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Items: 1 to 50 of 52

1.

Application of ultrasound-guided cholecystocentesis to the evaluation of the metabolite profiling in bile of dogs and cynomolgus monkeys.

Dierks EA, Luk CE, Cai H, MacGuire J, Fox M, Smalley J, Fancher RM, Janovitz E, Foster K, Sun Q.

Pharmacol Res Perspect. 2019 May 27;7(3):e00488. doi: 10.1002/prp2.488. eCollection 2019 Jun.

2.

Scientific and Regulatory Policy Committee Points to Consider*: Review of Scientific and Regulatory Policy Committee Points to Consider: Review of Current Practices for Ultrastructural Pathology Evaluations in Support of Nonclinical Toxicology Studies.

Keirstead ND, Janovitz EB, Meehan JT, LeRoy BE, Megill JR, Peterson RA, Masson RG, Marxfeld HA.

Toxicol Pathol. 2019 Jun;47(4):461-468. doi: 10.1177/0192623319835170. Epub 2019 Apr 24.

PMID:
31018785
3.

Assessing the risk of drug crystallization in vivo.

Ruepp S, Janovitz E, Brodie T, White R, Santella J, Hynes J, Carman J, Pan D, Wu Y, Hanumegowda U, Gemzik B, Megill J, DiPiero J, Drexler D, Su CC, Hageman M.

J Pharmacol Toxicol Methods. 2019 Mar - Apr;96:1-8. doi: 10.1016/j.vascn.2018.12.003. Epub 2018 Dec 13.

PMID:
30553974
4.

Evaluation of Uracil, Sodium Ascorbate, and Rosiglitazone as Promoters of Urinary Bladder Transitional Cell Carcinomas in Male Sprague-Dawley Rats.

Tirmenstein M, Janovitz E, Dorr T, Song Y, Chen SJ, Granaldi K, Chadwick KD, Mangipudy R, Graziano M, Attalla B, Haile S, Czajkowski M, Foster JR, Bergholm AM, Billger M, Söderberg M.

Toxicol Pathol. 2018 Feb;46(2):147-157. doi: 10.1177/0192623318756004.

PMID:
29471778
5.

Systemic Loss of C-terminal Src Kinase Expression Elicits Spontaneous Suppurative Inflammation in Conditional Knockout Mice.

Berman-Booty LD, Eraslan R, Hanumegowda U, Cantor GH, Bounous DI, Janovitz EB, Jones BK, Buiakova O, Hayward M, Wee S.

Vet Pathol. 2018 Mar;55(2):331-340. doi: 10.1177/0300985817747330. Epub 2018 Jan 16.

PMID:
29338616
6.

Mechanisms for Hepatobiliary Toxicity in Rats Treated with an Antagonist of Melanin Concentrating Hormone Receptor 1 (MCHR1).

Otieno MA, Bhaskaran V, Janovitz E, Callejas Y, Foster WB, Washburn W, Megill JR, Lehman-McKeeman L, Gemzik B.

Toxicol Sci. 2017 Feb;155(2):379-388. doi: 10.1093/toxsci/kfw216. Epub 2016 Oct 20.

PMID:
28025230
7.

From the Cover: Investigative Nonclinical Cardiovascular Safety and Toxicology Studies with BMS-986094, an NS5b RNA-Dependent RNA Polymerase Inhibitor.

Gill M, Horn K, Hennan J, White R, Bounous D, Clark S, Megill JR, Janovitz E, Davies M, Sanderson T, Graziano M.

Toxicol Sci. 2017 Feb;155(2):348-362. doi: 10.1093/toxsci/kfw211. Epub 2016 Nov 17.

PMID:
27864544
8.

Synthesis and Antiobesity Properties of 6-(4-Chlorophenyl)-3-(4-((3,3-difluoro-1-hydroxycyclobutyl)methoxy)-3-methoxyphenyl)thieno[3,2-d]pyrimidin-4(3H)-one (BMS-814580): A Highly Efficacious Melanin Concentrating Hormone Receptor 1 (MCHR1) Inhibitor.

Ahmad S, Washburn WN, Hernandez AS, Bisaha S, Ngu K, Wang W, Pelleymounter MA, Longhi D, Flynn N, Azzara AV, Rohrbach K, Devenny J, Rooney S, Thomas M, Glick S, Godonis H, Harvey S, Zhang H, Gemzik B, Janovitz EB, Huang C, Zhang L, Robl JA, Murphy BJ.

