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Items: 1 to 50 of 89

1.

Age-dependent dysregulation of redox genes may contribute to fibrotic pulmonary disease susceptibility.

Elko EA, Mahoney JM, Vacek P, van der Vliet A, Anathy V, van der Velden JLJL, Janssen-Heininger YMW, Seward DJ.

Free Radic Biol Med. 2019 Sep;141:438-446. doi: 10.1016/j.freeradbiomed.2019.07.011. Epub 2019 Jul 14.

PMID:
31315063
2.

Dysregulated Redox Regulation Contributes to Nuclear EGFR Localization and Pathogenicity in Lung Cancer.

Little AC, Hristova M, van Lith L, Schiffers C, Dustin CM, Habibovic A, Danyal K, Heppner DE, Lin MJ, van der Velden J, Janssen-Heininger YM, van der Vliet A.

Sci Rep. 2019 Mar 19;9(1):4844. doi: 10.1038/s41598-019-41395-8.

3.

Peroxiredoxins and Beyond; Redox Systems Regulating Lung Physiology and Disease.

Elko EA, Cunniff B, Seward DJ, Chia SB, Aboushousha R, van de Wetering C, van der Velden J, Manuel A, Shukla A, Heintz NH, Anathy V, van der Vliet A, Janssen-Heininger YMW.

Antioxid Redox Signal. 2019 Apr 5. doi: 10.1089/ars.2019.7752. [Epub ahead of print]

PMID:
30799628
4.

Oxidative stress in chronic lung disease: From mitochondrial dysfunction to dysregulated redox signaling.

van der Vliet A, Janssen-Heininger YMW, Anathy V.

Mol Aspects Med. 2018 Oct;63:59-69. doi: 10.1016/j.mam.2018.08.001. Epub 2018 Aug 22. Review.

PMID:
30098327
5.

Reducing protein oxidation reverses lung fibrosis.

Anathy V, Lahue KG, Chapman DG, Chia SB, Casey DT, Aboushousha R, van der Velden JLJ, Elko E, Hoffman SM, McMillan DH, Jones JT, Nolin JD, Abdalla S, Schneider R, Seward DJ, Roberson EC, Liptak MD, Cousins ME, Butnor KJ, Taatjes DJ, Budd RC, Irvin CG, Ho YS, Hakem R, Brown KK, Matsui R, Bachschmid MM, Gomez JL, Kaminski N, van der Vliet A, Janssen-Heininger YMW.

Nat Med. 2018 Aug;24(8):1128-1135. doi: 10.1038/s41591-018-0090-y. Epub 2018 Jul 9.

6.

Rust never sleeps: The continuing story of the Iron Bolt.

van der Vliet A, Dick TP, Aust SD, Koppenol WH, Ursini F, Kettle AJ, Beckman JS, O'Donnell V, Darley-Usmar V, Lancaster J Jr, Hogg N, Davies KJA, Forman HJ, Janssen-Heininger YMW.

Free Radic Biol Med. 2018 Aug 20;124:353-357. doi: 10.1016/j.freeradbiomed.2018.06.017. Epub 2018 Jun 18. Review.

PMID:
29913216
7.

TGF-β1-induced deposition of provisional extracellular matrix by tracheal basal cells promotes epithelial-to-mesenchymal transition in a c-Jun NH2-terminal kinase-1-dependent manner.

van der Velden JL, Wagner DE, Lahue KG, Abdalla ST, Lam YW, Weiss DJ, Janssen-Heininger YMW.

Am J Physiol Lung Cell Mol Physiol. 2018 Jun 1;314(6):L984-L997. doi: 10.1152/ajplung.00053.2017. Epub 2018 Feb 22.

8.

IL-1/inhibitory κB kinase ε-induced glycolysis augment epithelial effector function and promote allergic airways disease.

