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Fibrosis stage is an independent predictor of outcome in primary biliary cholangitis despite biochemical treatment response.

Murillo Perez CF, Hirschfield GM, Corpechot C, Floreani A, Mayo MJ, van der Meer A, Ponsioen CY, Lammers WJ, Parés A, Invernizzi P, Carbone M, Maria Battezzati P, Nevens F, Kowdley KV, Thorburn D, Mason AL, Trivedi PJ, Lindor KD, Bruns T, Dalekos GN, Gatselis NK, Verhelst X, Janssen HLA, Hansen BE, Gulamhusein A; GLOBAL PBC Study Group.

Aliment Pharmacol Ther. 2019 Oct 17. doi: 10.1111/apt.15533. [Epub ahead of print]


Management of insomnia in sleep disordered breathing.

Janssen HCJP, Venekamp LN, Peeters GAM, Pijpers A, Pevernagie DAA.

Eur Respir Rev. 2019 Oct 9;28(153). pii: 190080. doi: 10.1183/16000617.0080-2019. Print 2019 Sep 30. Review.


Letter to the Editor: Reply (HEP-19-1537 and 19-1551).

Choi HSJ, Brouwer WP, Hansen BE, Janssen HLA, Patel K.

Hepatology. 2019 Oct 8. doi: 10.1002/hep.30980. [Epub ahead of print]


Remote vitals monitoring in rodents using video recordings.

Kunczik J, Barbosa Pereira C, Zieglowski L, Tolba R, Wassermann L, Häger C, Bleich A, Janssen H, Thum T, Czaplik M.

Biomed Opt Express. 2019 Aug 5;10(9):4422-4436. doi: 10.1364/BOE.10.004422. eCollection 2019 Sep 1.


A new species of Lycodon Boie, 1826 (Serpentes, Colubridae) from northern Vietnam.

Janssen HY, Pham CT, Ngo HT, Le MD, Nguyen TQ, Ziegler T.

Zookeys. 2019 Sep 10;875:1-29. doi: 10.3897/zookeys.875.35933. eCollection 2019.


CAPS1 Suppresses Tumorigenesis in Cholangiocarcinoma.

Weng S, Janssen HLA, Zhang N, Tang W, Bai E, Yang B, Dong L.

Dig Dis Sci. 2019 Sep 27. doi: 10.1007/s10620-019-05843-9. [Epub ahead of print]


Frontline Science: Low regulatory T cells predict perioperative major adverse cardiovascular and cerebrovascular events after noncardiac surgery.

Scholz AS, Handke J, Gillmann HJ, Zhang Q, Dehne S, Janssen H, Arens C, Espeter F, Sander A, Giannitsis E, Uhle F, Weigand MA, Motsch J, Larmann J.

J Leukoc Biol. 2019 Sep 15. doi: 10.1002/JLB.5HI1018-392RR. [Epub ahead of print]


Hepatitis C Core-Antigen Testing from Dried Blood Spots.

Biondi MJ, van Tilborg M, Smookler D, Heymann G, Aquino A, Perusini S, Mandel E, Kozak RA, Cherepanov V, Kowgier M, Hansen B, Goneau LW, Janssen HLA, Mazzulli T, Cloherty G, de Knegt RJ, Feld JJ.

Viruses. 2019 Sep 6;11(9). pii: E830. doi: 10.3390/v11090830.


Comprehensive analysis of long non‑coding RNA‑messenger RNA‑microRNA co‑expression network identifies cell cycle‑related lncRNA in hepatocellular carcinoma.

Zhu HR, Yu XN, Zhang GC, Shi X, Bilegsaikhan E, Guo HY, Liu LL, Cai Y, Song GQ, Liu TT, Dong L, Janssen HLA, Weng SQ, Wu J, Shen XZ, Zhu JM.

Int J Mol Med. 2019 Aug 23. doi: 10.3892/ijmm.2019.4323. [Epub ahead of print]


Integrated impedance bridge for absolute capacitance measurements at cryogenic temperatures and finite magnetic fields.

