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Items: 1 to 50 of 311

1.

The old and new biochemistry of polyamines.

Bae DH, Lane DJR, Jansson PJ, Richardson DR.

Biochim Biophys Acta. 2018 Jun 8. pii: S0304-4165(18)30166-1. doi: 10.1016/j.bbagen.2018.06.004. [Epub ahead of print] Review.

PMID:
29890242
2.

Coupling of the polyamine and iron metabolism pathways in the regulation of proliferation: Mechanistic links to alterations in key polyamine biosynthetic and catabolic enzymes.

Lane DJR, Bae DH, Siafakas AR, Suryo Rahmanto Y, Al-Akra L, Jansson PJ, Casero RA Jr, Richardson DR.

Biochim Biophys Acta. 2018 May 16. pii: S0925-4439(18)30177-7. doi: 10.1016/j.bbadis.2018.05.007. [Epub ahead of print]

PMID:
29777905
3.

Novel chelators based on adamantane-derived semicarbazones and hydrazones that target multiple hallmarks of Alzheimer's disease.

Palanimuthu D, Wu Z, Jansson PJ, Braidy N, Bernhardt PV, Richardson DR, Kalinowski DS.

Dalton Trans. 2018 May 29;47(21):7190-7205. doi: 10.1039/c8dt01099d.

PMID:
29749416
4.

Differential anti-inflammatory effects of budesonide and a p38 MAPK inhibitor AZD7624 on COPD pulmonary cells.

Higham A, Karur P, Jackson N, Cunoosamy DM, Jansson P, Singh D.

Int J Chron Obstruct Pulmon Dis. 2018 Apr 19;13:1279-1288. doi: 10.2147/COPD.S159936. eCollection 2018.

5.

Man with hand pain.

Jansson PS, Lee SJ, Samuels-Kalow ME.

Emerg Med J. 2018 Apr 28. pii: emermed-2018-207679. doi: 10.1136/emermed-2018-207679. [Epub ahead of print] No abstract available.

PMID:
29705729
6.

Identification of differential phosphorylation and sub-cellular localization of the metastasis suppressor, NDRG1.

Park KC, Menezes SV, Kalinowski DS, Sahni S, Jansson PJ, Kovacevic Z, Richardson DR.

Biochim Biophys Acta. 2018 Aug;1864(8):2644-2663. doi: 10.1016/j.bbadis.2018.04.011. Epub 2018 Apr 19.

PMID:
29679718
7.

The development of AZD7624 for prevention of exacerbations in COPD: a randomized controlled trial.

Patel NR, Cunoosamy DM, Fagerås M, Taib Z, Asimus S, Hegelund-Myrbäck T, Lundin S, Pardali K, Kurian N, Ersdal E, Kristensson C, Korsback K, Palmér R, Brown MN, Greenaway S, Siew L, Clarke GW, Rennard SI, Make BJ, Wise RA, Jansson P.

Int J Chron Obstruct Pulmon Dis. 2018 Mar 27;13:1009-1019. doi: 10.2147/COPD.S150576. eCollection 2018.

8.

AZD7624, an Inhaled p38 Inhibitor, Demonstrates Local Lung Inhibition of LPS-Induced TNFα with Minimal Systemic Exposure.

Pehrson R, Hegelund-Myrbäck T, Cunoosamy D, Asimus S, Jansson P, Patel N, Borde A, Lundin S.

J Pharmacol Exp Ther. 2018 Jun;365(3):567-572. doi: 10.1124/jpet.117.246132. Epub 2018 Mar 16.

PMID:
29549158
9.

Tumor stressors induce two mechanisms of intracellular P-glycoprotein-mediated resistance that are overcome by lysosomal-targeted thiosemicarbazones.

Al-Akra L, Bae DH, Sahni S, Huang MLH, Park KC, Lane DJR, Jansson PJ, Richardson DR.

J Biol Chem. 2018 Mar 9;293(10):3562-3587. doi: 10.1074/jbc.M116.772699. Epub 2018 Jan 5.

PMID:
29305422
10.

Altered Mental Status in an Elderly Male.

Jansson PS, Kabrhel C, Miller ES.

J Emerg Med. 2018 Feb;54(2):232-237. doi: 10.1016/j.jemermed.2017.11.025. Epub 2017 Dec 11. No abstract available.

