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Fatigue is highly prevalent in patients with COPD and correlates poorly with the degree of airflow limitation.

Goërtz YMJ, Spruit MA, Van 't Hul AJ, Peters JB, Van Herck M, Nakken N, Djamin RS, Burtin C, Thong MSY, Coors A, Meertens-Kerris Y, Wouters EFM, Prins JB, Franssen FME, Muris JWM, Vanfleteren LEGW, Sprangers MAG, Janssen DJA, Vercoulen JH.

Ther Adv Respir Dis. 2019 Jan-Dec;13:1753466619878128. doi: 10.1177/1753466619878128.


Effects of a comprehensive, inpatient pulmonary rehabilitation programme in a cachectic patient with very severe COPD and chronic respiratory failure.

Franssen FME, Vanfleteren LEGW, Janssen DJA, Wouters EFM, Spruit MA.

Breathe (Sheff). 2019 Sep;15(3):227-233. doi: 10.1183/20734735.0186-2019.


Pulmonary Rehabilitation Reduces Subjective Fatigue in COPD: A Responder Analysis.

Van Herck M, Antons J, Vercoulen JH, Goërtz YMJ, Ebadi Z, Burtin C, Janssen DJA, Thong MSY, Otker J, Coors A, Sprangers MAG, Muris JWM, Prins JB, Spruit MA, Peters JB.

J Clin Med. 2019 Aug 20;8(8). pii: E1264. doi: 10.3390/jcm8081264.


Premature Ending of a Medication Study in Dying Patients: Lessons Learned.

Theunissen M, Martens M, Janssen DJA, Schols JMGA, van den Beuken-van Everdingen MHJ.

J Pain Symptom Manage. 2019 Aug 9. pii: S0885-3924(19)30441-5. doi: 10.1016/j.jpainsymman.2019.07.027. [Epub ahead of print] No abstract available.


Palliative Care for people living with heart failure - European Association for Palliative Care Task Force expert position statement.

Sobanski PZ, Alt-Epping B, Currow DC, Goodlin SJ, Grodzicki T, Hogg K, Janssen DJA, Johnson MJ, Krajnik M, Leget C, Martínez-Sellés M, Moroni M, Mueller PS, Ryder M, Simon ST, Stowe E, Larkin PJ.

Cardiovasc Res. 2019 Aug 6. pii: cvz200. doi: 10.1093/cvr/cvz200. [Epub ahead of print]


Multi-disciplinary palliative care is effective in people with symptomatic heart failure: A systematic review and narrative synthesis.

Datla S, Verberkt CA, Hoye A, Janssen DJA, Johnson MJ.

Palliat Med. 2019 Sep;33(8):1003-1016. doi: 10.1177/0269216319859148. Epub 2019 Jul 15.


Clustering of 27,525,663 Death Records from the United States Based on Health Conditions Associated with Death: An Example of big Health Data Exploration.

Janssen DJA, Rechberger S, Wouters EFM, Schols JMGA, Johnson MJ, Currow DC, Curtis JR, Spruit MA.

J Clin Med. 2019 Jun 27;8(7). pii: E922. doi: 10.3390/jcm8070922.


The superexacerbator phenotype in patients with COPD: a descriptive analysis.

Vanfleteren LEGW, Boonen LMC, Spruit MA, Janssen DJA, Wouters EFM, Franssen FME.

ERJ Open Res. 2019 Jun 4;5(2). pii: 00235-2018. doi: 10.1183/23120541.00235-2018. eCollection 2019 Apr.


Disease-Specific Comorbidity Clusters in COPD and Accelerated Aging.

Triest FJJ, Franssen FME, Reynaert N, Gaffron S, Spruit MA, Janssen DJA, Rutten EPA, Wouters EFM, Vanfleteren LEGW.

J Clin Med. 2019 Apr 14;8(4). pii: E511. doi: 10.3390/jcm8040511.


Revealing Methodological Challenges in Chronic Obstructive Pulmonary Disease Studies Assessing Comorbidities: A Narrative Review.

Houben-Wilke S, Triest FJJ, Franssen FME, Janssen DJA, Wouters EFM, Vanfleteren LEGW.

Chronic Obstr Pulm Dis. 2019 Apr 9;6(2):166-177. doi: 10.15326/jcopdf.6.2.2018.0145. Epub 2019 Apr 9. Review.


Pulmonary rehabilitation, physical activity, respiratory failure and palliative respiratory care.

