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Items: 24

1.

GZ-11608, a Vesicular Monoamine Transporter-2 Inhibitor, Decreases the Neurochemical and Behavioral Effects of Methamphetamine.

Lee NR, Zheng G, Leggas M, Janganati V, Nickell JR, Crooks PA, Bardo MT, Dwoskin L.

J Pharmacol Exp Ther. 2019 Aug 14. pii: jpet.119.258699. doi: 10.1124/jpet.119.258699. [Epub ahead of print]

2.

MMB triazole analogs are potent NF-κB inhibitors and anti-cancer agents against both hematological and solid tumor cells.

Janganati V, Ponder J, Balasubramaniam M, Bhat-Nakshatri P, Bar EE, Nakshatri H, Jordan CT, Crooks PA.

Eur J Med Chem. 2018 Sep 5;157:562-581. doi: 10.1016/j.ejmech.2018.08.010. Epub 2018 Aug 10.

3.

Fluoroethoxy-1,4-diphenethylpiperidine and piperazine derivatives: Potent and selective inhibitors of [3H]dopamine uptake at the vesicular monoamine transporter-2.

Hankosky ER, Joolakanti SR, Nickell JR, Janganati V, Dwoskin LP, Crooks PA.

Bioorg Med Chem Lett. 2017 Dec 15;27(24):5467-5472. doi: 10.1016/j.bmcl.2017.10.039. Epub 2017 Oct 20.

4.

Succinamide derivatives of melampomagnolide B and their anti-cancer activities.

Janganati V, Ponder J, Thakkar S, Jordan CT, Crooks PA.

Bioorg Med Chem. 2017 Jul 15;25(14):3694-3705. doi: 10.1016/j.bmc.2017.05.008. Epub 2017 May 8.

5.

Indole carboxylic acid esters of melampomagnolide B are potent anticancer agents against both hematological and solid tumor cells.

Bommagani S, Ponder J, Penthala NR, Janganati V, Jordan CT, Borrelli MJ, Crooks PA.

Eur J Med Chem. 2017 Aug 18;136:393-405. doi: 10.1016/j.ejmech.2017.05.031. Epub 2017 May 11.

6.

Identification of a melampomagnolide B analog as a potential lead molecule for treatment of acute myelogenous leukemia.

Albayati ZAF, Janganati V, Chen Z, Ponder J, Breen PJ, Jordan CT, Crooks PA.

Bioorg Med Chem. 2017 Feb 1;25(3):1235-1241. doi: 10.1016/j.bmc.2016.12.036. Epub 2016 Dec 26.

7.

N-[11CH3]Dimethylaminoparthenolide (DMAPT) uptake into orthotopic 9LSF glioblastoma tumors in the rat.

Penthala NR, Janganati V, Alpe TL, Apana SM, Berridge MS, Crooks PA, Borrelli MJ.

Bioorg Med Chem Lett. 2016 Dec 15;26(24):5883-5886. doi: 10.1016/j.bmcl.2016.11.015. Epub 2016 Nov 9.

8.

Synthesis and in vitro evaluation of water-soluble 1,4-diphenethylpiperazine analogs as novel inhibitors of the vesicular monoamine transporter-2.

Nickell JR, Culver JP, Janganati V, Zheng G, Dwoskin LP, Crooks PA.

Bioorg Med Chem Lett. 2016 Sep 15;26(18):4441-4445. doi: 10.1016/j.bmcl.2016.08.001. Epub 2016 Aug 2.

9.

1,4-Diphenalkylpiperidines: A new scaffold for the design of potent inhibitors of the vesicular monoamine transporter-2.

Nickell JR, Culver JP, Janganati V, Zheng G, Dwoskin LP, Crooks PA.

Bioorg Med Chem Lett. 2016 Jul 1;26(13):2997-3000. doi: 10.1016/j.bmcl.2016.05.025. Epub 2016 May 10.

10.

Lobelane analogues containing 4-hydroxy and 4-(2-fluoroethoxy) aromatic substituents: Potent and selective inhibitors of [(3)H]dopamine uptake at the vesicular monoamine transporter-2.

Joolakanti SR, Nickell JR, Janganati V, Zheng G, Dwoskin LP, Crooks PA.

Bioorg Med Chem Lett. 2016 May 15;26(10):2422-2427. doi: 10.1016/j.bmcl.2016.03.119. Epub 2016 Apr 1.

11.

Dimers of Melampomagnolide B Exhibit Potent Anticancer Activity against Hematological and Solid Tumor Cells.

Janganati V, Ponder J, Jordan CT, Borrelli MJ, Penthala NR, Crooks PA.

J Med Chem. 2015 Nov 25;58(22):8896-906. doi: 10.1021/acs.jmedchem.5b01187. Epub 2015 Nov 16.

