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Bitopertin, a selective oral GLYT1 inhibitor, improves anemia in a mouse model of beta-thalassemia.

Matte A, Federti E, Winter M, Koerner A, Harmeier A, Mazer N, Tomka T, Di Paolo ML, De Falco L, Andolfo I, Beneduce E, Iolascon A, Macias-Garcia A, Chen JJ, Janin A, Leboeuf C, Turrini F, Brugnara C, De Franceschi L.

JCI Insight. 2019 Oct 8. pii: 130111. doi: 10.1172/jci.insight.130111. [Epub ahead of print]


Genomics applied to the treatment of breast cancer.

Hamdan D, Nguyen TT, Leboeuf C, Meles S, Janin A, Bousquet G.

Oncotarget. 2019 Jul 30;10(46):4786-4801. doi: 10.18632/oncotarget.27102. eCollection 2019 Jul 30. Review.


Pulsed-laser irradiation of multifunctional gold nanoshells to overcome trastuzumab resistance in HER2-overexpressing breast cancer.

Nunes T, Pons T, Hou X, Van Do K, Caron B, Rigal M, Di Benedetto M, Palpant B, Leboeuf C, Janin A, Bousquet G.

J Exp Clin Cancer Res. 2019 Jul 12;38(1):306. doi: 10.1186/s13046-019-1305-x.


Se préparer à la souffrance liée au climat.

Janin A.

Rev Med Suisse. 2019 Jun 5;15(654):1200. French. No abstract available.


Whole Exome Sequencing Reveals a Large Genetic Heterogeneity and Revisits the Causes of Hypertrophic Cardiomyopathy.

Nguyen K, Roche S, Donal E, Odent S, Eicher JC, Faivre L, Millat G, Salgado D, Desvignes JP, Lavoute C, Haentjens J, Consolino É, Janin A, Cerino M, Réant P, Rooryck C, Charron P, Richard P, Casalta AC, Michel N, Magdinier F, Béroud C, Lévy N, Habib G.

Circ Genom Precis Med. 2019 May;12(5):e002500. doi: 10.1161/CIRCGEN.119.002500. No abstract available.


A Constitutional Activating MET Mutation Makes the Genetic Link between Malignancies and Chronic Inflammatory Diseases.

El Bouchtaoui M, Do Cruzeiro M, Leboeuf C, Loisel-Ferreira I, Fedronie C, Ferreira C, Ait El Far R, Ziol M, Espié M, Falgarone G, Cassinat B, Kiladjian JJ, Feugeas JP, Janin A, Bousquet G.

Clin Cancer Res. 2019 Jul 15;25(14):4504-4515. doi: 10.1158/1078-0432.CCR-18-3261. Epub 2019 Apr 19.


Normal serum ApoB48 and red cells vitamin E concentrations after supplementation in a novel compound heterozygous case of abetalipoproteinemia.

Di Filippo M, Collardeau Frachon S, Janin A, Rajan S, Marmontel O, Decourt C, Rubio A, Nony S, Dumont S, Cuerq C, Charrière S, Moulin P, Lachaux A, Hussain MM, Bozon D, Peretti N.

Atherosclerosis. 2019 May;284:75-82. doi: 10.1016/j.atherosclerosis.2019.02.016. Epub 2019 Mar 3.


Re-exploring immune-related side effects of docetaxel in an observational study: Blood hypereosinophilia.

Hamdan D, Leboeuf C, Le Foll C, Bousquet G, Janin A.

Cancer Med. 2019 May;8(5):2005-2012. doi: 10.1002/cam4.2062. Epub 2019 Mar 10.


A successful compartmental approach for the treatment of breast cancer brain metastases.

Nguyen TT, Angeli E, Darrouzain F, Nguyen QT, Desvignes C, Rigal M, Nevine O, Nicolas P, Le QV, Winterman S, Pailler MC, Zelek L, Paintaud G, Janin A, Bousquet G.

Cancer Chemother Pharmacol. 2019 Mar;83(3):573-580. doi: 10.1007/s00280-018-3752-z. Epub 2019 Jan 5.


Bone and Joint Tissue Penetration of the Staphylococcus-Selective Antibiotic Afabicin in Patients Undergoing Elective Hip Replacement Surgery.

Menetrey A, Janin A, Pullman J, Overcash JS, Haouala A, Leylavergne F, Turbe L, Wittke F, Nicolas-Métral V.

