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Items: 1 to 50 of 208

1.

Assessment of temporal functional changes and miRNA profiling of human iPSC-derived cardiomyocytes.

Kumar N, Dougherty JA, Manring HR, Elmadbouh I, Mergaye M, Czirok A, Greta Isai D, Belevych AE, Yu L, Janssen PML, Fadda P, Gyorke S, Ackermann MA, Angelos MG, Khan M.

Sci Rep. 2019 Sep 12;9(1):13188. doi: 10.1038/s41598-019-49653-5.

2.

Impact of heart rate on cross-bridge cycling kinetics in failing and non-failing human myocardium.

Chung JH, Milani-Nejad N, Davis JP, Weisleder N, Whitson BA, Mohler PJ, Janssen PML.

Am J Physiol Heart Circ Physiol. 2019 Jul 26. doi: 10.1152/ajpheart.00163.2019. [Epub ahead of print]

PMID:
31347914
3.

Ankyrin-B dysfunction predisposes to arrhythmogenic cardiomyopathy and is amenable to therapy.

Roberts JD, Murphy NP, Hamilton RM, Lubbers ER, James CA, Kline CF, Gollob MH, Krahn AD, Sturm AC, Musa H, El-Refaey M, Koenig S, Aneq MÅ, Hoorntje ET, Graw SL, Davies RW, Rafiq MA, Koopmann TT, Aafaqi S, Fatah M, Chiasson DA, Taylor MR, Simmons SL, Han M, van Opbergen CJ, Wold LE, Sinagra G, Mittal K, Tichnell C, Murray B, Codima A, Nazer B, Nguyen DT, Marcus FI, Sobriera N, Lodder EM, van den Berg MP, Spears DA, Robinson JF, Ursell PC, Green AK, Skanes AC, Tang AS, Gardner MJ, Hegele RA, van Veen TA, Wilde AA, Healey JS, Janssen PM, Mestroni L, van Tintelen JP, Calkins H, Judge DP, Hund TJ, Scheinman MM, Mohler PJ.

J Clin Invest. 2019 Jul 2;129(8):3171-3184. doi: 10.1172/JCI125538. eCollection 2019 Jul 2.

4.

Patient mutations linked to arrhythmogenic cardiomyopathy enhance calpain-mediated desmoplakin degradation.

Ng R, Manring H, Papoutsidakis N, Albertelli T, Tsai N, See CJ, Li X, Park J, Stevens TL, Bobbili PJ, Riaz M, Ren Y, Stoddard CE, Janssen PM, Bunch TJ, Hall SP, Lo YC, Jacoby DL, Qyang Y, Wright N, Ackermann MA, Campbell SG.

JCI Insight. 2019 Jun 13;5. pii: 128643. doi: 10.1172/jci.insight.128643.

5.

Defining new mechanistic roles for αII spectrin in cardiac function.

Lubbers ER, Murphy NP, Musa H, Huang CY, Gupta R, Price MV, Han M, Daoud G, Gratz D, El Refaey M, Xu X, Hoeflinger NK, Friel EL, Lancione P, Wallace MJ, Cavus O, Simmons SL, Williams JL, Skaf M, Koenig SN, Janssen PML, Rasband MN, Hund TJ, Mohler PJ.

J Biol Chem. 2019 Jun 14;294(24):9576-9591. doi: 10.1074/jbc.RA119.007714. Epub 2019 May 7.

PMID:
31064843
6.

Ablation of the calpain-targeted site in cardiac myosin binding protein-C is cardioprotective during ischemia-reperfusion injury.

Barefield DY, McNamara JW, Lynch TL, Kuster DWD, Govindan S, Haar L, Wang Y, Taylor EN, Lorenz JN, Nieman ML, Zhu G, Luther PK, Varró A, Dobrev D, Ai X, Janssen PML, Kass DA, Jones WK, Gilbert RJ, Sadayappan S.

J Mol Cell Cardiol. 2019 Apr;129:236-246. doi: 10.1016/j.yjmcc.2019.03.006. Epub 2019 Mar 9.