Qian X, Aboushousha R, van de Wetering C, Chia SB, Amiel E, Schneider RW, van der Velden JLJ, Lahue KG, Hoagland DA, Casey DT, Daphtary N, Ather JL, Randall MJ, Aliyeva M, Black KE, Chapman DG, Lundblad LKA, McMillan DH, Dixon AE, Anathy V, Irvin CG, Poynter ME, Wouters EFM, Vacek PM, Henket M, Schleich F, Louis R, van der Vliet A, Janssen-Heininger YMW.

J Allergy Clin Immunol. 2018 Aug;142(2):435-450.e10. doi: 10.1016/j.jaci.2017.08.043. Epub 2017 Nov 3.

9.

The Duffy antigen receptor for chemokines regulates asthma pathophysiology.

Chapman DG, Mougey EB, Van der Velden JL, Lahue KG, Aliyeva M, Daphtary N, George KL, Hoffman SM, Schneider RW, Tracy RP, Worthen GS, Poynter ME, Peters SP, Lima JJ, Janssen-Heininger YMW, Irvin CG.

Clin Exp Allergy. 2017 Sep;47(9):1214-1222. doi: 10.1111/cea.12949. Epub 2017 Jun 9.

10.

Mitochondrial ROS induced by chronic ethanol exposure promote hyper-activation of the NLRP3 inflammasome.

Hoyt LR, Randall MJ, Ather JL, DePuccio DP, Landry CC, Qian X, Janssen-Heininger YM, van der Vliet A, Dixon AE, Amiel E, Poynter ME.

Redox Biol. 2017 Aug;12:883-896. doi: 10.1016/j.redox.2017.04.020. Epub 2017 Apr 25.

11.

Epigenetic and Transcriptomic Regulation of Lung Repair during Recovery from Influenza Infection.

Pociask DA, Robinson KM, Chen K, McHugh KJ, Clay ME, Huang GT, Benos PV, Janssen-Heininger YMW, Kolls JK, Anathy V, Alcorn JF.

Am J Pathol. 2017 Apr;187(4):851-863. doi: 10.1016/j.ajpath.2016.12.012. Epub 2017 Feb 10.

12.

The role of sulfenic acids in cellular redox signaling: Reconciling chemical kinetics and molecular detection strategies.

Heppner DE, Janssen-Heininger YMW, van der Vliet A.

Arch Biochem Biophys. 2017 Feb 15;616:40-46. doi: 10.1016/j.abb.2017.01.008. Epub 2017 Jan 23.

13.

Involvement of c-Jun N-Terminal Kinase in TNF-α-Driven Remodeling.

Eurlings IM, Reynaert NL, van de Wetering C, Aesif SW, Mercken EM, de Cabo R, van der Velden JL, Janssen-Heininger YM, Wouters EF, Dentener MA.

Am J Respir Cell Mol Biol. 2017 Mar;56(3):393-401. doi: 10.1165/rcmb.2015-0195OC.

14.

DUOX1 mediates persistent epithelial EGFR activation, mucous cell metaplasia, and airway remodeling during allergic asthma.

Habibovic A, Hristova M, Heppner DE, Danyal K, Ather JL, Janssen-Heininger YM, Irvin CG, Poynter ME, Lundblad LK, Dixon AE, Geiszt M, van der Vliet A.

JCI Insight. 2016 Nov 3;1(18):e88811. doi: 10.1172/jci.insight.88811.

15.

The redox mechanism for vascular barrier dysfunction associated with metabolic disorders: Glutathionylation of Rac1 in endothelial cells.

Han J, Weisbrod RM, Shao D, Watanabe Y, Yin X, Bachschmid MM, Seta F, Janssen-Heininger YMW, Matsui R, Zang M, Hamburg NM, Cohen RA.

Redox Biol. 2016 Oct;9:306-319. doi: 10.1016/j.redox.2016.09.003. Epub 2016 Sep 11.

16.

JNK inhibition reduces lung remodeling and pulmonary fibrotic systemic markers.

van der Velden JL, Ye Y, Nolin JD, Hoffman SM, Chapman DG, Lahue KG, Abdalla S, Chen P, Liu Y, Bennett B, Khalil N, Sutherland D, Smith W, Horan G, Assaf M, Horowitz Z, Chopra R, Stevens RM, Palmisano M, Janssen-Heininger YM, Schafer PH.