Antimicrob Agents Chemother. 2019 Feb 26;63(3). pii: e01669-18. doi: 10.1128/AAC.01669-18. Print 2019 Mar.


Targeting Cancer Stem Cells to Overcome Chemoresistance.

Nunes T, Hamdan D, Leboeuf C, El Bouchtaoui M, Gapihan G, Nguyen TT, Meles S, Angeli E, Ratajczak P, Lu H, Di Benedetto M, Bousquet G, Janin A.

Int J Mol Sci. 2018 Dec 13;19(12). pii: E4036. doi: 10.3390/ijms19124036. Review.


Doxorubicin-loaded dextran-based nano-carriers for highly efficient inhibition of lymphoma cell growth and synchronous reduction of cardiac toxicity.

Fang Y, Wang H, Dou HJ, Fan X, Fei XC, Wang L, Cheng S, Janin A, Wang L, Zhao WL.

Int J Nanomedicine. 2018 Sep 24;13:5673-5683. doi: 10.2147/IJN.S161203. eCollection 2018.


Nesprins and Lamins in Health and Diseases of Cardiac and Skeletal Muscles.

Janin A, Gache V.

Front Physiol. 2018 Sep 7;9:1277. doi: 10.3389/fphys.2018.01277. eCollection 2018. Review.


Aberrant Splicing Is the Pathogenicity Mechanism of the p.Glu314Lys Variant in CYP11A1 Gene.

Goursaud C, Mallet D, Janin A, Menassa R, Tardy-Guidollet V, Russo G, Lienhardt-Roussie A, Lecointre C, Plotton I, Morel Y, Roucher-Boulez F.

Front Endocrinol (Lausanne). 2018 Sep 5;9:491. doi: 10.3389/fendo.2018.00491. eCollection 2018.


TRPM4 mutations to cause autosomal recessive and not autosomal dominant Brugada type 1 syndrome.

Janin A, Bessière F, Georgescu T, Chanavat V, Chevalier P, Millat G.

Eur J Med Genet. 2019 Jun;62(6):103527. doi: 10.1016/j.ejmg.2018.08.008. Epub 2018 Aug 22.


Differential MicroRNA Expression Levels in Cutaneous Acute Graft-Versus-Host Disease.

Atarod S, Norden J, Bibby LA, Janin A, Ratajczak P, Lendrem C, Pearce KF, Wang XN, O'Reilly S, Van Laar JM, Collin M, Dickinson AM, Crossland RE.

Front Immunol. 2018 Jul 10;9:1485. doi: 10.3389/fimmu.2018.01485. eCollection 2018.


First identification of homozygous truncating CSRP3 variants in two unrelated cases with hypertrophic cardiomyopathy.

Janin A, Bessière F, Chauveau S, Chevalier P, Millat G.

Gene. 2018 Nov 15;676:110-116. doi: 10.1016/j.gene.2018.07.036. Epub 2018 Jul 17.


Micromolecular methods for diagnosis and therapeutic strategy: a case study.

Elbouchtaoui M, Tengher I, Miquel C, Brugière C, Benbara A, Zelek L, Ziol M, Bouhidel F, Janin A, Bousquet G, Leboeuf C.

Oncotarget. 2018 Apr 27;9(32):22862-22869. doi: 10.18632/oncotarget.25161. eCollection 2018 Apr 27.


Semi-passive in-situ pilot scale bioreactor successfully removed sulfate and metals from mine impacted water under subarctic climatic conditions.

Nielsen G, Hatam I, Abuan KA, Janin A, Coudert L, Blais JF, Mercier G, Baldwin SA.

Water Res. 2018 Sep 1;140:268-279. doi: 10.1016/j.watres.2018.04.035. Epub 2018 Apr 23.


Necrobiotic xanthogranuloma: a paraneoplastic skin lesion of haematological malignancies?

Omarjee L, Janin A, Etienne G, Bellou A, Stivalet O, Jaquinandi V, Mahe G.

Eur J Dermatol. 2018 Jun 1;28(3):384-386. doi: 10.1684/ejd.2018.3256. No abstract available.


SMAD6 overexpression leads to accelerated myogenic differentiation of LMNA mutated cells.

Janin A, Bauer D, Ratti F, Valla C, Bertrand A, Christin E, Chopin E, Streichenberger N, Bonne G, Gache V, Cohen T, Méjat A.

Sci Rep. 2018 Apr 4;8(1):5618. doi: 10.1038/s41598-018-23918-x.


