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Items: 1 to 50 of 89

1.

Modified nucleotides may have enhanced early RNA catalysis.

Wolk SK, Mayfield WS, Gelinas AD, Astling D, Guillot J, Brody EN, Janjic N, Gold L.

Proc Natl Acad Sci U S A. 2020 Mar 30. pii: 201809041. doi: 10.1073/pnas.1809041117. [Epub ahead of print]

PMID:
32229566
2.

Multiple-Ascending-Dose Phase 1 Clinical Study of the Safety, Tolerability, and Pharmacokinetics of CRS3123, a Narrow-Spectrum Agent with Minimal Disruption of Normal Gut Microbiota.

Lomeli BK, Galbraith H, Schettler J, Saviolakis GA, El-Amin W, Osborn B, Ravel J, Hazleton K, Lozupone CA, Evans RJ, Bell SJ, Ochsner UA, Jarvis TC, Baqar S, Janjic N.

Antimicrob Agents Chemother. 2019 Dec 20;64(1). pii: e01395-19. doi: 10.1128/AAC.01395-19. Print 2019 Dec 20.

3.

Effects of codon optimization on coagulation factor IX translation and structure: Implications for protein and gene therapies.

Alexaki A, Hettiarachchi GK, Athey JC, Katneni UK, Simhadri V, Hamasaki-Katagiri N, Nanavaty P, Lin B, Takeda K, Freedberg D, Monroe D, McGill JR, Peters R, Kames JM, Holcomb DD, Hunt RC, Sauna ZE, Gelinas A, Janjic N, DiCuccio M, Bar H, Komar AA, Kimchi-Sarfaty C.

Sci Rep. 2019 Oct 29;9(1):15449. doi: 10.1038/s41598-019-51984-2.

4.

Targeting Unique Epitopes on Highly Similar Proteins GDF-11 and GDF-8 with Modified DNA Aptamers.

Ochsner UA, Green LS, Rice TP, Olivas E, Janjic N, Katilius E.

Biochemistry. 2019 Nov 19;58(46):4632-4640. doi: 10.1021/acs.biochem.9b00760. Epub 2019 Nov 7.

PMID:
31638376
5.

Vascular dysfunction following breath-hold diving.

Barak OF, Janjic N, Drvis I, Mijacika T, Mudnic I, Coombs GB, Thom SR, Madic D, Dujic Z.

Can J Physiol Pharmacol. 2020 Feb;98(2):124-130. doi: 10.1139/cjpp-2019-0341.

6.

Correction: Discovery and validation of a prognostic proteomic signature for tuberculosis progression: A prospective cohort study.

Penn-Nicholson A, Hraha T, Thompson EG, Sterling D, Mbandi SK, Wall KM, Fisher M, Suliman S, Shankar S, Hanekom WA, Janjic N, Hatherill M, Kaufmann SHE, Sutherland J, Walzl G, De Groote MA, Ochsner U, Zak DE, Scriba TJ; ACS and GC6–74 cohort study groups.

PLoS Med. 2019 Jul 18;16(7):e1002880. doi: 10.1371/journal.pmed.1002880. eCollection 2019 Jul.

7.

Discovery and validation of a prognostic proteomic signature for tuberculosis progression: A prospective cohort study.

Penn-Nicholson A, Hraha T, Thompson EG, Sterling D, Mbandi SK, Wall KM, Fisher M, Suliman S, Shankar S, Hanekom WA, Janjic N, Hatherill M, Kaufmann SHE, Sutherland J, Walzl G, De Groote MA, Ochsner U, Zak DE, Scriba TJ; ACS and GC6–74 cohort study groups.

PLoS Med. 2019 Apr 16;16(4):e1002781. doi: 10.1371/journal.pmed.1002781. eCollection 2019 Apr. Erratum in: PLoS Med. 2019 Jul 18;16(7):e1002880.

8.

Evaluation of The Final Time and Velocity of a 100 m Run Under the Realistic Conditions.

Janjić N, Kapor D, Doder D, Savić I.

J Hum Kinet. 2019 Mar 27;66:19-29. doi: 10.2478/hukin-2018-0048. eCollection 2019 Mar.

9.

Proteomic Profiles in Advanced Age-Related Macular Degeneration Using an Aptamer-Based Proteomic Technology.

Lynch AM, Wagner BD, Weiss SJ, Wall KM, Palestine AG, Mathias MT, Siringo FS, Cathcart JN, Patnaik JL, Drolet DW, Janjic N, Mandava N.

