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Items: 30

1.

Use of capillary Western immunoassay (Wes) for quantification of dystrophin levels in skeletal muscle of healthy controls and individuals with Becker and Duchenne muscular dystrophy.

Beekman C, Janson AA, Baghat A, van Deutekom JC, Datson NA.

PLoS One. 2018 Apr 11;13(4):e0195850. doi: 10.1371/journal.pone.0195850. eCollection 2018.

2.

Dystrophin levels and clinical severity in Becker muscular dystrophy patients.

van den Bergen JC, Wokke BH, Janson AA, van Duinen SG, Hulsker MA, Ginjaar HB, van Deutekom JC, Aartsma-Rus A, Kan HE, Verschuuren JJ.

J Neurol Neurosurg Psychiatry. 2014 Jul;85(7):747-53. doi: 10.1136/jnnp-2013-306350. Epub 2013 Nov 29.

PMID:
24292997
3.

DMD transcript imbalance determines dystrophin levels.

Spitali P, van den Bergen JC, Verhaart IE, Wokke B, Janson AA, van den Eijnde R, den Dunnen JT, Laros JF, Verschuuren JJ, 't Hoen PA, Aartsma-Rus A.

FASEB J. 2013 Dec;27(12):4909-16. doi: 10.1096/fj.13-232025. Epub 2013 Aug 23.

PMID:
23975932
4.

Systemic administration of PRO051 in Duchenne's muscular dystrophy.

Goemans NM, Tulinius M, van den Akker JT, Burm BE, Ekhart PF, Heuvelmans N, Holling T, Janson AA, Platenburg GJ, Sipkens JA, Sitsen JM, Aartsma-Rus A, van Ommen GJ, Buyse G, Darin N, Verschuuren JJ, Campion GV, de Kimpe SJ, van Deutekom JC.

N Engl J Med. 2011 Apr 21;364(16):1513-22. doi: 10.1056/NEJMoa1011367. Epub 2011 Mar 23. Erratum in: N Engl J Med. 2011 Oct 6;365(14):1361.

5.

Guidelines for antisense oligonucleotide design and insight into splice-modulating mechanisms.

Aartsma-Rus A, van Vliet L, Hirschi M, Janson AA, Heemskerk H, de Winter CL, de Kimpe S, van Deutekom JC, 't Hoen PA, van Ommen GJ.

Mol Ther. 2009 Mar;17(3):548-53. doi: 10.1038/mt.2008.205. Epub 2008 Sep 23.

6.

Local dystrophin restoration with antisense oligonucleotide PRO051.

van Deutekom JC, Janson AA, Ginjaar IB, Frankhuizen WS, Aartsma-Rus A, Bremmer-Bout M, den Dunnen JT, Koop K, van der Kooi AJ, Goemans NM, de Kimpe SJ, Ekhart PF, Venneker EH, Platenburg GJ, Verschuuren JJ, van Ommen GJ.

N Engl J Med. 2007 Dec 27;357(26):2677-86.

7.

Antisense-induced exon skipping for duplications in Duchenne muscular dystrophy.

Aartsma-Rus A, Janson AA, van Ommen GJ, van Deutekom JC.

BMC Med Genet. 2007 Jul 5;8:43.

8.

Therapeutic modulation of DMD splicing by blocking exonic splicing enhancer sites with antisense oligonucleotides.

Aartsma-Rus A, Janson AA, Heemskerk JA, De Winter CL, Van Ommen GJ, Van Deutekom JC.

Ann N Y Acad Sci. 2006 Oct;1082:74-6.

PMID:
17145928
9.

Duplications in the DMD gene.

White SJ, Aartsma-Rus A, Flanigan KM, Weiss RB, Kneppers AL, Lalic T, Janson AA, Ginjaar HB, Breuning MH, den Dunnen JT.

Hum Mutat. 2006 Sep;27(9):938-45.

PMID:
16917894
10.

Functional analysis of 114 exon-internal AONs for targeted DMD exon skipping: indication for steric hindrance of SR protein binding sites.

Aartsma-Rus A, De Winter CL, Janson AA, Kaman WE, Van Ommen GJ, Den Dunnen JT, Van Deutekom JC.

Oligonucleotides. 2005 Dec;15(4):284-97.

PMID:
16396622
11.

Targeted exon skipping in transgenic hDMD mice: A model for direct preclinical screening of human-specific antisense oligonucleotides.

Bremmer-Bout M, Aartsma-Rus A, de Meijer EJ, Kaman WE, Janson AA, Vossen RH, van Ommen GJ, den Dunnen JT, van Deutekom JC.

Mol Ther. 2004 Aug;10(2):232-40.

12.

Comparative analysis of antisense oligonucleotide analogs for targeted DMD exon 46 skipping in muscle cells.

Aartsma-Rus A, Kaman WE, Bremmer-Bout M, Janson AA, den Dunnen JT, van Ommen GJ, van Deutekom JC.

Gene Ther. 2004 Sep;11(18):1391-8.

PMID:
15229633
13.

Antisense-induced multiexon skipping for Duchenne muscular dystrophy makes more sense.

Aartsma-Rus A, Janson AA, Kaman WE, Bremmer-Bout M, van Ommen GJ, den Dunnen JT, van Deutekom JC.

Am J Hum Genet. 2004 Jan;74(1):83-92. Epub 2003 Dec 16.

14.

Therapeutic antisense-induced exon skipping in cultured muscle cells from six different DMD patients.

Aartsma-Rus A, Janson AA, Kaman WE, Bremmer-Bout M, den Dunnen JT, Baas F, van Ommen GJ, van Deutekom JC.