Perineural Invasion in Human Cutaneous Squamous Cell Carcinoma Is Linked to Neurotrophins, Epithelial-Mesenchymal Transition, and NCAM1.

Brugière C, El Bouchtaoui M, Leboeuf C, Gapihan G, Ait El Far R, Sy M, Lepage AL, Ratajczak P, Janin A, Verneuil L.

J Invest Dermatol. 2018 Sep;138(9):2063-2066. doi: 10.1016/j.jid.2018.02.044. Epub 2018 Mar 28. No abstract available.


Cardiac voltage-gated sodium channel mutations associated with left atrial dysfunction and stroke in children.

Moreau A, Janin A, Millat G, Chevalier P.

Europace. 2018 Oct 1;20(10):1692-1698. doi: 10.1093/europace/euy041.


Blockade of the renin-angiotensin-aldosterone system in patients with arrhythmogenic right ventricular dysplasia: A double-blind, multicenter, prospective, randomized, genotype-driven study (BRAVE study).

Morel E, Manati AW, Nony P, Maucort-Boulch D, Bessière F, Cai X, Besseyre des Horts T, Janin A, Moreau A, Chevalier P.

Clin Cardiol. 2018 Mar;41(3):300-306. doi: 10.1002/clc.22884. Epub 2018 Mar 25.


Single, short in-del, and copy number variations detection in monogenic dyslipidemia using a next-generation sequencing strategy.

Marmontel O, Charrière S, Simonet T, Bonnet V, Dumont S, Mahl M, Jacobs C, Nony S, Chabane K, Bozon D, Janin A, Peretti N, Lachaux A, Bardel C, Millat G, Moulin P, Marçais C, Di Filippo M.

Clin Genet. 2018 Jul;94(1):132-140. doi: 10.1111/cge.13250. Epub 2018 Apr 25.


A Novel Missense Mutation p.Gly162Glu of the Gene MYL2 Involved in Hypertrophic Cardiomyopathy: A Pedigree Analysis of a Proband.

Renaudin P, Janin A, Millat G, Chevalier P.

Mol Diagn Ther. 2018 Apr;22(2):219-223. doi: 10.1007/s40291-018-0324-1.


A novel way to manage trastuzumab cardiotoxicity.

Hamdan D, Darrouzain F, Bejan-Angoulvant T, Isorni C, Zelek L, Paintaud G, Janin A, Bousquet G.

Cancer Chemother Pharmacol. 2018 Apr;81(4):791-796. doi: 10.1007/s00280-018-3555-2. Epub 2018 Mar 1.


EGFR is involved in dermatofibrosarcoma protuberans progression to high grade sarcoma.

Osio A, Xu S, El Bouchtaoui M, Leboeuf C, Gapihan G, Lemaignan C, Bousquet G, Lebbé C, Janin A, Battistella M.

Oncotarget. 2018 Jan 3;9(9):8478-8488. doi: 10.18632/oncotarget.23899. eCollection 2018 Feb 2.


Synergistic promoting effects of pentoxifylline and simvastatin on the apoptosis of triple-negative MDA-MB-231 breast cancer cells.

Castellanos-Esparza YC, Wu S, Huang L, Buquet C, Shen R, Sanchez-Gonzalez B, García Latorre EA, Boyer O, Varin R, Jiménez-Zamudio LA, Janin A, Vannier JP, Li H, Lu H.

Int J Oncol. 2018 Apr;52(4):1246-1254. doi: 10.3892/ijo.2018.4272. Epub 2018 Feb 9.


Reccurrent F8 Intronic Deletion Found in Mild Hemophilia A Causes Alu Exonization.

Jourdy Y, Janin A, Fretigny M, Lienhart A, Négrier C, Bozon D, Vinciguerra C.

Am J Hum Genet. 2018 Feb 1;102(2):199-206. doi: 10.1016/j.ajhg.2017.12.010. Epub 2018 Jan 18.


KIR3DL2 expression in patients with adult T-cell lymphoma/leukaemia.

Hurabielle C, Leboeuf C, Ram-Wolff C, Meignin V, Rivet J, Vignon-Pennamen MD, Bonnafous C, Sicard H, Fite C, Raffoux E, Arnulf B, Oksenhendler E, Sicre de Fontbrune F, Peffault de Latour R, Socié G, Bouaziz JD, Lebbé C, Bensussan A, Janin A, Bagot M, Battistella M.

