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Items: 1 to 50 of 96

1.

Inflammation-Induced Alternative Pre-mRNA Splicing in Mouse Alveolar Macrophages.

Janssen WJ, Danhorn T, Harris C, Mould KJ, Lee FF, Hedin BR, D'Alessandro A, Leach SM, Alper S.

G3 (Bethesda). 2020 Feb 6;10(2):555-567. doi: 10.1534/g3.119.400935.

2.

Interstitial Macrophage-Derived Thrombospondin-1 Contributes to Hypoxia-Induced Pulmonary Hypertension.

Kumar R, Mickael C, Kassa B, Sanders L, Hernandez-Saavedra D, Koyanagi DE, Kumar S, Pugliese SC, Thomas S, McClendon J, Maloney JP, Janssen WJ, Stenmark KR, Tuder RM, Graham BB.

Cardiovasc Res. 2019 Nov 9. pii: cvz304. doi: 10.1093/cvr/cvz304. [Epub ahead of print]

PMID:
31710666
3.

Inflammation via myeloid differentiation primary response gene 88 signaling mediates the fibrotic response to implantable synthetic poly(ethylene glycol) hydrogels.

Amer LD, Saleh LS, Walker C, Thomas S, Janssen WJ, Alper S, Bryant SJ.

Acta Biomater. 2019 Dec;100:105-117. doi: 10.1016/j.actbio.2019.09.043. Epub 2019 Sep 27.

PMID:
31568879
4.

Redistribution of EC-SOD resolves bleomycin-induced inflammation via increased apoptosis of recruited alveolar macrophages.

Allawzi A, McDermott I, Delaney C, Nguyen K, Banimostafa L, Trumpie A, Hernandez-Lagunas L, Riemondy K, Gillen A, Hesselberth J, El Kasmi K, Sucharov CC, Janssen WJ, Stenmark K, Bowler R, Nozik-Grayck E.

FASEB J. 2019 Dec;33(12):13465-13475. doi: 10.1096/fj.201901038RR. Epub 2019 Sep 27.

PMID:
31560857
5.

Improving the Quality and Reproducibility of Flow Cytometry in the Lung. An Official American Thoracic Society Workshop Report.

Tighe RM, Redente EF, Yu YR, Herold S, Sperling AI, Curtis JL, Duggan R, Swaminathan S, Nakano H, Zacharias WJ, Janssen WJ, Freeman CM, Brinkman RR, Singer BD, Jakubzick CV, Misharin AV.

Am J Respir Cell Mol Biol. 2019 Aug;61(2):150-161. doi: 10.1165/rcmb.2019-0191ST.

PMID:
31368812
6.

Single cell RNA sequencing identifies unique inflammatory airspace macrophage subsets.

Mould KJ, Jackson ND, Henson PM, Seibold M, Janssen WJ.

JCI Insight. 2019 Mar 7;4(5). pii: 126556. doi: 10.1172/jci.insight.126556. eCollection 2019 Mar 7.

7.

Mucociliary Defense: Emerging Cellular, Molecular, and Animal Models.

Benam KH, Vladar EK, Janssen WJ, Evans CM.

Ann Am Thorac Soc. 2018 Nov;15(Suppl 3):S210-S215. doi: 10.1513/AnnalsATS.201806-439AW. Review.

8.

Cholestenoic acid is a prognostic biomarker in acute respiratory distress syndrome.

Madenspacher JH, Stapleton RD, Suratt BT, Dixon AE, Lih FB, Lowe JM, Mould KJ, Janssen WJ, Morrell ED, Wurfel MM, Garantziotis S, Tomer KB, Fessler MB.

J Allergy Clin Immunol. 2019 Jan;143(1):440-442.e8. doi: 10.1016/j.jaci.2018.09.017. Epub 2018 Oct 5. No abstract available.

9.

Mouse Models of Viral Infection.

Empey KM, Peebles RS Jr, Janssen WJ.

Methods Mol Biol. 2018;1809:395-414. doi: 10.1007/978-1-4939-8570-8_26.

PMID:
29987803
10.

Modulation of Myeloid Cell Function Using Conditional and Inducible Transgenic Approaches.

McCubbrey AL, Janssen WJ.

Methods Mol Biol. 2018;1809:145-168. doi: 10.1007/978-1-4939-8570-8_13.

PMID:
29987790
11.

Recombinant IFN-β for Postseptic Acute Lung Injury-What's the Mechanism?

