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Items: 1 to 50 of 137

1.

Deciphering the genomic, epigenomic, and transcriptomic landscapes of pre-invasive lung cancer lesions.

Teixeira VH, Pipinikas CP, Pennycuick A, Lee-Six H, Chandrasekharan D, Beane J, Morris TJ, Karpathakis A, Feber A, Breeze CE, Ntolios P, Hynds RE, Falzon M, Capitanio A, Carroll B, Durrenberger PF, Hardavella G, Brown JM, Lynch AG, Farmery H, Paul DS, Chambers RC, McGranahan N, Navani N, Thakrar RM, Swanton C, Beck S, George PJ, Spira A, Campbell PJ, Thirlwell C, Janes SM.

Nat Med. 2019 Jan 21. doi: 10.1038/s41591-018-0323-0. [Epub ahead of print]

PMID:
30664780
2.

Non-Invasive Longitudinal Bioluminescence Imaging of Human Mesoangioblasts in Bioengineered Esophagi.

Crowley C, Butler CR, Camilli C, Hynds RE, Kolluri KK, Janes SM, De Coppi P, Urbani L.

Tissue Eng Part C Methods. 2019 Feb;25(2):103-113. doi: 10.1089/ten.TEC.2018.0351.

PMID:
30648471
3.

Using a Three-Dimensional Collagen Matrix to Deliver Respiratory Progenitor Cells to Decellularized Trachea In Vivo.

Hamilton NJI, Hynds RE, Gowers KHC, Tait A, Butler CR, Hopper C, Burns AJ, Birchall MA, Lowdell M, Janes SM.

Tissue Eng Part C Methods. 2019 Feb;25(2):93-102. doi: 10.1089/ten.TEC.2018.0241.

PMID:
30648458
4.

Retrospective response analysis of BAP1 expression to predict the clinical activity of systemic cytotoxic chemotherapy in mesothelioma.

Kumar N, Alrifai D, Kolluri KK, Sage EK, Ishii Y, Guppy N, Borg E, Falzon M, Nankivell M, Nicholson AG, Janes SM.

Lung Cancer. 2019 Jan;127:164-166. doi: 10.1016/j.lungcan.2018.12.004. Epub 2018 Dec 5.

PMID:
30642545
5.

The secret lives of cancer cell lines.

Hynds RE, Vladimirou E, Janes SM.

Dis Model Mech. 2018 Nov 16;11(11). pii: dmm037366. doi: 10.1242/dmm.037366.

6.

Cross-talk between human airway epithelial cells and 3T3-J2 feeder cells involves partial activation of human MET by murine HGF.

Hynds RE, Gowers KHC, Nigro E, Butler CR, Bonfanti P, Giangreco A, Prêle CM, Janes SM.

PLoS One. 2018 May 17;13(5):e0197129. doi: 10.1371/journal.pone.0197129. eCollection 2018.

7.

The Care and Outcomes of Older Persons with Lung Cancer in England and the United States, 2008-2012.

Andreano A, Peake MD, Janes SM, Valsecchi MG, Pritchard-Jones K, Hoag JR, Gross CP.

J Thorac Oncol. 2018 Jul;13(7):904-914. doi: 10.1016/j.jtho.2018.04.022. Epub 2018 May 1.

PMID:
29727739
8.

Smokers' interest in a lung cancer screening programme: a national survey in England.

Quaife SL, Vrinten C, Ruparel M, Janes SM, Beeken RJ, Waller J, McEwen A.

BMC Cancer. 2018 May 2;18(1):497. doi: 10.1186/s12885-018-4430-6.

9.

Expansion of airway basal epithelial cells from primary human non-small cell lung cancer tumors.

Hynds RE, Ben Aissa A, Gowers KHC, Watkins TBK, Bosshard-Carter L, Rowan AJ, Veeriah S, Wilson GA, Quezada SA, Swanton C; TRACERx Consortium, Janes SM.

Int J Cancer. 2018 Jul 1;143(1):160-166. doi: 10.1002/ijc.31383. Epub 2018 Apr 6.

10.