Br J Dermatol. 2018 Jul;179(1):197-199. doi: 10.1111/bjd.16322. Epub 2018 May 9. No abstract available.


Histone modifier gene mutations in peripheral T-cell lymphoma not otherwise specified.

Ji MM, Huang YH, Huang JY, Wang ZF, Fu D, Liu H, Liu F, Leboeuf C, Wang L, Ye J, Lu YM, Janin A, Cheng S, Zhao WL.

Haematologica. 2018 Apr;103(4):679-687. doi: 10.3324/haematol.2017.182444. Epub 2018 Jan 5.


Early repolarization syndrome caused by de novo duplication of KCND3 detected by next-generation sequencing.

Chauveau S, Janin A, Till M, Morel E, Chevalier P, Millat G.

HeartRhythm Case Rep. 2017 Oct 20;3(12):574-578. doi: 10.1016/j.hrcr.2017.08.003. eCollection 2017 Dec. No abstract available.


Pretreatment Liver Injury Predicts Poor Prognosis of DLBCL Patients.

Shi Q, Shen R, Wang CF, Fan X, Qian Y, Ou-Yang BS, Zhao Y, Leboeuf C, Janin A, Cheng S, Wang L, Zhao WL.

Mediators Inflamm. 2017;2017:7960907. doi: 10.1155/2017/7960907. Epub 2017 Sep 17.


KIR3DL2 expression in cutaneous T-cell lymphomas: expanding the spectrum for KIR3DL2 targeting.

Battistella M, Leboeuf C, Ram-Wolff C, Hurabielle C, Bonnafous C, Sicard H, Bensussan A, Bagot M, Janin A.

Blood. 2017 Dec 28;130(26):2900-2902. doi: 10.1182/blood-2017-06-792382. Epub 2017 Oct 31. No abstract available.


Data demonstrating the role of peroxiredoxin 2 as important anti-oxidant system in lung homeostasis.

Federti E, Matte A, Ghigo A, Andolfo I, James C, Siciliano A, Leboeuf C, Janin A, Manna F, Choi SY, Iolascon A, Beneduce E, Melisi D, Kim DW, Levi S, De Franceschi L.

Data Brief. 2017 Sep 30;15:376-381. doi: 10.1016/j.dib.2017.09.062. eCollection 2017 Dec.


Nuclear envelopathies: a complex LINC between nuclear envelope and pathology.

Janin A, Bauer D, Ratti F, Millat G, Méjat A.

Orphanet J Rare Dis. 2017 Aug 30;12(1):147. doi: 10.1186/s13023-017-0698-x. Review.


Peroxiredoxin-2 plays a pivotal role as multimodal cytoprotector in the early phase of pulmonary hypertension.

Federti E, Matté A, Ghigo A, Andolfo I, James C, Siciliano A, Leboeuf C, Janin A, Manna F, Choi SY, Iolascon A, Beneduce E, Melisi D, Kim DW, Levi S, De Franceschi L.

Free Radic Biol Med. 2017 Nov;112:376-386. doi: 10.1016/j.freeradbiomed.2017.08.004. Epub 2017 Aug 9.


Peroxiredoxin-2: A Novel Regulator of Iron Homeostasis in Ineffective Erythropoiesis.

Matte A, De Falco L, Federti E, Cozzi A, Iolascon A, Levi S, Mohandas N, Zamo A, Bruno M, Lebouef C, Janin A, Siciliano A, Ganz T, Federico G, Carlomagno F, Mueller S, Silva I, Carbone C, Melisi D, Kim DW, Choi SY, De Franceschi L.

Antioxid Redox Signal. 2018 Jan 1;28(1):1-14. doi: 10.1089/ars.2017.7051. Epub 2017 Sep 6.


JAM-A overexpression is related to disease progression in diffuse large B-cell lymphoma and downregulated by lenalidomide.

Xu PP, Sun YF, Fang Y, Song Q, Yan ZX, Chen Y, Jiang XF, Fei XC, Zhao Y, Leboeuf C, Li B, Wang CF, Janin A, Wang L, Zhao WL.

Sci Rep. 2017 Aug 7;7(1):7433. doi: 10.1038/s41598-017-07964-5.


MYC is a positive regulator of choline metabolism and impedes mitophagy-dependent necroptosis in diffuse large B-cell lymphoma.