Hum Mol Genet. 2003 Apr 15;12(8):907-14.

PMID:
12668614
15.

Targeted exon skipping as a potential gene correction therapy for Duchenne muscular dystrophy.

Aartsma-Rus A, Bremmer-Bout M, Janson AA, den Dunnen JT, van Ommen GJ, van Deutekom JC.

Neuromuscul Disord. 2002 Oct;12 Suppl 1:S71-7.

PMID:
12206800
16.

Exploiting the natural diversity in adenovirus tropism for therapy and prevention of disease.

Havenga MJ, Lemckert AA, Ophorst OJ, van Meijer M, Germeraad WT, Grimbergen J, van Den Doel MA, Vogels R, van Deutekom J, Janson AA, de Bruijn JD, Uytdehaag F, Quax PH, Logtenberg T, Mehtali M, Bout A.

J Virol. 2002 May;76(9):4612-20.

17.

Antisense-induced exon skipping restores dystrophin expression in DMD patient derived muscle cells.

van Deutekom JC, Bremmer-Bout M, Janson AA, Ginjaar IB, Baas F, den Dunnen JT, van Ommen GJ.

Hum Mol Genet. 2001 Jul 15;10(15):1547-54.

PMID:
11468272
18.

HLA-class II-associated control of antigen recognition by T cells in leprosy: a prominent role for the 30/31-kDa antigens.

Thole JE, Janson AA, Cornelisse Y, Schreuder GM, Wieles B, Naafs B, de Vries RR, Ottenhoff TH.

J Immunol. 1999 Jun 1;162(11):6912-8.

19.

IL-2 and IL-12 act in synergy to overcome antigen-specific T cell unresponsiveness in mycobacterial disease.

de Jong R, Janson AA, Faber WR, Naafs B, Ottenhoff TH.

J Immunol. 1997 Jul 15;159(2):786-93.

PMID:
9218596
20.

Analysis of T-cell and B-cell responses to recombinant M. leprae antigens in leprosy patients and in healthy contacts: significant T-cell responses to antigens in M. leprae nonresponders.

Thole JE, Janson AA, Kifle A, Howe RC, McLean K, Nurilygn A, Filley E, Shannon EJ, Bulla GJ, Hermans J, et al.

Int J Lepr Other Mycobact Dis. 1995 Sep;63(3):369-80.

PMID:
7594920
21.

A Mycobacterium leprae-specific gene encoding an immunologically recognized 45 kDa protein.

Rinke de Wit TF, Clark-Curtiss JE, Abebe F, Kolk AH, Janson AA, van Agterveld M, Thole JE.

Mol Microbiol. 1993 Nov;10(4):829-38.

PMID:
7934845
22.

The Mycobacterium leprae antigen 85 complex gene family: identification of the genes for the 85A, 85C, and related MPT51 proteins.

Rinke de Wit TF, Bekelie S, Osland A, Wieles B, Janson AA, Thole JE.

Infect Immun. 1993 Sep;61(9):3642-7.

23.

Functional analysis of DR17(DR3)-restricted mycobacterial T cell epitopes reveals DR17-binding motif and enables the design of allele-specific competitor peptides.

Geluk A, Van Meijgaarden KE, Janson AA, Drijfhout JW, Meloen RH, De Vries RR, Ottenhoff TH.

J Immunol. 1992 Nov 1;149(9):2864-71.

PMID:
1383331
24.

Mycobacteria contain two groEL genes: the second Mycobacterium leprae groEL gene is arranged in an operon with groES.

Rinke de Wit TF, Bekelie S, Osland A, Miko TL, Hermans PW, van Soolingen D, Drijfhout JW, Schöningh R, Janson AA, Thole JE.

Mol Microbiol. 1992 Jul;6(14):1995-2007.

PMID:
1354834
25.

Molecular and immunological analysis of a fibronectin-binding protein antigen secreted by Mycobacterium leprae.

Thole JE, Schöningh R, Janson AA, Garbe T, Cornelisse YE, Clark-Curtiss JE, Kolk AH, Ottenhoff TH, De Vries RR, Abou-Zeid C.

Mol Microbiol. 1992 Jan;6(2):153-63.

PMID:
1532043
26.
27.

Diversity in antigen recognition by Mycobacterium tuberculosis-reactive T cell clones from the synovial fluid of rheumatoid arthritis patients.

Res PC, Orsini DL, Van Laar JM, Janson AA, Abou-Zeid C, De Vries RR.

Eur J Immunol. 1991 May;21(5):1297-302.

PMID:
1903707
28.

Use of flanking sequences to study secondary structure-activity correlations of a Mycobacterium leprae T cell epitope.

Anderson DC, Van Schooten WC, Barry ME, Janson AA, DeVries RR.

Eur J Immunol. 1990 Dec;20(12):2691-7.

PMID:
1702724
29.

A Mycobacterium leprae-specific human T cell epitope cross-reactive with an HLA-DR2 peptide.

Anderson DC, van Schooten WC, Barry ME, Janson AA, Buchanan TM, de Vries RR.

Science. 1988 Oct 14;242(4876):259-61.

PMID:
2459778
30.

Use of recombinant antigens expressed in Escherichia coli K-12 to map B-cell and T-cell epitopes on the immunodominant 65-kilodalton protein of Mycobacterium bovis BCG.

Thole JE, van Schooten WC, Keulen WJ, Hermans PW, Janson AA, de Vries RR, Kolk AH, van Embden JD.

Infect Immun. 1988 Jun;56(6):1633-40.

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