Emerging resistance pathways in lung cancer: what has ROS-1 taught us?

Alrifai D, Forster MD, Janes SM.

Transl Lung Cancer Res. 2018 Feb;7(Suppl 1):S9-S12. doi: 10.21037/tlcr.2017.11.13. No abstract available.

11.

Loss of functional BAP1 augments sensitivity to TRAIL in cancer cells.

Kolluri KK, Alifrangis C, Kumar N, Ishii Y, Price S, Michaut M, Williams S, Barthorpe S, Lightfoot H, Busacca S, Sharkey A, Yuan Z, Sage EK, Vallath S, Le Quesne J, Tice DA, Alrifai D, von Karstedt S, Montinaro A, Guppy N, Waller DA, Nakas A, Good R, Holmes A, Walczak H, Fennell DA, Garnett M, Iorio F, Wessels L, McDermott U, Janes SM.

Elife. 2018 Jan 18;7. pii: e30224. doi: 10.7554/eLife.30224.

12.

Regenerating human epithelia with cultured stem cells: feeder cells, organoids and beyond.

Hynds RE, Bonfanti P, Janes SM.

EMBO Mol Med. 2018 Feb;10(2):139-150. doi: 10.15252/emmm.201708213. Review.

13.

Corrigendum: Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution.

Abbosh C, Birkbak NJ, Wilson GA, Jamal-Hanjani M, Constantin T, Salari R, Le Quesne J, Moore DA, Veeriah S, Rosenthal R, Marafioti T, Kirkizlar E, Watkins TBK, McGranahan N, Ward S, Martinson L, Riley J, Fraioli F, Al Bakir M, Grönroos E, Zambrana F, Endozo R, Bi WL, Fennessy FM, Sponer N, Johnson D, Laycock J, Shafi S, Czyzewska-Khan J, Rowan A, Chambers T, Matthews N, Turajlic S, Hiley C, Lee SM, Forster MD, Ahmad T, Falzon M, Borg E, Lawrence D, Hayward M, Kolvekar S, Panagiotopoulos N, Janes SM, Thakrar R, Ahmed A, Blackhall F, Summers Y, Hafez D, Naik A, Ganguly A, Kareht S, Shah R, Joseph L, Quinn AM, Crosbie PA, Naidu B, Middleton G, Langman G, Trotter S, Nicolson M, Remmen H, Kerr K, Chetty M, Gomersall L, Fennell DA, Nakas A, Rathinam S, Anand G, Khan S, Russell P, Ezhil V, Ismail B, Irvin-Sellers M, Prakash V, Lester JF, Kornaszewska M, Attanoos R, Adams H, Davies H, Oukrif D, Akarca AU, Hartley JA, Lowe HL, Lock S, Iles N, Bell H, Ngai Y, Elgar G, Szallasi Z, Schwarz RF, Herrero J, Stewart A, Quezada SA, Peggs KS, Van Loo P, Dive C, Lin CJ, Rabinowitz M, Aerts HJWL, Hackshaw A, Shaw JA, Zimmermann BG, Swanton C.

Nature. 2018 Feb 8;554(7691):264. doi: 10.1038/nature25161. Epub 2017 Dec 20.

PMID:
29258292
14.

Long term radiological features of radiation-induced lung damage.

Veiga C, Landau D, McClelland JR, Ledermann JA, Hawkes D, Janes SM, Devaraj A.

Radiother Oncol. 2018 Feb;126(2):300-306. doi: 10.1016/j.radonc.2017.11.003. Epub 2017 Nov 27.

PMID:
29191458
15.

Autologous Cell Seeding in Tracheal Tissue Engineering.

Maughan EF, Hynds RE, Proctor TJ, Janes SM, Elliott M, Birchall MA, Lowdell MW, De Coppi P.

Curr Stem Cell Rep. 2017;3(4):279-289. doi: 10.1007/s40778-017-0108-2. Epub 2017 Oct 26. Review.

16.

Impact of radiographer immediate reporting of chest X-rays from general practice on the lung cancer pathway (radioX): study protocol for a randomised control trial.