Mould KJ, Janssen WJ.

Am J Respir Cell Mol Biol. 2018 Jul;59(1):1-2. doi: 10.1165/rcmb.2018-0054ED. No abstract available.

PMID:
29957050
12.

Rapid clearance of heavy chain-modified hyaluronan during resolving acute lung injury.

Ni K, Gill A, Tseng V, Mikosz AM, Koike K, Beatman EL, Xu CY, Cao D, Gally F, Mould KJ, Serban KA, Schweitzer KS, March KL, Janssen WJ, Nozik-Grayck E, Garantziotis S, Petrache I.

Respir Res. 2018 May 31;19(1):107. doi: 10.1186/s12931-018-0812-1.

13.

Correction to: Dual RNA-seq reveals viral infections in asthmatic children without respiratory illness which are associated with changes in the airway transcriptome.

Wesolowska-Andersen A, Everman JL, Davidson R, Rios C, Herrin R, Eng C, Janssen WJ, Liu AH, Oh SS, Kumar R, Fingerlin TE, Rodriguez-Santana J, Burchard EG, Seibold MA.

Genome Biol. 2018 Apr 10;19(1):49. doi: 10.1186/s13059-018-1423-3.

14.

Proline-serine-threonine phosphatase interacting protein 1 (PSTPIP1) controls immune synapse stability in human T cells.

Janssen WJM, Grobarova V, Leleux J, Jongeneel L, van Gijn M, van Montfrans JM, Boes M.

J Allergy Clin Immunol. 2018 Dec;142(6):1947-1955. doi: 10.1016/j.jaci.2018.01.030. Epub 2018 Feb 9.

PMID:
29432774
15.

Promoter Specificity and Efficacy in Conditional and Inducible Transgenic Targeting of Lung Macrophages.

McCubbrey AL, Allison KC, Lee-Sherick AB, Jakubzick CV, Janssen WJ.

Front Immunol. 2017 Nov 24;8:1618. doi: 10.3389/fimmu.2017.01618. eCollection 2017.

16.

Phagocytosis of microparticles by alveolar macrophages during acute lung injury requires MerTK.

Mohning MP, Thomas SM, Barthel L, Mould KJ, McCubbrey AL, Frasch SC, Bratton DL, Henson PM, Janssen WJ.

Am J Physiol Lung Cell Mol Physiol. 2018 Jan 1;314(1):L69-L82. doi: 10.1152/ajplung.00058.2017. Epub 2017 Sep 21.

17.

Neutrophil transfer of miR-223 to lung epithelial cells dampens acute lung injury in mice.

Neudecker V, Brodsky KS, Clambey ET, Schmidt EP, Packard TA, Davenport B, Standiford TJ, Weng T, Fletcher AA, Barthel L, Masterson JC, Furuta GT, Cai C, Blackburn MR, Ginde AA, Graner MW, Janssen WJ, Zemans RL, Evans CM, Burnham EL, Homann D, Moss M, Kreth S, Zacharowski K, Henson PM, Eltzschig HK.

Sci Transl Med. 2017 Sep 20;9(408). pii: eaah5360. doi: 10.1126/scitranslmed.aah5360.

18.

Deletion of c-FLIP from CD11bhi Macrophages Prevents Development of Bleomycin-induced Lung Fibrosis.

McCubbrey AL, Barthel L, Mohning MP, Redente EF, Mould KJ, Thomas SM, Leach SM, Danhorn T, Gibbings SL, Jakubzick CV, Henson PM, Janssen WJ.

Am J Respir Cell Mol Biol. 2018 Jan;58(1):66-78. doi: 10.1165/rcmb.2017-0154OC.

19.

TGF-β activation by bone marrow-derived thrombospondin-1 causes Schistosoma- and hypoxia-induced pulmonary hypertension.

Kumar R, Mickael C, Kassa B, Gebreab L, Robinson JC, Koyanagi DE, Sanders L, Barthel L, Meadows C, Fox D, Irwin D, Li M, McKeon BA, Riddle S, Dale Brown R, Morgan LE, Evans CM, Hernandez-Saavedra D, Bandeira A, Maloney JP, Bull TM, Janssen WJ, Stenmark KR, Tuder RM, Graham BB.

Nat Commun. 2017 May 30;8:15494. doi: 10.1038/ncomms15494.

20.

A Time- and Compartment-Specific Activation of Lung Macrophages in Hypoxic Pulmonary Hypertension.