Clin Transl Med. 2016 Dec;5(1):36. doi: 10.1186/s40169-016-0117-2. Epub 2016 Sep 2.

17.

Attenuation of lung fibrosis in mice with a clinically relevant inhibitor of glutathione-S-transferase π.

McMillan DH, van der Velden JL, Lahue KG, Qian X, Schneider RW, Iberg MS, Nolin JD, Abdalla S, Casey DT, Tew KD, Townsend DM, Henderson CJ, Wolf CR, Butnor KJ, Taatjes DJ, Budd RC, Irvin CG, van der Vliet A, Flemer S, Anathy V, Janssen-Heininger YM.

JCI Insight. 2016 Jun 2;1(8). pii: 85717. doi: 10.1172/jci.insight.85717.

18.

Glutathione S-transferase pi modulates NF-κB activation and pro-inflammatory responses in lung epithelial cells.

Jones JT, Qian X, van der Velden JL, Chia SB, McMillan DH, Flemer S, Hoffman SM, Lahue KG, Schneider RW, Nolin JD, Anathy V, van der Vliet A, Townsend DM, Tew KD, Janssen-Heininger YM.

Redox Biol. 2016 Aug;8:375-82. doi: 10.1016/j.redox.2016.03.005. Epub 2016 Mar 26.

19.

Ablation of Glutaredoxin-1 Modulates House Dust Mite-Induced Allergic Airways Disease in Mice.

Hoffman SM, Qian X, Nolin JD, Chapman DG, Chia SB, Lahue KG, Schneider R, Ather JL, Randall MJ, McMillan DH, Jones JT, Taatjes DJ, Aliyeva M, Daphtary N, Abdalla S, Lundblad LK, Ho YS, Anathy V, Irvin CG, Wouters EF, Reynaert NL, Dixon AE, van der Vliet A, Poynter ME, Janssen-Heininger YM.

Am J Respir Cell Mol Biol. 2016 Sep;55(3):377-86. doi: 10.1165/rcmb.2015-0401OC.

20.

Ablation of the Thiol Transferase Glutaredoxin-1 Augments Protein S-Glutathionylation and Modulates Type 2 Inflammatory Responses and IL-17 in a House Dust Mite Model of Allergic Airway Disease in Mice.

Hoffman SM, Nolin JD, Jones JT, Lahue KG, Chapman DG, Aliyeva M, Daphtary N, Lundblad LK, Abdalla S, Ather JL, Ho YS, Irvin CG, Anathy V, Wouters EF, Poynter ME, Janssen-Heininger YM.

Ann Am Thorac Soc. 2016 Mar;13 Suppl 1:S97. doi: 10.1513/AnnalsATS.201510-656MG.

21.

Airway epithelial dual oxidase 1 mediates allergen-induced IL-33 secretion and activation of type 2 immune responses.

Hristova M, Habibovic A, Veith C, Janssen-Heininger YM, Dixon AE, Geiszt M, van der Vliet A.

J Allergy Clin Immunol. 2016 May;137(5):1545-1556.e11. doi: 10.1016/j.jaci.2015.10.003. Epub 2015 Nov 17.

22.

Protein disulfide isomerase-endoplasmic reticulum resident protein 57 regulates allergen-induced airways inflammation, fibrosis, and hyperresponsiveness.

Hoffman SM, Chapman DG, Lahue KG, Cahoon JM, Rattu GK, Daphtary N, Aliyeva M, Fortner KA, Erzurum SC, Comhair SA, Woodruff PG, Bhakta N, Dixon AE, Irvin CG, Janssen-Heininger YM, Poynter ME, Anathy V.

J Allergy Clin Immunol. 2016 Mar;137(3):822-32.e7. doi: 10.1016/j.jaci.2015.08.018. Epub 2015 Oct 4.

23.

Animal models of allergic airways disease: where are we and where to next?