Transl Vis Sci Technol. 2019 Jan 25;8(1):14. doi: 10.1167/tvst.8.1.14. eCollection 2019 Jan.

10.

Modified aptamers enable quantitative sub-10-nm cellular DNA-PAINT imaging.

Strauss S, Nickels PC, Strauss MT, Jimenez Sabinina V, Ellenberg J, Carter JD, Gupta S, Janjic N, Jungmann R.

Nat Methods. 2018 Sep;15(9):685-688. doi: 10.1038/s41592-018-0105-0. Epub 2018 Aug 20.

11.

Genomic atlas of the human plasma proteome.

Sun BB, Maranville JC, Peters JE, Stacey D, Staley JR, Blackshaw J, Burgess S, Jiang T, Paige E, Surendran P, Oliver-Williams C, Kamat MA, Prins BP, Wilcox SK, Zimmerman ES, Chi A, Bansal N, Spain SL, Wood AM, Morrell NW, Bradley JR, Janjic N, Roberts DJ, Ouwehand WH, Todd JA, Soranzo N, Suhre K, Paul DS, Fox CS, Plenge RM, Danesh J, Runz H, Butterworth AS.

Nature. 2018 Jun;558(7708):73-79. doi: 10.1038/s41586-018-0175-2. Epub 2018 Jun 6.

12.

Structural basis for IL-1α recognition by a modified DNA aptamer that specifically inhibits IL-1α signaling.

Ren X, Gelinas AD, von Carlowitz I, Janjic N, Pyle AM.

Nat Commun. 2017 Oct 9;8(1):810. doi: 10.1038/s41467-017-00864-2.

13.

Pharmacokinetic Properties of DNA Aptamers with Base Modifications.

Gupta S, Drolet DW, Wolk SK, Waugh SM, Rohloff JC, Carter JD, Mayfield WS, Otis MR, Fowler CR, Suzuki T, Hirota M, Ishikawa Y, Schneider DJ, Janjic N.

Nucleic Acid Ther. 2017 Dec;27(6):345-353. doi: 10.1089/nat.2017.0683. Epub 2017 Sep 29.

14.

Potential of High-Affinity, Slow Off-Rate Modified Aptamer Reagents for Mycobacterium tuberculosis Proteins as Tools for Infection Models and Diagnostic Applications.

Russell TM, Green LS, Rice T, Kruh-Garcia NA, Dobos K, De Groote MA, Hraha T, Sterling DG, Janjic N, Ochsner UA.

J Clin Microbiol. 2017 Oct;55(10):3072-3088. doi: 10.1128/JCM.00469-17. Epub 2017 Aug 9.

15.

Discovery and Validation of a Six-Marker Serum Protein Signature for the Diagnosis of Active Pulmonary Tuberculosis.

De Groote MA, Sterling DG, Hraha T, Russell TM, Green LS, Wall K, Kraemer S, Ostroff R, Janjic N, Ochsner UA.

J Clin Microbiol. 2017 Oct;55(10):3057-3071. doi: 10.1128/JCM.00467-17. Epub 2017 Aug 9.

16.

A Model for Determining the Effect of the Wind Velocity on 100 m Sprinting Performance.

Janjic N, Kapor D, Doder D, Petrovic A, Doder R.

J Hum Kinet. 2017 Jun 22;57:159-167. doi: 10.1515/hukin-2017-0057. eCollection 2017 Jun.

17.

Safety, Tolerability, Systemic Exposure, and Metabolism of CRS3123, a Methionyl-tRNA Synthetase Inhibitor Developed for Treatment of Clostridium difficile, in a Phase 1 Study.

Nayak SU, Griffiss JM, Blumer J, O'Riordan MA, Gray W, McKenzie R, Jurao RA, An AT, Le M, Bell SJ, Ochsner UA, Jarvis TC, Janjic N, Zenilman JM.

Antimicrob Agents Chemother. 2017 Jul 25;61(8). pii: e02760-16. doi: 10.1128/AAC.02760-16. Print 2017 Aug.

18.

Correction for De Groote et al., "Highly Multiplexed Proteomic Analysis of Quantiferon Supernatants To Identify Biomarkers of Latent Tuberculosis Infection".

De Groote MA, Higgins M, Hraha T, Wall K, Wilson ML, Sterling DG, Janjic N, Reves R, Ochsner UA, Belknap R.

J Clin Microbiol. 2017 May;55(5):1598. doi: 10.1128/JCM.00333-17. No abstract available.

19.

Selection of DNA aptamers with two modified bases.