12.

Synthesis and evaluation of a series of resveratrol analogues as potent anti-cancer agents that target tubulin.

Madadi NR, Zong H, Ketkar A, Zheng C, Penthala NR, Janganati V, Bommagani S, Eoff RL, Guzman ML, Crooks PA.

Medchemcomm. 2015 May 1;6(3):788-794.

13.

Synthesis, anticancer activity and molecular docking studies on a series of heterocyclic trans-cyanocombretastatin analogues as antitubulin agents.

Penthala NR, Zong H, Ketkar A, Madadi NR, Janganati V, Eoff RL, Guzman ML, Crooks PA.

Eur J Med Chem. 2015 Mar 6;92:212-20. doi: 10.1016/j.ejmech.2014.12.050. Epub 2014 Dec 29.

14.

Crystal structure of (E)-13-{4-[(Z)-2-cyano-2-(3,4,5-tri-meth-oxy-phen-yl)ethen-yl]phen-yl}parthenolide methanol hemisolvate.

Penthala NR, Bommagani S, Janganati V, Parkin S, Crooks PA.

Acta Crystallogr Sect E Struct Rep Online. 2014 Sep 6;70(Pt 10):o1092-3. doi: 10.1107/S1600536814019333. eCollection 2014 Oct 1.

15.
16.

Heck products of parthenolide and melampomagnolide-B as anticancer modulators that modify cell cycle progression.

Penthala NR, Bommagani S, Janganati V, MacNicol KB, Cragle CE, Madadi NR, Hardy LL, MacNicol AM, Crooks PA.

Eur J Med Chem. 2014 Oct 6;85:517-25. doi: 10.1016/j.ejmech.2014.08.022. Epub 2014 Aug 7.

17.

Anti-cancer activity of carbamate derivatives of melampomagnolide B.

Janganati V, Penthala NR, Madadi NR, Chen Z, Crooks PA.

Bioorg Med Chem Lett. 2014 Aug 1;24(15):3499-502. doi: 10.1016/j.bmcl.2014.05.059. Epub 2014 May 27.

18.

Monosuccinate ester of melampomagnolide B.

Janganati V, Penthala NR, Madadi NR, Parkin S, Crooks PA.

Acta Crystallogr Sect E Struct Rep Online. 2014 Feb 28;70(Pt 3):o372-3. doi: 10.1107/S1600536814002815. eCollection 2014 Mar 1.

19.

(E)-13-(2-Bromo-phen-yl)micheliolide.

Penthala NR, Bommagani S, Janganati V, Parkin S, Crooks PA.

Acta Crystallogr Sect E Struct Rep Online. 2014 Feb 5;70(Pt 3):o251-2. doi: 10.1107/S1600536814002177. eCollection 2014 Mar 1.

20.

Heterocyclic aminoparthenolide derivatives modulate G(2)-M cell cycle progression during Xenopus oocyte maturation.

Janganati V, Penthala NR, Cragle CE, MacNicol AM, Crooks PA.

Bioorg Med Chem Lett. 2014 Apr 15;24(8):1963-7. doi: 10.1016/j.bmcl.2014.02.067. Epub 2014 Mar 4.

21.

13-(N,N-Di-methyl-amino)-micheliolide 0.08-hydrate.

Bommagani S, Penthala NR, Janganati V, Parkin S, Crooks PA.

Acta Crystallogr Sect E Struct Rep Online. 2013 Nov 20;69(Pt 12):o1789-90. doi: 10.1107/S1600536813030304. eCollection 2013 Nov 20.

22.

13-(Imidazol-1-yl)-11,13-di-hydro-melampomagnolide B monohydrate.

Janganati V, Penthala NR, Parkin S, Crooks PA.

Acta Crystallogr Sect E Struct Rep Online. 2013 Nov 6;69(Pt 12):o1734-5. doi: 10.1107/S1600536813029188. eCollection 2013 Nov 6.

23.

(E)-13-(4-Amino-phen-yl)parthenolide.

Penthala NR, Janganati V, Parkin S, Varughese KI, Crooks PA.

Acta Crystallogr Sect E Struct Rep Online. 2013 Oct 26;69(Pt 11):o1709-10. doi: 10.1107/S1600536813028730. eCollection 2013 Oct 26.

24.

Synthesis and anti-proliferative activity of aromatic substituted 5-((1-benzyl-1H-indol-3-yl)methylene)-1,3-dimethylpyrimidine-2,4,6(1H,3H,5H)-trione analogs against human tumor cell lines.

Madadi NR, Penthala NR, Janganati V, Crooks PA.

Bioorg Med Chem Lett. 2014 Jan 15;24(2):601-3. doi: 10.1016/j.bmcl.2013.12.013. Epub 2013 Dec 9.

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