J Med Chem. 2016 Oct 13;59(19):8848-8858. Epub 2016 Sep 15.

PMID:
27564419
9.

Utilization of the Zucker Diabetic Fatty (ZDF) Rat Model for Investigating Hypoglycemia-related Toxicities.

Tirmenstein M, Horvath J, Graziano M, Mangipudy R, Dorr T, Colman K, Zinker B, Kirby M, Cheng PT, Patrone L, Kozlosky J, Reilly TP, Wang V, Janovitz E.

Toxicol Pathol. 2015 Aug;43(6):825-37. doi: 10.1177/0192623315581020. Epub 2015 Jun 17.

PMID:
26085543
10.

Identification of a nonbasic melanin hormone receptor 1 antagonist as an antiobesity clinical candidate.

Washburn WN, Manfredi M, Devasthale P, Zhao G, Ahmad S, Hernandez A, Robl JA, Wang W, Mignone J, Wang Z, Ngu K, Pelleymounter MA, Longhi D, Zhao R, Wang B, Huang N, Flynn N, Azzara AV, Barrish JC, Rohrbach K, Devenny JJ, Rooney S, Thomas M, Glick S, Godonis HE, Harvey SJ, Cullen MJ, Zhang H, Caporuscio C, Stetsko P, Grubb M, Maxwell BD, Yang H, Apedo A, Gemzik B, Janovitz EB, Huang C, Zhang L, Freeden C, Murphy BJ.

J Med Chem. 2014 Sep 25;57(18):7509-22. doi: 10.1021/jm500026w. Epub 2014 Sep 9.

PMID:
25165888
11.

Carcinogenicity risk assessment supports the chronic safety of dapagliflozin, an inhibitor of sodium-glucose co-transporter 2, in the treatment of type 2 diabetes mellitus.

Reilly TP, Graziano MJ, Janovitz EB, Dorr TE, Fairchild C, Lee F, Chen J, Wong T, Whaley JM, Tirmenstein M.

Diabetes Ther. 2014 Jun;5(1):73-96. doi: 10.1007/s13300-014-0053-3. Epub 2014 Jan 29.

12.

Occurrence of spontaneous pancreatic lesions in normal and diabetic rats: a potential confounding factor in the nonclinical assessment of GLP-1-based therapies.

Chadwick KD, Fletcher AM, Parrula MC, Bonner-Weir S, Mangipudy RS, Janovitz E, Graziano MJ, Roy D, Reilly TP.

Diabetes. 2014 Apr;63(4):1303-14. doi: 10.2337/db13-1268. Epub 2013 Nov 12.

13.

Nonclinical toxicology assessments support the chronic safety of dapagliflozin, a first-in-class sodium-glucose cotransporter 2 inhibitor.

Tirmenstein M, Dorr TE, Janovitz EB, Hagan D, Abell LM, Onorato JM, Whaley JM, Graziano MJ, Reilly TP.

Int J Toxicol. 2013 Sep-Oct;32(5):336-50. doi: 10.1177/1091581813505331. Epub 2013 Oct 4.

PMID:
24097127
14.

Use of animal models of human disease for nonclinical safety assessment of novel pharmaceuticals.

Morgan SJ, Elangbam CS, Berens S, Janovitz E, Vitsky A, Zabka T, Conour L.

Toxicol Pathol. 2013;41(3):508-18. doi: 10.1177/0192623312457273. Epub 2012 Sep 11.

PMID:
22968286
15.

Cannabinoid receptor antagonist-induced striated muscle toxicity and ethylmalonic-adipic aciduria in beagle dogs.

Tomlinson L, Tirmenstein MA, Janovitz EB, Aranibar N, Ott KH, Kozlosky JC, Patrone LM, Achanzar WE, Augustine KA, Brannen KC, Carlson KE, Charlap JH, Dubrow KM, Kang L, Rosini LT, Panzica-Kelly JM, Flint OP, Moulin FJ, Megill JR, Zhang H, Bennett MJ, Horvath JJ.

Toxicol Sci. 2012 Oct;129(2):268-79. doi: 10.1093/toxsci/kfs217. Epub 2012 Jul 21.

PMID:
22821849
16.

