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Items: 1 to 50 of 329

1.

Oligonucleotide-directed STAT3 alternative splicing switch drives anti-tumorigenic outcomes in MCF10 human breast cancer cells.

Tano V, Jans DA, Bogoyevitch MA.

Biochem Biophys Res Commun. 2019 Jun 11;513(4):1076-1082. doi: 10.1016/j.bbrc.2019.04.054. Epub 2019 Apr 19.

PMID:
31010684
2.

Novel Flavivirus Antiviral That Targets the Host Nuclear Transport Importin α/β1 Heterodimer.

Yang SNY, Atkinson SC, Fraser JE, Wang C, Maher B, Roman N, Forwood JK, Wagstaff KM, Borg NA, Jans DA.

Cells. 2019 Mar 24;8(3). pii: E281. doi: 10.3390/cells8030281.

3.

Zika Virus NS5 Forms Supramolecular Nuclear Bodies That Sequester Importin-α and Modulate the Host Immune and Pro-Inflammatory Response in Neuronal Cells.

Ng IHW, Chan KW, Tan MJA, Gwee CP, Smith KM, Jeffress SJ, Saw WG, Swarbrick CMD, Watanabe S, Jans DA, Grüber G, Forwood JK, Vasudevan SG.

ACS Infect Dis. 2019 Jun 14;5(6):932-948. doi: 10.1021/acsinfecdis.8b00373. Epub 2019 Mar 19.

PMID:
30848123
4.

Inhibitors of nuclear transport.

Jans DA, Martin AJ, Wagstaff KM.

Curr Opin Cell Biol. 2019 Feb 28;58:50-60. doi: 10.1016/j.ceb.2019.01.001. [Epub ahead of print] Review.

PMID:
30826604
5.

Novel RU486 (mifepristone) analogues with increased activity against Venezuelan Equine Encephalitis Virus but reduced progesterone receptor antagonistic activity.

DeBono A, Thomas DR, Lundberg L, Pinkham C, Cao Y, Graham JD, Clarke CL, Wagstaff KM, Shechter S, Kehn-Hall K, Jans DA.

Sci Rep. 2019 Feb 22;9(1):2634. doi: 10.1038/s41598-019-38671-y.

6.

Editorial: Targeted Subcellular Delivery of Anti-cancer Agents.

Jans DA, Sobolev AS.

Front Pharmacol. 2019 Jan 22;9:1577. doi: 10.3389/fphar.2018.01577. eCollection 2018. No abstract available.

7.

Molecular dissection of an inhibitor targeting the HIV integrase dependent preintegration complex nuclear import.

Wagstaff KM, Headey S, Telwatte S, Tyssen D, Hearps AC, Thomas DR, Tachedjian G, Jans DA.

Cell Microbiol. 2019 Jan;21(1):e12953. doi: 10.1111/cmi.12953. Epub 2018 Sep 27.

PMID:
30216959
8.

Author Correction: Novel inhibitors targeting Venezuelan equine encephalitis virus capsid protein identified using In Silico Structure-Based-Drug-Design.

Shechter S, Thomas DR, Lundberg L, Pinkham C, Lin SC, Wagstaff KM, Debono A, Kehn-Hall K, Jans DA.

Sci Rep. 2018 Sep 4;8(1):13487. doi: 10.1038/s41598-018-31644-7.

9.

PKA-site phosphorylation of importin13 regulates its subcellular localization and nuclear transport function.

Liu X, Lin W, Shi X, Davies RG, Wagstaff KM, Tao T, Jans DA.

Biochem J. 2018 Aug 31;475(16):2699-2712. doi: 10.1042/BCJ20180082.

PMID:
30045875
10.

Nucleocytoplasmic Trafficking of Dengue Non-structural Protein 5 as a Target for Antivirals.

Jans DA, Martin AJ.

Adv Exp Med Biol. 2018;1062:199-213. doi: 10.1007/978-981-10-8727-1_15. Review.

PMID:
29845535
11.