Woznitza N, Devaraj A, Janes SM, Duffy SW, Bhowmik A, Rowe S, Piper K, Maughn S, Baldwin DR.

Trials. 2017 Nov 6;18(1):521. doi: 10.1186/s13063-017-2268-x.

17.

Airway Basal Cell Heterogeneity and Lung Squamous Cell Carcinoma.

Hynds RE, Janes SM.

Cancer Prev Res (Phila). 2017 Sep;10(9):491-493. doi: 10.1158/1940-6207.CAPR-17-0202. Epub 2017 Aug 18.

18.

A comparison of tracheal scaffold strategies for pediatric transplantation in a rabbit model.

Maughan EF, Butler CR, Crowley C, Teoh GZ, den Hondt M, Hamilton NJ, Hynds RE, Lange P, Ansari T, Urbani L, Janes SM, de Coppi P, Birchall MA, Elliott MJ.

Laryngoscope. 2017 Dec;127(12):E449-E457. doi: 10.1002/lary.26611. Epub 2017 Aug 4.

PMID:
28776693
19.

Defining the path: lung cancer CT screening in Europe.

Callister ME, Janes SM.

Thorax. 2017 Sep;72(9):778-779. doi: 10.1136/thoraxjnl-2017-210268. Epub 2017 Jul 19. No abstract available.

PMID:
28724640
20.

Preinvasive disease of the airway.

Thakrar RM, Pennycuick A, Borg E, Janes SM.

Cancer Treat Rev. 2017 Jul;58:77-90. doi: 10.1016/j.ctrv.2017.05.009. Epub 2017 Jul 10. Review.

PMID:
28704777
21.

Tracheal Replacement Therapy with a Stem Cell-Seeded Graft: Lessons from Compassionate Use Application of a GMP-Compliant Tissue-Engineered Medicine.

Elliott MJ, Butler CR, Varanou-Jenkins A, Partington L, Carvalho C, Samuel E, Crowley C, Lange P, Hamilton NJ, Hynds RE, Ansari T, Sibbons P, Fierens A, McLaren C, Roebuck D, Wallis C, Muthialu N, Hewitt R, Crabbe D, Janes SM, De Coppi P, Lowdell MW, Birchall MA.

Stem Cells Transl Med. 2017 Jun;6(6):1458-1464. doi: 10.1002/sctm.16-0443.

22.

Optimized isolation and expansion of human airway epithelial basal cells from endobronchial biopsy samples.

Gowers KHC, Hynds RE, Thakrar RM, Carroll B, Birchall MA, Janes SM.

J Tissue Eng Regen Med. 2018 Jan;12(1):e313-e317. doi: 10.1002/term.2466. Epub 2017 Aug 22.

23.

Streamlining staging of lung and colorectal cancer with whole body MRI; study protocols for two multicentre, non-randomised, single-arm, prospective diagnostic accuracy studies (Streamline C and Streamline L).

Taylor SA, Mallett S, Miles A, Beare S, Bhatnagar G, Bridgewater J, Glynne-Jones R, Goh V, Groves AM, Janes SM, Koh DM, Morris S, Morton A, Navani N, Oliver A, Padhani AR, Punwani S, Rockall AG, Halligan S.

BMC Cancer. 2017 May 2;17(1):299. doi: 10.1186/s12885-017-3281-x.

24.

Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution.