Spruit MA, Rochester CL, Pitta F, Kenn K, Schols AMWJ, Hart N, Wouters EFM, Nava S, Dreher M, Janssen DJA, Johnson MJ, Curtis RJ, Sastry M, Franssen FME.

Thorax. 2019 Jul;74(7):693-699. doi: 10.1136/thoraxjnl-2018-212044. Epub 2019 Mar 14.


Timely recognition of palliative care needs of patients with advanced chronic heart failure: a pilot study of a Dutch translation of the Needs Assessment Tool: Progressive Disease - Heart Failure (NAT:PD-HF).

Janssen DJ, Boyne J, Currow DC, Schols JM, Johnson MJ, La Rocca HB.

Eur J Cardiovasc Nurs. 2019 Jun;18(5):375-388. doi: 10.1177/1474515119831510. Epub 2019 Feb 13.


Cluster-randomised trial of a nurse-led advance care planning session in patients with COPD and their loved ones.

Houben CHM, Spruit MA, Luyten H, Pennings HJ, van den Boogaart VEM, Creemers JPHM, Wesseling G, Wouters EFM, Janssen DJA.

Thorax. 2019 Apr;74(4):328-336. doi: 10.1136/thoraxjnl-2018-211943. Epub 2019 Jan 19.


Comprehensive Lung Function Assessment Does not Allow to Infer Response to Pulmonary Rehabilitation in Patients with COPD.

Augustin IML, Wouters EFM, Houben-Wilke S, Gaffron S, Janssen DJA, Franssen FME, Spruit MA.

J Clin Med. 2018 Dec 27;8(1). pii: E27. doi: 10.3390/jcm8010027.


Treatment of Pain in Cancer: Towards Personalised Medicine.

van den Beuken-van Everdingen MHJ, van Kuijk SMJ, Janssen DJA, Joosten EAJ.

Cancers (Basel). 2018 Dec 10;10(12). pii: E502. doi: 10.3390/cancers10120502. Review.


Impact of pulmonary rehabilitation on activities of daily living in patients with chronic obstructive pulmonary disease.

Vaes AW, Delbressine JML, Mesquita R, Goertz YMJ, Janssen DJA, Nakken N, Franssen FME, Vanfleteren LEGW, Wouters EFM, Spruit MA.

J Appl Physiol (1985). 2019 Mar 1;126(3):607-615. doi: 10.1152/japplphysiol.00790.2018. Epub 2018 Nov 29.


Fatigue is Highly Prevalent in Patients with Asthma and Contributes to the Burden of Disease.

Van Herck M, Spruit MA, Burtin C, Djamin R, Antons J, Goërtz YMJ, Ebadi Z, Janssen DJA, Vercoulen JH, Peters JB, Thong MSY, Otker J, Coors A, Sprangers MAG, Muris JWM, Wouters EFM, van 't Hul AJ.

J Clin Med. 2018 Nov 23;7(12). pii: E471. doi: 10.3390/jcm7120471.


Contribution of individual COPD assessment test (CAT) items to CAT total score and effects of pulmonary rehabilitation on CAT scores.

Houben-Wilke S, Janssen DJA, Franssen FME, Vanfleteren LEGW, Wouters EFM, Spruit MA.

Health Qual Life Outcomes. 2018 Oct 30;16(1):205. doi: 10.1186/s12955-018-1034-4.


How Religiosity Shapes Rejection of Homosexuality Across the Globe.

Janssen DJ, Scheepers P.

J Homosex. 2018 Oct 29:1-28. doi: 10.1080/00918369.2018.1522809. [Epub ahead of print]


Cognitive impairment in chronic obstructive pulmonary disease: disease burden, determinants and possible future interventions.

van Beers M, Janssen DJA, Gosker HR, Schols AMWJ.

Expert Rev Respir Med. 2018 Dec;12(12):1061-1074. doi: 10.1080/17476348.2018.1533405. Epub 2018 Oct 14. Review.


The respiratory physiome: Clustering based on a comprehensive lung function assessment in patients with COPD.

Augustin IML, Spruit MA, Houben-Wilke S, Franssen FME, Vanfleteren LEGW, Gaffron S, Janssen DJA, Wouters EFM.

PLoS One. 2018 Sep 12;13(9):e0201593. doi: 10.1371/journal.pone.0201593. eCollection 2018.


Opioid Prescribing Behavior in Long-Term Geriatric Care in the Netherlands.

Martens MJM, Janssen DJA, Schols JMGA, van den Beuken-van Everdingen MHJ.