Chapman DG, Tully JE, Nolin JD, Janssen-Heininger YM, Irvin CG.

J Cell Biochem. 2014 Dec;115(12):2055-64. doi: 10.1002/jcb.24881. Review.

24.

The glutaredoxin/S-glutathionylation axis regulates interleukin-17A-induced proinflammatory responses in lung epithelial cells in association with S-glutathionylation of nuclear factor κB family proteins.

Nolin JD, Tully JE, Hoffman SM, Guala AS, van der Velden JL, Poynter ME, van der Vliet A, Anathy V, Janssen-Heininger YM.

Free Radic Biol Med. 2014 Aug;73:143-53. doi: 10.1016/j.freeradbiomed.2014.04.028. Epub 2014 May 9.

25.

Identification of DUOX1-dependent redox signaling through protein S-glutathionylation in airway epithelial cells.

Hristova M, Veith C, Habibovic A, Lam YW, Deng B, Geiszt M, Janssen-Heininger YM, van der Vliet A.

Redox Biol. 2014 Jan 15;2:436-46. doi: 10.1016/j.redox.2013.12.030. eCollection 2014.

26.

Absence of c-Jun NH2-terminal kinase 1 protects against house dust mite-induced pulmonary remodeling but not airway hyperresponsiveness and inflammation.

van der Velden JL, Hoffman SM, Alcorn JF, Tully JE, Chapman DG, Lahue KG, Guala AS, Lundblad LK, Aliyeva M, Daphtary N, Irvin CG, Janssen-Heininger YM.

Am J Physiol Lung Cell Mol Physiol. 2014 May 1;306(9):L866-75. doi: 10.1152/ajplung.00153.2013. Epub 2014 Mar 7.

27.

Glutaredoxin-1 attenuates S-glutathionylation of the death receptor fas and decreases resolution of Pseudomonas aeruginosa pneumonia.

Anathy V, Aesif SW, Hoffman SM, Bement JL, Guala AS, Lahue KG, Leclair LW, Suratt BT, Cool CD, Wargo MJ, Janssen-Heininger YM.

Am J Respir Crit Care Med. 2014 Feb 15;189(4):463-74. doi: 10.1164/rccm.201310-1905OC.

28.

Epithelial NF-κB orchestrates house dust mite-induced airway inflammation, hyperresponsiveness, and fibrotic remodeling.

Tully JE, Hoffman SM, Lahue KG, Nolin JD, Anathy V, Lundblad LK, Daphtary N, Aliyeva M, Black KE, Dixon AE, Poynter ME, Irvin CG, Janssen-Heininger YM.

J Immunol. 2013 Dec 15;191(12):5811-21. doi: 10.4049/jimmunol.1301329. Epub 2013 Nov 13.

29.

Hydrogen peroxide as a damage signal in tissue injury and inflammation: murderer, mediator, or messenger?

van der Vliet A, Janssen-Heininger YM.

J Cell Biochem. 2014 Mar;115(3):427-35. doi: 10.1002/jcb.24683. Review.

30.

Emerging mechanisms of glutathione-dependent chemistry in biology and disease.

Janssen-Heininger YM, Nolin JD, Hoffman SM, van der Velden JL, Tully JE, Lahue KG, Abdalla ST, Chapman DG, Reynaert NL, van der Vliet A, Anathy V.

J Cell Biochem. 2013 Sep;114(9):1962-8. doi: 10.1002/jcb.24551. Review.

31.

Increased glutaredoxin-1 and decreased protein S-glutathionylation in sputum of asthmatics.

Kuipers I, Louis R, Manise M, Dentener MA, Irvin CG, Janssen-Heininger YM, Brightling CE, Wouters EF, Reynaert NL.

Eur Respir J. 2013 Feb;41(2):469-72. doi: 10.1183/09031936.00115212. No abstract available.

32.

Dual oxidase-1 is required for airway epithelial cell migration and bronchiolar reepithelialization after injury.

