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Items: 12

1.

KDM5B Promotes Drug Resistance by Regulating Melanoma-Propagating Cell Subpopulations.

Liu X, Zhang SM, McGeary MK, Krykbaeva I, Lai L, Jansen DJ, Kales SC, Simeonov A, Hall MD, Kelly DP, Bosenberg MW, Yan Q.

Mol Cancer Ther. 2019 Mar;18(3):706-717. doi: 10.1158/1535-7163.MCT-18-0395. Epub 2018 Dec 6.

PMID:
30523048
2.

Structure-Based Engineering of Irreversible Inhibitors against Histone Lysine Demethylase KDM5A.

Horton JR, Woodcock CB, Chen Q, Liu X, Zhang X, Shanks J, Rai G, Mott BT, Jansen DJ, Kales SC, Henderson MJ, Cyr M, Pohida K, Hu X, Shah P, Xu X, Jadhav A, Maloney DJ, Hall MD, Simeonov A, Fu H, Vertino PM, Cheng X.

J Med Chem. 2018 Dec 13;61(23):10588-10601. doi: 10.1021/acs.jmedchem.8b01219. Epub 2018 Nov 15.

3.

KDM5 histone demethylases repress immune response via suppression of STING.

Wu L, Cao J, Cai WL, Lang SM, Horton JR, Jansen DJ, Liu ZZ, Chen JF, Zhang M, Mott BT, Pohida K, Rai G, Kales SC, Henderson MJ, Hu X, Jadhav A, Maloney DJ, Simeonov A, Zhu S, Iwasaki A, Hall MD, Cheng X, Shadel GS, Yan Q.

PLoS Biol. 2018 Aug 6;16(8):e2006134. doi: 10.1371/journal.pbio.2006134. eCollection 2018 Aug.

4.

Insights into the Action of Inhibitor Enantiomers against Histone Lysine Demethylase 5A.

Horton JR, Liu X, Wu L, Zhang K, Shanks J, Zhang X, Rai G, Mott BT, Jansen DJ, Kales SC, Henderson MJ, Pohida K, Fang Y, Hu X, Jadhav A, Maloney DJ, Hall MD, Simeonov A, Fu H, Vertino PM, Yan Q, Cheng X.

J Med Chem. 2018 Apr 12;61(7):3193-3208. doi: 10.1021/acs.jmedchem.8b00261. Epub 2018 Mar 23.

5.

Structural Basis for KDM5A Histone Lysine Demethylase Inhibition by Diverse Compounds.

Horton JR, Liu X, Gale M, Wu L, Shanks JR, Zhang X, Webber PJ, Bell JSK, Kales SC, Mott BT, Rai G, Jansen DJ, Henderson MJ, Urban DJ, Hall MD, Simeonov A, Maloney DJ, Johns MA, Fu H, Jadhav A, Vertino PM, Yan Q, Cheng X.

Cell Chem Biol. 2016 Jul 21;23(7):769-781. doi: 10.1016/j.chembiol.2016.06.006. Epub 2016 Jul 14.

6.

Synthesis and Sulfur Electrophilicity of the Nuphar Thiaspirane Pharmacophore.

Tada N, Jansen DJ, Mower MP, Blewett MM, Umotoy JC, Cravatt BF, Wolan DW, Shenvi RA.

ACS Cent Sci. 2016 Jun 22;2(6):401-8. doi: 10.1021/acscentsci.6b00113. Epub 2016 Jun 13.

7.

Synthesis of medicinally relevant terpenes: reducing the cost and time of drug discovery.

Jansen DJ, Shenvi RA.

Future Med Chem. 2014 Jun;6(10):1127-48. doi: 10.4155/fmc.14.71.

8.

Synthesis of (-)-neothiobinupharidine.

Jansen DJ, Shenvi RA.

J Am Chem Soc. 2013 Jan 30;135(4):1209-12. doi: 10.1021/ja310778t. Epub 2013 Jan 11.

PMID:
23298203
9.

A stereoselective hydroamination transform to access polysubstituted indolizidines.

Pronin SV, Tabor MG, Jansen DJ, Shenvi RA.

J Am Chem Soc. 2012 Feb 1;134(4):2012-5. doi: 10.1021/ja211090n. Epub 2012 Jan 20.

PMID:
22263967
10.

Intramolecular azide-alkyne [3 + 2] cycloaddition: versatile route to new heterocyclic structural scaffolds.

Li R, Jansen DJ, Datta A.

Org Biomol Chem. 2009 May 7;7(9):1921-30. doi: 10.1039/b818962e. Epub 2009 Mar 20.

PMID:
19590789
11.

Doxazosin-to-terazosin switch for benign prostatic hyperplasia.

Jansen DJ Jr, Resch ND, Hoffman RM.

Am J Health Syst Pharm. 1999 Jul 1;56(13):1351. No abstract available.

PMID:
10683137

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