7.

Modeling heart failure in animal models for novel drug discovery and development.

Janssen PML, Elnakish MT.

Expert Opin Drug Discov. 2019 Apr;14(4):355-363. doi: 10.1080/17460441.2019.1582636. Epub 2019 Mar 12.

PMID:
30861352
8.

Stretching Single Titin Molecules from Failing Human Hearts Reveals Titin's Role in Blunting Cardiac Kinetic Reserve.

Chen MP, Kiduko SA, Saad NS, Canan BD, Kilic A, Mohler PJ, Janssen PML.

Cardiovasc Res. 2019 Feb 18. pii: cvz043. doi: 10.1093/cvr/cvz043. [Epub ahead of print]

PMID:
30778519
9.

Effect of Workflow Improvements in Endovascular Stroke Treatment.

Janssen PM, Venema E, Dippel DWJ.

Stroke. 2019 Mar;50(3):665-674. doi: 10.1161/STROKEAHA.118.021633.

PMID:
30776995
10.

Mineralocorticoid receptor antagonists improve membrane integrity independent of muscle force in muscular dystrophy.

Hauck JS, Lowe J, Rastogi N, McElhanon KE, Petrosino JM, Peczkowski KK, Chadwick AN, Zins JG, Accornero F, Janssen PML, Weisleder NL, Rafael-Fortney JA.

Hum Mol Genet. 2019 Jun 15;28(12):2030-2045. doi: 10.1093/hmg/ddz039.

PMID:
30759207
11.

MG 53 Protein Protects Aortic Valve Interstitial Cells From Membrane Injury and Fibrocalcific Remodeling.

Adesanya TMA, Russell M, Park KH, Zhou X, Sermersheim MA, Gumpper K, Koenig SN, Tan T, Whitson BA, Janssen PML, Lincoln J, Zhu H, Ma J.

J Am Heart Assoc. 2019 Feb 19;8(4):e009960. doi: 10.1161/JAHA.118.009960.

12.

Protein Kinase A as a Promising Target for Heart Failure Drug Development.

Saad NS, Elnakish MT, Ahmed AAE, Janssen PML.

Arch Med Res. 2018 Nov;49(8):530-537. doi: 10.1016/j.arcmed.2018.12.008. Epub 2019 Jan 11. Review.

PMID:
30642654
13.

Human Atrial Fibrillation Drivers Resolved With Integrated Functional and Structural Imaging to Benefit Clinical Mapping.

Hansen BJ, Zhao J, Li N, Zolotarev A, Zakharkin S, Wang Y, Atwal J, Kalyanasundaram A, Abudulwahed SH, Helfrich KM, Bratasz A, Powell KA, Whitson B, Mohler PJ, Janssen PML, Simonetti OP, Hummel JD, Fedorov VV.

JACC Clin Electrophysiol. 2018 Dec;4(12):1501-1515. doi: 10.1016/j.jacep.2018.08.024. Epub 2018 Nov 1.

PMID:
30573112
14.

Novel Mechanistic Roles for Ankyrin-G in Cardiac Remodeling and Heart Failure.

Makara MA, Curran J, Lubbers ER, Murphy NP, Little SC, Musa H, Smith SA, Unudurthi SD, Rajaram MVS, Janssen PML, Boyden PA, Bradley EA, Hund TJ, Mohler PJ.

JACC Basic Transl Sci. 2018 Nov 12;3(5):675-689. doi: 10.1016/j.jacbts.2018.07.008. eCollection 2018 Oct.

15.

Myocardial relaxation in human heart failure: Why sarcomere kinetics should be center-stage.

Janssen PML.

Arch Biochem Biophys. 2019 Jan;661:145-148. doi: 10.1016/j.abb.2018.11.011. Epub 2018 Nov 14. Review.

PMID:
30447209
16.

Assessment of PKA and PKC inhibitors on force and kinetics of non-failing and failing human myocardium.

Saad NS, Elnakish MT, Brundage EA, Biesiadecki BJ, Kilic A, Ahmed AAE, Mohler PJ, Janssen PML.