Verbiest GJ, Janssen H, Xu D, Ge X, Goldsche M, Sonntag J, Khodkov T, Banszerus L, von den Driesch N, Buca D, Watanabe K, Taniguchi T, Stampfer C.

Rev Sci Instrum. 2019 Aug;90(8):084706. doi: 10.1063/1.5089207.


Limited sustained response after stopping nucleos(t)ide analogues in patients with chronic hepatitis B: results from a randomised controlled trial (Toronto STOP study).

Liem KS, Fung S, Wong DK, Yim C, Noureldin S, Chen J, Feld JJ, Hansen BE, Janssen HLA.

Gut. 2019 Aug 28. pii: gutjnl-2019-318981. doi: 10.1136/gutjnl-2019-318981. [Epub ahead of print]


Antiviral treatment for treatment-naïve chronic hepatitis B: systematic review and network meta-analysis of randomized controlled trials.

Wong WWL, Pechivanoglou P, Wong J, Bielecki JM, Haines A, Erman A, Saeed Y, Phoon A, Tadrous M, Younis M, Rayad NZ, Rac V, Janssen HLA, Krahn MD.

Syst Rev. 2019 Aug 19;8(1):207. doi: 10.1186/s13643-019-1126-1.


Factors Associated With Progression and Outcomes of Early Stage Primary Biliary Cholangitis.

Gatselis NK, Goet JC, Zachou K, Lammers WJ, Janssen HLA, Hirschfield G, Corpechot C, Lindor KD, Invernizzi P, Mayo MJ, Battezzati PM, Floreani A, Pares A, Lygoura V, Nevens F, Mason AL, Kowdley KV, Ponsioen CY, Bruns T, Thorburn D, Verhelst X, Harms MH, van Buuren HR, Hansen BE, Dalekos GN; Global Primary Biliary Cholangitis Study Group.

Clin Gastroenterol Hepatol. 2019 Aug 13. pii: S1542-3565(19)30888-2. doi: 10.1016/j.cgh.2019.08.013. [Epub ahead of print]


Idiopathic Noncirrhotic Portal Hypertension.

Janssen HLA.

Gastroenterol Hepatol (N Y). 2019 Jul;15(7):393-395. No abstract available.


Distinguishing drug isomers in the forensic laboratory: GC-VUV in addition to GC-MS for orthogonal selectivity and the use of library match scores as a new source of information.

Kranenburg RF, García-Cicourel AR, Kukurin C, Janssen HG, Schoenmakers PJ, van Asten AC.

Forensic Sci Int. 2019 Jul 26;302:109900. doi: 10.1016/j.forsciint.2019.109900. [Epub ahead of print]


Comprehensive off-line silver phase liquid chromatography × gas chromatography with flame ionization and vacuum ultraviolet detection for the detailed characterization of mineral oil aromatic hydrocarbons.

García-Cicourel AR, van de Velde B, Verduin J, Janssen HG.

J Chromatogr A. 2019 Jul 23:460391. doi: 10.1016/j.chroma.2019.460391. [Epub ahead of print]


Caucasian Ethnicity, but Not Treatment Cessation is Associated with HBsAg Loss Following Nucleos(t)ide Analogue-Induced HBeAg Seroconversion.

Van Hees S, Chi H, Hansen B, Bourgeois S, Van Vlierberghe H, Sersté T, Francque S, Wong D, Sprengers D, Moreno C, Nevens F, Janssen H, Vanwolleghem T.

Viruses. 2019 Jul 26;11(8). pii: E687. doi: 10.3390/v11080687.


Patient readiness for risk-reduction education and lifestyle change following transient ischemic attack.

Geldens N, Crowfoot G, Sweetapple A, Vyslysel G, Mason G, English C, Janssen H.