Abbosh C, Birkbak NJ, Wilson GA, Jamal-Hanjani M, Constantin T, Salari R, Le Quesne J, Moore DA, Veeriah S, Rosenthal R, Marafioti T, Kirkizlar E, Watkins TBK, McGranahan N, Ward S, Martinson L, Riley J, Fraioli F, Al Bakir M, Grönroos E, Zambrana F, Endozo R, Bi WL, Fennessy FM, Sponer N, Johnson D, Laycock J, Shafi S, Czyzewska-Khan J, Rowan A, Chambers T, Matthews N, Turajlic S, Hiley C, Lee SM, Forster MD, Ahmad T, Falzon M, Borg E, Lawrence D, Hayward M, Kolvekar S, Panagiotopoulos N, Janes SM, Thakrar R, Ahmed A, Blackhall F, Summers Y, Hafez D, Naik A, Ganguly A, Kareht S, Shah R, Joseph L, Marie Quinn A, Crosbie PA, Naidu B, Middleton G, Langman G, Trotter S, Nicolson M, Remmen H, Kerr K, Chetty M, Gomersall L, Fennell DA, Nakas A, Rathinam S, Anand G, Khan S, Russell P, Ezhil V, Ismail B, Irvin-Sellers M, Prakash V, Lester JF, Kornaszewska M, Attanoos R, Adams H, Davies H, Oukrif D, Akarca AU, Hartley JA, Lowe HL, Lock S, Iles N, Bell H, Ngai Y, Elgar G, Szallasi Z, Schwarz RF, Herrero J, Stewart A, Quezada SA, Peggs KS, Van Loo P, Dive C, Lin CJ, Rabinowitz M, Aerts HJWL, Hackshaw A, Shaw JA, Zimmermann BG; TRACERx consortium; PEACE consortium, Swanton C.

Nature. 2017 Apr 26;545(7655):446-451. doi: 10.1038/nature22364. Erratum in: Nature. 2017 Dec 20;:.

25.

Tracking the Evolution of Non-Small-Cell Lung Cancer.

Jamal-Hanjani M, Wilson GA, McGranahan N, Birkbak NJ, Watkins TBK, Veeriah S, Shafi S, Johnson DH, Mitter R, Rosenthal R, Salm M, Horswell S, Escudero M, Matthews N, Rowan A, Chambers T, Moore DA, Turajlic S, Xu H, Lee SM, Forster MD, Ahmad T, Hiley CT, Abbosh C, Falzon M, Borg E, Marafioti T, Lawrence D, Hayward M, Kolvekar S, Panagiotopoulos N, Janes SM, Thakrar R, Ahmed A, Blackhall F, Summers Y, Shah R, Joseph L, Quinn AM, Crosbie PA, Naidu B, Middleton G, Langman G, Trotter S, Nicolson M, Remmen H, Kerr K, Chetty M, Gomersall L, Fennell DA, Nakas A, Rathinam S, Anand G, Khan S, Russell P, Ezhil V, Ismail B, Irvin-Sellers M, Prakash V, Lester JF, Kornaszewska M, Attanoos R, Adams H, Davies H, Dentro S, Taniere P, O'Sullivan B, Lowe HL, Hartley JA, Iles N, Bell H, Ngai Y, Shaw JA, Herrero J, Szallasi Z, Schwarz RF, Stewart A, Quezada SA, Le Quesne J, Van Loo P, Dive C, Hackshaw A, Swanton C; TRACERx Consortium.

N Engl J Med. 2017 Jun 1;376(22):2109-2121. doi: 10.1056/NEJMoa1616288. Epub 2017 Apr 26.

26.

Evolutionary dynamics in pre-invasive neoplasia.

Abbosh C, Venkatesan S, Janes SM, Fitzgerald RC, Swanton C.

Curr Opin Syst Biol. 2017 Apr;2:1-8. doi: 10.1016/j.coisb.2017.02.009.

27.

TRAIL delivery by MSC-derived extracellular vesicles is an effective anticancer therapy.

Yuan Z, Kolluri KK, Gowers KH, Janes SM.

J Extracell Vesicles. 2017 Jan 18;6(1):1265291. doi: 10.1080/20013078.2017.1265291. eCollection 2017.

28.

Vacuum-assisted decellularization: an accelerated protocol to generate tissue-engineered human tracheal scaffolds.

Butler CR, Hynds RE, Crowley C, Gowers KH, Partington L, Hamilton NJ, Carvalho C, Platé M, Samuel ER, Burns AJ, Urbani L, Birchall MA, Lowdell MW, De Coppi P, Janes SM.

Biomaterials. 2017 Apr;124:95-105. doi: 10.1016/j.biomaterials.2017.02.001. Epub 2017 Feb 5.

29.

Epithelial cell migration as a potential therapeutic target in early lung cancer.

Millar FR, Janes SM, Giangreco A.