Pugliese SC, Kumar S, Janssen WJ, Graham BB, Frid MG, Riddle SR, El Kasmi KC, Stenmark KR.

J Immunol. 2017 Jun 15;198(12):4802-4812. doi: 10.4049/jimmunol.1601692. Epub 2017 May 12.

21.

High resolution computed tomography pattern of usual interstitial pneumonia in rheumatoid arthritis-associated interstitial lung disease: Relationship to survival.

Yunt ZX, Chung JH, Hobbs S, Fernandez-Perez ER, Olson AL, Huie TJ, Keith RC, Janssen WJ, Goldstein BL, Lynch DA, Brown KK, Swigris JJ, Solomon JJ.

Respir Med. 2017 May;126:100-104. doi: 10.1016/j.rmed.2017.03.027. Epub 2017 Mar 30.

22.

Cell Origin Dictates Programming of Resident versus Recruited Macrophages during Acute Lung Injury.

Mould KJ, Barthel L, Mohning MP, Thomas SM, McCubbrey AL, Danhorn T, Leach SM, Fingerlin TE, O'Connor BP, Reisz JA, D'Alessandro A, Bratton DL, Jakubzick CV, Janssen WJ.

Am J Respir Cell Mol Biol. 2017 Sep;57(3):294-306. doi: 10.1165/rcmb.2017-0061OC.

23.

Three Unique Interstitial Macrophages in the Murine Lung at Steady State.

Gibbings SL, Thomas SM, Atif SM, McCubbrey AL, Desch AN, Danhorn T, Leach SM, Bratton DL, Henson PM, Janssen WJ, Jakubzick CV.

Am J Respir Cell Mol Biol. 2017 Jul;57(1):66-76. doi: 10.1165/rcmb.2016-0361OC.

24.

Power of Place: Intravascular Superoxide Dismutase for Prevention of Acute Respiratory Distress Syndrome.

Janssen WJ, Nozik-Grayck E.

Am J Respir Cell Mol Biol. 2017 Feb;56(2):147-149. doi: 10.1165/rcmb.2016-0407ED. No abstract available.

25.

IgG trough levels and progression of pulmonary disease in pediatric and adult common variable immunodeficiency disorder patients.

Janssen WJM, Mohamed Hoesein F, Van de Ven AAJM, Maarschalk J, van Royen F, de Jong PA, Sanders EAM, van Montfrans JM, Ellerbroek PM.

J Allergy Clin Immunol. 2017 Jul;140(1):303-306.e4. doi: 10.1016/j.jaci.2016.11.050. Epub 2017 Jan 23. No abstract available.

PMID:
28126376
26.

Dual RNA-seq reveals viral infections in asthmatic children without respiratory illness which are associated with changes in the airway transcriptome.

Wesolowska-Andersen A, Everman JL, Davidson R, Rios C, Herrin R, Eng C, Janssen WJ, Liu AH, Oh SS, Kumar R, Fingerlin TE, Rodriguez-Santana J, Burchard EG, Seibold MA.

Genome Biol. 2017 Jan 19;18(1):12. doi: 10.1186/s13059-016-1140-8. Erratum in: Genome Biol. 2018 Apr 10;19(1):49.

27.

CD73 regulates anti-inflammatory signaling between apoptotic cells and endotoxin-conditioned tissue macrophages.

Murphy PS, Wang J, Bhagwat SP, Munger JC, Janssen WJ, Wright TW, Elliott MR.

Cell Death Differ. 2017 Mar;24(3):559-570. doi: 10.1038/cdd.2016.159. Epub 2017 Jan 6.

28.

Scratching Below the Surface.

Mathai SK, Josephson SA, Badlam J, Saint S, Janssen WJ.

N Engl J Med. 2016 Dec 1;375(22):2188-2193. No abstract available.

PMID:
27959764
29.

Myeloid Cell Turnover and Clearance.

Janssen WJ, Bratton DL, Jakubzick CV, Henson PM.

Microbiol Spectr. 2016 Nov;4(6). doi: 10.1128/microbiolspec.MCHD-0005-2015. Review.

30.

Control of lung defence by mucins and macrophages: ancient defence mechanisms with modern functions.

Janssen WJ, Stefanski AL, Bochner BS, Evans CM.

Eur Respir J. 2016 Oct;48(4):1201-1214. doi: 10.1183/13993003.00120-2015. Epub 2016 Sep 1. Review.

31.

