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Streptococcus pneumoniae G5 domains bind different ligands.

Paukovich N, Redzic JS, Chi YC, Rahkola JT, Issaian A, Blue A, Hansen KC, Janoff EN, Eisenmesser EZ.

Protein Sci. 2019 Aug 7. doi: 10.1002/pro.3693. [Epub ahead of print]


HIV-Associated Cryptococcal Immune Reconstitution Inflammatory Syndrome Is Associated with Aberrant T Cell Function and Increased Cytokine Responses.

Meya DB, Okurut S, Zziwa G, Cose S, Boulware DR, Janoff EN.

J Fungi (Basel). 2019 May 23;5(2). pii: E42. doi: 10.3390/jof5020042.


Complementary Role of CD4+ T Cells in Response to Pneumococcal Polysaccharide Vaccines in Humans.

Jha V, Janoff EN.

Vaccines (Basel). 2019 Feb 11;7(1). pii: E18. doi: 10.3390/vaccines7010018. Review.


Effective B cell activation in vitro during viremic HIV-1 infection with surrogate T cell stimulation.

Nicholson LK, Pratap H, Bowers E, Gunzburger E, Bandi SR, Gardner EM, Palmer BE, Wright T, Kittelson J, Janoff EN.

Immunobiology. 2018 Dec;223(12):839-849. doi: 10.1016/j.imbio.2018.08.007. Epub 2018 Sep 7.


Divergent humoral responses to 23-valent pneumococcal polysaccharide vaccine in critically-ill burn and neurosurgical patients.

Mueller SW, Baumgartner LJ, MacLaren R, Neumann R, Wiktor AJ, Kiser TH, Lindberg G, Cava L, Fish DN, Janoff EN.

PLoS One. 2018 May 14;13(5):e0197037. doi: 10.1371/journal.pone.0197037. eCollection 2018.


Monocyte Phenotype and IFN-γ-Inducible Cytokine Responses Are Associated with Cryptococcal Immune Reconstitution Inflammatory Syndrome.

Meya DB, Okurut S, Zziwa G, Cose S, Bohjanen PR, Mayanja-Kizza H, Joloba M, Boulware DR, Yukari Manabe C, Wahl S, Janoff EN.

J Fungi (Basel). 2017 Jun 2;3(2). pii: E28. doi: 10.3390/jof3020028.


Expression of immunoglobulin D is increased in chronic rhinosinusitis.

Sokoya M, Ramakrishnan VR, Frank DN, Rahkola J, Getz A, Kingdom TT, Kofonow JM, Nguyen Q, Janoff EN.

Ann Allergy Asthma Immunol. 2017 Oct;119(4):317-323.e1. doi: 10.1016/j.anai.2017.07.024.


Childhood pneumococcal disease in Africa - A systematic review and meta-analysis of incidence, serotype distribution, and antimicrobial susceptibility.

Iroh Tam PY, Thielen BK, Obaro SK, Brearley AM, Kaizer AM, Chu H, Janoff EN.

Vaccine. 2017 Apr 4;35(15):1817-1827. doi: 10.1016/j.vaccine.2017.02.045. Epub 2017 Mar 9. Review.


Resolution of Q Fever-Associated Cryoglobulinemia With Anti-CD20 Monoclonal Antibody Treatment.

Hawkins KL, Janoff EN, Janson RW.

J Investig Med High Impact Case Rep. 2017 Jan 1;5(1):2324709616686612. doi: 10.1177/2324709616686612. eCollection 2017 Jan-Mar.


Streptococcus pneumoniae IgA1 protease: A metalloprotease that can catalyze in a split manner in vitro.

Chi YC, Rahkola JT, Kendrick AA, Holliday MJ, Paukovich N, Roberts TS, Janoff EN, Eisenmesser EZ.

Protein Sci. 2017 Mar;26(3):600-610. doi: 10.1002/pro.3110. Epub 2017 Feb 23.


