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Items: 1 to 50 of 233

1.

Biochemical properties of a Pseudomonas aminotransferase involved in caprolactam metabolism.

Palacio CM, Rozeboom HJ, Lanfranchi E, Meng Q, Otzen M, Janssen DB.

FEBS J. 2019 Jun 4. doi: 10.1111/febs.14950. [Epub ahead of print]

PMID:
31162815
2.

Efficient Enzymatic Cyclization of Disulfide-Rich Peptides by Using Peptide Ligases.

Schmidt M, Huang YH, Texeira de Oliveira EF, Toplak A, Wijma HJ, Janssen DB, van Maarseveen JH, Craik DJ, Nuijens T.

Chembiochem. 2019 Jun 14;20(12):1524-1529. doi: 10.1002/cbic.201900033. Epub 2019 Apr 25.

PMID:
30735312
3.

Microbial Synthesis and Transformation of Inorganic and Organic Chlorine Compounds.

Atashgahi S, Liebensteiner MG, Janssen DB, Smidt H, Stams AJM, Sipkema D.

Front Microbiol. 2018 Dec 12;9:3079. doi: 10.3389/fmicb.2018.03079. eCollection 2018. Review.

4.

Exploring the Selective Demethylation of Aryl Methyl Ethers with a Pseudomonas Rieske Monooxygenase.

Lanfranchi E, Trajković M, Barta K, de Vries JG, Janssen DB.

Chembiochem. 2019 Jan 2;20(1):118-125. doi: 10.1002/cbic.201800594. Epub 2018 Dec 17.

PMID:
30362644
5.

Characterization of the caprolactam degradation pathway in Pseudomonas jessenii using mass spectrometry-based proteomics.

Otzen M, Palacio C, Janssen DB.

Appl Microbiol Biotechnol. 2018 Aug;102(15):6699-6711. doi: 10.1007/s00253-018-9073-7. Epub 2018 May 31.

6.

Computational redesign of enzymes for regio- and enantioselective hydroamination.

Li R, Wijma HJ, Song L, Cui Y, Otzen M, Tian Y, Du J, Li T, Niu D, Chen Y, Feng J, Han J, Chen H, Tao Y, Janssen DB, Wu B.

Nat Chem Biol. 2018 Jul;14(7):664-670. doi: 10.1038/s41589-018-0053-0. Epub 2018 May 21.

PMID:
29785057
7.

Design of a substrate-tailored peptiligase variant for the efficient synthesis of thymosin-α1.

Schmidt M, Toplak A, Rozeboom HJ, Wijma HJ, Quaedflieg PJLM, van Maarseveen JH, Janssen DB, Nuijens T.

Org Biomol Chem. 2018 Jan 24;16(4):609-618. doi: 10.1039/c7ob02812a.

PMID:
29300408
8.

Exploring PTDH-P450BM3 Variants for the Synthesis of Drug Metabolites.

Beyer N, Kulig JK, Fraaije MW, Hayes MA, Janssen DB.

Chembiochem. 2018 Feb 16;19(4):326-337. doi: 10.1002/cbic.201700470. Epub 2018 Jan 17.

PMID:
29181885
9.

A Computational Library Design Protocol for Rapid Improvement of Protein Stability: FRESCO.

Wijma HJ, Fürst MJLJ, Janssen DB.

Methods Mol Biol. 2018;1685:69-85. doi: 10.1007/978-1-4939-7366-8_5.

PMID:
29086304
10.

Metal Dependence of the Xylose Isomerase from Piromyces sp. E2 Explored by Activity Profiling and Protein Crystallography.

Lee M, Rozeboom HJ, de Waal PP, de Jong RM, Dudek HM, Janssen DB.

Biochemistry. 2017 Nov 14;56(45):5991-6005. doi: 10.1021/acs.biochem.7b00777. Epub 2017 Nov 2.

11.