Identification of 1- and 3-methylhistidine as biomarkers of skeletal muscle toxicity by nuclear magnetic resonance-based metabolic profiling.

Aranibar N, Vassallo JD, Rathmacher J, Stryker S, Zhang Y, Dai J, Janovitz EB, Robertson D, Reily M, Lowe-Krentz L, Lehman-McKeeman L.

Anal Biochem. 2011 Mar 1;410(1):84-91. doi: 10.1016/j.ab.2010.11.023. Epub 2010 Nov 19.

PMID:
21094120
17.

Proposal of a 2-tier histologic grading system for canine cutaneous mast cell tumors to more accurately predict biological behavior.

Kiupel M, Webster JD, Bailey KL, Best S, DeLay J, Detrisac CJ, Fitzgerald SD, Gamble D, Ginn PE, Goldschmidt MH, Hendrick MJ, Howerth EW, Janovitz EB, Langohr I, Lenz SD, Lipscomb TP, Miller MA, Misdorp W, Moroff S, Mullaney TP, Neyens I, O'Toole D, Ramos-Vara J, Scase TJ, Schulman FY, Sledge D, Smedley RC, Smith K, W Snyder P, Southorn E, Stedman NL, Steficek BA, Stromberg PC, Valli VE, Weisbrode SE, Yager J, Heller J, Miller R.

Vet Pathol. 2011 Jan;48(1):147-55. doi: 10.1177/0300985810386469. Epub 2010 Nov 9.

PMID:
21062911
18.

Biomarkers of drug-induced skeletal muscle injury in the rat: troponin I and myoglobin.

Vassallo JD, Janovitz EB, Wescott DM, Chadwick C, Lowe-Krentz LJ, Lehman-McKeeman LD.

Toxicol Sci. 2009 Oct;111(2):402-12. doi: 10.1093/toxsci/kfp166. Epub 2009 Jul 23.

PMID:
19628585
19.

(3R,5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(methyl(1-methyl-1h-1,2,4-triazol-5-yl)amino)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoic acid (BMS-644950): a rationally designed orally efficacious 3-hydroxy-3-methylglutaryl coenzyme-a reductase inhibitor with reduced myotoxicity potential.

Ahmad S, Madsen CS, Stein PD, Janovitz E, Huang C, Ngu K, Bisaha S, Kennedy LJ, Chen BC, Zhao R, Sitkoff D, Monshizadegan H, Yin X, Ryan CS, Zhang R, Giancarli M, Bird E, Chang M, Chen X, Setters R, Search D, Zhuang S, Nguyen-Tran V, Cuff CA, Harrity T, Darienzo CJ, Li T, Reeves RA, Blanar MA, Barrish JC, Zahler R, Robl JA.

J Med Chem. 2008 May 8;51(9):2722-33. doi: 10.1021/jm800001n. Epub 2008 Apr 15.

PMID:
18412317
20.

Discovery of dapagliflozin: a potent, selective renal sodium-dependent glucose cotransporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes.

Meng W, Ellsworth BA, Nirschl AA, McCann PJ, Patel M, Girotra RN, Wu G, Sher PM, Morrison EP, Biller SA, Zahler R, Deshpande PP, Pullockaran A, Hagan DL, Morgan N, Taylor JR, Obermeier MT, Humphreys WG, Khanna A, Discenza L, Robertson JG, Wang A, Han S, Wetterau JR, Janovitz EB, Flint OP, Whaley JM, Washburn WN.

J Med Chem. 2008 Mar 13;51(5):1145-9. doi: 10.1021/jm701272q. Epub 2008 Feb 9.

PMID:
18260618
21.

The Guinea pig as a preclinical model for demonstrating the efficacy and safety of statins.

Madsen CS, Janovitz E, Zhang R, Nguyen-Tran V, Ryan CS, Yin X, Monshizadegan H, Chang M, D'Arienzo C, Scheer S, Setters R, Search D, Chen X, Zhuang S, Kunselman L, Peters A, Harrity T, Apedo A, Huang C, Cuff CA, Kowala MC, Blanar MA, Sun CQ, Robl JA, Stein PD.

J Pharmacol Exp Ther. 2008 Feb;324(2):576-86. Epub 2007 Nov 6.

PMID:
17986646
22.