PMID:
29242011
11.

Deterioration of Limb Muscle Function during Acute Exacerbation of Chronic Obstructive Pulmonary Disease.

Abdulai RM, Jensen TJ, Patel NR, Polkey MI, Jansson P, Celli BR, Rennard SI.

Am J Respir Crit Care Med. 2018 Feb 15;197(4):433-449. doi: 10.1164/rccm.201703-0615CI.

12.

Epidemiology, Pathophysiology, Stratification, and Natural History of Pulmonary Embolism.

Giordano NJ, Jansson PS, Young MN, Hagan KA, Kabrhel C.

Tech Vasc Interv Radiol. 2017 Sep;20(3):135-140. doi: 10.1053/j.tvir.2017.07.002. Epub 2017 Jul 5. Review.

PMID:
29029707
13.

A Young Man with Abdominal Pain and Distension.

Jansson PS, Prucnal CK, Kosowsky JM.

J Emerg Med. 2017 Nov;53(5):756-757. doi: 10.1016/j.jemermed.2017.08.022. Epub 2017 Oct 5. No abstract available.

PMID:
28987307
14.

Mitochondrial dysfunction in the neuro-degenerative and cardio-degenerative disease, Friedreich's ataxia.

Chiang S, Kalinowski DS, Jansson PJ, Richardson DR, Huang ML.

Neurochem Int. 2018 Jul;117:35-48. doi: 10.1016/j.neuint.2017.08.002. Epub 2017 Aug 4. Review.

PMID:
28782591
15.

Exploiting Cancer Metal Metabolism using Anti-Cancer Metal-Binding Agents.

Merlot AM, Kalinowski DS, Kovacevic Z, Jansson PJ, Sahni S, Huang ML, Lane DL, Lok H, Richardson DR.

Curr Med Chem. 2017 Jul 5. doi: 10.2174/0929867324666170705120809. [Epub ahead of print]

PMID:
28685681
16.

Young Woman With Abdominal Pain and Distention.

Jansson PS, Bortoletto P, Duanmu Y, Rempell JS.

Ann Emerg Med. 2017 Jul;70(1):e5-e6. doi: 10.1016/j.annemergmed.2017.01.039. No abstract available.

PMID:
28645420
17.

Statement of Retraction. The SNARE Protein SNAP23 and the SNARE-Interacting Protein Munc18c in Human Skeletal Muscle Are Implicated in Insulin Resistance/Type 2 Diabetes. Diabetes 2010;59:1870-1878. DOI: 10.2337/db09-1503. PMID: 20460426.

Boström P, Andersson L, Vind B, Håversen L, Rutberg M, Wickström Y, Larsson E, Jansson PA, Svensson MK, Brånemark R, Ling C, Beck-Nielsen H, Borén J, Højlund K, Olofsson SO.

Diabetes. 2017 May;66(5):1426. doi: 10.2337/db17-rt05a. Epub 2017 Feb 23. No abstract available.

18.

The mechanistic role of chemically diverse metal ions in the induction of autophagy.

Sahni S, Bae DH, Jansson PJ, Richardson DR.

Pharmacol Res. 2017 May;119:118-127. doi: 10.1016/j.phrs.2017.01.009. Epub 2017 Jan 10. Review.

PMID:
28087444
19.

Metabolic effects of Lactobacillus reuteri DSM 17938 in people with type 2 diabetes: A randomized controlled trial.

Mobini R, Tremaroli V, Ståhlman M, Karlsson F, Levin M, Ljungberg M, Sohlin M, Bertéus Forslund H, Perkins R, Bäckhed F, Jansson PA.

Diabetes Obes Metab. 2017 Apr;19(4):579-589. doi: 10.1111/dom.12861. Epub 2017 Feb 7.

PMID:
28009106
20.

Young Man With Abdominal Pain.

Jansson PS, Eicken JJ, Hoyler JE, Rempell JS.

Ann Emerg Med. 2017 Jan;69(1):e9-e10. doi: 10.1016/j.annemergmed.2016.08.434. No abstract available.

PMID:
27993314
22.

A Nitric Oxide Storage and Transport System That Protects Activated Macrophages from Endogenous Nitric Oxide Cytotoxicity.

Lok HC, Sahni S, Jansson PJ, Kovacevic Z, Hawkins CL, Richardson DR.