Gorissen SH, Hristova M, Habibovic A, Sipsey LM, Spiess PC, Janssen-Heininger YM, van der Vliet A.

Am J Respir Cell Mol Biol. 2013 Mar;48(3):337-45. doi: 10.1165/rcmb.2012-0393OC. Epub 2012 Dec 13.

33.

Genetic ablation of glutaredoxin-1 causes enhanced resolution of airways hyperresponsiveness and mucus metaplasia in mice with allergic airways disease.

Hoffman SM, Tully JE, Lahue KG, Anathy V, Nolin JD, Guala AS, van der Velden JL, Ho YS, Aliyeva M, Daphtary N, Lundblad LK, Irvin CG, Janssen-Heininger YM.

Am J Physiol Lung Cell Mol Physiol. 2012 Sep 15;303(6):L528-38. doi: 10.1152/ajplung.00167.2012. Epub 2012 Jun 29.

34.

Oxidative processing of latent Fas in the endoplasmic reticulum controls the strength of apoptosis.

Anathy V, Roberson E, Cunniff B, Nolin JD, Hoffman S, Spiess P, Guala AS, Lahue KG, Goldman D, Flemer S, van der Vliet A, Heintz NH, Budd RC, Tew KD, Janssen-Heininger YM.

Mol Cell Biol. 2012 Sep;32(17):3464-78. doi: 10.1128/MCB.00125-12. Epub 2012 Jul 2.

35.

Cooperation between classical and alternative NF-κB pathways regulates proinflammatory responses in epithelial cells.

Tully JE, Nolin JD, Guala AS, Hoffman SM, Roberson EC, Lahue KG, van der Velden J, Anathy V, Blackwell TS, Janssen-Heininger YM.

Am J Respir Cell Mol Biol. 2012 Oct;47(4):497-508. doi: 10.1165/rcmb.2012-0014OC. Epub 2012 May 31.

36.

Differential requirement for c-Jun N-terminal kinase 1 in lung inflammation and host defense.

Van der Velden J, Janssen-Heininger YM, Mandalapu S, Scheller EV, Kolls JK, Alcorn JF.

PLoS One. 2012;7(4):e34638. doi: 10.1371/journal.pone.0034638. Epub 2012 Apr 13.

37.

Induction of a mesenchymal expression program in lung epithelial cells by wingless protein (Wnt)/β-catenin requires the presence of c-Jun N-terminal kinase-1 (JNK1).

van der Velden JL, Guala AS, Leggett SE, Sluimer J, Badura EC, Janssen-Heininger YM.

Am J Respir Cell Mol Biol. 2012 Sep;47(3):306-14. doi: 10.1165/rcmb.2011-0297OC. Epub 2012 Mar 29.

38.

Airway Hyperresponsiveness and Inflammation: Causation, Correlation, or No Relation?

Janssen-Heininger YM, Irvin CG, Scheller EV, Brown AL, Kolls JK, Alcorn JF.

J Allergy Ther. 2012 Jan 26;2012(Suppl 1). pii: 008.

39.

Redox-based regulation of apoptosis: S-glutathionylation as a regulatory mechanism to control cell death.

Anathy V, Roberson EC, Guala AS, Godburn KE, Budd RC, Janssen-Heininger YM.

Antioxid Redox Signal. 2012 Mar 15;16(6):496-505. doi: 10.1089/ars.2011.4281. Epub 2011 Dec 22. Review.

40.

Influenza induces endoplasmic reticulum stress, caspase-12-dependent apoptosis, and c-Jun N-terminal kinase-mediated transforming growth factor-β release in lung epithelial cells.

Roberson EC, Tully JE, Guala AS, Reiss JN, Godburn KE, Pociask DA, Alcorn JF, Riches DW, Dienz O, Janssen-Heininger YM, Anathy V.

Am J Respir Cell Mol Biol. 2012 May;46(5):573-81. doi: 10.1165/rcmb.2010-0460OC. Epub 2011 Jul 28.

41.

Activation of the glutaredoxin-1 gene by nuclear factor κB enhances signaling.