Discovery of (R)-9-ethyl-1,3,4,10b-tetrahydro-7-trifluoromethylpyrazino[2,1-a]isoindol- 6(2H)-one, a selective, orally active agonist of the 5-HT(2C) receptor.

Wacker DA, Varnes JG, Malmstrom SE, Cao X, Hung CP, Ung T, Wu G, Zhang G, Zuvich E, Thomas MA, Keim WJ, Cullen MJ, Rohrbach KW, Qu Q, Narayanan R, Rossi K, Janovitz E, Lehman-McKeeman L, Malley MF, Devenny J, Pelleymounter MA, Miller KJ, Robl JA.

J Med Chem. 2007 Mar 22;50(6):1365-79. Epub 2007 Feb 23.

PMID:
17315987
23.

The dual peroxisome proliferator-activated receptor alpha/gamma activator muraglitazar prevents the natural progression of diabetes in db/db mice.

Tozzo E, Ponticiello R, Swartz J, Farrelly D, Zebo R, Welzel G, Egan D, Kunselman L, Peters A, Gu L, French M, Chen S, Devasthale P, Janovitz E, Staal A, Harrity T, Belder R, Cheng PT, Whaley J, Taylor S, Hariharan N.

J Pharmacol Exp Ther. 2007 Apr;321(1):107-15. Epub 2007 Jan 26.

PMID:
17259449
24.

Fatal herpesvirus encephalitis in a reticulated giraffe (Giraffa camelopardalis reticulata).

Hoenerhoff MJ, Janovitz EB, Richman LK, Murphy DA, Butler TC, Kiupel M.

Vet Pathol. 2006 Sep;43(5):769-72.

PMID:
16966458
25.

Choroid plexus papilloma in a Scottish highland cow.

Hoenerhoff MJ, Janovitz E, Ramos-Vara J, Kiupel M.

J Comp Pathol. 2006 Aug-Oct;135(2-3):146-149. doi: 10.1016/j.jcpa.2006.04.002. Epub 2006 Sep 6.

PMID:
16952368
26.

Retinoblastoma in the eye of a llama (Llama glama).

Fugaro MN, Kiupel M, Montiani-Ferreira F, Hawkins JF, Janovitz EB.

Vet Ophthalmol. 2005 Jul-Aug;8(4):287-90.

PMID:
16008711
27.

Epidemiologic study of relationships between consumption of commercial canned food and risk of hyperthyroidism in cats.

Edinboro CH, Scott-Moncrieff JC, Janovitz E, Thacker HL, Glickman LT.

J Am Vet Med Assoc. 2004 Mar 15;224(6):879-86.

PMID:
15070058
28.

Expression and characterization of human transient receptor potential melastatin 3 (hTRPM3).

Lee N, Chen J, Sun L, Wu S, Gray KR, Rich A, Huang M, Lin JH, Feder JN, Janovitz EB, Levesque PC, Blanar MA.

J Biol Chem. 2003 Jun 6;278(23):20890-7. Epub 2003 Apr 2.

29.

Nephrotoxicosis in a cat following ingestion of Asiatic hybrid lily (Lilium sp).

Brady MA, Janovitz EB.

J Vet Diagn Invest. 2000 Nov;12(6):566-8. No abstract available.

PMID:
11108459
30.

Avian pox in sanderlings from Florida.

Kreuder C, Irizarry-Rovira AR, Janovitz EB, Deitschel PJ, DeNicola DB.

J Wildl Dis. 1999 Jul;35(3):582-5.

PMID:
10479096
31.

Unilateral cerebral necrosis resembling feline ischemic encephalopathy in an African lion (Panthera leo).

Raymond JT, Butler TC, Janovitz EB.

J Zoo Wildl Med. 1998 Sep;29(3):328-30.

PMID:
9809608
32.

A canine model of familial mammary gland neoplasia.

Schafer KA, Kelly G, Schrader R, Griffith WC, Muggenburg BA, Tierney LA, Lechner JF, Janovitz EB, Hahn FF.

Vet Pathol. 1998 May;35(3):168-77.

PMID:
9598580
33.

Pseudorabies in captive coyotes.

Raymond JT, Gillespie RG, Woodruff M, Janovitz EB.

J Wildl Dis. 1997 Oct;33(4):916-8.

PMID:
9391985
34.