Disabil Rehabil. 2019 Jul 25:1-6. doi: 10.1080/09638288.2019.1626918. [Epub ahead of print]


The Potential of Cannabidiol as a Treatment for Psychosis and Addiction: Who Benefits Most? A Systematic Review.

Batalla A, Janssen H, Gangadin SS, Bossong MG.

J Clin Med. 2019 Jul 19;8(7). pii: E1058. doi: 10.3390/jcm8071058. Review.


Nonalcoholic Steatohepatitis Is Associated With Liver-Related Outcomes and All-Cause Mortality in Chronic Hepatitis B.

Choi HSJ, Brouwer WP, Zanjir WMR, de Man RA, Feld JJ, Hansen BE, Janssen HLA, Patel K.

Hepatology. 2019 Jul 15. doi: 10.1002/hep.30857. [Epub ahead of print]


Acute thromboses and occlusions of dual layer carotid stents in endovascular treatment of tandem occlusions.

Pfaff JAR, Maurer C, Broussalis E, Janssen H, Blanc R, Dargazanli C, Costalat V, Piotin M, Runck F, Berlis A, Killer-Oberpfalzer M, Hensler JT, Bendszus M, Wodarg F, Möhlenbruch MA.

J Neurointerv Surg. 2019 Jul 15. pii: neurintsurg-2019-015032. doi: 10.1136/neurintsurg-2019-015032. [Epub ahead of print]


New-generation positional therapy in patients with positional central sleep apnea.

Benoist LBL, Vonk PE, de Vries N, Janssen HCJP, Verbraecken J.

Eur Arch Otorhinolaryngol. 2019 Sep;276(9):2611-2619. doi: 10.1007/s00405-019-05545-y. Epub 2019 Jul 13.


Methods for one- and two-dimensional gas chromatography with flame ionization detection for identification of Mycobacterium tuberculosis in sputum.

Arslan FN, Kolk A, Janssen HG.

J Chromatogr B Analyt Technol Biomed Life Sci. 2019 Aug 15;1124:204-217. doi: 10.1016/j.jchromb.2019.06.012. Epub 2019 Jun 8.


Immunocrit, serum amino acid concentrations and growth performance in light and heavy piglets depending on sow's farrowing system.

Schnier S, Middendorf L, Janssen H, Brüning C, Rohn K, Visscher C.

Porcine Health Manag. 2019 Jun 14;5:14. doi: 10.1186/s40813-019-0121-1. eCollection 2019.



Brahmania M, Janssen HLA.

Clin Gastroenterol Hepatol. 2019 Jun 17. pii: S1542-3565(19)30657-3. doi: 10.1016/j.cgh.2019.06.019. [Epub ahead of print] No abstract available.


[Perioperative cardiovasular morbidity and mortality in noncardiac surgical interventions : Measures for optimal anesthesiological care].

Janßen H, Dehne S, Giannitsis E, Weigand MA, Larmann J.

Anaesthesist. 2019 Jun 14. doi: 10.1007/s00101-019-0616-9. [Epub ahead of print] Review. German.


What is the effect of interrupting prolonged sitting with frequent bouts of physical activity or standing on first or recurrent stroke risk factors? A scoping review.

Mackie P, Weerasekara I, Crowfoot G, Janssen H, Holliday E, Dunstan D, English C.

PLoS One. 2019 Jun 13;14(6):e0217981. doi: 10.1371/journal.pone.0217981. eCollection 2019.


Patient-reported outcomes in patients chronic viral hepatitis without cirrhosis: The impact of hepatitis B and C viral replication.

Younossi ZM, Stepanova M, Younossi I, Papatheodoridis G, Janssen HLA, Agarwal K, Nguyen MH, Gane E, Tsai N, Nader F.

Liver Int. 2019 Oct;39(10):1837-1844. doi: 10.1111/liv.14171. Epub 2019 Jul 2.


Prevalence and Impact of Hepatitis E Virus Infection Among Persons With Chronic Hepatitis B Living in the US and Canada.