Ontogeny of CD4+ T Lymphocytes With Phenotypic Susceptibility to HIV-1 During Exclusive and Nonexclusive Breastfeeding in HIV-1-Exposed Ugandan Infants.

McFarland EJ, Powell TM, Onyango-Makumbi C, Zhang W, Melander K, Naluyima P, Okurut S, Eller MA, Fowler MG, Janoff EN.

J Infect Dis. 2017 Feb 1;215(3):368-377. doi: 10.1093/infdis/jiw553.


WITHDRAWN: The microbiome and human disease pathogenesis: how do you do what you do to me …?

Janoff EN.

Transl Res. 2016 Oct 19. pii: S1931-5244(16)30273-0. doi: 10.1016/j.trsl.2016.10.006. [Epub ahead of print]


The microbiome and human disease pathogenesis: how do you do what you do to me …?

Janoff EN.

Transl Res. 2017 Jan;179:1-6. doi: 10.1016/j.trsl.2016.10.007. Epub 2016 Oct 19. No abstract available.


Mechanism of Mitochondrial Transcription Factor A Attenuation of CpG-Induced Antibody Production.

Malarkey CS, Gustafson CE, Saifee JF, Torres RM, Churchill ME, Janoff EN.

PLoS One. 2016 Jun 9;11(6):e0157157. doi: 10.1371/journal.pone.0157157. eCollection 2016.


Mother-to-Child HIV-1 Transmission Events Are Differentially Impacted by Breast Milk and Its Components from HIV-1-Infected Women.

Shen R, Achenbach J, Shen Y, Palaia J, Rahkola JT, Nick HJ, Smythies LE, McConnell M, Fowler MG, Smith PD, Janoff EN.

PLoS One. 2015 Dec 17;10(12):e0145150. doi: 10.1371/journal.pone.0145150. eCollection 2015.


The immunopathogenesis of cryptococcal immune reconstitution inflammatory syndrome: understanding a conundrum.

Meya DB, Manabe YC, Boulware DR, Janoff EN.

Curr Opin Infect Dis. 2016 Feb;29(1):10-22. doi: 10.1097/QCO.0000000000000224. Review.


Listening to Our Patients: Learning About Suicide Risk and Protective Factors From Veterans With HIV/AIDS.

Signoracci GM, Stearns-Yoder KA, Holliman BD, Huggins JA, Janoff EN, Brenner LA.

J Holist Nurs. 2016 Dec;34(4):318-328. Epub 2015 Nov 16.


The relationship of circulating proteins in early pregnancy with preterm birth.

Lynch AM, Wagner BD, Deterding RR, Giclas PC, Gibbs RS, Janoff EN, Holers VM, Santoro NF.

Am J Obstet Gynecol. 2016 Apr;214(4):517.e1-517.e8. doi: 10.1016/j.ajog.2015.11.001. Epub 2015 Nov 11.


MRSA colonization and the nasal microbiome in adults at high risk of colonization and infection.

Bessesen MT, Kotter CV, Wagner BD, Adams JC, Kingery S, Benoit JB, Robertson CE, Janoff EN, Frank DN.

J Infect. 2015 Dec;71(6):649-57. doi: 10.1016/j.jinf.2015.08.008. Epub 2015 Sep 1.


Cellular immune activation in cerebrospinal fluid from ugandans with cryptococcal meningitis and immune reconstitution inflammatory syndrome.

Meya DB, Okurut S, Zziwa G, Rolfes MA, Kelsey M, Cose S, Joloba M, Naluyima P, Palmer BE, Kambugu A, Mayanja-Kizza H, Bohjanen PR, Eller MA, Wahl SM, Boulware DR, Manabe YC, Janoff EN.

J Infect Dis. 2015 May 15;211(10):1597-606. doi: 10.1093/infdis/jiu664. Epub 2014 Dec 9.