Gawande BN, Rohloff JC, Carter JD, von Carlowitz I, Zhang C, Schneider DJ, Janjic N.

Proc Natl Acad Sci U S A. 2017 Mar 14;114(11):2898-2903. doi: 10.1073/pnas.1615475114. Epub 2017 Mar 6.

20.

Highly Multiplexed Proteomic Analysis of Quantiferon Supernatants To Identify Biomarkers of Latent Tuberculosis Infection.

De Groote MA, Higgins M, Hraha T, Wall K, Wilson ML, Sterling DG, Janjic N, Reves R, Ochsner UA, Belknap R.

J Clin Microbiol. 2017 Feb;55(2):391-402. doi: 10.1128/JCM.01646-16. Epub 2016 Nov 16. Erratum in: J Clin Microbiol. 2017 May;55(5):1598.

21.

Structural model of the dimeric Parkinson's protein LRRK2 reveals a compact architecture involving distant interdomain contacts.

Guaitoli G, Raimondi F, Gilsbach BK, Gómez-Llorente Y, Deyaert E, Renzi F, Li X, Schaffner A, Jagtap PK, Boldt K, von Zweydorf F, Gotthardt K, Lorimer DD, Yue Z, Burgin A, Janjic N, Sattler M, Versées W, Ueffing M, Ubarretxena-Belandia I, Kortholt A, Gloeckner CJ.

Proc Natl Acad Sci U S A. 2016 Jul 26;113(30):E4357-66. doi: 10.1073/pnas.1523708113. Epub 2016 Jun 29.

22.

Model for assessment of the velocity and force at the start of sprint race.

Janjić NJ, Kapor DV, Doder DV, Petrović A, Jarić S.

J Sports Sci. 2017 Feb;35(3):302-309. Epub 2016 Mar 28.

PMID:
27019402
23.

Embracing proteins: structural themes in aptamer-protein complexes.

Gelinas AD, Davies DR, Janjic N.

Curr Opin Struct Biol. 2016 Feb;36:122-32. doi: 10.1016/j.sbi.2016.01.009. Epub 2016 Feb 24. Review.

24.

Fit for the Eye: Aptamers in Ocular Disorders.

Drolet DW, Green LS, Gold L, Janjic N.

Nucleic Acid Ther. 2016 Jun;26(3):127-46. doi: 10.1089/nat.2015.0573. Epub 2016 Jan 12. Review.

25.

Chemically Modified Interleukin-6 Aptamer Inhibits Development of Collagen-Induced Arthritis in Cynomolgus Monkeys.

Hirota M, Murakami I, Ishikawa Y, Suzuki T, Sumida S, Ibaragi S, Kasai H, Horai N, Drolet DW, Gupta S, Janjic N, Schneider DJ.

Nucleic Acid Ther. 2016 Feb;26(1):10-9. doi: 10.1089/nat.2015.0567. Epub 2015 Nov 18.

26.

Influence of 5-N-carboxamide modifications on the thermodynamic stability of oligonucleotides.

Wolk SK, Shoemaker RK, Mayfield WS, Mestdagh AL, Janjic N.

Nucleic Acids Res. 2015 Oct 30;43(19):9107-22. doi: 10.1093/nar/gkv981. Epub 2015 Oct 4.

27.

Non-helical DNA Triplex Forms a Unique Aptamer Scaffold for High Affinity Recognition of Nerve Growth Factor.

Jarvis TC, Davies DR, Hisaminato A, Resnicow DI, Gupta S, Waugh SM, Nagabukuro A, Wadatsu T, Hishigaki H, Gawande B, Zhang C, Wolk SK, Mayfield WS, Nakaishi Y, Burgin AB, Stewart LJ, Edwards TE, Gelinas AD, Schneider DJ, Janjic N.

Structure. 2015 Jul 7;23(7):1293-304. doi: 10.1016/j.str.2015.03.027. Epub 2015 May 28.

28.

Nucleic Acid Ligands With Protein-like Side Chains: Modified Aptamers and Their Use as Diagnostic and Therapeutic Agents.

Rohloff JC, Gelinas AD, Jarvis TC, Ochsner UA, Schneider DJ, Gold L, Janjic N.

Mol Ther Nucleic Acids. 2014 Oct 7;3:e201. doi: 10.1038/mtna.2014.49. Review.

29.

Surgical treatment of shoulder rotator cuff injuries.

Ninković S, Simnjanovski M, Harhaji V, Kovacev N, Janjic N, Obradović M.

Med Pregl. 2014 Jul-Aug;67(7-8):239-45.

PMID:
25151764
30.