J Biol Chem. 2016 Dec 30;291(53):27042-27061. doi: 10.1074/jbc.M116.763714. Epub 2016 Nov 19.

23.

A lifestyle intervention in primary care prevents deterioration of insulin resistance in patients with impaired glucose tolerance: A randomised controlled trial.

Hellgren MI, Jansson PA, Wedel H, Lindblad U.

Scand J Public Health. 2016 Aug 22. pii: 1403494816663539. [Epub ahead of print]

PMID:
27550085
24.

Structure-Activity Relationships of Di-2-pyridylketone, 2-Benzoylpyridine, and 2-Acetylpyridine Thiosemicarbazones for Overcoming Pgp-Mediated Drug Resistance.

Stacy AE, Palanimuthu D, Bernhardt PV, Kalinowski DS, Jansson PJ, Richardson DR.

J Med Chem. 2016 Sep 22;59(18):8601-20. doi: 10.1021/acs.jmedchem.6b01050. Epub 2016 Aug 30.

PMID:
27524608
25.

Copper and conquer: copper complexes of di-2-pyridylketone thiosemicarbazones as novel anti-cancer therapeutics.

Park KC, Fouani L, Jansson PJ, Wooi D, Sahni S, Lane DJ, Palanimuthu D, Lok HC, Kovačević Z, Huang ML, Kalinowski DS, Richardson DR.

Metallomics. 2016 Sep 1;8(9):874-86. doi: 10.1039/c6mt00105j. Epub 2016 Jun 23. Review.

PMID:
27334916
26.

A Genome-Wide mQTL Analysis in Human Adipose Tissue Identifies Genetic Variants Associated with DNA Methylation, Gene Expression and Metabolic Traits.

Volkov P, Olsson AH, Gillberg L, Jørgensen SW, Brøns C, Eriksson KF, Groop L, Jansson PA, Nilsson E, Rönn T, Vaag A, Ling C.

PLoS One. 2016 Jun 20;11(6):e0157776. doi: 10.1371/journal.pone.0157776. eCollection 2016.

27.

Microdialysis and proteomics of subcutaneous interstitial fluid reveals increased galectin-1 in type 2 diabetes patients.

Fryk E, Sundelin JP, Strindberg L, Pereira MJ, Federici M, Marx N, Nyström FH, Schmelz M, Svensson PA, Eriksson JW, Borén J, Jansson PA.

Metabolism. 2016 Jul;65(7):998-1006. doi: 10.1016/j.metabol.2016.04.003. Epub 2016 Apr 13.

PMID:
27282870
28.

Bonnie and Clyde: Vitamin C and iron are partners in crime in iron deficiency anaemia and its potential role in the elderly.

Lane DJ, Jansson PJ, Richardson DR.

Aging (Albany NY). 2016 May;8(5):1150-2. doi: 10.18632/aging.100966. No abstract available.

29.

Turning the gun on cancer: Utilizing lysosomal P-glycoprotein as a new strategy to overcome multi-drug resistance.

Seebacher N, Lane DJ, Richardson DR, Jansson PJ.

Free Radic Biol Med. 2016 Jul;96:432-45. doi: 10.1016/j.freeradbiomed.2016.04.201. Epub 2016 May 3. Review.

PMID:
27154979
30.

Targeting autophagy in antitumor agent design: furthering the 'lysosomal love' strategy.

Sahni S, Kovacevic Z, Kalinowski DS, Huang M, Menezes S, Krishan S, Lane DJ, Jansson PJ, Richardson DR.

Future Med Chem. 2016 May;8(7):727-9. doi: 10.4155/fmc-2016-0066. Epub 2016 May 5. No abstract available.

PMID:
27149429
31.

DNA methylation of loci within ABCG1 and PHOSPHO1 in blood DNA is associated with future type 2 diabetes risk.

Dayeh T, Tuomi T, Almgren P, Perfilyev A, Jansson PA, de Mello VD, Pihlajamäki J, Vaag A, Groop L, Nilsson E, Ling C.

Epigenetics. 2016 Jul 2;11(7):482-8. doi: 10.1080/15592294.2016.1178418. Epub 2016 May 5.

32.

Lysosomal membrane stability plays a major role in the cytotoxic activity of the anti-proliferative agent, di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT).

