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Items: 1 to 50 of 57

1.

Efficient Pre-mRNA Cleavage Prevents Replication-Stress-Associated Genome Instability.

Teloni F, Michelena J, Lezaja A, Kilic S, Ambrosi C, Menon S, Dobrovolna J, Imhof R, Janscak P, Baubec T, Altmeyer M.

Mol Cell. 2019 Feb 21;73(4):670-683.e12. doi: 10.1016/j.molcel.2018.11.036. Epub 2019 Jan 10.

2.

Replication fork reversal triggers fork degradation in BRCA2-defective cells.

Mijic S, Zellweger R, Chappidi N, Berti M, Jacobs K, Mutreja K, Ursich S, Ray Chaudhuri A, Nussenzweig A, Janscak P, Lopes M.

Nat Commun. 2017 Oct 16;8(1):859. doi: 10.1038/s41467-017-01164-5.

3.

RECQ5 Helicase Cooperates with MUS81 Endonuclease in Processing Stalled Replication Forks at Common Fragile Sites during Mitosis.

Di Marco S, Hasanova Z, Kanagaraj R, Chappidi N, Altmannova V, Menon S, Sedlackova H, Langhoff J, Surendranath K, Hühn D, Bhowmick R, Marini V, Ferrari S, Hickson ID, Krejci L, Janscak P.

Mol Cell. 2017 Jun 1;66(5):658-671.e8. doi: 10.1016/j.molcel.2017.05.006.

4.

Interplay with the Mre11-Rad50-Nbs1 complex and phosphorylation by GSK3β implicate human B-Myb in DNA-damage signaling.

Henrich SM, Usadel C, Werwein E, Burdova K, Janscak P, Ferrari S, Hess D, Klempnauer KH.

Sci Rep. 2017 Jan 27;7:41663. doi: 10.1038/srep41663.

5.

Distinct functions of human RecQ helicases during DNA replication.

Urban V, Dobrovolna J, Janscak P.

Biophys Chem. 2017 Jun;225:20-26. doi: 10.1016/j.bpc.2016.11.005. Epub 2016 Nov 15. Review.

PMID:
27876204
6.

The MMS22L-TONSL heterodimer directly promotes RAD51-dependent recombination upon replication stress.

Piwko W, Mlejnkova LJ, Mutreja K, Ranjha L, Stafa D, Smirnov A, Brodersen MM, Zellweger R, Sturzenegger A, Janscak P, Lopes M, Peter M, Cejka P.

EMBO J. 2016 Dec 1;35(23):2584-2601. Epub 2016 Oct 26.

7.

RECQ5 helicase promotes resolution of conflicts between replication and transcription in human cells.

Urban V, Dobrovolna J, Hühn D, Fryzelkova J, Bartek J, Janscak P.

J Cell Biol. 2016 Aug 15;214(4):401-15. doi: 10.1083/jcb.201507099. Epub 2016 Aug 8.

8.

A Comparative Study of G-Quadruplex Unfolding and DNA Reeling Activities of Human RECQ5 Helicase.

Budhathoki JB, Maleki P, Roy WA, Janscak P, Yodh JG, Balci H.

Biophys J. 2016 Jun 21;110(12):2585-2596. doi: 10.1016/j.bpj.2016.05.016.

9.

The Mismatch-Binding Factor MutSβ Can Mediate ATR Activation in Response to DNA Double-Strand Breaks.

Burdova K, Mihaljevic B, Sturzenegger A, Chappidi N, Janscak P.

Mol Cell. 2015 Aug 20;59(4):603-14. doi: 10.1016/j.molcel.2015.06.026. Epub 2015 Jul 23.

10.

Functional coupling of duplex translocation to DNA cleavage in a type I restriction enzyme.

Csefalvay E, Lapkouski M, Guzanova A, Csefalvay L, Baikova T, Shevelev I, Bialevich V, Shamayeva K, Janscak P, Kuta Smatanova I, Panjikar S, Carey J, Weiserova M, Ettrich R.

PLoS One. 2015 Jun 3;10(6):e0128700. doi: 10.1371/journal.pone.0128700. eCollection 2015.

11.

Mechanistic insight into the interaction of BLM helicase with intra-strand G-quadruplex structures.