Pharmacokinetics and toxicity predictors of new s-triazines, herbicide candidates, in correlation with chromatogrpahic retention constants.

Milošević N, Janjić N, Milić N, Milanović M, Popović J, Antonović D.

J Agric Food Chem. 2014 Aug 27;62(34):8579-85. doi: 10.1021/jf502405k. Epub 2014 Aug 14.

PMID:
25093448
31.

Model for the determination of instantaneous values of the velocity, instantaneous, and average acceleration for 100-m sprinters.

JanjiĆ NJ, Kapor DV, Doder DV, Doder RZ, SaviĆ BV.

J Strength Cond Res. 2014 Dec;28(12):3432-9. doi: 10.1519/JSC.0000000000000606.

PMID:
24983854
32.

Specific capture and detection of Staphylococcus aureus with high-affinity modified aptamers to cell surface components.

Baumstummler A, Lehmann D, Janjic N, Ochsner UA.

Lett Appl Microbiol. 2014 Oct;59(4):422-31. doi: 10.1111/lam.12295. Epub 2014 Jul 2.

33.

Systematic selection of modified aptamer pairs for diagnostic sandwich assays.

Ochsner UA, Green LS, Gold L, Janjic N.

Biotechniques. 2014 Mar 1;56(3):125-8, 130, 132-3. doi: 10.2144/000114134. eCollection 2014.

34.

Aptamer-based proteomic signature of intensive phase treatment response in pulmonary tuberculosis.

Nahid P, Bliven-Sizemore E, Jarlsberg LG, De Groote MA, Johnson JL, Muzanyi G, Engle M, Weiner M, Janjic N, Sterling DG, Ochsner UA.

Tuberculosis (Edinb). 2014 May;94(3):187-96. doi: 10.1016/j.tube.2014.01.006. Epub 2014 Feb 7.

35.

Crystal structure of interleukin-6 in complex with a modified nucleic acid ligand.

Gelinas AD, Davies DR, Edwards TE, Rohloff JC, Carter JD, Zhang C, Gupta S, Ishikawa Y, Hirota M, Nakaishi Y, Jarvis TC, Janjic N.

J Biol Chem. 2014 Mar 21;289(12):8720-34. doi: 10.1074/jbc.M113.532697. Epub 2014 Jan 12.

36.

Chemically modified DNA aptamers bind interleukin-6 with high affinity and inhibit signaling by blocking its interaction with interleukin-6 receptor.

Gupta S, Hirota M, Waugh SM, Murakami I, Suzuki T, Muraguchi M, Shibamori M, Ishikawa Y, Jarvis TC, Carter JD, Zhang C, Gawande B, Vrkljan M, Janjic N, Schneider DJ.

J Biol Chem. 2014 Mar 21;289(12):8706-19. doi: 10.1074/jbc.M113.532580. Epub 2014 Jan 12.

37.

[Comparative analysis of the position of the graft in the femur after anterior cruciate ligament reconstruction done through the front inner portal and through the shin bone].

Harhaji V, Ninković S, Milojević Z, Till V, Ristić V, Harhaji S, Janjić N, Milankov M.

Acta Chir Iugosl. 2013;60(2):81-5. Serbian.

PMID:
24298743
38.

Detection of Clostridium difficile toxins A, B and binary toxin with slow off-rate modified aptamers.

Ochsner UA, Katilius E, Janjic N.

Diagn Microbiol Infect Dis. 2013 Jul;76(3):278-85. doi: 10.1016/j.diagmicrobio.2013.03.029. Epub 2013 May 13.

PMID:
23680240
39.

Elucidating novel serum biomarkers associated with pulmonary tuberculosis treatment.

De Groote MA, Nahid P, Jarlsberg L, Johnson JL, Weiner M, Muzanyi G, Janjic N, Sterling DG, Ochsner UA.

PLoS One. 2013 Apr 18;8(4):e61002. doi: 10.1371/journal.pone.0061002. Print 2013.

40.

Highly multiplexed proteomic platform for biomarker discovery, diagnostics, and therapeutics.

Mehan MR, Ostroff R, Wilcox SK, Steele F, Schneider D, Jarvis TC, Baird GS, Gold L, Janjic N.

Adv Exp Med Biol. 2013;735:283-300. Review.

PMID:
23402035
41.

Unique motifs and hydrophobic interactions shape the binding of modified DNA ligands to protein targets.

Davies DR, Gelinas AD, Zhang C, Rohloff JC, Carter JD, O'Connell D, Waugh SM, Wolk SK, Mayfield WS, Burgin AB, Edwards TE, Stewart LJ, Gold L, Janjic N, Jarvis TC.