Eur Respir Rev. 2017 Jan 31;26(143). pii: 160069. doi: 10.1183/16000617.0069-2016. Print 2017 Jan. Review.

30.

Genetically modified mesenchymal stromal cells in cancer therapy.

Sage EK, Thakrar RM, Janes SM.

Cytotherapy. 2016 Nov;18(11):1435-1445. doi: 10.1016/j.jcyt.2016.09.003. Review.

31.

Lung cancer screening: improving understanding of the psychological impact.

Quaife SL, Janes SM.

Thorax. 2016 Nov;71(11):971-972. doi: 10.1136/thoraxjnl-2016-208966. Epub 2016 Aug 31. No abstract available.

PMID:
27581619
32.

Expansion of Human Airway Basal Stem Cells and Their Differentiation as 3D Tracheospheres.

Hynds RE, Butler CR, Janes SM, Giangreco A.

Methods Mol Biol. 2016 Aug 19. [Epub ahead of print]

PMID:
27539459
33.

Attitudes towards lung cancer screening in socioeconomically deprived and heavy smoking communities: informing screening communication.

Quaife SL, Marlow LAV, McEwen A, Janes SM, Wardle J.

Health Expect. 2017 Aug;20(4):563-573. doi: 10.1111/hex.12481. Epub 2016 Jul 11.

34.

Airway tissue engineering for congenital laryngotracheal disease.

Maughan E, Lesage F, Butler CR, Hynds RE, Hewitt R, Janes SM, Deprest JA, Coppi PD.

Semin Pediatr Surg. 2016 Jun;25(3):186-90. doi: 10.1053/j.sempedsurg.2016.02.012. Epub 2016 Feb 22. Review.

PMID:
27301606
35.

Hyperthermia treatment of tumors by mesenchymal stem cell-delivered superparamagnetic iron oxide nanoparticles.

Kalber TL, Ordidge KL, Southern P, Loebinger MR, Kyrtatos PG, Pankhurst QA, Lythgoe MF, Janes SM.

Int J Nanomedicine. 2016 May 9;11:1973-83. doi: 10.2147/IJN.S94255. eCollection 2016.

36.

Cryopreservation of human mesenchymal stromal cells expressing TRAIL for human anti-cancer therapy.

Yuan Z, Lourenco Sda S, Sage EK, Kolluri KK, Lowdell MW, Janes SM.

Cytotherapy. 2016 Jul;18(7):860-9. doi: 10.1016/j.jcyt.2016.04.005.

37.

Combined cell-gene therapy for lung cancer: rationale, challenges and prospects.

Thakrar RM, Sage EK, Janes SM.

Expert Opin Biol Ther. 2016 Jul;16(7):853-7. doi: 10.1080/14712598.2016.1188074. Epub 2016 Jun 3. No abstract available.

PMID:
27248673
38.

The Lung Screen Uptake Trial (LSUT): protocol for a randomised controlled demonstration lung cancer screening pilot testing a targeted invitation strategy for high risk and 'hard-to-reach' patients.

Quaife SL, Ruparel M, Beeken RJ, McEwen A, Isitt J, Nolan G, Sennett K, Baldwin DR, Duffy SW, Janes SM, Wardle J.

BMC Cancer. 2016 Apr 20;16:281. doi: 10.1186/s12885-016-2316-z.

39.

CADM1 inhibits squamous cell carcinoma progression by reducing STAT3 activity.

Vallath S, Sage EK, Kolluri KK, Lourenco SN, Teixeira VS, Chimalapati S, George PJ, Janes SM, Giangreco A.

Sci Rep. 2016 Apr 1;6:24006. doi: 10.1038/srep24006.

40.

Review of the British Thoracic Society Winter Meeting 2015, 2-4 December, London, UK.

José RJ, Chalmers JD, Greening NJ, Janes SM; BTS Science and Research Committee.

Thorax. 2016 Jun;71(6):555-9. doi: 10.1136/thoraxjnl-2016-208299. Epub 2016 Mar 25.

PMID:
27015800
41.