Chatterjee S, Zagelbaum J, Savitsky P, Sturzenegger A, Huttner D, Janscak P, Hickson ID, Gileadi O, Rothenberg E.

Nat Commun. 2014 Nov 24;5:5556. doi: 10.1038/ncomms6556.

12.

RecQ-core of BLM unfolds telomeric G-quadruplex in the absence of ATP.

Budhathoki JB, Ray S, Urban V, Janscak P, Yodh JG, Balci H.

Nucleic Acids Res. 2014 Oct;42(18):11528-45. doi: 10.1093/nar/gku856. Epub 2014 Sep 22.

13.

DNA2 cooperates with the WRN and BLM RecQ helicases to mediate long-range DNA end resection in human cells.

Sturzenegger A, Burdova K, Kanagaraj R, Levikova M, Pinto C, Cejka P, Janscak P.

J Biol Chem. 2014 Sep 26;289(39):27314-26. doi: 10.1074/jbc.M114.578823. Epub 2014 Aug 13.

14.

Human RECQ5 helicase promotes repair of DNA double-strand breaks by synthesis-dependent strand annealing.

Paliwal S, Kanagaraj R, Sturzenegger A, Burdova K, Janscak P.

Nucleic Acids Res. 2014 Feb;42(4):2380-90. doi: 10.1093/nar/gkt1263. Epub 2013 Dec 6.

15.

FBH1 helicase disrupts RAD51 filaments in vitro and modulates homologous recombination in mammalian cells.

Simandlova J, Zagelbaum J, Payne MJ, Chu WK, Shevelev I, Hanada K, Chatterjee S, Reid DA, Liu Y, Janscak P, Rothenberg E, Hickson ID.

J Biol Chem. 2013 Nov 22;288(47):34168-80. doi: 10.1074/jbc.M113.484493. Epub 2013 Oct 9.

16.

Prolyl isomerase PIN1 regulates DNA double-strand break repair by counteracting DNA end resection.

Steger M, Murina O, Hühn D, Ferretti LP, Walser R, Hänggi K, Lafranchi L, Neugebauer C, Paliwal S, Janscak P, Gerrits B, Del Sal G, Zerbe O, Sartori AA.

Mol Cell. 2013 May 9;50(3):333-43. doi: 10.1016/j.molcel.2013.03.023. Epub 2013 Apr 25.

17.

Involvement of Werner syndrome protein in MUTYH-mediated repair of oxidative DNA damage.

Kanagaraj R, Parasuraman P, Mihaljevic B, van Loon B, Burdova K, König C, Furrer A, Bohr VA, Hübscher U, Janscak P.

Nucleic Acids Res. 2012 Sep 1;40(17):8449-59. Epub 2012 Jun 29.

18.

The human RecQ helicases BLM and RECQL4 cooperate to preserve genome stability.

Singh DK, Popuri V, Kulikowicz T, Shevelev I, Ghosh AK, Ramamoorthy M, Rossi ML, Janscak P, Croteau DL, Bohr VA.

Nucleic Acids Res. 2012 Aug;40(14):6632-48. doi: 10.1093/nar/gks349. Epub 2012 Apr 28.

19.

The ubiquitin-selective segregase VCP/p97 orchestrates the response to DNA double-strand breaks.

Meerang M, Ritz D, Paliwal S, Garajova Z, Bosshard M, Mailand N, Janscak P, Hübscher U, Meyer H, Ramadan K.

Nat Cell Biol. 2011 Oct 23;13(11):1376-82. doi: 10.1038/ncb2367.

PMID:
22020440
20.

RECQ5 helicase associates with the C-terminal repeat domain of RNA polymerase II during productive elongation phase of transcription.

Kanagaraj R, Huehn D, MacKellar A, Menigatti M, Zheng L, Urban V, Shevelev I, Greenleaf AL, Janscak P.

Nucleic Acids Res. 2010 Dec;38(22):8131-40. doi: 10.1093/nar/gkq697. Epub 2010 Aug 12.

21.

Physical interaction of RECQ5 helicase with RAD51 facilitates its anti-recombinase activity.

Schwendener S, Raynard S, Paliwal S, Cheng A, Kanagaraj R, Shevelev I, Stark JM, Sung P, Janscak P.

J Biol Chem. 2010 May 21;285(21):15739-45. doi: 10.1074/jbc.M110.110478. Epub 2010 Mar 25.