McGivern DR, Lin HS, Wang J, Benzine T, Janssen HLA, Khalili M, Lisker-Melman M, Fontana RJ, Belle SH, Fried MW.

Open Forum Infect Dis. 2019 Apr 9;6(5):ofz175. doi: 10.1093/ofid/ofz175. eCollection 2019 May.


Hepatitis B core-related antigen monitoring during peginterferon alfa treatment for HBeAg-negative chronic hepatitis B.

van Campenhout MJH, Rijckborst V, Brouwer WP, van Oord GW, Ferenci P, Tabak F, Akdogan M, Pinarbasi B, Simon K, de Knegt RJ, Boonstra A, Janssen HLA, Hansen BE.

J Viral Hepat. 2019 Oct;26(10):1156-1163. doi: 10.1111/jvh.13117. Epub 2019 Aug 4.


The degradation and performance of electrospun supramolecular vascular scaffolds examined upon in vitro enzymatic exposure.

van Haaften EE, Duijvelshoff R, Ippel BD, Söntjens SHM, van Houtem MHCJ, Janssen HM, Smits AIPM, Kurniawan NA, Dankers PYW, Bouten CVC.

Acta Biomater. 2019 Jul 1;92:48-59. doi: 10.1016/j.actbio.2019.05.037. Epub 2019 May 17.


Elevated Presepsin Is Associated With Perioperative Major Adverse Cardiovascular and Cerebrovascular Complications in Elevated-Risk Patients Undergoing Noncardiac Surgery: The Leukocytes and Cardiovascular Perioperative Events Study.

Handke J, Scholz AS, Gillmann HJ, Janssen H, Dehne S, Arens C, Kummer L, Uhle F, Weigand MA, Motsch J, Larmann J.

Anesth Analg. 2019 Jun;128(6):1344-1353. doi: 10.1213/ANE.0000000000003738.


Elevated serum levels of soluble CD14 in HBeAg-positive chronic HBV patients upon Peginterferon treatment are associated with treatment response.

Dou Y, van Montfoort N, van den Bosch A, Janssen HLA, de Man RA, Buschow SI, Woltman AM.

J Viral Hepat. 2019 Sep;26(9):1076-1085. doi: 10.1111/jvh.13127. Epub 2019 Jun 3.


Macrophage-Driven Biomaterial Degradation Depends on Scaffold Microarchitecture.

Wissing TB, Bonito V, van Haaften EE, van Doeselaar M, Brugmans MMCP, Janssen HM, Bouten CVC, Smits AIPM.

Front Bioeng Biotechnol. 2019 Apr 26;7:87. doi: 10.3389/fbioe.2019.00087. eCollection 2019.


Nonalcoholic Fatty Liver Disease in The Rotterdam Study: About Muscle Mass, Sarcopenia, Fat Mass, and Fat Distribution.

Alferink LJM, Trajanoska K, Erler NS, Schoufour JD, de Knegt RJ, Ikram MA, Janssen HLA, Franco OH, Metselaar HJ, Rivadeneira F, Darwish Murad S.

J Bone Miner Res. 2019 Jul;34(7):1254-1263. doi: 10.1002/jbmr.3713. Epub 2019 May 10.


"This is our life now. Our new normal": A qualitative study of the unmet needs of carers of stroke survivors.

Denham AMJ, Wynne O, Baker AL, Spratt NJ, Turner A, Magin P, Janssen H, English C, Loh M, Bonevski B.

PLoS One. 2019 May 8;14(5):e0216682. doi: 10.1371/journal.pone.0216682. eCollection 2019.


Distinct phenotype and function of circulating Vδ1+ and Vδ2+ γδT-cells in acute and chronic hepatitis B.

Chang KM, Traum D, Park JJ, Ho S, Ojiro K, Wong DK, Wahed AS, Terrault NA, Khalili M, Sterling RK, Janssen HLA, Shuhart MC, Lau DT, Roberts LR, Johnson GS, Kaplan DE, Betts MR, Lee WM, Lok ASF; Hepatitis B Research Network (HBRN).