Contribution of the residue at position 4 within classical nuclear localization signals to modulating interaction with importins and nuclear targeting.

Smith KM, Di Antonio V, Bellucci L, Thomas DR, Caporuscio F, Ciccarese F, Ghassabian H, Wagstaff KM, Forwood JK, Jans DA, Palù G, Alvisi G.

Biochim Biophys Acta Mol Cell Res. 2018 Aug;1865(8):1114-1129. doi: 10.1016/j.bbamcr.2018.05.006. Epub 2018 May 8.

PMID:
29750988
12.

TrawlerWeb: an online de novo motif discovery tool for next-generation sequencing datasets.

Dang LT, Tondl M, Chiu MHH, Revote J, Paten B, Tano V, Tokolyi A, Besse F, Quaife-Ryan G, Cumming H, Drvodelic MJ, Eichenlaub MP, Hallab JC, Stolper JS, Rossello FJ, Bogoyevitch MA, Jans DA, Nim HT, Porrello ER, Hudson JE, Ramialison M.

BMC Genomics. 2018 Apr 5;19(1):238. doi: 10.1186/s12864-018-4630-0.

13.

Nucleocytoplasmic shuttling of the West Nile virus RNA-dependent RNA polymerase NS5 is critical to infection.

Lopez-Denman AJ, Russo A, Wagstaff KM, White PA, Jans DA, Mackenzie JM.

Cell Microbiol. 2018 Aug;20(8):e12848. doi: 10.1111/cmi.12848. Epub 2018 Apr 24.

PMID:
29582535
14.

Identification of novel antivirals inhibiting recognition of Venezuelan equine encephalitis virus capsid protein by the Importin α/β1 heterodimer through high-throughput screening.

Thomas DR, Lundberg L, Pinkham C, Shechter S, DeBono A, Baell J, Wagstaff KM, Hick CA, Kehn-Hall K, Jans DA.

Antiviral Res. 2018 Mar;151:8-19. doi: 10.1016/j.antiviral.2018.01.007. Epub 2018 Jan 11.

15.

Recognition by host nuclear transport proteins drives disorder-to-order transition in Hendra virus V.

Atkinson SC, Audsley MD, Lieu KG, Marsh GA, Thomas DR, Heaton SM, Paxman JJ, Wagstaff KM, Buckle AM, Moseley GW, Jans DA, Borg NA.

Sci Rep. 2018 Jan 10;8(1):358. doi: 10.1038/s41598-017-18742-8.

16.

Novel inhibitors targeting Venezuelan equine encephalitis virus capsid protein identified using In Silico Structure-Based-Drug-Design.

Shechter S, Thomas DR, Lundberg L, Pinkham C, Lin SC, Wagstaff KM, Debono A, Kehn-Hall K, Jans DA.

Sci Rep. 2017 Dec 18;7(1):17705. doi: 10.1038/s41598-017-17672-9. Erratum in: Sci Rep. 2018 Sep 4;8(1):13487.

17.

Nuclear import inhibitor N-(4-hydroxyphenyl) retinamide targets Zika virus (ZIKV) nonstructural protein 5 to inhibit ZIKV infection.

Wang C, Yang SNY, Smith K, Forwood JK, Jans DA.

Biochem Biophys Res Commun. 2017 Dec 2;493(4):1555-1559. doi: 10.1016/j.bbrc.2017.10.016. Epub 2017 Oct 4.

PMID:
28988109
18.

Mitochondrial protein p32/HAPB1/gC1qR/C1qbp is required for efficient respiratory syncytial virus production.

Hu M, Li HM, Bogoyevitch MA, Jans DA.

Biochem Biophys Res Commun. 2017 Aug 5;489(4):460-465. doi: 10.1016/j.bbrc.2017.05.171. Epub 2017 May 30.

PMID:
28576489
19.

Development of a pipeline for automated, high-throughput analysis of paraspeckle proteins reveals specific roles for importin α proteins.