Gutierrez EM, Seebacher NA, Arzuman L, Kovacevic Z, Lane DJ, Richardson V, Merlot AM, Lok H, Kalinowski DS, Sahni S, Jansson PJ, Richardson DR.

Biochim Biophys Acta. 2016 Jul;1863(7 Pt A):1665-81. doi: 10.1016/j.bbamcr.2016.04.017. Epub 2016 Apr 19.

33.

Mechanism of the induction of endoplasmic reticulum stress by the anti-cancer agent, di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT): Activation of PERK/eIF2α, IRE1α, ATF6 and calmodulin kinase.

Merlot AM, Shafie NH, Yu Y, Richardson V, Jansson PJ, Sahni S, Lane DJR, Kovacevic Z, Kalinowski DS, Richardson DR.

Biochem Pharmacol. 2016 Jun 1;109:27-47. doi: 10.1016/j.bcp.2016.04.001. Epub 2016 Apr 6.

PMID:
27059255
34.

Zinc(II)-Thiosemicarbazone Complexes Are Localized to the Lysosomal Compartment Where They Transmetallate with Copper Ions to Induce Cytotoxicity.

Stacy AE, Palanimuthu D, Bernhardt PV, Kalinowski DS, Jansson PJ, Richardson DR.

J Med Chem. 2016 May 26;59(10):4965-84. doi: 10.1021/acs.jmedchem.6b00238. Epub 2016 Apr 26.

PMID:
27023111
35.

Endothelin-1 as a predictor of impaired glucose tolerance and type 2 diabetes--A longitudinal study in the Vara-Skövde Cohort.

Olausson J, Daka B, Hellgren MI, Larsson CA, Petzold M, Lindblad U, Jansson PA.

Diabetes Res Clin Pract. 2016 Mar;113:33-7. doi: 10.1016/j.diabres.2016.01.027. Epub 2016 Feb 2.

PMID:
26972958
36.

Roads to melanoma: Key pathways and emerging players in melanoma progression and oncogenic signaling.

Paluncic J, Kovacevic Z, Jansson PJ, Kalinowski D, Merlot AM, Huang ML, Lok HC, Sahni S, Lane DJ, Richardson DR.

Biochim Biophys Acta. 2016 Apr;1863(4):770-84. doi: 10.1016/j.bbamcr.2016.01.025. Epub 2016 Feb 1. Review.

37.

Redox cycling metals: Pedaling their roles in metabolism and their use in the development of novel therapeutics.

Kalinowski DS, Stefani C, Toyokuni S, Ganz T, Anderson GJ, Subramaniam NV, Trinder D, Olynyk JK, Chua A, Jansson PJ, Sahni S, Lane DJ, Merlot AM, Kovacevic Z, Huang ML, Lee CS, Richardson DR.

Biochim Biophys Acta. 2016 Apr;1863(4):727-48. doi: 10.1016/j.bbamcr.2016.01.026. Epub 2016 Feb 2. Review.

38.

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).

Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, Agnello M, Agostinis P, Aguilar PV, Aguirre-Ghiso J, Airoldi EM, Ait-Si-Ali S, Akematsu T, Akporiaye ET, Al-Rubeai M, Albaiceta GM, Albanese C, Albani D, Albert ML, Aldudo J, Algül H, Alirezaei M, Alloza I, Almasan A, Almonte-Beceril M, Alnemri ES, Alonso C, Altan-Bonnet N, Altieri DC, Alvarez S, Alvarez-Erviti L, Alves S, Amadoro G, Amano A, Amantini C, Ambrosio S, Amelio I, Amer AO, Amessou M, Amon A, An Z, Anania FA, Andersen SU, Andley UP, Andreadi CK, Andrieu-Abadie N, Anel A, Ann DK, Anoopkumar-Dukie S, Antonioli M, Aoki H, Apostolova N, Aquila S, Aquilano K, Araki K, Arama E, Aranda A, Araya J, Arcaro A, Arias E, Arimoto H, Ariosa AR, Armstrong JL, Arnould T, Arsov I, Asanuma K, Askanas V, Asselin E, Atarashi R, Atherton SS, Atkin JD, Attardi LD, Auberger P, Auburger G, Aurelian L, Autelli R, Avagliano L, Avantaggiati ML, Avrahami L, Awale S, Azad N, Bachetti T, Backer JM, Bae DH, Bae JS, Bae ON, Bae SH, Baehrecke EH, Baek SH, Baghdiguian S, Bagniewska-Zadworna A, Bai H, Bai J, Bai XY, Bailly Y, Balaji KN, Balduini W, Ballabio A, Balzan R, Banerjee R, Bánhegyi G, Bao H, Barbeau B, Barrachina MD, Barreiro E, Bartel B, Bartolomé A, Bassham DC, Bassi MT, Bast RC Jr, Basu A, Batista MT, Batoko H, Battino M, Bauckman K, Baumgarner BL, Bayer KU, Beale R, Beaulieu JF, Beck GR Jr, Becker C, Beckham JD, Bédard PA, Bednarski PJ, Begley TJ, Behl C, Behrends C, Behrens GM, Behrns KE, Bejarano E, Belaid A, Belleudi F, Bénard G, Berchem G, Bergamaschi D, Bergami M, Berkhout B, Berliocchi L, Bernard A, Bernard M, Bernassola F, Bertolotti A, Bess AS, Besteiro S, Bettuzzi S, Bhalla S, Bhattacharyya S, Bhutia SK, Biagosch C, Bianchi MW, Biard-Piechaczyk M, Billes V, Bincoletto C, Bingol B, Bird SW, Bitoun M, Bjedov I, Blackstone C, Blanc L, Blanco GA, Blomhoff HK, Boada-Romero E, Böckler S, Boes M, Boesze-Battaglia K, Boise LH, Bolino A, Boman A, Bonaldo P, Bordi M, Bosch J, Botana LM, Botti J, Bou G, Bouché M, Bouchecareilh M, Boucher MJ, Boulton ME, Bouret SG, Boya P, Boyer-Guittaut M, Bozhkov PV, Brady N, Braga VM, Brancolini C, Braus GH, Bravo-San Pedro JM, Brennan LA, Bresnick EH, Brest P, Bridges D, Bringer MA, Brini M, Brito GC, Brodin B, Brookes PS, Brown EJ, Brown K, Broxmeyer HE, Bruhat A, Brum PC, Brumell JH, Brunetti-Pierri N, Bryson-Richardson RJ, Buch S, Buchan AM, Budak H, Bulavin DV, Bultman SJ, Bultynck G, Bumbasirevic V, Burelle Y, Burke RE, Burmeister M, Bütikofer P, Caberlotto L, Cadwell K, Cahova M, Cai D, Cai J, Cai Q, Calatayud S, Camougrand N, Campanella M, Campbell GR, Campbell M, Campello S, Candau R, Caniggia I, Cantoni L, Cao L, Caplan AB, Caraglia M, Cardinali C, Cardoso SM, Carew JS, Carleton LA, Carlin CR, Carloni S, Carlsson SR, Carmona-Gutierrez D, Carneiro LA, Carnevali O, Carra S, Carrier A, Carroll B, Casas C, Casas J, Cassinelli G, Castets P, Castro-Obregon S, Cavallini G, Ceccherini I, Cecconi F, Cederbaum AI, Ceña V, Cenci S, Cerella C, Cervia D, Cetrullo S, Chaachouay H, Chae HJ, Chagin AS, Chai CY, Chakrabarti