PLoS Pathog. 2019 Apr 18;15(4):e1007715. doi: 10.1371/journal.ppat.1007715. eCollection 2019 Apr.


A global scientific strategy to cure hepatitis B.

Revill PA, Chisari FV, Block JM, Dandri M, Gehring AJ, Guo H, Hu J, Kramvis A, Lampertico P, Janssen HLA, Levrero M, Li W, Liang TJ, Lim SG, Lu F, Penicaud MC, Tavis JE, Thimme R; Members of the ICE-HBV Working Groups; ICE-HBV Stakeholders Group Chairs; ICE-HBV Senior Advisors, Zoulim F.

Lancet Gastroenterol Hepatol. 2019 Jul;4(7):545-558. doi: 10.1016/S2468-1253(19)30119-0. Epub 2019 Apr 10. Erratum in: Lancet Gastroenterol Hepatol. 2019 Jul;4(7):e7.


Ursodeoxycholic acid therapy and liver transplant-free survival in patients with primary biliary cholangitis.

Harms MH, van Buuren HR, Corpechot C, Thorburn D, Janssen HLA, Lindor KD, Hirschfield GM, Parés A, Floreani A, Mayo MJ, Invernizzi P, Battezzati PM, Nevens F, Ponsioen CY, Mason AL, Kowdley KV, Lammers WJ, Hansen BE, van der Meer AJ.

J Hepatol. 2019 Aug;71(2):357-365. doi: 10.1016/j.jhep.2019.04.001. Epub 2019 Apr 11.


Diet-dependent acid load - the missing link between an animal protein-rich diet and non-alcoholic fatty liver disease?

Alferink LJM, Kiefte-de Jong JC, Erler NS, de Knegt RJ, Hoorn EJ, Ikram MA, Janssen HLA, Metselaar HJ, Franco OH, Murad SD.

J Clin Endocrinol Metab. 2019 Apr 12. pii: jc.2018-02792. doi: 10.1210/jc.2018-02792. [Epub ahead of print]


Optimisation of the use of APRI and FIB-4 to rule out cirrhosis in patients with chronic hepatitis B: results from the SONIC-B study.

Sonneveld MJ, Brouwer WP, Chan HL, Piratvisuth T, Jia JD, Zeuzem S, Liaw YF, Hansen BE, Choi H, Wat C, Pavlovic V, Gaggar A, Xie Q, Buti M, de Knegt RJ, Janssen HLA.

Lancet Gastroenterol Hepatol. 2019 Jul;4(7):538-544. doi: 10.1016/S2468-1253(19)30087-1. Epub 2019 Apr 9.


Age, race and viral genotype are associated with the prevalence of hepatitis B e antigen in children and adults with chronic hepatitis B.

Di Bisceglie AM, King WC, Lisker-Melman M, Khalili M, Belle SH, Feld JJ, Ghany MG, Janssen HLA, Lau D, Lee WM, Ling SC, Cooper S, Rosenthal P, Schwarz KB, Sterling RK, Teckman JH, Terrault N; Hepatitis B Research Network (HBRN).

J Viral Hepat. 2019 Jul;26(7):856-865. doi: 10.1111/jvh.13104. Epub 2019 May 2.


Volatile organic compound profiles in outlet air from extracorporeal life-support devices differ from breath profiles in critically ill patients.

Leopold JH, Philipp A, Bein T, Redel A, Gruber M, Schultz MJ, Abu-Hanna A, Brinkman P, Janssen HG, Bos LDJ.

ERJ Open Res. 2019 Apr 1;5(2). pii: 00134-2018. doi: 10.1183/23120541.00134-2018. eCollection 2019 Apr.


First international descriptive and interventional survey for cholesterol and non-cholesterol sterol determination by gas- and liquid-chromatography-Urgent need for harmonisation of analytical methods.