Impaired haemophilus influenzae type b transplacental antibody transmission and declining antibody avidity through the first year of life represent potential vulnerabilities for HIV-exposed but -uninfected infants.

Gaensbauer JT, Rakhola JT, Onyango-Makumbi C, Mubiru M, Westcott JE, Krebs NF, Asturias EJ, Fowler MG, McFarland E, Janoff EN.

Clin Vaccine Immunol. 2014 Dec;21(12):1661-7. doi: 10.1128/CVI.00356-14. Epub 2014 Oct 8.


Timing of antiretroviral therapy after diagnosis of cryptococcal meningitis.

Boulware DR, Meya DB, Muzoora C, Rolfes MA, Huppler Hullsiek K, Musubire A, Taseera K, Nabeta HW, Schutz C, Williams DA, Rajasingham R, Rhein J, Thienemann F, Lo MW, Nielsen K, Bergemann TL, Kambugu A, Manabe YC, Janoff EN, Bohjanen PR, Meintjes G; COAT Trial Team.

N Engl J Med. 2014 Jun 26;370(26):2487-98. doi: 10.1056/NEJMoa1312884.


Antibody blocks acquisition of bacterial colonization through agglutination.

Roche AM, Richard AL, Rahkola JT, Janoff EN, Weiser JN.

Mucosal Immunol. 2015 Jan;8(1):176-85. doi: 10.1038/mi.2014.55. Epub 2014 Jun 25.


Decreased mutation frequencies among immunoglobulin G variable region genes during viremic HIV-1 infection.

Bowers E, Scamurra RW, Asrani A, Beniguel L, MaWhinney S, Keays KM, Thurn JR, Janoff EN.

PLoS One. 2014 Jan 7;9(1):e81913. doi: 10.1371/journal.pone.0081913. eCollection 2014.


Neutralization of HIV subtypes A and D by breast milk IgG from women with HIV infection in Uganda.

Palaia JM, McConnell M, Achenbach JE, Gustafson CE, Stoermer KA, Nolan M, Guay LA, Leitner TK, Matovu F, Taylor AW, Fowler MG, Janoff EN.

J Infect. 2014 Mar;68(3):264-72. doi: 10.1016/j.jinf.2013.11.002. Epub 2013 Nov 13.


Limited expression of APRIL and its receptors prior to intestinal IgA plasma cell development during human infancy.

Gustafson CE, Higbee D, Yeckes AR, Wilson CC, De Zoeten EF, Jedlicka P, Janoff EN.

Mucosal Immunol. 2014 May;7(3):467-77. doi: 10.1038/mi.2013.64. Epub 2013 Sep 18.


Pneumococcal IgA1 protease subverts specific protection by human IgA1.

Janoff EN, Rubins JB, Fasching C, Charboneau D, Rahkola JT, Plaut AG, Weiser JN.

Mucosal Immunol. 2014 Mar;7(2):249-56. doi: 10.1038/mi.2013.41. Epub 2013 Jul 3.


Mouse marginal zone B cells harbor specificities similar to human broadly neutralizing HIV antibodies.

Pujanauski LM, Janoff EN, McCarter MD, Pelanda R, Torres RM.

Proc Natl Acad Sci U S A. 2013 Jan 22;110(4):1422-7. doi: 10.1073/pnas.1213713110. Epub 2013 Jan 3.


The world within: living with our microbial guests and guides.

Janoff EN, Gustafson C, Frank DN.

Transl Res. 2012 Oct;160(4):239-45. doi: 10.1016/j.trsl.2012.05.005. Epub 2012 Jun 22. No abstract available.


Altered vaginal microbiota are associated with perinatal mother-to-child transmission of HIV in African women from Burkina Faso.

Frank DN, Manigart O, Leroy V, Meda N, Valéa D, Zhang W, Dabis F, Pace NR, Van de Perre P, Janoff EN.

J Acquir Immune Defic Syndr. 2012 Jul 1;60(3):299-306. doi: 10.1097/QAI.0b013e31824e4bdb.