Genome Sequence of the Dichloromethane-Degrading Bacterium Hyphomicrobium sp. Strain GJ21.

Bringel F, Postema CP, Mangenot S, Bibi-Triki S, Chaignaud P, Farhan Ul Haque M, Gruffaz C, Hermon L, Louhichi Y, Maucourt B, Muller EEL, Nadalig T, Lajus A, Rouy Z, Médigue C, Barbe V, Janssen DB, Vuilleumier S.

Genome Announc. 2017 Jul 27;5(30). pii: e00622-17. doi: 10.1128/genomeA.00622-17.

12.

Mutations in PMR1 stimulate xylose isomerase activity and anaerobic growth on xylose of engineered Saccharomyces cerevisiae by influencing manganese homeostasis.

Verhoeven MD, Lee M, Kamoen L, van den Broek M, Janssen DB, Daran JG, van Maris AJ, Pronk JT.

Sci Rep. 2017 Apr 12;7:46155. doi: 10.1038/srep46155.

13.

A robust cosolvent-compatible halohydrin dehalogenase by computational library design.

Arabnejad H, Dal Lago M, Jekel PA, Floor RJ, Thunnissen AWH, Terwisscha van Scheltinga AC, Wijma HJ, Janssen DB.

Protein Eng Des Sel. 2017 Mar 1;30(3):173-187. doi: 10.1093/protein/gzw068.

PMID:
27999093
14.

P450BM3 fused to phosphite dehydrogenase allows phosphite-driven selective oxidations.

Beyer N, Kulig JK, Bartsch A, Hayes MA, Janssen DB, Fraaije MW.

Appl Microbiol Biotechnol. 2017 Mar;101(6):2319-2331. doi: 10.1007/s00253-016-7993-7. Epub 2016 Nov 29.

15.

Enzymatic network for production of ether amines from alcohols.

Palacio CM, Crismaru CG, Bartsch S, Navickas V, Ditrich K, Breuer M, Abu R, Woodley JM, Baldenius K, Wu B, Janssen DB.

Biotechnol Bioeng. 2016 Sep;113(9):1853-61. doi: 10.1002/bit.25954. Epub 2016 Mar 9.

PMID:
26915048
16.

Ultrahigh-throughput discovery of promiscuous enzymes by picodroplet functional metagenomics.

Colin PY, Kintses B, Gielen F, Miton CM, Fischer G, Mohamed MF, Hyvönen M, Morgavi DP, Janssen DB, Hollfelder F.

Nat Commun. 2015 Dec 7;6:10008. doi: 10.1038/ncomms10008.

17.

Metabolism of β-valine via a CoA-dependent ammonia lyase pathway.

Otzen M, Crismaru CG, Postema CP, Wijma HJ, Heberling MM, Szymanski W, de Wildeman S, Janssen DB.

Appl Microbiol Biotechnol. 2015 Nov;99(21):8987-98. doi: 10.1007/s00253-015-6551-z. Epub 2015 May 26.

18.

Peptide synthesis in neat organic solvents with novel thermostable proteases.

Toplak A, Nuijens T, Quaedflieg PJ, Wu B, Janssen DB.

Enzyme Microb Technol. 2015 Jun;73-74:20-8. doi: 10.1016/j.enzmictec.2015.03.003. Epub 2015 Mar 11.

PMID:
26002500
19.

Lyophilization conditions for the storage of monooxygenases.

van Beek HL, Beyer N, Janssen DB, Fraaije MW.

J Biotechnol. 2015 Jun 10;203:41-4. doi: 10.1016/j.jbiotec.2015.03.010. Epub 2015 Mar 26.

PMID:
25817248
20.

X-ray crystallographic validation of structure predictions used in computational design for protein stabilization.

Floor RJ, Wijma HJ, Jekel PA, Terwisscha van Scheltinga AC, Dijkstra BW, Janssen DB.

Proteins. 2015 May;83(5):940-51. doi: 10.1002/prot.24791. Epub 2015 Mar 25.