Selective and inducible targeting of CD11b+ mononuclear phagocytes in the murine lung with hCD68-rtTA transgenic systems.

McCubbrey AL, Barthel L, Mould KJ, Mohning MP, Redente EF, Janssen WJ.

Am J Physiol Lung Cell Mol Physiol. 2016 Jul 1;311(1):L87-L100. doi: 10.1152/ajplung.00141.2016. Epub 2016 May 17.

32.

Mucins and Their Sugars. Critical Mediators of Hyperreactivity and Inflammation.

Raclawska DS, Ttofali F, Fletcher AA, Harper DN, Bochner BS, Janssen WJ, Evans CM.

Ann Am Thorac Soc. 2016 Mar;13 Suppl 1:S98-9. doi: 10.1513/AnnalsATS.201511-743MG.

33.

Neonatal thymectomy reveals differentiation and plasticity within human naive T cells.

van den Broek T, Delemarre EM, Janssen WJ, Nievelstein RA, Broen JC, Tesselaar K, Borghans JA, Nieuwenhuis EE, Prakken BJ, Mokry M, Jansen NJ, van Wijk F.

J Clin Invest. 2016 Mar 1;126(3):1126-36. doi: 10.1172/JCI84997. Epub 2016 Feb 22.

34.

F-actin remodeling defects as revealed in primary immunodeficiency disorders.

Janssen WJ, Geluk HC, Boes M.

Clin Immunol. 2016 Mar;164:34-42. doi: 10.1016/j.clim.2016.01.009. Epub 2016 Jan 21. Review.

PMID:
26802313
35.

MicroRNA-34a Negatively Regulates Efferocytosis by Tissue Macrophages in Part via SIRT1.

McCubbrey AL, Nelson JD, Stolberg VR, Blakely PK, McCloskey L, Janssen WJ, Freeman CM, Curtis JL.

J Immunol. 2016 Feb 1;196(3):1366-75. doi: 10.4049/jimmunol.1401838. Epub 2015 Dec 30.

36.

Flow Cytometric Analysis of Mononuclear Phagocytes in Nondiseased Human Lung and Lung-Draining Lymph Nodes.

Desch AN, Gibbings SL, Goyal R, Kolde R, Bednarek J, Bruno T, Slansky JE, Jacobelli J, Mason R, Ito Y, Messier E, Randolph GJ, Prabagar M, Atif SM, Segura E, Xavier RJ, Bratton DL, Janssen WJ, Henson PM, Jakubzick CV.

Am J Respir Crit Care Med. 2016 Mar 15;193(6):614-26. doi: 10.1164/rccm.201507-1376OC.

37.

Antigen-specific IgA titres after 23-valent pneumococcal vaccine indicate transient antibody deficiency disease in children.

Janssen WJ, Nierkens S, Sanders EA, Boes M, van Montfrans JM.

Vaccine. 2015 Nov 17;33(46):6320-6. doi: 10.1016/j.vaccine.2015.09.041. Epub 2015 Sep 28.

PMID:
26413880
38.

The Causal Role of IL-4 and IL-13 in Schistosoma mansoni Pulmonary Hypertension.

Kumar R, Mickael C, Chabon J, Gebreab L, Rutebemberwa A, Garcia AR, Koyanagi DE, Sanders L, Gandjeva A, Kearns MT, Barthel L, Janssen WJ, Mauad T, Bandeira A, Schmidt E, Tuder RM, Graham BB.

Am J Respir Crit Care Med. 2015 Oct 15;192(8):998-1008. doi: 10.1164/rccm.201410-1820OC.

39.

Tracheal dysplasia precedes bronchial dysplasia in mouse model of N-nitroso trischloroethylurea induced squamous cell lung cancer.

Ghosh M, Dwyer-Nield LD, Kwon JB, Barthel L, Janssen WJ, Merrick DT, Keith RL.

PLoS One. 2015 Apr 10;10(4):e0122823. doi: 10.1371/journal.pone.0122823. eCollection 2015.

40.

Conceptual approaches to lung injury and repair.

Zemans RL, Henson PM, Henson JE, Janssen WJ.

Ann Am Thorac Soc. 2015 Mar;12 Suppl 1:S9-15. doi: 10.1513/AnnalsATS.201408-402MG. Review.

41.

Anchored to asthma.

Mohning MP, Janssen WJ, Groshong SD, Canham EM.

Ann Am Thorac Soc. 2015 Mar;12(3):448-50. doi: 10.1513/AnnalsATS.201410-456CC. No abstract available.