G, Chamilos G, Chan EY, Chan MT, Chandra D, Chandra P, Chang CP, Chang RC, Chang TY, Chatham JC, Chatterjee S, Chauhan S, Che Y, Cheetham ME, Cheluvappa R, Chen CJ, Chen G, Chen GC, Chen G, Chen H, Chen JW, Chen JK, Chen M, Chen M, Chen P, Chen Q, Chen Q, Chen SD, Chen S, Chen SS, Chen W, Chen WJ, Chen WQ, Chen W, Chen X, Chen YH, Chen YG, Chen Y, Chen Y, Chen Y, Chen YJ, Chen YQ, Chen Y, Chen Z, Chen Z, Cheng A, Cheng CH, Cheng H, Cheong H, Cherry S, Chesney J, Cheung CH, Chevet E, Chi HC, Chi SG, Chiacchiera F, Chiang HL, Chiarelli R, Chiariello M, Chieppa M, Chin LS, Chiong M, Chiu GN, Cho DH, Cho SG, Cho WC, Cho YY, Cho YS, Choi AM, Choi EJ, Choi EK, Choi J, Choi ME, Choi SI, Chou TF, Chouaib S, Choubey D, Choubey V, Chow KC, Chowdhury K, Chu CT, Chuang TH, Chun T, Chung H, Chung T, Chung YL, Chwae YJ, Cianfanelli V, Ciarcia R, Ciechomska IA, Ciriolo MR, Cirone M, Claerhout S, Clague MJ, Clària J, Clarke PG, Clarke R, Clementi E, Cleyrat C, Cnop M, Coccia EM, Cocco T, Codogno P, Coers J, Cohen EE, Colecchia D, Coletto L, Coll NS, Colucci-Guyon E, Comincini S, Condello M, Cook KL, Coombs GH, Cooper CD, Cooper JM, Coppens I, Corasaniti MT, Corazzari M, Corbalan R, Corcelle-Termeau E, Cordero MD, Corral-Ramos C, Corti O, Cossarizza A, Costelli P, Costes S, Cotman SL, Coto-Montes A, Cottet S, Couve E, Covey LR, Cowart LA, Cox JS, Coxon FP, Coyne CB, Cragg MS, Craven RJ, Crepaldi T, Crespo JL, Criollo A, Crippa V, Cruz MT, Cuervo AM, Cuezva JM, Cui T, Cutillas PR, Czaja MJ, Czyzyk-Krzeska MF, Dagda RK, Dahmen U, Dai C, Dai W, Dai Y, Dalby KN, Dalla Valle L, Dalmasso G, D'Amelio M, Damme M, Darfeuille-Michaud A, Dargemont C, Darley-Usmar VM, Dasarathy S, Dasgupta B, Dash S, Dass CR, Davey HM, Davids LM, Dávila D, Davis RJ, Dawson TM, Dawson VL, Daza P, de Belleroche J, de Figueiredo P, de Figueiredo RC, de la Fuente J, De Martino L, De Matteis A, De Meyer GR, De Milito A, De Santi M, de Souza W, De Tata V, De Zio D, Debnath J, Dechant R, Decuypere JP, Deegan S, Dehay B, Del Bello B, Del Re DP, Delage-Mourroux R, Delbridge LM, Deldicque L, Delorme-Axford E, Deng Y, Dengjel J, Denizot M, Dent P, Der CJ, Deretic V, Derrien B, Deutsch E, Devarenne TP, Devenish RJ, Di Bartolomeo S, Di Daniele N, Di Domenico F, Di Nardo A, Di Paola S, Di Pietro A, Di Renzo L, DiAntonio A, Díaz-Araya G, Díaz-Laviada I, Diaz-Meco MT, Diaz-Nido J, Dickey CA, Dickson RC, Diederich M, Digard P, Dikic I, Dinesh-Kumar SP, Ding C, Ding WX, Ding Z, Dini L, Distler JH, Diwan A, Djavaheri-Mergny M, Dmytruk K, Dobson RC, Doetsch V, Dokladny K, Dokudovskaya S, Donadelli M, Dong XC, Dong X, Dong Z, Donohue TM Jr, Doran KS, D'Orazi G, Dorn GW 2nd, Dosenko V, Dridi S, Drucker L, Du J, Du LL, Du L, du Toit A, Dua P, Duan L, Duann P, Dubey VK, Duchen MR, Duchosal MA, Duez H, Dugail I, Dumit VI, Duncan MC, 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C-Reactive Protein Concentrations and Level of Physical Activity in Men and Women With Normal and Impaired Glucose Tolerance. A Cross-Sectional Population-Based Study in Sweden.