PMID:
25739581
21.

Functional Exchangeability of Oxidase and Dehydrogenase Reactions in the Biosynthesis of Hydroxyphenylglycine, a Nonribosomal Peptide Building Block.

Diez V, Loznik M, Taylor S, Winn M, Rattray NJ, Podmore H, Micklefield J, Goodacre R, Medema MH, Müller U, Bovenberg R, Janssen DB, Takano E.

ACS Synth Biol. 2015 Jul 17;4(7):796-807. doi: 10.1021/sb500368w. Epub 2015 Mar 9.

PMID:
25713978
22.

A single point mutation enhances hydroxynitrile synthesis by halohydrin dehalogenase.

Schallmey M, Jekel P, Tang L, Majerić Elenkov M, Höffken HW, Hauer B, Janssen DB.

Enzyme Microb Technol. 2015 Mar;70:50-7. doi: 10.1016/j.enzmictec.2014.12.009. Epub 2014 Dec 24.

PMID:
25659632
23.

Enantioselective enzymes by computational design and in silico screening.

Wijma HJ, Floor RJ, Bjelic S, Marrink SJ, Baker D, Janssen DB.

Angew Chem Int Ed Engl. 2015 Mar 16;54(12):3726-30. doi: 10.1002/anie.201411415. Epub 2015 Feb 4.

PMID:
25651000
24.

Ironing out their differences: dissecting the structural determinants of a phenylalanine aminomutase and ammonia lyase.

Heberling MM, Masman MF, Bartsch S, Wybenga GG, Dijkstra BW, Marrink SJ, Janssen DB.

ACS Chem Biol. 2015 Apr 17;10(4):989-97. doi: 10.1021/cb500794h. Epub 2015 Jan 20.

PMID:
25494407
25.

Computational library design for increasing haloalkane dehalogenase stability.

Floor RJ, Wijma HJ, Colpa DI, Ramos-Silva A, Jekel PA, Szymański W, Feringa BL, Marrink SJ, Janssen DB.

Chembiochem. 2014 Jul 21;15(11):1660-72. doi: 10.1002/cbic.201402128. Epub 2014 Jun 27.

PMID:
24976371
26.

A Pseudomonas putida strain genetically engineered for 1,2,3-trichloropropane bioremediation.

Samin G, Pavlova M, Arif MI, Postema CP, Damborsky J, Janssen DB.

Appl Environ Microbiol. 2014 Sep;80(17):5467-76. doi: 10.1128/AEM.01620-14. Epub 2014 Jun 27.

27.

Computationally efficient and accurate enantioselectivity modeling by clusters of molecular dynamics simulations.

Wijma HJ, Marrink SJ, Janssen DB.

J Chem Inf Model. 2014 Jul 28;54(7):2079-92. doi: 10.1021/ci500126x. Epub 2014 Jun 30.

PMID:
24916632
28.

Structural investigations into the stereochemistry and activity of a phenylalanine-2,3-aminomutase from Taxus chinensis.

Wybenga GG, Szymanski W, Wu B, Feringa BL, Janssen DB, Dijkstra BW.

Biochemistry. 2014 May 20;53(19):3187-98. doi: 10.1021/bi500187a. Epub 2014 May 12.

PMID:
24786474
29.

Stabilization of cyclohexanone monooxygenase by a computationally designed disulfide bond spanning only one residue.

van Beek HL, Wijma HJ, Fromont L, Janssen DB, Fraaije MW.

FEBS Open Bio. 2014 Feb 3;4:168-74. doi: 10.1016/j.fob.2014.01.009. eCollection 2014.

30.

Computationally designed libraries for rapid enzyme stabilization.

Wijma HJ, Floor RJ, Jekel PA, Baker D, Marrink SJ, Janssen DB.

Protein Eng Des Sel. 2014 Feb;27(2):49-58. doi: 10.1093/protein/gzt061. Epub 2014 Jan 8.