J Am Med Dir Assoc. 2018 Nov;19(11):974-980. doi: 10.1016/j.jamda.2018.07.009. Epub 2018 Aug 28.


Identifying causes of perceptual differences in problematic activities of daily life between patients with COPD and proxies: A qualitative study.

Nakken N, Spruit MA, van den Bogaart EHA, Crutzen R, Muris JWM, Wouters EFM, Janssen DJA.

Aust Occup Ther J. 2019 Feb;66(1):44-51. doi: 10.1111/1440-1630.12512. Epub 2018 Aug 29.


Adverse respiratory effects of opioids for chronic breathlessness: to what extent can we learn lessons from chronic pain?

Verberkt CA, van den Beuken-van Everdingen MHJ, Schols JMGA, Datla S, Dirksen CD, Johnson MJ, van Kuijk SMJ, Wouters EFM, Janssen DJA.

Eur Respir J. 2018 Jul 19;52(1). pii: 1800882. doi: 10.1183/13993003.00882-2018. Print 2018 Jul. No abstract available.


Fatigue in patients with chronic obstructive pulmonary disease: protocol of the Dutch multicentre, longitudinal, observational FAntasTIGUE study.

Goërtz YMJ, Looijmans M, Prins JB, Janssen DJA, Thong MSY, Peters JB, Burtin C, Meertens-Kerris Y, Coors A, Muris JWM, Sprangers MAG, Wouters EFM, Vercoulen JH, Spruit MA.

BMJ Open. 2018 Apr 10;8(4):e021745. doi: 10.1136/bmjopen-2018-021745.


Pulmonary rehabilitation for patients with COPD during and after an exacerbation-related hospitalisation: back to the future?

Spruit MA, Singh SJ, Rochester CL, Greening NJ, Franssen FME, Pitta F, Troosters T, Nolan C, Vogiatzis I, Clini EM, Man WD, Burtin C, Goldstein RS, Vanfleteren LEGW, Kenn K, Nici L, Janssen DJA, Casaburi R, Shioya T, Garvey C, Carlin BW, ZuWallack RL, Steiner M, Wouters EFM, Puhan MA.

Eur Respir J. 2018 Jan 11;51(1). pii: 1701312. doi: 10.1183/13993003.01312-2017. Print 2018 Jan. No abstract available.


Palliative care needs assessment in chronic heart failure.

Janssen DJA, Johnson MJ, Spruit MA.

Curr Opin Support Palliat Care. 2018 Mar;12(1):25-31. doi: 10.1097/SPC.0000000000000317. Review.


Redefining Cut-Points for High Symptom Burden of the Global Initiative for Chronic Obstructive Lung Disease Classification in 18,577 Patients With Chronic Obstructive Pulmonary Disease.

Smid DE, Franssen FME, Gonik M, Miravitlles M, Casanova C, Cosio BG, de Lucas-Ramos P, Marin JM, Martinez C, Mir I, Soriano JB, de Torres JP, Agusti A, Atalay NB, Billington J, Boutou AK, Brighenti-Zogg S, Chaplin E, Coster S, Dodd JW, Dürr S, Fernandez-Villar A, Groenen MTJ, Guimarães M, Hejduk K, Higgins V, Hopkinson NS, Horita N, Houben-Wilke S, Janssen DJA, Jehn M, Joerres R, Karch A, Kelly JL, Kim YI, Kimura H, Koblizek V, Kocks JH, Kon SSC, Kwon N, Ladeira I, Lee SD, Leuppi JD, Locantore N, Lopez-Campos JL, D-C Man W, Maricic L, Mendoza L, Miedinger D, Mihaltan F, Minami S, van der Molen T, Murrells TJ, Nakken N, Nishijima Y, Norman IJ, Novotna B, O'Donnell DE, Ogata Y, Pereira ED, Piercy J, Price D, Pothirat C, Raghavan N, Ringbaek T, Sajkov D, Sigari N, Singh S, Small M, da Silva GF, Tanner RJ, Tsiligianni IG, Tulek B, Tzanakis N, Vanfleteren LEGW, Watz H, Webb KA, Wouters EFM, Xie GG, Yoshikawa M, Spruit MA.

J Am Med Dir Assoc. 2017 Dec 1;18(12):1097.e11-1097.e24. doi: 10.1016/j.jamda.2017.09.003. Review.


Respiratory adverse effects of opioids for breathlessness: a systematic review and meta-analysis.

