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Expression profiling and intracellular localization studies of the novel Proline-, Histidine-, and Glycine-rich protein 1 suggest an essential role in gastro-intestinal epithelium and a potential clinical application in colorectal cancer diagnostics.

Oltedal S, Skaland I, Maple-Grødem J, Tjensvoll K, Janssen EAM, Gilje B, Smaaland R, Heikkilä R, Nordgård O.

BMC Gastroenterol. 2018 Feb 7;18(1):26. doi: 10.1186/s12876-018-0752-8.


Serum concentrations of active tamoxifen metabolites predict long-term survival in adjuvantly treated breast cancer patients.

Helland T, Henne N, Bifulco E, Naume B, Borgen E, Kristensen VN, Kvaløy JT, Lash TL, Alnæs GIG, van Schaik RH, Janssen EAM, Hustad S, Lien EA, Mellgren G, Søiland H.

Breast Cancer Res. 2017 Nov 28;19(1):125. doi: 10.1186/s13058-017-0916-4.


CYP2C19*2 and CYP2C19*17 variants and effect of tamoxifen on breast cancer recurrence: Analysis of the International Tamoxifen Pharmacogenomics Consortium dataset.

Damkier P, Kjærsgaard A, Barker KA, Cronin-Fenton D, Crawford A, Hellberg Y, Janssen EAM, Langefeld C, Ahern TP, Lash TL.

Sci Rep. 2017 Aug 10;7(1):7727. doi: 10.1038/s41598-017-08091-x.


Novel immunohistochemistry-based signatures to predict metastatic site of triple-negative breast cancers.

Klimov S, Rida PC, Aleskandarany MA, Green AR, Ellis IO, Janssen EA, Rakha EA, Aneja R.

Br J Cancer. 2017 Sep 5;117(6):826-834. doi: 10.1038/bjc.2017.224. Epub 2017 Jul 18.


Amplified centrosomes and mitotic index display poor concordance between patient tumors and cultured cancer cells.

Mittal K, Choi DH, Ogden A, Donthamsetty S, Melton BD, Gupta MV, Pannu V, Cantuaria G, Varambally S, Reid MD, Jonsdottir K, Janssen EA, Aleskandarany MA, Ellis IO, Rakha EA, Rida PC, Aneja R.

Sci Rep. 2017 Mar 8;7:43984. doi: 10.1038/srep43984.


Quality assurance of human papillomavirus (HPV) testing in the implementation of HPV primary screening in Norway: an inter-laboratory reproducibility study.

Engesæter B, van Diermen Hidle B, Hansen M, Moltu P, Staby KM, Borchgrevink-Persen S, Vintermyr OK, Lönnberg S, Nygård M, Janssen EA, Castle PE, Christiansen IK.

BMC Infect Dis. 2016 Nov 24;16(1):698.


Epigenome-wide DNA methylation patterns associated with fatigue in primary Sjögren's syndrome.

Brække Norheim K, Imgenberg-Kreuz J, Jonsdottir K, Janssen EA, Syvänen AC, Sandling JK, Nordmark G, Omdal R.

Rheumatology (Oxford). 2016 Jun;55(6):1074-82. doi: 10.1093/rheumatology/kew008. Epub 2016 Mar 10.


Low Protein A20 in Minor Salivary Glands is Associated with Lymphoma in Primary Sjögren's Syndrome.

Johnsen SJ, Gudlaugsson E, Skaland I, Janssen EA, Jonsson MV, Helgeland L, Berget E, Jonsson R, Omdal R.

Scand J Immunol. 2016 Mar;83(3):181-7. doi: 10.1111/sji.12405.


The Role of MicroRNAs as Predictors of Response to Tamoxifen Treatment in Breast Cancer Patients.

Egeland NG, Lunde S, Jonsdottir K, Lende TH, Cronin-Fenton D, Gilje B, Janssen EA, Søiland H.

Int J Mol Sci. 2015 Oct 14;16(10):24243-75. doi: 10.3390/ijms161024243. Review.