31.

Selective steroid oxyfunctionalisation by CYP154C5, a bacterial cytochrome P450.

Bracco P, Janssen DB, Schallmey A.

Microb Cell Fact. 2013 Oct 17;12:95. doi: 10.1186/1475-2859-12-95.

32.

Kinetic resolution and stereoselective synthesis of 3-substituted aspartic acids by using engineered methylaspartate ammonia lyases.

Raj H, Szymanski W, de Villiers J, Puthan Veetil V, Quax WJ, Shimamoto K, Janssen DB, Feringa BL, Poelarends GJ.

Chemistry. 2013 Aug 19;19(34):11148-52. doi: 10.1002/chem.201301832. Epub 2013 Jul 12.

PMID:
23852946
33.

Proteolysin, a novel highly thermostable and cosolvent-compatible protease from the thermophilic bacterium Coprothermobacter proteolyticus.

Toplak A, Wu B, Fusetti F, Quaedflieg PJ, Janssen DB.

Appl Environ Microbiol. 2013 Sep;79(18):5625-32. doi: 10.1128/AEM.01479-13. Epub 2013 Jul 12.

34.

Structure- and sequence-analysis inspired engineering of proteins for enhanced thermostability.

Wijma HJ, Floor RJ, Janssen DB.

Curr Opin Struct Biol. 2013 Aug;23(4):588-94. doi: 10.1016/j.sbi.2013.04.008. Epub 2013 May 15. Review.

PMID:
23683520
35.

Computational design gains momentum in enzyme catalysis engineering.

Wijma HJ, Janssen DB.

FEBS J. 2013 Jul;280(13):2948-60. doi: 10.1111/febs.12324. Epub 2013 Jun 3. Review.

36.

Biocatalytic and structural properties of a highly engineered halohydrin dehalogenase.

Schallmey M, Floor RJ, Hauer B, Breuer M, Jekel PA, Wijma HJ, Dijkstra BW, Janssen DB.

Chembiochem. 2013 May 10;14(7):870-81. doi: 10.1002/cbic.201300005. Epub 2013 Apr 12.

PMID:
23585096
37.

Priming ammonia lyases and aminomutases for industrial and therapeutic applications.

Heberling MM, Wu B, Bartsch S, Janssen DB.

Curr Opin Chem Biol. 2013 Apr;17(2):250-60. doi: 10.1016/j.cbpa.2013.02.013. Epub 2013 Apr 1. Review.

PMID:
23557642
38.

Purification and use of E. coli peptide deformylase for peptide deprotection in chemoenzymatic peptide synthesis.

Di Toma C, Sonke T, Quaedflieg PJ, Volker Wagner AF, Janssen DB.

Protein Expr Purif. 2013 May;89(1):73-9. doi: 10.1016/j.pep.2013.01.004. Epub 2013 Jan 26. Erratum in: Protein Expr Purif. 2013 Aug;90(2):141. Volker Wagner, A F [added].

PMID:
23357810
39.

Azobenzene photoswitches for Staudinger-Bertozzi ligation.

Szymański W, Wu B, Poloni C, Janssen DB, Feringa BL.

Angew Chem Int Ed Engl. 2013 Feb 11;52(7):2068-72. doi: 10.1002/anie.201208596. Epub 2013 Jan 10. No abstract available.

PMID:
23307784
40.

Biochemical properties and crystal structure of a β-phenylalanine aminotransferase from Variovorax paradoxus.

Crismaru CG, Wybenga GG, Szymanski W, Wijma HJ, Wu B, Bartsch S, de Wildeman S, Poelarends GJ, Feringa BL, Dijkstra BW, Janssen DB.

Appl Environ Microbiol. 2013 Jan;79(1):185-95. doi: 10.1128/AEM.02525-12. Epub 2012 Oct 19.

41.

Transformation and biodegradation of 1,2,3-trichloropropane (TCP).