Verberkt CA, van den Beuken-van Everdingen MHJ, Schols JMGA, Datla S, Dirksen CD, Johnson MJ, van Kuijk SMJ, Wouters EFM, Janssen DJA.

Eur Respir J. 2017 Nov 22;50(5). pii: 1701153. doi: 10.1183/13993003.01153-2017. Print 2017 Nov. Review.


Advance care planning for patients with chronic respiratory diseases: a systematic review of preferences and practices.

Jabbarian LJ, Zwakman M, van der Heide A, Kars MC, Janssen DJA, van Delden JJ, Rietjens JAC, Korfage IJ.

Thorax. 2018 Mar;73(3):222-230. doi: 10.1136/thoraxjnl-2016-209806. Epub 2017 Nov 6. Review.


Knowledge gaps in patients with COPD and their proxies.

Nakken N, Janssen DJA, van den Bogaart EHA, Muris JWM, Vercoulen JH, Custers FL, Bootsma GP, Gronenschild MHM, Wouters EFM, Spruit MA.

BMC Pulm Med. 2017 Oct 30;17(1):136. doi: 10.1186/s12890-017-0481-8.


The patient with a complex chronic respiratory disease: a specialist of his own life?

Houben-Wilke S, Augustin IM, Wouters BB, Stevens RA, Janssen DJ, Spruit MA, Vanfleteren LE, Franssen FM, Wouters EF.

Expert Rev Respir Med. 2017 Dec;11(12):919-924. doi: 10.1080/17476348.2017.1392242. Epub 2017 Oct 25.


Definition and recommendations for advance care planning: an international consensus supported by the European Association for Palliative Care.

Rietjens JAC, Sudore RL, Connolly M, van Delden JJ, Drickamer MA, Droger M, van der Heide A, Heyland DK, Houttekier D, Janssen DJA, Orsi L, Payne S, Seymour J, Jox RJ, Korfage IJ; European Association for Palliative Care.

Lancet Oncol. 2017 Sep;18(9):e543-e551. doi: 10.1016/S1470-2045(17)30582-X. Review.


Cognitive impairment and clinical characteristics in patients with chronic obstructive pulmonary disease.

Cleutjens FAHM, Spruit MA, Ponds RWHM, Vanfleteren LEGW, Franssen FME, Gijsen C, Dijkstra JB, Wouters EFM, Janssen DJA.

Chron Respir Dis. 2018 May;15(2):91-102. doi: 10.1177/1479972317709651. Epub 2017 May 29.



Houben CHM, Spruit MA, Schols JMGA, Wouters EFM, Janssen DJA.

Chest. 2017 May;151(5):1182-1183. doi: 10.1016/j.chest.2017.01.014. No abstract available.


The Relationship between Cerebral Small Vessel Disease, Hippocampal Volume and Cognitive Functioning in Patients with COPD: An MRI Study.

Cleutjens FAHM, Ponds RWHM, Spruit MA, Burgmans S, Jacobs HIL, Gronenschild EHBM, Staals J, Franssen FME, Dijkstra JB, Vanfleteren LEGW, Hofman PA, Wouters EFM, Janssen DJA.

Front Aging Neurosci. 2017 Mar 30;9:88. doi: 10.3389/fnagi.2017.00088. eCollection 2017.


The Impact of Cognitive Impairment on Efficacy of Pulmonary Rehabilitation in Patients With COPD.

Cleutjens FAHM, Spruit MA, Ponds RWHM, Vanfleteren LEGW, Franssen FME, Dijkstra JB, Gijsen C, Wouters EFM, Janssen DJA.

J Am Med Dir Assoc. 2017 May 1;18(5):420-426. doi: 10.1016/j.jamda.2016.11.016. Epub 2017 Jan 17.


Gender differences in partners of patients with COPD and their perceptions about the patients.

Nakken N, Janssen DJ, van Vliet M, de Vries GJ, Clappers-Gielen GA, Michels AJ, Muris JW, Vercoulen JH, Wouters EF, Spruit MA.

Int J Chron Obstruct Pulmon Dis. 2016 Dec 23;12:95-104. doi: 10.2147/COPD.S118871. eCollection 2017.


Activity Levels and Exercise Motivation in Patients With COPD and Their Resident Loved Ones.

Mesquita R, Nakken N, Janssen DJA, van den Bogaart EHA, Delbressine JML, Essers JMN, Meijer K, van Vliet M, de Vries GJ, Muris JWM, Pitta F, Wouters EFM, Spruit MA.