Xiong J, Wang L, Fei XC, Jiang XF, Zheng Z, Zhao Y, Wang CF, Li B, Chen SJ, Janin A, Gale RP, Zhao WL.

Blood Cancer J. 2017 Jul 7;7(7):e0. doi: 10.1038/bcj.2017.61.


MiR21 sensitized B-lymphoma cells to ABT-199 via ICOS/ICOSL-mediated interaction of Treg cells with endothelial cells.

Zheng Z, Xu PP, Wang L, Zhao HJ, Weng XQ, Zhong HJ, Qu B, Xiong J, Zhao Y, Wang XF, Janin A, Zhao WL.

J Exp Clin Cancer Res. 2017 Jun 21;36(1):82. doi: 10.1186/s13046-017-0551-z.


Increased risk of brain metastases in women with breast cancer and p16 expression in metastatic lymph-nodes.

Furet E, El Bouchtaoui M, Feugeas JP, Miquel C, Leboeuf C, Beytout C, Bertheau P, Le Rhun E, Bonneterre J, Janin A, Bousquet G.

Oncotarget. 2017 Jun 6;8(23):37332-37341. doi: 10.18632/oncotarget.16953.


Targeting autophagic cancer stem-cells to reverse chemoresistance in human triple negative breast cancer.

Bousquet G, El Bouchtaoui M, Sophie T, Leboeuf C, de Bazelaire C, Ratajczak P, Giacchetti S, de Roquancourt A, Bertheau P, Verneuil L, Feugeas JP, Espié M, Janin A.

Oncotarget. 2017 May 23;8(21):35205-35221. doi: 10.18632/oncotarget.16925.


Truncating mutations on myofibrillar myopathies causing genes as prevalent molecular explanations on patients with dilated cardiomyopathy.

Janin A, N'Guyen K, Habib G, Dauphin C, Chanavat V, Bouvagnet P, Eschalier R, Streichenberger N, Chevalier P, Millat G.

Clin Genet. 2017 Dec;92(6):616-623. doi: 10.1111/cge.13043. Epub 2017 May 18.


Atrial fibrillation is associated with hypermethylation in human left atrium, and treatment with decitabine reduces atrial tachyarrhythmias in spontaneously hypertensive rats.

Doñate Puertas R, Meugnier E, Romestaing C, Rey C, Morel E, Lachuer J, Gadot N, Scridon A, Julien C, Tronc F, Chapuis B, Valla C, Janin A, Pirola L, Méjat A, Rome S, Chevalier P.

Transl Res. 2017 Jun;184:57-67.e5. doi: 10.1016/j.trsl.2017.03.004. Epub 2017 Mar 30.


PDGFRa amplification in multiple skin lesions of undifferentiated pleomorphic sarcoma: A clue for intimal sarcoma metastases.

Osio A, Vignon-Pennamen MD, Pedeutour F, Le Maignan C, Koskas F, Lebbé C, Janin A, Battistella M.

J Cutan Pathol. 2017 May;44(5):477-479. doi: 10.1111/cup.12907. Epub 2017 Feb 15.


Correction: Validation of a preclinical model for assessment of drug efficacy in melanoma.

Delyon J, Varna M, Feugeas JP, Sadoux A, Yahiaoui S, Podgorniak MP, Leclert G, Mazouz Dorval S, Dumaz N, Janin A, Mourah S, Lebbé C.

Oncotarget. 2016 Jul 26;7(30):48850. doi: 10.18632/oncotarget.10822. No abstract available.


Primary mediastinal large B-cell lymphoma: transcriptional regulation by miR-92a through FOXP1 targeting.

Romero M, Gapihan G, Castro-Vega LJ, Acevedo A, Wang L, Li ZW, El Bouchtaoui M, Di Benedetto M, Ratajczak P, Feugeas JP, Thieblemont C, Saavedra C, Janin A.

Oncotarget. 2017 Mar 7;8(10):16243-16258. doi: 10.18632/oncotarget.12988.


Everolimus affects vasculogenic mimicry in renal carcinoma resistant to sunitinib.

Serova M, Tijeras-Raballand A, Dos Santos C, Martinet M, Neuzillet C, Lopez A, Mitchell DC, Bryan BA, Gapihan G, Janin A, Bousquet G, Riveiro ME, Bieche I, Faivre S, Raymond E, de Gramont A.

Oncotarget. 2016 Jun 21;7(25):38467-86. doi: 10.18632/oncotarget.9542.

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