PMID:
25786151
42.

The polymeric mucin Muc5ac is required for allergic airway hyperreactivity.

Evans CM, Raclawska DS, Ttofali F, Liptzin DR, Fletcher AA, Harper DN, McGing MA, McElwee MM, Williams OW, Sanchez E, Roy MG, Kindrachuk KN, Wynn TA, Eltzschig HK, Blackburn MR, Tuvim MJ, Janssen WJ, Schwartz DA, Dickey BF.

Nat Commun. 2015 Feb 17;6:6281. doi: 10.1038/ncomms7281.

43.

Endogenous airway mucins carry glycans that bind Siglec-F and induce eosinophil apoptosis.

Kiwamoto T, Katoh T, Evans CM, Janssen WJ, Brummet ME, Hudson SA, Zhu Z, Tiemeyer M, Bochner BS.

J Allergy Clin Immunol. 2015 May;135(5):1329-1340.e9. doi: 10.1016/j.jaci.2014.10.027. Epub 2014 Dec 12.

44.

General parity between trio and pairwise breeding of laboratory mice in static caging.

Kedl RM, Wysocki LJ, Janssen WJ, Born WK, Rosenbaum MD, Granowski J, Kench JA, Fong DL, Switzer LA, Cruse M, Huang H, Jakubzick CV, Kosmider B, Takeda K, Stranova TJ, Klumm RC, Delgado C, Tummala S, De Langhe S, Cambier J, Haskins K, Lenz LL, Curran-Everett D.

J Immunol. 2014 Nov 15;193(10):4757-60. doi: 10.4049/jimmunol.1402306.

45.

A novel FcγRIIa Q27W gene variant is associated with common variable immune deficiency through defective FcγRIIa downstream signaling.

Flinsenberg TW, Janssen WJ, Herczenik E, Boross P, Nederend M, Jongeneel LH, Scholman RC, Boelens JJ, Maas C, van Gijn ME, van Montfrans JM, Leusen JH, Boes M.

Clin Immunol. 2014 Nov;155(1):108-17. doi: 10.1016/j.clim.2014.09.006. Epub 2014 Sep 19.

PMID:
25242138
46.

Kinetics of the angiogenic response in lung endothelium following acute inflammatory injury with bleomycin.

Yunt ZX, Mohning MP, Barthel L, Kearns MT, Tuder RM, Hyde DM, Henson PM, Janssen WJ.

Exp Lung Res. 2014 Oct;40(8):415-25. doi: 10.3109/01902148.2014.938202. Epub 2014 Aug 25.

47.

Dendritic cell subsets require cis-activation for cytotoxic CD8 T-cell induction.

Desch AN, Gibbings SL, Clambey ET, Janssen WJ, Slansky JE, Kedl RM, Henson PM, Jakubzick C.

Nat Commun. 2014 Aug 19;5:4674. doi: 10.1038/ncomms5674.

48.

Increased prevalence of gastrointestinal viruses and diminished secretory immunoglobulin a levels in antibody deficiencies.

van de Ven AA, Janssen WJ, Schulz LS, van Loon AM, Voorkamp K, Sanders EA, Kusters JG, Nierkens S, Boes M, Wensing AM, van Montfrans JM.

J Clin Immunol. 2014 Nov;34(8):962-70. doi: 10.1007/s10875-014-0087-3. Epub 2014 Aug 19.

PMID:
25135597
49.

Fas ligand-expressing lymphocytes enhance alveolar macrophage apoptosis in the resolution of acute pulmonary inflammation.

Kearns MT, Barthel L, Bednarek JM, Yunt ZX, Henson PM, Janssen WJ.

Am J Physiol Lung Cell Mol Physiol. 2014 Jul 1;307(1):L62-70. doi: 10.1152/ajplung.00273.2013. Epub 2014 May 16.

50.

Protein tyrosine phosphatase α mediates profibrotic signaling in lung fibroblasts through TGF-β responsiveness.

Aschner Y, Khalifah AP, Briones N, Yamashita C, Dolgonos L, Young SK, Campbell MN, Riches DW, Redente EF, Janssen WJ, Henson PM, Sap J, Vacaresse N, Kapus A, McCulloch CA, Zemans RL, Downey GP.

Am J Pathol. 2014 May;184(5):1489-502. doi: 10.1016/j.ajpath.2014.01.016. Epub 2014 Mar 17.

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