Hellgren MI, Larsson CA, Daka B, Petzold M, Jansson PA, Lindblad U.

J Phys Act Health. 2016 Jun;13(6):625-31. doi: 10.1123/jpah.2015-0168. Epub 2015 Dec 21.

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Novel Mechanism of Cytotoxicity for the Selective Selenosemicarbazone, 2-Acetylpyridine 4,4-Dimethyl-3-selenosemicarbazone (Ap44mSe): Lysosomal Membrane Permeabilization.

Al-Eisawi Z, Stefani C, Jansson PJ, Arvind A, Sharpe PC, Basha MT, Iskander GM, Kumar N, Kovacevic Z, Lane DJ, Sahni S, Bernhardt PV, Richardson DR, Kalinowski DS.

J Med Chem. 2016 Jan 14;59(1):294-312. doi: 10.1021/acs.jmedchem.5b01399. Epub 2015 Dec 31.

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Glucose Modulation Induces Lysosome Formation and Increases Lysosomotropic Drug Sequestration via the P-Glycoprotein Drug Transporter.

Seebacher NA, Lane DJ, Jansson PJ, Richardson DR.

J Biol Chem. 2016 Feb 19;291(8):3796-820. doi: 10.1074/jbc.M115.682450. Epub 2015 Nov 24.

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Circulating concentrations of endothelin-1 predict coronary heart disease in women but not in men: a longitudinal observational study in the Vara-Skövde Cohort.

Daka B, Olausson J, Larsson CA, Hellgren MI, Råstam L, Jansson PA, Lindblad U.

BMC Cardiovasc Disord. 2015 Nov 14;15:146. doi: 10.1186/s12872-015-0141-y.

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Postprandial effects of the phosphodiesterase-5 inhibitor tadalafil in people with well-controlled Type 2 diabetes mellitus: a randomized controlled trial.

Sjögren L, Olausson J, Strindberg L, Mobini R, Fogelstrand P, Mattsson Hultén L, Jansson PA.

Diabet Med. 2016 Sep;33(9):1299-301. doi: 10.1111/dme.12999. No abstract available.

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The molecular effect of metastasis suppressors on Src signaling and tumorigenesis: new therapeutic targets.

Liu W, Kovacevic Z, Peng Z, Jin R, Wang P, Yue F, Zheng M, Huang ML, Jansson PJ, Richardson V, Kalinowski DS, Lane DJ, Merlot AM, Sahni S, Richardson DR.

Oncotarget. 2015 Nov 3;6(34):35522-41. doi: 10.18632/oncotarget.5849. Review.

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A needs assessment in patient safety education for fourth-year medical students.

Jansson PS, An-Grogan Y, Eller SG, Woods DM, Kontrick AV, Salzman DH.

Am J Med Qual. 2015 Nov-Dec;30(6):601. doi: 10.1177/1062860615606018. Epub 2015 Sep 15. No abstract available.

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Identification of differential anti-neoplastic activity of copper bis(thiosemicarbazones) that is mediated by intracellular reactive oxygen species generation and lysosomal membrane permeabilization.

Stefani C, Al-Eisawi Z, Jansson PJ, Kalinowski DS, Richardson DR.

J Inorg Biochem. 2015 Nov;152:20-37. doi: 10.1016/j.jinorgbio.2015.08.010. Epub 2015 Aug 17.

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The renaissance of polypharmacology in the development of anti-cancer therapeutics: Inhibition of the "Triad of Death" in cancer by Di-2-pyridylketone thiosemicarbazones.

Jansson PJ, Kalinowski DS, Lane DJ, Kovacevic Z, Seebacher NA, Fouani L, Sahni S, Merlot AM, Richardson DR.

Pharmacol Res. 2015 Oct;100:255-60. doi: 10.1016/j.phrs.2015.08.013. Epub 2015 Aug 28. Review.

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Low concentrations of serum testosterone predict acute myocardial infarction in men with type 2 diabetes mellitus.

Daka B, Langer RD, Larsson CA, Rosén T, Jansson PA, Råstam L, Lindblad U.

BMC Endocr Disord. 2015 Jul 25;15:35. doi: 10.1186/s12902-015-0034-1.

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INVESTIGATING THE EFFICACY OF CLINICAL TRIAL MONITORING STRATEGIES: Design and Implementation of the Cluster Randomized START Monitoring Substudy.

Hullsiek KH, Kagan JM, Engen N, Grarup J, Hudson F, Denning ET, Carey C, Courtney-Rodgers D, Finley EB, Jansson PO, Pearson MT, Peavy DE, Belloso WH.

Ther Innov Regul Sci. 2015 Mar 1;49(2):225-233.

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Making a case for albumin – a highly promising drug-delivery system.

Merlot AM, Kalinowski DS, Kovacevic Z, Jansson PJ, Lane DJ, Huang ML, Sahni S, Richardson DR.

Future Med Chem. 2015;7(5):553-6. doi: 10.4155/fmc.15.15. No abstract available.

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