Life Sci. 2018 Dec 15;215:119-127. doi: 10.1016/j.lfs.2018.10.065. Epub 2018 Nov 3.

PMID:
30399377
17.

Memantine, an NMDA receptor antagonist, attenuates cardiac remodeling, lipid peroxidation and neutrophil recruitment in heart failure: A cardioprotective agent?

Abbaszadeh S, Javidmehr A, Askari B, Janssen PML, Soraya H.

Biomed Pharmacother. 2018 Dec;108:1237-1243. doi: 10.1016/j.biopha.2018.09.153. Epub 2018 Oct 2.

18.

Impaired adhesion of induced pluripotent stem cell-derived cardiac progenitor cells (iPSC-CPCs) to isolated extracellular matrix from failing hearts.

McKown EN, DeAguero JL, Canan BD, Kilic A, Zhu Y, Janssen PML, Delfín DA.

Heliyon. 2018 Oct 18;4(10):e00870. doi: 10.1016/j.heliyon.2018.e00870. eCollection 2018 Oct.

19.

Force-frequency relationship and early relaxation kinetics are preserved upon sarcoplasmic blockade in human myocardium.

Chung JH, Canan BD, Whitson BA, Kilic A, Janssen PML.

Physiol Rep. 2018 Oct;6(20):e13898. doi: 10.14814/phy2.13898.

20.

NF-κB inhibition rescues cardiac function by remodeling calcium genes in a Duchenne muscular dystrophy model.

Peterson JM, Wang DJ, Shettigar V, Roof SR, Canan BD, Bakkar N, Shintaku J, Gu JM, Little SC, Ratnam NM, Londhe P, Lu L, Gaw CE, Petrosino JM, Liyanarachchi S, Wang H, Janssen PML, Davis JP, Ziolo MT, Sharma SM, Guttridge DC.

Nat Commun. 2018 Aug 24;9(1):3431. doi: 10.1038/s41467-018-05910-1.

21.

Synchronization of Intracellular Ca2+ Release in Multicellular Cardiac Preparations.

Slabaugh JL, Brunello L, Elnakish MT, Milani-Nejad N, Gyorke S, Janssen PML.

Front Physiol. 2018 Jul 20;9:968. doi: 10.3389/fphys.2018.00968. eCollection 2018.

22.

Force-Dependent Recruitment from the Myosin Off State Contributes to Length-Dependent Activation.

Campbell KS, Janssen PML, Campbell SG.

Biophys J. 2018 Aug 7;115(3):543-553. doi: 10.1016/j.bpj.2018.07.006. Epub 2018 Jul 11.

23.

Mineralocorticoid Receptor Antagonists in Muscular Dystrophy Mice During Aging and Exercise.

Lowe J, Kadakia FK, Zins JG, Haupt M, Peczkowski KK, Rastogi N, Floyd KT, Gomez-Sanchez EP, Gomez-Sanchez CE, Elnakish MT, Rafael-Fortney JA, Janssen PML.

J Neuromuscul Dis. 2018;5(3):295-306. doi: 10.3233/JND-180323.

24.

Etiology-dependent impairment of relaxation kinetics in right ventricular end-stage failing human myocardium.

Chung JH, Martin BL, Canan BD, Elnakish MT, Milani-Nejad N, Saad NS, Repas SJ, Schultz JEJ, Murray JD, Slabaugh JL, Gearinger RL, Conkle J, Karaze T, Rastogi N, Chen MP, Crecelius W, Peczkowski KK, Ziolo MT, Fedorov VV, Kilic A, Whitson BA, Higgins RSD, Smith SA, Mohler PJ, Binkley PF, Janssen PML.

J Mol Cell Cardiol. 2018 Aug;121:81-93. doi: 10.1016/j.yjmcc.2018.07.005. Epub 2018 Jul 5.

25.

Human Myocardium Has a Robust α1A-Subtype Adrenergic Receptor Inotropic Response.