Proc Natl Acad Sci U S A. 2012 Dec 4;109(49):19971-6. doi: 10.1073/pnas.1213933109. Epub 2012 Nov 8.

42.

Protein signature of lung cancer tissues.

Mehan MR, Ayers D, Thirstrup D, Xiong W, Ostroff RM, Brody EN, Walker JJ, Gold L, Jarvis TC, Janjic N, Baird GS, Wilcox SK.

PLoS One. 2012;7(4):e35157. doi: 10.1371/journal.pone.0035157. Epub 2012 Apr 11.

43.

Isometric force development of some muscle groups in athletes.

Doder DV, Babiak JJ, Janjić NJ, Doder RZ.

J Strength Cond Res. 2012 Jan;26(1):293-8. doi: 10.1519/JSC.0b013e31821d5c89.

PMID:
22201699
44.

Making the cut: untangling clinical protein biomarker discovery and validation.

Gold L, Williams S, Janjic N, Saccomano N, Steele F.

Biomark Med. 2011 Apr;5(2):189-91. doi: 10.2217/bmm.11.11. No abstract available.

PMID:
21473721
45.

Aptamers and the RNA world, past and present.

Gold L, Janjic N, Jarvis T, Schneider D, Walker JJ, Wilcox SK, Zichi D.

Cold Spring Harb Perspect Biol. 2012 Mar 1;4(3). pii: a003582. doi: 10.1101/cshperspect.a003582. Review.

46.

Rapid histochemistry using slow off-rate modified aptamers with anionic competition.

Gupta S, Thirstrup D, Jarvis TC, Schneider DJ, Wilcox SK, Carter J, Zhang C, Gelinas A, Weiss A, Janjic N, Baird GS.

Appl Immunohistochem Mol Morphol. 2011 May;19(3):273-8. doi: 10.1097/PAI.0b013e3182008c29.

PMID:
21217521
47.

Aptamer-based multiplexed proteomic technology for biomarker discovery.

Gold L, Ayers D, Bertino J, Bock C, Bock A, Brody EN, Carter J, Dalby AB, Eaton BE, Fitzwater T, Flather D, Forbes A, Foreman T, Fowler C, Gawande B, Goss M, Gunn M, Gupta S, Halladay D, Heil J, Heilig J, Hicke B, Husar G, Janjic N, Jarvis T, Jennings S, Katilius E, Keeney TR, Kim N, Koch TH, Kraemer S, Kroiss L, Le N, Levine D, Lindsey W, Lollo B, Mayfield W, Mehan M, Mehler R, Nelson SK, Nelson M, Nieuwlandt D, Nikrad M, Ochsner U, Ostroff RM, Otis M, Parker T, Pietrasiewicz S, Resnicow DI, Rohloff J, Sanders G, Sattin S, Schneider D, Singer B, Stanton M, Sterkel A, Stewart A, Stratford S, Vaught JD, Vrkljan M, Walker JJ, Watrobka M, Waugh S, Weiss A, Wilcox SK, Wolfson A, Wolk SK, Zhang C, Zichi D.

PLoS One. 2010 Dec 7;5(12):e15004. doi: 10.1371/journal.pone.0015004.

48.

Discovery and analysis of 4H-pyridopyrimidines, a class of selective bacterial protein synthesis inhibitors.

Ribble W, Hill WE, Ochsner UA, Jarvis TC, Guiles JW, Janjic N, Bullard JM.

Antimicrob Agents Chemother. 2010 Nov;54(11):4648-57. doi: 10.1128/AAC.00638-10. Epub 2010 Aug 9.

49.

Hybrid hamstring graft tibial fixation in anterior cruciate ligament reconstruction.

Milankov MZ, Miljkovic N, Janjic N.

Arch Orthop Trauma Surg. 2010 Aug;130(8):1033-6. doi: 10.1007/s00402-010-1124-1. Epub 2010 Jun 4.

PMID:
20524003
50.

Pharmacokinetic-pharmacodynamic assessment of faropenem in a lethal murine Bacillus anthracis inhalation postexposure prophylaxis model.

Gill SC, Rubino CM, Bassett J, Miller L, Ambrose PG, Bhavnani SM, Beaudry A, Li J, Stone KC, Critchley I, Janjic N, Heine HS.

Antimicrob Agents Chemother. 2010 May;54(5):1678-83. doi: 10.1128/AAC.00737-08. Epub 2010 Feb 9.

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