mol Biol. 2010 Sep;43(3):296-304. doi: 10.1165/rcmb.2008-0373OC. Epub 2009 Oct 20.

PMID:
19843708
32.

CCR7 deficiency on dendritic cells enhances fungal clearance in a murine model of pulmonary invasive aspergillosis.

Hartigan AJ, Westwick J, Jarai G, Hogaboam CM.

J Immunol. 2009 Oct 15;183(8):5171-9. doi: 10.4049/jimmunol.0901027. Epub 2009 Sep 25.

33.

Cloning and pharmacological characterization of CCR7, CCL21 and CCL19 from Macaca fascicularis.

Moxley R, Day E, Brown K, Mahnke M, Zurini M, Schmitz R, Jones CE, Jarai G.

Eur J Pharm Sci. 2009 Jun 28;37(3-4):264-71. doi: 10.1016/j.ejps.2009.02.013. Epub 2009 Mar 6.

PMID:
19491014
34.

Inhibition of collagen-induced discoidin domain receptor 1 and 2 activation by imatinib, nilotinib and dasatinib.

Day E, Waters B, Spiegel K, Alnadaf T, Manley PW, Buchdunger E, Walker C, Jarai G.

Eur J Pharmacol. 2008 Dec 3;599(1-3):44-53. doi: 10.1016/j.ejphar.2008.10.014. Epub 2008 Oct 11.

PMID:
18938156
35.

The sphingosine 1-phosphate receptor agonist FTY720 differentially affects the sequestration of CD4+/CD25+ T-regulatory cells and enhances their functional activity.

Sawicka E, Dubois G, Jarai G, Edwards M, Thomas M, Nicholls A, Albert R, Newson C, Brinkmann V, Walker C.

J Immunol. 2005 Dec 15;175(12):7973-80.

36.

Effects of interleukin-1beta, interleukin-13 and transforming growth factor-beta on gene expression in human airway smooth muscle using gene microarrays.

Jarai G, Sukkar M, Garrett S, Duroudier N, Westwick J, Adcock I, Chung KF.

Eur J Pharmacol. 2004 Aug 30;497(3):255-65.

PMID:
15336943
37.

Expression and characterization of a 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid receptor highly expressed on human eosinophils and neutrophils.

Jones CE, Holden S, Tenaillon L, Bhatia U, Seuwen K, Tranter P, Turner J, Kettle R, Bouhelal R, Charlton S, Nirmala NR, Jarai G, Finan P.

Mol Pharmacol. 2003 Mar;63(3):471-7.

PMID:
12606753
38.

IL-10 expression profiling in human monocytes.

Williams L, Jarai G, Smith A, Finan P.

J Leukoc Biol. 2002 Oct;72(4):800-9.

PMID:
12377950
39.

Cloning and expression analysis of a novel G-protein-coupled receptor selectively expressed on granulocytes.

Yousefi S, Cooper PR, Potter SL, Mueck B, Jarai G.

J Leukoc Biol. 2001 Jun;69(6):1045-52.

PMID:
11404393
40.

Identification of genes induced by inflammatory cytokines in airway epithelium.

Cooper P, Potter S, Mueck B, Yousefi S, Jarai G.

Am J Physiol Lung Cell Mol Physiol. 2001 May;280(5):L841-52.

41.

cDNA representational difference analysis of human neutrophils stimulated by GM-CSF.

Yousefi S, Cooper PR, Mueck B, Potter SL, Jarai G.

Biochem Biophys Res Commun. 2000 Oct 22;277(2):401-9.

PMID:
11032736
42.

cDNA-RDA of genes expressed in fetal and adult lungs identifies factors important in development and function.

Cooper P, Mueck B, Yousefi S, Potter S, Jarai G.

Am J Physiol Lung Cell Mol Physiol. 2000 Feb;278(2):L284-93.

43.

Cloning, characterization and expression of pepF, a gene encoding a serine carboxypeptidase from Aspergillus niger.

van den Hombergh JP, Jarai G, Buxton FP, Visser J.

Gene. 1994 Dec 30;151(1-2):73-9.

PMID:
7828908
44.
45.
46.
47.

The leu-1 gene of Neurospora crassa: nucleotide and deduced amino acid sequence comparisons.

Li Q, Jarai G, Yaghmai B, Marzluf GA.

Gene. 1993 Dec 22;136(1-2):301-5.

PMID:
8294021
48.

NIT2, the nitrogen regulatory protein of Neurospora crassa, binds upstream of nia, the tomato nitrate reductase gene, in vitro.

Jarai G, Truong HN, Daniel-Vedele F, Marzluf GA.

Curr Genet. 1992 Jan;21(1):37-41.

PMID:
1531184
50.

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