Janssen PML, Canan BD, Kilic A, Whitson BA, Baker AJ.

J Cardiovasc Pharmacol. 2018 Sep;72(3):136-142. doi: 10.1097/FJC.0000000000000604.

26.

Common Coding Variants in SCN10A Are Associated With the Nav1.8 Late Current and Cardiac Conduction.

Macri V, Brody JA, Arking DE, Hucker WJ, Yin X, Lin H, Mills RW, Sinner MF, Lubitz SA, Liu CT, Morrison AC, Alonso A, Li N, Fedorov VV, Janssen PM, Bis JC, Heckbert SR, Dolmatova EV, Lumley T, Sitlani CM, Cupples LA, Pulit SL, Newton-Cheh C, Barnard J, Smith JD, Van Wagoner DR, Chung MK, Vlahakes GJ, O'Donnell CJ, Rotter JI, Margulies KB, Morley MP, Cappola TP, Benjamin EJ, Muzny D, Gibbs RA, Jackson RD, Magnani JW, Herndon CN, Rich SS, Psaty BM, Milan DJ, Boerwinkle E, Mohler PJ, Sotoodehnia N, Ellinor PT.

Circ Genom Precis Med. 2018 May;11(5):e001663. doi: 10.1161/CIRCGEN.116.001663.

27.

Altered regulation of cardiac ankyrin repeat protein in heart failure.

Kempton A, Cefalu M, Justice C, Baich T, Derbala M, Canan B, Janssen PML, Mohler PJ, Smith SA.

Heliyon. 2018 Feb 1;4(1):e00514. doi: 10.1016/j.heliyon.2018.e00514. eCollection 2018 Jan.

28.

Defining the molecular signatures of human right heart failure.

Williams JL, Cavus O, Loccoh EC, Adelman S, Daugherty JC, Smith SA, Canan B, Janssen PML, Koenig S, Kline CF, Mohler PJ, Bradley EA.

Life Sci. 2018 Mar 1;196:118-126. doi: 10.1016/j.lfs.2018.01.021. Epub 2018 Jan 31.

29.

Length-Dependent Prolongation of Force Relaxation Is Unaltered by Delay of Intracellular Calcium Decline in Early-Stage Rabbit Right Ventricular Hypertrophy.

Monasky MM, Torres CAA, Janssen PML.

Front Physiol. 2017 Dec 4;8:945. doi: 10.3389/fphys.2017.00945. eCollection 2017.

30.

Increased cross-bridge recruitment contributes to transient increase in force generation beyond maximal capacity in human myocardium.

Milani-Nejad N, Chung JH, Canan BD, Fedorov VV, Whitson BA, Kilic A, Mohler PJ, Janssen PML.

J Mol Cell Cardiol. 2018 Jan;114:116-123. doi: 10.1016/j.yjmcc.2017.11.007. Epub 2017 Nov 12.

31.

Memantine, an NMDA Receptor Antagonist, Prevents Thyroxin-induced Hypertension, but Not Cardiac Remodeling.

Repas SJ, Saad NS, Janssen PML, Elnakish MT.

J Cardiovasc Pharmacol. 2017 Nov;70(5):305-313. doi: 10.1097/FJC.0000000000000521.

PMID:
29112047
32.

Notch1 haploinsufficiency causes ascending aortic aneurysms in mice.

Koenig SN, LaHaye S, Feller JD, Rowland P, Hor KN, Trask AJ, Janssen PM, Radtke F, Lilly B, Garg V.

JCI Insight. 2017 Nov 2;2(21). pii: 91353. doi: 10.1172/jci.insight.91353.

33.

TGF-β1 affects cell-cell adhesion in the heart in an NCAM1-dependent mechanism.

Ackermann MA, Petrosino JM, Manring HR, Wright P, Shettigar V, Kilic A, Janssen PML, Ziolo MT, Accornero F.

J Mol Cell Cardiol. 2017 Nov;112:49-57. doi: 10.1016/j.yjmcc.2017.08.015. Epub 2017 Sep 1.

34.