Chest. 2017 May;151(5):1028-1038. doi: 10.1016/j.chest.2016.12.021. Epub 2017 Jan 10.


Domain-specific cognitive impairment in patients with COPD and control subjects.

Cleutjens FA, Franssen FM, Spruit MA, Vanfleteren LE, Gijsen C, Dijkstra JB, Ponds RW, Wouters EF, Janssen DJ.

Int J Chron Obstruct Pulmon Dis. 2016 Dec 19;12:1-11. doi: 10.2147/COPD.S119633. eCollection 2017.


Instability of Willingness to Accept Life-Sustaining Treatments in Patients With Advanced Chronic Organ Failure During 1 Year.

Houben CHM, Spruit MA, Schols JMGA, Wouters EFM, Janssen DJA.

Chest. 2017 May;151(5):1081-1087. doi: 10.1016/j.chest.2016.12.003. Epub 2016 Dec 19.


Sleep quality disturbances and cognitive functioning in elderly patients with COPD.

Cleutjens FA, Pedone C, Janssen DJ, Wouters EF, Incalzi RA.

ERJ Open Res. 2016 Sep 28;2(3). pii: 00054-2016. eCollection 2016 Jul.


Patient versus proxy-reported problematic activities of daily life in patients with COPD.

Nakken N, Janssen DJ, van den Bogaart EH, van Vliet M, de Vries GJ, Bootsma GP, Gronenschild MH, Delbressine JM, Muris JW, Wouters EF, Spruit MA.

Respirology. 2017 Feb;22(2):307-314. doi: 10.1111/resp.12915. Epub 2016 Oct 12.


Responsiveness and MCID Estimates for CAT, CCQ, and HADS in Patients With COPD Undergoing Pulmonary Rehabilitation: A Prospective Analysis.

Smid DE, Franssen FM, Houben-Wilke S, Vanfleteren LE, Janssen DJ, Wouters EF, Spruit MA.

J Am Med Dir Assoc. 2017 Jan;18(1):53-58. doi: 10.1016/j.jamda.2016.08.002. Epub 2016 Sep 10.


Relationship between pulmonary rehabilitation and care dependency in COPD.

Janssen DJ, Wilke S, Smid DE, Franssen FM, Augustin IM, Wouters EF, Spruit MA.

Thorax. 2016 Nov;71(11):1054-1056. doi: 10.1136/thoraxjnl-2016-208836. Epub 2016 Jul 8.


Barriers and facilitators to end-of-life communication in advanced chronic organ failure.

Van den Heuvel LA, Spruit MA, Schols JM, Hoving C, Wouters EF, Janssen DJ.

Int J Palliat Nurs. 2016 May;22(5):222-9. doi: 10.12968/ijpn.2016.22.5.222.


[A rare cause of abdominal pain in children].

Haarman MG, Janssen DJ, van der Wal MA, Kenter S.

Ned Tijdschr Geneeskd. 2016;160:A9597. Dutch.


Measurement properties of the Timed Up & Go test in patients with COPD.

Mesquita R, Wilke S, Smid DE, Janssen DJ, Franssen FM, Probst VS, Wouters EF, Muris JW, Pitta F, Spruit MA.

Chron Respir Dis. 2016 Nov;13(4):344-352. doi: 10.1177/1479972316647178. Epub 2016 Jul 8.


Update on Prevalence of Pain in Patients With Cancer: Systematic Review and Meta-Analysis.

van den Beuken-van Everdingen MH, Hochstenbach LM, Joosten EA, Tjan-Heijnen VC, Janssen DJ.

J Pain Symptom Manage. 2016 Jun;51(6):1070-1090.e9. doi: 10.1016/j.jpainsymman.2015.12.340. Epub 2016 Apr 23. Review.


Definition of a COPD self-management intervention: International Expert Group consensus.

Effing TW, Vercoulen JH, Bourbeau J, Trappenburg J, Lenferink A, Cafarella P, Coultas D, Meek P, van der Valk P, Bischoff EW, Bucknall C, Dewan NA, Early F, Fan V, Frith P, Janssen DJ, Mitchell K, Morgan M, Nici L, Patel I, Walters H, Rice KL, Singh S, Zuwallack R, Benzo R, Goldstein R, Partridge MR, van der Palen J.

Eur Respir J. 2016 Jul;48(1):46-54. doi: 10.1183/13993003.00025-2016. Epub 2016 Apr 13.

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