Aesif SW, Kuipers I, van der Velden J, Tully JE, Guala AS, Anathy V, Sheely JI, Reynaert NL, Wouters EF, van der Vliet A, Janssen-Heininger YM.

Free Radic Biol Med. 2011 Sep 15;51(6):1249-57. doi: 10.1016/j.freeradbiomed.2011.06.025. Epub 2011 Jun 27.

42.

Cigarette smoke targets glutaredoxin 1, increasing s-glutathionylation and epithelial cell death.

Kuipers I, Guala AS, Aesif SW, Konings G, Bouwman FG, Mariman EC, Wouters EF, Janssen-Heininger YM, Reynaert NL.

Am J Respir Cell Mol Biol. 2011 Nov;45(5):931-7. doi: 10.1165/rcmb.2010-0249OC. Epub 2011 Mar 31.

43.

SPLUNC1 regulation in airway epithelial cells: role of Toll-like receptor 2 signaling.

Chu HW, Gally F, Thaikoottathil J, Janssen-Heininger YM, Wu Q, Zhang G, Reisdorph N, Case S, Minor M, Smith S, Jiang D, Michels N, Simon G, Martin RJ.

Respir Res. 2010 Nov 5;11:155. doi: 10.1186/1465-9921-11-155.

44.

Regulation of apoptosis through cysteine oxidation: implications for fibrotic lung disease.

Janssen-Heininger YM, Aesif SW, van der Velden J, Guala AS, Reiss JN, Roberson EC, Budd RC, Reynaert NL, Anathy V.

Ann N Y Acad Sci. 2010 Aug;1203:23-8. doi: 10.1111/j.1749-6632.2010.05553.x. Review.

45.

Protocols for the detection of s-glutathionylated and s-nitrosylated proteins in situ.

Aesif SW, Janssen-Heininger YM, Reynaert NL.

Methods Enzymol. 2010;474:289-96. doi: 10.1016/S0076-6879(10)74017-9. Epub 2010 Jun 20.

46.

c-Jun N-terminal kinase 1 promotes transforming growth factor-β1-induced epithelial-to-mesenchymal transition via control of linker phosphorylation and transcriptional activity of Smad3.

Velden JL, Alcorn JF, Guala AS, Badura EC, Janssen-Heininger YM.

Am J Respir Cell Mol Biol. 2011 Apr;44(4):571-81. doi: 10.1165/rcmb.2009-0282OC. Epub 2010 Jun 25.

47.

Airway epithelial NF-κB activation promotes allergic sensitization to an innocuous inhaled antigen.

Ather JL, Hodgkins SR, Janssen-Heininger YM, Poynter ME.

Am J Respir Cell Mol Biol. 2011 May;44(5):631-8. doi: 10.1165/rcmb.2010-0106OC. Epub 2010 Jun 25.

48.

Ablation of glutaredoxin-1 attenuates lipopolysaccharide-induced lung inflammation and alveolar macrophage activation.

Aesif SW, Anathy V, Kuipers I, Guala AS, Reiss JN, Ho YS, Janssen-Heininger YM.

Am J Respir Cell Mol Biol. 2011 Apr;44(4):491-9. doi: 10.1165/rcmb.2009-0136OC. Epub 2010 Jun 10.

49.

Asbestos, lung cancers, and mesotheliomas: from molecular approaches to targeting tumor survival pathways.

Heintz NH, Janssen-Heininger YM, Mossman BT.

Am J Respir Cell Mol Biol. 2010 Feb;42(2):133-9. doi: 10.1165/rcmb.2009-0206TR. Review.

50.

Distinct functions of airway epithelial nuclear factor-kappaB activity regulate nitrogen dioxide-induced acute lung injury.

Ather JL, Alcorn JF, Brown AL, Guala AS, Suratt BT, Janssen-Heininger YM, Poynter ME.

Am J Respir Cell Mol Biol. 2010 Oct;43(4):443-51. doi: 10.1165/rcmb.2008-0416OC. Epub 2009 Nov 9.

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