Major AT, Miyamoto Y, Lo CY, Jans DA, Loveland KL.

Sci Rep. 2017 Feb 27;7:43323. doi: 10.1038/srep43323.

20.

Mice Lacking Hbp1 Function Are Viable and Fertile.

Spiller CM, Wilhelm D, Jans DA, Bowles J, Koopman P.

PLoS One. 2017 Jan 20;12(1):e0170576. doi: 10.1371/journal.pone.0170576. eCollection 2017.

21.

c-Jun N-terminal kinase activity is required for efficient respiratory syncytial virus production.

Caly L, Li HM, Bogoyevitch MA, Jans DA.

Biochem Biophys Res Commun. 2017 Jan 29;483(1):64-68. doi: 10.1016/j.bbrc.2017.01.005. Epub 2017 Jan 4.

PMID:
28062184
22.

Nuclear localization and secretion competence are conserved among henipavirus matrix proteins.

McLinton EC, Wagstaff KM, Lee A, Moseley GW, Marsh GA, Wang LF, Jans DA, Lieu KG, Netter HJ.

J Gen Virol. 2017 Apr;98(4):563-576. doi: 10.1099/jgv.0.000703. Epub 2017 Apr 14.

PMID:
28056216
23.

Interactome of the inhibitory isoform of the nuclear transporter Importin 13.

Fatima S, Wagstaff KM, Lieu KG, Davies RG, Tanaka SS, Yamaguchi YL, Loveland KL, Tam PP, Jans DA.

Biochim Biophys Acta Mol Cell Res. 2017 Mar;1864(3):546-561. doi: 10.1016/j.bbamcr.2016.12.017. Epub 2016 Dec 16.

24.

Selective Inhibitor of Nuclear Export (SINE) Compounds Alter New World Alphavirus Capsid Localization and Reduce Viral Replication in Mammalian Cells.

Lundberg L, Pinkham C, de la Fuente C, Brahms A, Shafagati N, Wagstaff KM, Jans DA, Tamir S, Kehn-Hall K.

PLoS Negl Trop Dis. 2016 Nov 30;10(11):e0005122. doi: 10.1371/journal.pntd.0005122. eCollection 2016 Nov.

25.

Rhinovirus 16 2A Protease Affects Nuclear Localization of 3CD during Infection.

Walker E, Jensen L, Croft S, Wei K, Fulcher AJ, Jans DA, Ghildyal R.

J Virol. 2016 Nov 28;90(24):11032-11042. Print 2016 Dec 15.

26.

Quantitative Analysis of the Microtubule Interaction of Rabies Virus P3 Protein: Roles in Immune Evasion and Pathogenesis.

Brice A, Whelan DR, Ito N, Shimizu K, Wiltzer-Bach L, Lo CY, Blondel D, Jans DA, Bell TD, Moseley GW.

Sci Rep. 2016 Sep 21;6:33493. doi: 10.1038/srep33493.

27.

The C-terminal 18 Amino Acid Region of Dengue Virus NS5 Regulates its Subcellular Localization and Contains a Conserved Arginine Residue Essential for Infectious Virus Production.

Tay MY, Smith K, Ng IH, Chan KW, Zhao Y, Ooi EE, Lescar J, Luo D, Jans DA, Forwood JK, Vasudevan SG.

PLoS Pathog. 2016 Sep 13;12(9):e1005886. doi: 10.1371/journal.ppat.1005886. eCollection 2016 Sep.

28.

Nucleocytoplasmic trafficking of Nipah virus W protein involves multiple discrete interactions with the nuclear import and export machinery.

Audsley MD, Jans DA, Moseley GW.

Biochem Biophys Res Commun. 2016 Oct 21;479(3):429-433. doi: 10.1016/j.bbrc.2016.09.043. Epub 2016 Sep 10.

PMID:
27622322
29.

Roles of nuclear trafficking in infection by cytoplasmic negative-strand RNA viruses: paramyxoviruses and beyond.

Audsley MD, Jans DA, Moseley GW.