Lütjohann D, Björkhem I, Friedrichs S, Kerksiek A, Lövgren-Sandblom A, Geilenkeuser WJ, Ahrends R, Andrade I, Ansorena D, Astiasarán I, Baila-Rueda L, Barriuso B, Becker S, Bretillon L, Browne RW, Caccia C, Ceglarek U, Cenarro A, Crick PJ, Fauler G, Garcia-Llatas G, Gray R, Griffiths WJ, Gylling H, Harding S, Helmschrodt C, Iuliano L, Janssen HG, Jones P, Kaipiainen L, Kannenberg F, Lagarda MJ, Leoni V, Lottenberg AM, MacKay DS, Matysik S, McDonald J, Menendez-Carreño M, Myrie SB, Sutti Nunes V, Ostlund RE, Polisecki E, Ramos F, Rideout TC, Schaefer EJ, Schmitz G, Wang Y, Zerbinati C, Diczfalusy U, Schött HF.

J Steroid Biochem Mol Biol. 2019 Jun;190:115-125. doi: 10.1016/j.jsbmb.2019.03.025. Epub 2019 Mar 30.


Combined GS-4774 and Tenofovir Therapy Can Improve HBV-Specific T-Cell Responses in Patients With Chronic Hepatitis.

Boni C, Janssen HLA, Rossi M, Yoon SK, Vecchi A, Barili V, Yoshida EM, Trinh H, Rodell TC, Laccabue D, Alfieri A, Brillo F, Fisicaro P, Acerbi G, Pedrazzi G, Andreone P, Cursaro C, Margotti M, Santoro R, Piazzolla V, Brunetto MR, Coco B, Cavallone D, Zhao Y, Joshi A, Woo J, Lau AH, Gaggar A, Subramanian GM, Massetto B, Fung S, Ahn SH, Ma X, Mangia A, Ferrari C.

Gastroenterology. 2019 Jul;157(1):227-241.e7. doi: 10.1053/j.gastro.2019.03.044. Epub 2019 Mar 28.


USP32 regulates late endosomal transport and recycling through deubiquitylation of Rab7.

Sapmaz A, Berlin I, Bos E, Wijdeven RH, Janssen H, Konietzny R, Akkermans JJ, Erson-Bensan AE, Koning RI, Kessler BM, Neefjes J, Ovaa H.

Nat Commun. 2019 Mar 29;10(1):1454. doi: 10.1038/s41467-019-09437-x.


Diffusion-weighted magnetic resonance imaging for detection of postoperative intracranial pyogenic abscesses in neurosurgery.

Schwartz C, Lenski M, Romagna A, Schichor C, Tonn JC, Brueckmann H, Janssen H, Liebig T, Forbrig R, Thon N.

Acta Neurochir (Wien). 2019 May;161(5):985-993. doi: 10.1007/s00701-019-03875-8. Epub 2019 Mar 26.


Prevalence and predictors of complementary and alternative medicine modalities in patients with chronic hepatitis B.

Liem KS, Yim C, Ying TD, Zanjir WR, Fung S, Wong DK, Shah H, Feld JJ, Hansen BE, Janssen HLA.

Liver Int. 2019 Aug;39(8):1418-1427. doi: 10.1111/liv.14105. Epub 2019 Apr 22.



Chi H, Peng J, Janssen HLA.

Clin Gastroenterol Hepatol. 2019 Apr;17(5):1001-1002. doi: 10.1016/j.cgh.2018.10.005. No abstract available.


Relationship between hepatitis B core-related antigen levels and sustained HBeAg seroconversion in patients treated with nucleo(s)tide analogues.

Sonneveld MJ, van Oord GW, van Campenhout MJ, De Man RA, Janssen HLA, de Knegt RJ, Boonstra A, van der Eijk AA.

J Viral Hepat. 2019 Jul;26(7):828-834. doi: 10.1111/jvh.13097. Epub 2019 Apr 16.


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