Three-dimensional Integrated Functional, Structural, and Computational Mapping to Define the Structural "Fingerprints" of Heart-Specific Atrial Fibrillation Drivers in Human Heart Ex Vivo.

Zhao J, Hansen BJ, Wang Y, Csepe TA, Sul LV, Tang A, Yuan Y, Li N, Bratasz A, Powell KA, Kilic A, Mohler PJ, Janssen PML, Weiss R, Simonetti OP, Hummel JD, Fedorov VV.

J Am Heart Assoc. 2017 Aug 22;6(8). pii: e005922. doi: 10.1161/JAHA.117.005922.

35.

Recovery following Thyroxine Treatment Withdrawal, but Not Propylthiouracil, Averts In Vivo and Ex Vivo Thyroxine-Provoked Cardiac Complications in Adult FVB/N Mice.

Saad NS, Repas SJ, Floyd K, Janssen PML, Elnakish MT.

Biomed Res Int. 2017;2017:6071031. doi: 10.1155/2017/6071031. Epub 2017 Jul 16.

36.

In Vivo Genome Editing Restores Dystrophin Expression and Cardiac Function in Dystrophic Mice.

El Refaey M, Xu L, Gao Y, Canan BD, Adesanya TMA, Warner SC, Akagi K, Symer DE, Mohler PJ, Ma J, Janssen PML, Han R.

Circ Res. 2017 Sep 29;121(8):923-929. doi: 10.1161/CIRCRESAHA.117.310996. Epub 2017 Aug 8.

37.

Redundant and diverse intranodal pacemakers and conduction pathways protect the human sinoatrial node from failure.

Li N, Hansen BJ, Csepe TA, Zhao J, Ignozzi AJ, Sul LV, Zakharkin SO, Kalyanasundaram A, Davis JP, Biesiadecki BJ, Kilic A, Janssen PML, Mohler PJ, Weiss R, Hummel JD, Fedorov VV.

Sci Transl Med. 2017 Jul 26;9(400). pii: eaam5607. doi: 10.1126/scitranslmed.aam5607.

38.

Deletion of Pofut1 in Mouse Skeletal Myofibers Induces Muscle Aging-Related Phenotypes in cis and in trans.

Zygmunt DA, Singhal N, Kim ML, Cramer ML, Crowe KE, Xu R, Jia Y, Adair J, Martinez-Pena Y Valenzuela I, Akaaboune M, White P, Janssen PM, Martin PT.

Mol Cell Biol. 2017 May 2;37(10). pii: e00426-16. doi: 10.1128/MCB.00426-16. Print 2017 May 15.

39.

Novel application of 3D contrast-enhanced CMR to define fibrotic structure of the human sinoatrial node in vivo.

Csepe TA, Zhao J, Sul LV, Wang Y, Hansen BJ, Li N, Ignozzi AJ, Bratasz A, Powell KA, Kilic A, Mohler PJ, Janssen PML, Hummel JD, Simonetti OP, Fedorov VV.

Eur Heart J Cardiovasc Imaging. 2017 May 1;18(8):862-869. doi: 10.1093/ehjci/jew304.

40.

Myofilament Calcium Sensitivity: Consequences of the Effective Concentration of Troponin I.

Siddiqui JK, Tikunova SB, Walton SD, Liu B, Meyer M, de Tombe PP, Neilson N, Kekenes-Huskey PM, Salhi HE, Janssen PM, Biesiadecki BJ, Davis JP.

Front Physiol. 2016 Dec 21;7:632. doi: 10.3389/fphys.2016.00632. eCollection 2016.

41.

Myofilament Calcium Sensitivity: Mechanistic Insight into TnI Ser-23/24 and Ser-150 Phosphorylation Integration.

Salhi HE, Hassel NC, Siddiqui JK, Brundage EA, Ziolo MT, Janssen PM, Davis JP, Biesiadecki BJ.

Front Physiol. 2016 Dec 15;7:567. doi: 10.3389/fphys.2016.00567. eCollection 2016.

42.