22.

Human RECQL5beta stimulates flap endonuclease 1.

Speina E, Dawut L, Hedayati M, Wang Z, May A, Schwendener S, Janscak P, Croteau DL, Bohr VA.

Nucleic Acids Res. 2010 May;38(9):2904-16. doi: 10.1093/nar/gkp1217. Epub 2010 Jan 16.

23.

p300-mediated acetylation of the Rothmund-Thomson-syndrome gene product RECQL4 regulates its subcellular localization.

Dietschy T, Shevelev I, Pena-Diaz J, Hühn D, Kuenzle S, Mak R, Miah MF, Hess D, Fey M, Hottiger MO, Janscak P, Stagljar I.

J Cell Sci. 2009 Apr 15;122(Pt 8):1258-67. doi: 10.1242/jcs.037747. Epub 2009 Mar 19. Erratum in: J Cell Sci. 2009 May 15;122(Pt 10):1701.

24.

MRE11 complex links RECQ5 helicase to sites of DNA damage.

Zheng L, Kanagaraj R, Mihaljevic B, Schwendener S, Sartori AA, Gerrits B, Shevelev I, Janscak P.

Nucleic Acids Res. 2009 May;37(8):2645-57. doi: 10.1093/nar/gkp147. Epub 2009 Mar 6.

25.

BLM helicase measures DNA unwound before switching strands and hRPA promotes unwinding reinitiation.

Yodh JG, Stevens BC, Kanagaraj R, Janscak P, Ha T.

EMBO J. 2009 Feb 18;28(4):405-16. doi: 10.1038/emboj.2008.298. Epub 2009 Jan 22.

26.

Structure of the motor subunit of type I restriction-modification complex EcoR124I.

Lapkouski M, Panjikar S, Janscak P, Smatanova IK, Carey J, Ettrich R, Csefalvay E.

Nat Struct Mol Biol. 2009 Jan;16(1):94-5. doi: 10.1038/nsmb.1523. Epub 2008 Dec 14.

PMID:
19079266
27.

Constitutive phosphorylation of MDC1 physically links the MRE11-RAD50-NBS1 complex to damaged chromatin.

Spycher C, Miller ES, Townsend K, Pavic L, Morrice NA, Janscak P, Stewart GS, Stucki M.

J Cell Biol. 2008 Apr 21;181(2):227-40. doi: 10.1083/jcb.200709008. Epub 2008 Apr 14.

28.

The zinc-binding motif of human RECQ5beta suppresses the intrinsic strand-annealing activity of its DExH helicase domain and is essential for the helicase activity of the enzyme.

Ren H, Dou SX, Zhang XD, Wang PY, Kanagaraj R, Liu JL, Janscak P, Hu JS, Xi XG.

Biochem J. 2008 Jun 15;412(3):425-33. doi: 10.1042/BJ20071150.

PMID:
18290761
29.

RECQL5/Recql5 helicase regulates homologous recombination and suppresses tumor formation via disruption of Rad51 presynaptic filaments.

Hu Y, Raynard S, Sehorn MG, Lu X, Bussen W, Zheng L, Stark JM, Barnes EL, Chi P, Janscak P, Jasin M, Vogel H, Sung P, Luo G.

Genes Dev. 2007 Dec 1;21(23):3073-84. Epub 2007 Nov 14.

30.

Physical and functional interactions between Werner syndrome helicase and mismatch-repair initiation factors.

Saydam N, Kanagaraj R, Dietschy T, Garcia PL, Peña-Diaz J, Shevelev I, Stagljar I, Janscak P.

Nucleic Acids Res. 2007;35(17):5706-16. Epub 2007 Aug 22.

31.

The Werner syndrome protein is required for recruitment of chromatin assembly factor 1 following DNA damage.

Jiao R, Harrigan JA, Shevelev I, Dietschy T, Selak N, Indig FE, Piotrowski J, Janscak P, Bohr VA, Stagljar I.

Oncogene. 2007 May 31;26(26):3811-22. Epub 2006 Dec 18.

PMID:
17173071
32.

Human RECQ5beta helicase promotes strand exchange on synthetic DNA structures resembling a stalled replication fork.

Kanagaraj R, Saydam N, Garcia PL, Zheng L, Janscak P.