Reduced Number of CD8+ Cells in Tonsillar Germinal Centres in Children with the Periodic Fever, Aphthous Stomatitis, Pharyngitis and Cervical Adenitis Syndrome.

Førsvoll J, Janssen EA, Møller I, Wathne N, Skaland I, Klos J, Kristoffersen EK, Øymar K.

Scand J Immunol. 2015 Jul;82(1):76-83. doi: 10.1111/sji.12303.


Prediction of spontaneous regression of cervical intraepithelial neoplasia lesions grades 2 and 3 by proteomic analysis.

Uleberg KE, Ovestad IT, Munk AC, Brede C, van Diermen B, Gudlaugsson E, Janssen EA, Hjelle A, Baak JP.

Int J Proteomics. 2014;2014:129064. doi: 10.1155/2014/129064. Epub 2014 Jun 15.


Prognostic comparison of proliferation markers and World Health Organization 1973/2004 grades in urothelial carcinomas of the urinary bladder.

Mangrud OM, Gudlaugsson E, Skaland I, Tasdemir I, Dalen I, van Diermen B, Baak JP, Janssen EA.

Hum Pathol. 2014 Jul;45(7):1496-503. doi: 10.1016/j.humpath.2014.03.001. Epub 2014 Mar 26.


Prognostic value of gene signatures and proliferation in lymph-node-negative breast cancer.

Jonsdottir K, Assmus J, Slewa A, Gudlaugsson E, Skaland I, Baak JP, Janssen EA.

PLoS One. 2014 Mar 5;9(3):e90642. doi: 10.1371/journal.pone.0090642. eCollection 2014.


Reproducibility and prognostic value of WHO1973 and WHO2004 grading systems in TaT1 urothelial carcinoma of the urinary bladder.

Mangrud OM, Waalen R, Gudlaugsson E, Dalen I, Tasdemir I, Janssen EA, Baak JP.

PLoS One. 2014 Jan 7;9(1):e83192. doi: 10.1371/journal.pone.0083192. eCollection 2014.


The prognostic value of mitotic activity index (MAI), phosphohistone H3 (PPH3), cyclin B1, cyclin A, and Ki67, alone and in combinations, in node-negative premenopausal breast cancer.

Klintman M, Strand C, Ahlin C, Beglerbegovic S, Fjällskog ML, Grabau D, Gudlaugsson E, Janssen EA, Lövgren K, Skaland I, Bendahl PO, Malmström P, Baak JP, Fernö M.

PLoS One. 2013 Dec 4;8(12):e81902. doi: 10.1371/journal.pone.0081902. eCollection 2013.


Validation of expression patterns for nine miRNAs in 204 lymph-node negative breast cancers.

Jonsdottir K, Janssen SR, Da Rosa FC, Gudlaugsson E, Skaland I, Baak JP, Janssen EA.

PLoS One. 2012;7(11):e48692. doi: 10.1371/journal.pone.0048692. Epub 2012 Nov 7.


Consistent condom use increases spontaneous regression in high-risk non-HPV16 but not in HPV16 CIN2-3 lesions, a prospective population-based cohort study.

Munk AC, Ovestad IT, Gudlaugsson E, Løvslett K, Fiane B, van Diermen-Hidle B, Kruse AJ, Skaland I, Janssen EA, Baak JP.

Infect Agent Cancer. 2012 Nov 5;7(1):30. doi: 10.1186/1750-9378-7-30.


Consistent condom use increases the regression rate of cervical intraepithelial neoplasia 2-3.

Munk AC, Gudlaugsson E, Malpica A, Fiane B, Løvslett KI, Kruse AJ, Øvestad IT, Voorhorst F, Janssen EA, Baak JP.

PLoS One. 2012;7(9):e45114. doi: 10.1371/journal.pone.0045114. Epub 2012 Sep 13.


Interaction of epithelial biomarkers, local immune response and condom use in cervical intraepithelial neoplasia 2-3 regression.