Kinetics of nevirapine and its impact on HIV-1 RNA levels in maternal plasma and breast milk over time after perinatal single-dose nevirapine.

Aizire J, McConnell MS, Mudiope P, Mubiru M, Matovu F, Parsons TL, Elbireer A, Nolan M, Janoff EN, Fowler MG.

J Acquir Immune Defic Syndr. 2012 Aug 15;60(5):483-8. doi: 10.1097/QAI.0b013e318246bf9e.


Clinical features and serum biomarkers in HIV immune reconstitution inflammatory syndrome after cryptococcal meningitis: a prospective cohort study.

Boulware DR, Meya DB, Bergemann TL, Wiesner DL, Rhein J, Musubire A, Lee SJ, Kambugu A, Janoff EN, Bohjanen PR.

PLoS Med. 2010 Dec 21;7(12):e1000384. doi: 10.1371/journal.pmed.1000384.


Systemic and mucosal differences in HIV burden, immune, and therapeutic responses.

Wahl SM, Redford M, Christensen S, Mack W, Cohn J, Janoff EN, Mestecky J, Jenson HB, Navazesh M, Cohen M, Reichelderfer P, Kovacs A; DATRI 009 Study Group.

J Acquir Immune Defic Syndr. 2011 Apr 15;56(5):401-11. doi: 10.1097/QAI.0b013e31820cdfdb.


HIV infection is associated with reduced serum alpha-1-antitrypsin concentrations.

Bryan CL, Beard KS, Pott GB, Rahkola J, Gardner EM, Janoff EN, Shapiro L.

Clin Invest Med. 2010 Dec 1;33(6):E384-9.


The association of ethnicity with antibody responses to pneumococcal vaccination among adults with HIV infection.

Crum-Cianflone NF, Roediger M, Huppler Hullsiek K, Ganesan A, Landrum M, Weintrob A, Agan B, Medina S, Rahkola J, Hale B, Janoff EN; Infectious Disease Clinical Research Program HIV Working Group.

Vaccine. 2010 Nov 10;28(48):7583-8. doi: 10.1016/j.vaccine.2010.09.056. Epub 2010 Sep 29.


Antiretroviral therapy down-regulates innate antiviral response genes in patients with AIDS in sub-saharan Africa.

Boulware DR, Meya DB, Bergemann TL, Williams D, Vlasova-St Louis IA, Rhein J, Staddon J, Kambugu A, Janoff EN, Bohjanen PR.

J Acquir Immune Defic Syndr. 2010 Dec;55(4):428-38. doi: 10.1097/QAI.0b013e3181ef4963.


A randomized clinical trial comparing revaccination with pneumococcal conjugate vaccine to polysaccharide vaccine among HIV-infected adults.

Crum-Cianflone NF, Huppler Hullsiek K, Roediger M, Ganesan A, Patel S, Landrum ML, Weintrob A, Agan BK, Medina S, Rahkola J, Hale BR, Janoff EN; Infectious Disease Clinical Research Program HIV Working Group.

J Infect Dis. 2010 Oct 1;202(7):1114-25. doi: 10.1086/656147.


Paucity of initial cerebrospinal fluid inflammation in cryptococcal meningitis is associated with subsequent immune reconstitution inflammatory syndrome.

Boulware DR, Bonham SC, Meya DB, Wiesner DL, Park GS, Kambugu A, Janoff EN, Bohjanen PR.

J Infect Dis. 2010 Sep 15;202(6):962-70. doi: 10.1086/655785.


The human nasal microbiota and Staphylococcus aureus carriage.

Frank DN, Feazel LM, Bessesen MT, Price CS, Janoff EN, Pace NR.

PLoS One. 2010 May 17;5(5):e10598. doi: 10.1371/journal.pone.0010598.


Pathogen-specific antibodies: codependent no longer.

Janoff EN, Frank DN.