Nucleic Acids Res. 2006;34(18):5217-31. Epub 2006 Sep 26.

33.

The Bloom's syndrome helicase promotes the annealing of complementary single-stranded DNA.

Cheok CF, Wu L, Garcia PL, Janscak P, Hickson ID.

Nucleic Acids Res. 2005 Jul 15;33(12):3932-41. Print 2005.

34.

The HRDC domain of BLM is required for the dissolution of double Holliday junctions.

Wu L, Chan KL, Ralf C, Bernstein DA, Garcia PL, Bohr VA, Vindigni A, Janscak P, Keck JL, Hickson ID.

EMBO J. 2005 Jul 20;24(14):2679-87. Epub 2005 Jun 30.

35.

Degradation of human exonuclease 1b upon DNA synthesis inhibition.

El-Shemerly M, Janscak P, Hess D, Jiricny J, Ferrari S.

Cancer Res. 2005 May 1;65(9):3604-9.

36.

On the DNA cleavage mechanism of Type I restriction enzymes.

Jindrova E, Schmid-Nuoffer S, Hamburger F, Janscak P, Bickle TA.

Nucleic Acids Res. 2005 Mar 23;33(6):1760-6. Print 2005.

37.

RPA alleviates the inhibitory effect of vinylphosphonate internucleotide linkages on DNA unwinding by BLM and WRN helicases.

Garcia PL, Bradley G, Hayes CJ, Krintel S, Soultanas P, Janscak P.

Nucleic Acids Res. 2004 Jul 15;32(12):3771-8. Print 2004.

38.

Human RECQ5beta, a protein with DNA helicase and strand-annealing activities in a single polypeptide.

Garcia PL, Liu Y, Jiricny J, West SC, Janscak P.

EMBO J. 2004 Jul 21;23(14):2882-91. Epub 2004 Jul 8.

39.

S-adenosyl methionine prevents promiscuous DNA cleavage by the EcoP1I type III restriction enzyme.

Peakman LJ, Antognozzi M, Bickle TA, Janscak P, Szczelkun MD.

J Mol Biol. 2003 Oct 17;333(2):321-35.

PMID:
14529619
40.
41.

Characterization and mutational analysis of the RecQ core of the bloom syndrome protein.

Janscak P, Garcia PL, Hamburger F, Makuta Y, Shiraishi K, Imai Y, Ikeda H, Bickle TA.

J Mol Biol. 2003 Jun 27;330(1):29-42.

PMID:
12818200
42.

Subunit assembly and mode of DNA cleavage of the type III restriction endonucleases EcoP1I and EcoP15I.

Janscak P, Sandmeier U, Szczelkun MD, Bickle TA.

J Mol Biol. 2001 Feb 23;306(3):417-31.

PMID:
11178902
43.

DNA supercoiling during ATP-dependent DNA translocation by the type I restriction enzyme EcoAI.

Janscak P, Bickle TA.

J Mol Biol. 2000 Jan 28;295(4):1089-99.

PMID:
10656812
44.

Two temperature-sensitive mutations in the DNA binding subunit of EcoKI with differing properties.

Janscak P, Weiserova M, Hubacek J, Holubova I, Dutta CF, Firman K.

FEMS Microbiol Lett. 2000 Jan 1;182(1):99-104.

46.

DNA translocation blockage, a general mechanism of cleavage site selection by type I restriction enzymes.

Janscak P, MacWilliams MP, Sandmeier U, Nagaraja V, Bickle TA.

EMBO J. 1999 May 4;18(9):2638-47.

48.

Analysis of the subunit assembly of the typeIC restriction-modification enzyme EcoR124I.

Janscak P, Dryden DT, Firman K.

Nucleic Acids Res. 1998 Oct 1;26(19):4439-45.

49.

Protein-protein and protein-DNA interactions in the type I restriction endonuclease R.EcoR124I.

Mernagh DR, Janscak P, Firman K, Kneale GG.

Biol Chem. 1998 Apr-May;379(4-5):497-503.

PMID:
9628343
50.

Selection of non-specific DNA cleavage sites by the type IC restriction endonuclease EcoR124I.

Szczelkun MD, Janscak P, Firman K, Halford SE.

J Mol Biol. 1997 Aug 8;271(1):112-23.

PMID:
9300058

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