Munk AC, Gudlaugsson E, Ovestad IT, Lovslett K, Fiane B, Hidle Bv, Kruse AJ, Skaland I, Janssen EA, Baak JP.

Gynecol Oncol. 2012 Dec;127(3):489-94. doi: 10.1016/j.ygyno.2012.09.010. Epub 2012 Sep 24.


Comparison of the effect of different techniques for measurement of Ki67 proliferation on reproducibility and prognosis prediction accuracy in breast cancer.

Gudlaugsson E, Skaland I, Janssen EA, Smaaland R, Shao Z, Malpica A, Voorhorst F, Baak JP.

Histopathology. 2012 Dec;61(6):1134-44. doi: 10.1111/j.1365-2559.2012.04329.x. Epub 2012 Sep 11.


The prognostic value of MARCKS-like 1 in lymph node-negative breast cancer.

Jonsdottir K, Zhang H, Jhagroe D, Skaland I, Slewa A, Björkblom B, Coffey ET, Gudlaugsson E, Smaaland R, Janssen EA, Baak JP.

Breast Cancer Res Treat. 2012 Sep;135(2):381-90. doi: 10.1007/s10549-012-2155-9. Epub 2012 Jul 8.


Comparison of a PNA clamp PCR and an ARMS/Scorpion PCR assay for the detection of K-ras mutations.

Nordgård O, Oltedal S, Janssen EA, Gilje B, Kørner H, Tjensvoll K, Smaaland R.

Diagn Mol Pathol. 2012 Mar;21(1):9-13. doi: 10.1097/PDM.0b013e31821e59dc.


Dietary supplementation of krill oil attenuates inflammation and oxidative stress in experimental ulcerative colitis in rats.

Grimstad T, Bjørndal B, Cacabelos D, Aasprong OG, Janssen EA, Omdal R, Svardal A, Hausken T, Bohov P, Portero-Otin M, Pamplona R, Berge RK.

Scand J Gastroenterol. 2012 Jan;47(1):49-58. doi: 10.3109/00365521.2011.634025. Epub 2011 Nov 30.


Comparison of different commercial methods for HPV detection in follow-up cytology after ASCUS/LSIL, prediction of CIN2-3 in follow up biopsies and spontaneous regression of CIN2-3.

Ovestad IT, Vennestrøm U, Andersen L, Gudlaugsson E, Munk AC, Malpica A, Feng W, Voorhorst F, Janssen EA, Baak JP.

Gynecol Oncol. 2011 Nov;123(2):278-83. doi: 10.1016/j.ygyno.2011.07.024. Epub 2011 Aug 10.


From SELDI-TOF MS to protein identification by on-chip elution.

Mæland Nilsen M, Uleberg KE, Janssen EA, Baak JP, Andersen OK, Hjelle A.

J Proteomics. 2011 Nov 18;74(12):2995-8. doi: 10.1016/j.jprot.2011.06.027. Epub 2011 Jul 23.


Discrimination of grade 2 and 3 cervical intraepithelial neoplasia by means of analysis of water soluble proteins recovered from cervical biopsies.

Uleberg KE, Munk AC, Brede C, Gudlaugsson E, van Diermen B, Skaland I, Malpica A, Janssen EA, Hjelle A, Baak JP.

Proteome Sci. 2011 Jun 28;9:36. doi: 10.1186/1477-5956-9-36.


A protein profile study to discriminate CIN lesions from normal cervical epithelium.

Uleberg KE, Munk AC, Skaland I, Furlan C, van Diermen B, Gudlaugsson E, Janssen EA, Malpica A, Feng W, Hjelle A, Baak JP.

Cell Oncol (Dordr). 2011 Oct;34(5):443-50. doi: 10.1007/s13402-011-0047-3. Epub 2011 May 15.


Biomarkers and microsatellite instability analysis of curettings can predict the behavior of FIGO stage I endometrial endometrioid adenocarcinoma.

Steinbakk A, Malpica A, Slewa A, Skaland I, Gudlaugsson E, Janssen EA, Løvslett K, Fiane B, Kruse AJ, Feng W, Yinhua Y, Baak JP.