J Clin Invest. 2010 Apr;120(4):1039-42. doi: 10.1172/JCI42695. Epub 2010 Mar 24.


Kinetics of viral shedding and immune responses in adults following administration of cold-adapted influenza vaccine.

Hammitt LL, Bartlett JP, Li S, Rahkola J, Lang N, Janoff EN, Levin MJ, Weinberg A.

Vaccine. 2009 Dec 9;27(52):7359-66. doi: 10.1016/j.vaccine.2009.09.041. Epub 2009 Oct 1.


Influenza in immunosuppressed populations: a review of infection frequency, morbidity, mortality, and vaccine responses.

Kunisaki KM, Janoff EN.

Lancet Infect Dis. 2009 Aug;9(8):493-504. doi: 10.1016/S1473-3099(09)70175-6. Review.


Exhaled nitric oxide, systemic inflammation, and the spirometric response to inhaled fluticasone propionate in severe chronic obstructive pulmonary disease: a prospective study.

Kunisaki KM, Rice KL, Janoff EN, Rector TS, Niewoehner DE.

Ther Adv Respir Dis. 2008 Apr;2(2):55-64. doi: 10.1177/1753465808088902.


Pneumococcal vaccination of elderly adults: new paradigms for protection.

Jackson LA, Janoff EN.

Clin Infect Dis. 2008 Nov 15;47(10):1328-38. doi: 10.1086/592691. Review.


Tuberculosis-associated immune reconstitution inflammatory syndrome: case definitions for use in resource-limited settings.

Meintjes G, Lawn SD, Scano F, Maartens G, French MA, Worodria W, Elliott JH, Murdoch D, Wilkinson RJ, Seyler C, John L, van der Loeff MS, Reiss P, Lynen L, Janoff EN, Gilks C, Colebunders R; International Network for the Study of HIV-associated IRIS.

Lancet Infect Dis. 2008 Aug;8(8):516-23. doi: 10.1016/S1473-3099(08)70184-1.


Oral keratinocytes support non-replicative infection and transfer of harbored HIV-1 to permissive cells.

Vacharaksa A, Asrani AC, Gebhard KH, Fasching CE, Giacaman RA, Janoff EN, Ross KF, Herzberg MC.

Retrovirology. 2008 Jul 17;5:66. doi: 10.1186/1742-4690-5-66.


Aging and infectious diseases: workshop on HIV infection and aging: what is known and future research directions.

Effros RB, Fletcher CV, Gebo K, Halter JB, Hazzard WR, Horne FM, Huebner RE, Janoff EN, Justice AC, Kuritzkes D, Nayfield SG, Plaeger SF, Schmader KE, Ashworth JR, Campanelli C, Clayton CP, Rada B, Woolard NF, High KP.

Clin Infect Dis. 2008 Aug 15;47(4):542-53. doi: 10.1086/590150.


Outcomes of cryptococcal meningitis in Uganda before and after the availability of highly active antiretroviral therapy.

Kambugu A, Meya DB, Rhein J, O'Brien M, Janoff EN, Ronald AR, Kamya MR, Mayanja-Kizza H, Sande MA, Bohjanen PR, Boulware DR.

Clin Infect Dis. 2008 Jun 1;46(11):1694-701. doi: 10.1086/587667.


Rapid diagnosis of influenza infection in older adults: influence on clinical care in a routine clinical setting.

D'Heilly SJ, Janoff EN, Nichol P, Nichol KL.

J Clin Virol. 2008 Jun;42(2):124-8. doi: 10.1016/j.jcv.2007.12.014. Epub 2008 Mar 4.


The evidence for using conjugate vaccines to protect HIV-infected children against pneumococcal disease.

Bliss SJ, O'Brien KL, Janoff EN, Cotton MF, Musoke P, Coovadia H, Levine OS.

Lancet Infect Dis. 2008 Jan;8(1):67-80. Epub 2007 Oct 31. Review.


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