Samin G, Janssen DB.

Environ Sci Pollut Res Int. 2012 Sep;19(8):3067-78. doi: 10.1007/s11356-012-0859-3. Epub 2012 Aug 8. Review.

42.

Degradation of chloroaromatics: structure and catalytic activities of wild-type chlorocatechol 2,3-dioxygenases and modified ones.

Schmidt E, Mandt C, Janssen DB, Pieper DH, Reineke W.

Environ Microbiol. 2013 Jan;15(1):183-90. doi: 10.1111/j.1462-2920.2012.02831.x. Epub 2012 Jul 23.

PMID:
22816508
43.

Novel dehalogenase mechanism for 2,3-dichloro-1-propanol utilization in Pseudomonas putida strain MC4.

Arif MI, Samin G, van Leeuwen JG, Oppentocht J, Janssen DB.

Appl Environ Microbiol. 2012 Sep;78(17):6128-36. doi: 10.1128/AEM.00760-12. Epub 2012 Jun 29.

44.

Structural determinants of the β-selectivity of a bacterial aminotransferase.

Wybenga GG, Crismaru CG, Janssen DB, Dijkstra BW.

J Biol Chem. 2012 Aug 17;287(34):28495-502. doi: 10.1074/jbc.M112.375238. Epub 2012 Jun 28.

45.

Engineering methylaspartate ammonia lyase for the asymmetric synthesis of unnatural amino acids.

Raj H, Szymański W, de Villiers J, Rozeboom HJ, Veetil VP, Reis CR, de Villiers M, Dekker FJ, de Wildeman S, Quax WJ, Thunnissen AM, Feringa BL, Janssen DB, Poelarends GJ.

Nat Chem. 2012 Apr 29;4(6):478-84. doi: 10.1038/nchem.1338.

PMID:
22614383
46.

Mechanism-inspired engineering of phenylalanine aminomutase for enhanced β-regioselective asymmetric amination of cinnamates.

Wu B, Szymański W, Wybenga GG, Heberling MM, Bartsch S, de Wildeman S, Poelarends GJ, Feringa BL, Dijkstra BW, Janssen DB.

Angew Chem Int Ed Engl. 2012 Jan 9;51(2):482-6. doi: 10.1002/anie.201106372. Epub 2011 Nov 23.

PMID:
22113970
47.

Directed evolution strategies for enantiocomplementary haloalkane dehalogenases: from chemical waste to enantiopure building blocks.

van Leeuwen JG, Wijma HJ, Floor RJ, van der Laan JM, Janssen DB.

Chembiochem. 2012 Jan 2;13(1):137-48. doi: 10.1002/cbic.201100579. Epub 2011 Nov 23.

PMID:
22109980
48.

Isolation and characterization of a Rhodococcus strain able to degrade 2-fluorophenol.

Duque AF, Hasan SA, Bessa VS, Carvalho MF, Samin G, Janssen DB, Castro PM.

Appl Microbiol Biotechnol. 2012 Jul;95(2):511-20. doi: 10.1007/s00253-011-3696-2. Epub 2011 Nov 19.

PMID:
22101783
49.

Characterization of a thermostable methylaspartate ammonia lyase from Carboxydothermus hydrogenoformans.

Raj H, Puthan Veetil V, Szymanski W, Dekker FJ, Quax WJ, Feringa BL, Janssen DB, Poelarends GJ.

Appl Microbiol Biotechnol. 2012 Apr;94(2):385-97. doi: 10.1007/s00253-011-3615-6. Epub 2011 Oct 18.

50.

A simple enantioconvergent and chemoenzymatic synthesis of optically active α-substituted amides.

Szymański W, Westerbeek A, Janssen DB, Feringa BL.

Angew Chem Int Ed Engl. 2011 Nov 4;50(45):10712-5. doi: 10.1002/anie.201105164. Epub 2011 Sep 16. No abstract available.

PMID:
21922620

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