Mod Pathol. 2011 Sep;24(9):1262-71. doi: 10.1038/modpathol.2011.75. Epub 2011 May 6.


High frequency microsatellite instability has a prognostic value in endometrial endometrioid adenocarcinoma, but only in FIGO stage 1 cases.

Steinbakk A, Malpica A, Slewa A, Gudlaugsson E, Janssen EA, Arends M, Kruse AJ, Yinhua Y, Feng W, Baak JP.

Cell Oncol (Dordr). 2011 Oct;34(5):457-65. doi: 10.1007/s13402-011-0040-x. Epub 2011 May 6. Erratum in: Cell Oncol (Dordr). 2011 Oct;34(5):509-10.


Mitotic activity and bone marrow micrometastases have independent prognostic value in node positive breast cancer patients.

Gilje B, Nordgård O, Tjensvoll K, Janssen EA, Søiland H, Smaaland R, Baak JP.

Breast Cancer Res Treat. 2011 Jul;128(1):137-46. doi: 10.1007/s10549-011-1487-1. Epub 2011 Apr 8.


The impact of epithelial biomarkers, local immune response and human papillomavirus genotype in the regression of cervical intraepithelial neoplasia grades 2-3.

Ovestad IT, Gudlaugsson E, Skaland I, Malpica A, Munk AC, Janssen EA, Baak JP.

J Clin Pathol. 2011 Apr;64(4):303-7. doi: 10.1136/jcp.2010.083626.


Molecular biomarkers in endometrial hyperplasias predict cancer progression.

Steinbakk A, Gudlaugsson E, Aasprong OG, Skaland I, Malpica A, Feng W, Janssen EA, Baak JP.

Am J Obstet Gynecol. 2011 Apr;204(4):357.e1-12. doi: 10.1016/j.ajog.2010.12.007. Epub 2011 Feb 16.


D2-40/p63 defined lymph vessel invasion has additional prognostic value in highly proliferating operable node negative breast cancer patients.

Gudlaugsson E, Skaland I, Undersrud E, Janssen EA, Søiland H, Baak JP.

Mod Pathol. 2011 Apr;24(4):502-11. doi: 10.1038/modpathol.2010.199. Epub 2011 Feb 11.


In patients younger than age 55 years with lymph node-negative breast cancer, proliferation by mitotic activity index is prognostically superior to adjuvant!

Lende TH, Janssen EA, Gudlaugsson E, Voorhorst F, Smaaland R, van Diest P, Søiland H, Baak JP.

J Clin Oncol. 2011 Mar 1;29(7):852-8. doi: 10.1200/JCO.2009.25.0407. Epub 2010 Dec 28.


High frequency microsatellite instability has a prognostic value in endometrial endometrioid adenocarcinoma, but only in FIGO stage 1 cases.

Steinbakk A, Malpica A, Slewa A, Gudlaugsson E, Janssen EA, Arends M, Kruse AJ, Yinhua Y, Feng W, Baak JP.

Anal Cell Pathol (Amst). 2010;33(5):245-55. doi: 10.3233/ACP-CLO-2010-0550.


Biologic profiling of lymph node negative breast cancers by means of microRNA expression.

Janssen EA, Slewa A, Gudlaugsson E, Jonsdottir K, Skaland I, Søiland H, Baak JP.

Mod Pathol. 2010 Dec;23(12):1567-76. doi: 10.1038/modpathol.2010.177. Epub 2010 Sep 3.


Local immune response in the microenvironment of CIN2-3 with and without spontaneous regression.

Øvestad IT, Gudlaugsson E, Skaland I, Malpica A, Kruse AJ, Janssen EA, Baak JP.

Mod Pathol. 2010 Sep;23(9):1231-40. doi: 10.1038/modpathol.2010.109. Epub 2010 May 28.


LOH at 1p31 (ARHI) and proliferation in lymph node-negative breast cancer.

Janssen EA, Øvestad IT, Skaland I, Søiland H, Gudlaugsson E, Kjellevold KH, Nysted A, Søreide JA, Baak JP.