J Gen Virol. 2016 Oct;97(10):2463-2481. doi: 10.1099/jgv.0.000575. Epub 2016 Aug 5. Review.

PMID:
27498841
30.

Secret life of importin-β; solenoid flexibility as the key to transport through the nuclear pore.

Alvisi G, Jans DA.

Acta Crystallogr D Struct Biol. 2016 Jun;72(Pt 6):703-4. doi: 10.1107/S2059798316008263. Epub 2016 May 25. No abstract available.

PMID:
27303790
31.

Corrigendum: Influenza A viruses escape from MxA restriction at the expense of efficient nuclear vRNP import.

Götz V, Magar L, Dornfeld D, Giese S, Pohlmann A, Höper D, Kong BW, Jans DA, Beer M, Haller O, Schwemmle M.

Sci Rep. 2016 May 9;6:25428. doi: 10.1038/srep25428. No abstract available.

32.

Dynamic Nucleolar Targeting of Dengue Virus Polymerase NS5 in Response to Extracellular pH.

Fraser JE, Rawlinson SM, Heaton SM, Jans DA.

J Virol. 2016 May 27;90(12):5797-5807. doi: 10.1128/JVI.02727-15. Print 2016 Jun 15.

33.

Quantifying the dynamics of the oligomeric transcription factor STAT3 by pair correlation of molecular brightness.

Hinde E, Pandžić E, Yang Z, Ng IH, Jans DA, Bogoyevitch MA, Gratton E, Gaus K.

Nat Commun. 2016 Mar 24;7:11047. doi: 10.1038/ncomms11047.

34.

Influenza A viruses escape from MxA restriction at the expense of efficient nuclear vRNP import.

Götz V, Magar L, Dornfeld D, Giese S, Pohlmann A, Höper D, Kong BW, Jans DA, Beer M, Haller O, Schwemmle M.

Sci Rep. 2016 Mar 18;6:23138. doi: 10.1038/srep23138. Erratum in: Sci Rep. 2016 May 09;6:25428.

35.

Novel dengue virus inhibitor 4-HPR activates ATF4 independent of protein kinase R-like Endoplasmic Reticulum Kinase and elevates levels of eIF2α phosphorylation in virus infected cells.

Fraser JE, Wang C, Chan KW, Vasudevan SG, Jans DA.

Antiviral Res. 2016 Jun;130:1-6. doi: 10.1016/j.antiviral.2016.03.006. Epub 2016 Mar 8.

PMID:
26965420
36.

Nuclear Trafficking of the Rabies Virus Interferon Antagonist P-Protein Is Regulated by an Importin-Binding Nuclear Localization Sequence in the C-Terminal Domain.

Rowe CL, Wagstaff KM, Oksayan S, Glover DJ, Jans DA, Moseley GW.

PLoS One. 2016 Mar 3;11(3):e0150477. doi: 10.1371/journal.pone.0150477. eCollection 2016.

37.

Fast track, dynein-dependent nuclear targeting of human immunodeficiency virus Vpr protein; impaired trafficking in a clinical isolate.

Caly L, Kassouf VT, Moseley GW, Diefenbach RJ, Cunningham AL, Jans DA.

Biochem Biophys Res Commun. 2016 Feb 12;470(3):735-740. doi: 10.1016/j.bbrc.2016.01.051. Epub 2016 Jan 11.

PMID:
26792716
38.

The immune evasion function of J and Beilong virus V proteins is distinct from that of other paramyxoviruses, consistent with their inclusion in the proposed genus Jeilongvirus.

Audsley MD, Marsh GA, Lieu KG, Tachedjian M, Joubert DA, Wang LF, Jans DA, Moseley GW.

J Gen Virol. 2016 Mar;97(3):581-92. doi: 10.1099/jgv.0.000388. Epub 2015 Dec 24.

PMID:
26703878
39.

Tumor cell-specific photothermal killing by SELEX-derived DNA aptamer-targeted gold nanorods.