Myofilament Calcium Sensitivity: Role in Regulation of In vivo Cardiac Contraction and Relaxation.

Chung JH, Biesiadecki BJ, Ziolo MT, Davis JP, Janssen PM.

Front Physiol. 2016 Dec 16;7:562. doi: 10.3389/fphys.2016.00562. eCollection 2016. Review.

43.

Myocardial Contractile Dysfunction Is Present without Histopathology in a Mouse Model of Limb-Girdle Muscular Dystrophy-2F and Is Prevented after Claudin-5 Virotherapy.

Milani-Nejad N, Schultz EJ, Slabaugh JL, Janssen PM, Rafael-Fortney JA.

Front Physiol. 2016 Dec 6;7:539. doi: 10.3389/fphys.2016.00539. eCollection 2016.

44.

Effects of zacopride, a moderate IK1 channel agonist, on triggered arrhythmia and contractility in human ventricular myocardium.

Elnakish MT, Canan BD, Kilic A, Mohler PJ, Janssen PM.

Pharmacol Res. 2017 Jan;115:309-318. doi: 10.1016/j.phrs.2016.11.033. Epub 2016 Nov 30.

45.

Altered protein levels in the isolated extracellular matrix of failing human hearts with dilated cardiomyopathy.

DeAguero JL, McKown EN, Zhang L, Keirsey J, Fischer EG, Samedi VG, Canan BD, Kilic A, Janssen PM, Delfín DA.

Cardiovasc Pathol. 2017 Jan - Feb;26:12-20. doi: 10.1016/j.carpath.2016.10.001. Epub 2016 Oct 15.

46.

Similar efficacy from specific and non-specific mineralocorticoid receptor antagonist treatment of muscular dystrophy mice.

Lowe J, Floyd KT, Rastogi N, Schultz EJ, Chadwick JA, Swager SA, Zins JG, Kadakia FK, Smart S, Gomez-Sanchez EP, Gomez-Sanchez CE, Raman SV, Janssen PM, Rafael-Fortney JA.

J Neuromuscul Dis. 2016;3(3):395-404.

47.

Adenosine-Induced Atrial Fibrillation: Localized Reentrant Drivers in Lateral Right Atria due to Heterogeneous Expression of Adenosine A1 Receptors and GIRK4 Subunits in the Human Heart.

Li N, Csepe TA, Hansen BJ, Sul LV, Kalyanasundaram A, Zakharkin SO, Zhao J, Guha A, Van Wagoner DR, Kilic A, Mohler PJ, Janssen PM, Biesiadecki BJ, Hummel JD, Weiss R, Fedorov VV.

Circulation. 2016 Aug 9;134(6):486-98. doi: 10.1161/CIRCULATIONAHA.115.021165. Epub 2016 Jul 26.

48.

The Need for Speed: Mice, Men, and Myocardial Kinetic Reserve.

Janssen PM, Biesiadecki BJ, Ziolo MT, Davis JP.

Circ Res. 2016 Jul 22;119(3):418-21. doi: 10.1161/CIRCRESAHA.116.309126. Review. No abstract available.

49.

Dysfunction of the β2-spectrin-based pathway in human heart failure.

Smith SA, Hughes LD, Kline CF, Kempton AN, Dorn LE, Curran J, Makara M, Webb TR, Wright P, Voigt N, Binkley PF, Janssen PM, Kilic A, Carnes CA, Dobrev D, Rasband MN, Hund TJ, Mohler PJ.

Am J Physiol Heart Circ Physiol. 2016 Jun 1;310(11):H1583-91. doi: 10.1152/ajpheart.00875.2015. Epub 2016 Apr 22.

50.

Influence of metabolic dysfunction on cardiac mechanics in decompensated hypertrophy and heart failure.

Tewari SG, Bugenhagen SM, Vinnakota KC, Rice JJ, Janssen PML, Beard DA.

J Mol Cell Cardiol. 2016 May;94:162-175. doi: 10.1016/j.yjmcc.2016.04.003. Epub 2016 Apr 13.

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