Cell Oncol. 2009;31(5):335-43. doi: 10.3233/CLO-2009-0479.


Evaluation of 5 different labeled polymer immunohistochemical detection systems.

Skaland I, Nordhus M, Gudlaugsson E, Klos J, Kjellevold KH, Janssen EA, Baak JP.

Appl Immunohistochem Mol Morphol. 2010 Jan;18(1):90-6. doi: 10.1097/PAI.0b013e3181b0eaad.


Prospective multicenter comparison of proliferation and other prognostic factors in lymph node negative lobular invasive breast cancer.

Gudlaugsson E, Skaland I, Janssen EA, van Diest PJ, Voorhorst FJ, Kjellevold K, zur Hausen A, Baak JP.

Breast Cancer Res Treat. 2010 May;121(1):35-40. doi: 10.1007/s10549-009-0442-x. Epub 2009 Jul 1.


Microsatellite instability and DNA ploidy in colorectal cancer: potential implications for patients undergoing systematic surveillance after resection.

Søreide K, Slewa A, Stokkeland PJ, van Diermen B, Janssen EA, Søreide JA, Baak JP, Kørner H.

Cancer. 2009 Jan 15;115(2):271-82. doi: 10.1002/cncr.24024.


Co-expression of estrogen receptor alpha and Apolipoprotein D in node positive operable breast cancer--possible relevance for survival and effects of adjuvant tamoxifen in postmenopausal patients.

Søiland H, Skaland I, Varhaug JE, Kørner H, Janssen EA, Gudlaugsson E, Baak JP, Søreide JA.

Acta Oncol. 2009;48(4):514-21. doi: 10.1080/02841860802620613.


The prognostic value of molecular biomarkers in tissue removed by curettage from FIGO stage 1 and 2 endometrioid type endometrial cancer.

Steinbakk A, Skaland I, Gudlaugsson E, Janssen EA, Kjellevold KH, Klos J, Løvslett K, Fiane B, Baak JP.

Am J Obstet Gynecol. 2009 Jan;200(1):78.e1-8. doi: 10.1016/j.ajog.2008.07.020. Epub 2008 Oct 30.


Prognostic relevance of androgen receptor detection in operable breast cancer.

Søiland H, Kørner H, Skaland I, Janssen EA, Gudlaugsson E, Varhaug JE, Baak JP, Søreide JA.

J Surg Oncol. 2008 Dec 1;98(7):551-8. doi: 10.1002/jso.21156.


Proliferation is the strongest prognosticator in node-negative breast cancer: significance, error sources, alternatives and comparison with molecular prognostic markers.

Baak JP, Gudlaugsson E, Skaland I, Guo LH, Klos J, Lende TH, Søiland H, Janssen EA, Zur Hausen A.

Breast Cancer Res Treat. 2009 May;115(2):241-54. doi: 10.1007/s10549-008-0126-y. Epub 2008 Jul 30. Review.


Adenomyoepitheliomatous lesions of the mammary glands in transgenic mice with targeted PLAG1 overexpression.

Declercq J, Skaland I, Van Dyck F, Janssen EA, Baak JP, Drijkoningen M, Van de Ven WJ.

Int J Cancer. 2008 Oct 1;123(7):1593-600. doi: 10.1002/ijc.23586.


Androgen receptor determination in breast cancer: a comparison of the dextran-coated charcoal method and quantitative immunohistochemical analysis.

Søiland H, Skaland I, van Diermen B, Janssen EA, Körner H, Varhaug JE, Søreide JA, Baak JP.

Appl Immunohistochem Mol Morphol. 2008 Jul;16(4):362-70. doi: 10.1097/PAI.0b013e31815b9c92.


Comparison of apolipoprotein D determination methods in breast cancer.

Søiland H, Skaland I, Janssen EA, Gudlaugsson E, Körner H, Varhaug JE, Søreide JA, Baak JP.

Anticancer Res. 2008 Mar-Apr;28(2B):1151-60.

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