Chandrasekaran R, Lee AS, Yap LW, Jans DA, Wagstaff KM, Cheng W.

Nanoscale. 2016 Jan 7;8(1):187-96. doi: 10.1039/c5nr07831h.

PMID:
26646051
40.

The protein arginine methyltransferase PRMT6 inhibits HIV-1 Tat nucleolar retention.

Fulcher AJ, Sivakumaran H, Jin H, Rawle DJ, Harrich D, Jans DA.

Biochim Biophys Acta. 2016 Feb;1863(2):254-62. doi: 10.1016/j.bbamcr.2015.11.019. Epub 2015 Dec 2.

41.

Respiratory virus modulation of host nucleocytoplasmic transport; target for therapeutic intervention?

Caly L, Ghildyal R, Jans DA.

Front Microbiol. 2015 Aug 14;6:848. doi: 10.3389/fmicb.2015.00848. eCollection 2015. Review.

42.

Putting things in place for fertilization: discovering roles for importin proteins in cell fate and spermatogenesis.

Loveland KL, Major AT, Butler R, Young JC, Jans DA, Miyamoto Y.

Asian J Androl. 2015 Jul-Aug;17(4):537-44. doi: 10.4103/1008-682X.154310. Review.

43.

Hyper-dependence of breast cancer cell types on the nuclear transporter Importin β1.

Kuusisto HV, Jans DA.

Biochim Biophys Acta. 2015 Aug;1853(8):1870-8. doi: 10.1016/j.bbamcr.2015.05.002. Epub 2015 May 8.

44.

Enhanced tumour cell nuclear targeting in a tumour progression model.

Nastasie MS, Thissen H, Jans DA, Wagstaff KM.

BMC Cancer. 2015 Feb 21;15:76. doi: 10.1186/s12885-015-1045-z.

45.

Fatty Acid-binding Proteins 1 and 2 Differentially Modulate the Activation of Peroxisome Proliferator-activated Receptor α in a Ligand-selective Manner.

Hughes ML, Liu B, Halls ML, Wagstaff KM, Patil R, Velkov T, Jans DA, Bunnett NW, Scanlon MJ, Porter CJ.

J Biol Chem. 2015 May 29;290(22):13895-906. doi: 10.1074/jbc.M114.605998. Epub 2015 Apr 6.

46.

Interactome of the negative regulator of nuclear import BRCA1-binding protein 2.

Fatima S, Wagstaff KM, Loveland KL, Jans DA.

Sci Rep. 2015 Mar 30;5:9459. doi: 10.1038/srep09459.

47.

LRGUK-1 is required for basal body and manchette function during spermatogenesis and male fertility.

Liu Y, DeBoer K, de Kretser DM, O'Donnell L, O'Connor AE, Merriner DJ, Okuda H, Whittle B, Jans DA, Efthymiadis A, McLachlan RI, Ormandy CJ, Goodnow CC, Jamsai D, O'Bryan MK.

PLoS Genet. 2015 Mar 17;11(3):e1005090. doi: 10.1371/journal.pgen.1005090. eCollection 2015 Mar.

48.

Specific interaction with the nuclear transporter importin α2 can modulate paraspeckle protein 1 delivery to nuclear paraspeckles.

Major AT, Hogarth CA, Miyamoto Y, Sarraj MA, Smith CL, Koopman P, Kurihara Y, Jans DA, Loveland KL.

Mol Biol Cell. 2015 Apr 15;26(8):1543-58. doi: 10.1091/mbc.E14-01-0678. Epub 2015 Feb 18.

49.

Basis of cargo recognition by importin αs: the power of structure.

Alvisi G, Jans DA.

Structure. 2015 Feb 3;23(2):251-2. doi: 10.1016/j.str.2015.01.005.

50.

Regulating post-mitotic nuclear access: Cdk1-phosphorylation of NLSs.

Alvisi G, Jans DA.

Cell Cycle. 2015;14(5):695-6. doi: 10.1080/15384101.2015.1010955. No abstract available.

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