Pulmonary blastomycosis in an Indian fruit bat (Pteropus giganteus).

Raymond JT, White MR, Kilbane TP, Janovitz EB.

J Vet Diagn Invest. 1997 Jan;9(1):85-7. No abstract available.

PMID:
9087933
35.

Malignant mast cell tumor in an African hedgehog (Atelerix albiventris).

Raymond JT, White MR, Janovitz EB.

J Wildl Dis. 1997 Jan;33(1):140-2.

PMID:
9027702
36.

Pulmonary and mediastinal metastases of a vaccination-site sarcoma in a cat.

Rudmann DG, Van Alstine WG, Doddy F, Sandusky GE, Barkdull T, Janovitz EB.

Vet Pathol. 1996 Jul;33(4):466-9.

PMID:
8817854
37.

Feline fibrosarcomas at vaccination sites and non-vaccination sites.

Doddy FD, Glickman LT, Glickman NW, Janovitz EB.

J Comp Pathol. 1996 Feb;114(2):165-74.

PMID:
8920216
38.

Baylisascaris procyonis larva migrans in a puppy: a case report and update for the veterinarian.

Rudmann DG, Kazacos KR, Storandt ST, Harris DL, Janovitz EB.

J Am Anim Hosp Assoc. 1996 Jan-Feb;32(1):73-6.

PMID:
8963740
39.

Response to high-dose radioactive iodine administration in cats with thyroid carcinoma that had previously undergone surgery.

Guptill L, Scott-Moncrieff CR, Janovitz EB, Blevins WE, Yohn SE, DeNicola DB.

J Am Vet Med Assoc. 1995 Oct 15;207(8):1055-8.

PMID:
7559045
40.

Protective immunity to Pasteurella multocida heat-labile toxin by intranasal immunization in rabbits.

Suckow MA, Bowersock TL, Nielsen K, Chrisp CE, Frandsen PL, Janovitz EB.

Lab Anim Sci. 1995 Oct;45(5):526-32.

PMID:
8569151
41.

Ependymoma of the neurohypophysis and hypernatremia in a horse.

Heath SE, Peter AT, Janovitz EB, Selvakumar R, Sandusky GE.

J Am Vet Med Assoc. 1995 Sep 15;207(6):738-41.

PMID:
7657573
42.
43.

Cycad (Zamia puertoriquensis) toxicosis in a group of dairy heifers in Puerto Rico.

Reams RY, Janovitz EB, Robinson FR, Sullivan JM, Rivera Casanova C, Más E.

J Vet Diagn Invest. 1993 Jul;5(3):488-94. No abstract available.

PMID:
8373871
44.

Sarcocystosis with involvement of the central nervous system in lambs.

Fitzgerald SD, Janovitz EB, Kazacos KR, Dubey JP, Murphy DA.

J Vet Diagn Invest. 1993 Apr;5(2):291-6. No abstract available.

PMID:
8507712
45.

Septicemic Enterococcus infection in an adult llama.

Burkhardt JE, Janovitz EB, Bowersock TL, Higgins R.

J Vet Diagn Invest. 1993 Jan;5(1):106-9. No abstract available.

PMID:
8466967
46.

Clinical neosporosis in a 4-week-old Hereford calf.

Dubey JP, Janovitz EB, Skowronek AJ.

Vet Parasitol. 1992 Jun;43(1-2):137-41.

PMID:
1496796
47.

Oronasal squamous cell carcinoma in an African hedgehog (Erinaceidae albiventris).

Rivera RY, Janovitz EB.

J Wildl Dis. 1992 Jan;28(1):148-50.

PMID:
1548796
48.

An anaplastic astrocytoma (glioblastoma) in the cerebellum of a dog.

Lenz SD, Janovitz EB, Lockridge K.

Vet Pathol. 1991 May;28(3):250-2. No abstract available.

PMID:
1858256
49.

Copper toxicosis in veal calves.

Sullivan JM, Janovitz EB, Robinson FR.

J Vet Diagn Invest. 1991 Apr;3(2):161-4.

PMID:
1892934
50.

Lymphosarcoma with disseminated skeletal involvement in a pup.

Rogers KS, Janovitz EB, Fooshee SK, Steyn PF, Frankum KE.

J Am Vet Med Assoc. 1989 Nov 1;195(9):1242-4.

PMID:
2584123

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