Positive (18)Fluorodeoxyglucose-Positron Emission Tomography/Computed Tomography Predicts Preinvasive Endobronchial Lesion Progression to Invasive Cancer.

Fraioli F, Kayani I, Smith LJ, Bomanji JB, Capitanio A, Falzon M, Carroll B, Navani N, Brown J, Thakrar RM, George PJ, Groves AM, Janes SM.

Am J Respir Crit Care Med. 2016 Mar 1;193(5):576-9. doi: 10.1164/rccm.201508-1617LE. No abstract available.

42.

Pulmonary nodules and CT screening: the past, present and future.

Ruparel M, Quaife SL, Navani N, Wardle J, Janes SM, Baldwin DR.

Thorax. 2016 Apr;71(4):367-75. doi: 10.1136/thoraxjnl-2015-208107. Epub 2016 Feb 26. Review.

43.

Rapid Expansion of Human Epithelial Stem Cells Suitable for Airway Tissue Engineering.

Butler CR, Hynds RE, Gowers KH, Lee Ddo H, Brown JM, Crowley C, Teixeira VH, Smith CM, Urbani L, Hamilton NJ, Thakrar RM, Booth HL, Birchall MA, De Coppi P, Giangreco A, O'Callaghan C, Janes SM.

Am J Respir Crit Care Med. 2016 Jul 15;194(2):156-68. doi: 10.1164/rccm.201507-1414OC.

44.

Reply to: "Recent Advances in Circumferential Tracheal Replacement and Transplantation".

Hamilton NJ, Kanani M, Roebuck DJ, Hewitt RJ, Cetto R, McLaren CA, Butler CR, Crowley C, Janes SM, O'Callaghan C, Culme-Seymour EJ, Mason C, De Coppi P, Lowdell MW, Elliott MJ, Birchall MA.

Am J Transplant. 2016 Apr;16(4):1336-7. doi: 10.1111/ajt.13736. Epub 2016 Mar 10. No abstract available.

45.

Surface modification of a POSS-nanocomposite material to enhance cellular integration of a synthetic bioscaffold.

Crowley C, Klanrit P, Butler CR, Varanou A, Platé M, Hynds RE, Chambers RC, Seifalian AM, Birchall MA, Janes SM.

Biomaterials. 2016 Mar;83:283-93. doi: 10.1016/j.biomaterials.2016.01.005. Epub 2016 Jan 5.

46.

Lung cancer screening: what we can learn from UKLS?

Ruparel M, Janes SM.

Thorax. 2016 Feb;71(2):103-4. doi: 10.1136/thoraxjnl-2015-208210. No abstract available.

PMID:
26769013
47.

Transcriptional Profiling of Endobronchial Ultrasound-Guided Lymph Node Samples Aids Diagnosis of Mediastinal Lymphadenopathy.

Tomlinson GS, Thomas N, Chain BM, Best K, Simpson N, Hardavella G, Brown J, Bhowmik A, Navani N, Janes SM, Miller RF, Noursadeghi M.

Chest. 2016 Feb;149(2):535-544. doi: 10.1378/chest.15-0647. Epub 2016 Jan 12.

48.

Correlation of Smoking-Associated DNA Methylation Changes in Buccal Cells With DNA Methylation Changes in Epithelial Cancer.

Teschendorff AE, Yang Z, Wong A, Pipinikas CP, Jiao Y, Jones A, Anjum S, Hardy R, Salvesen HB, Thirlwell C, Janes SM, Kuh D, Widschwendter M.

JAMA Oncol. 2015 Jul;1(4):476-85. doi: 10.1001/jamaoncol.2015.1053. Erratum in: JAMA Oncol. 2015 Jul;1(4):544.

PMID:
26181258
49.

Tissue-Engineered Tracheal Replacement in a Child: A 4-Year Follow-Up Study.

Hamilton NJ, Kanani M, Roebuck DJ, Hewitt RJ, Cetto R, Culme-Seymour EJ, Toll E, Bates AJ, Comerford AP, McLaren CA, Butler CR, Crowley C, McIntyre D, Sebire NJ, Janes SM, O'Callaghan C, Mason C, De Coppi P, Lowdell MW, Elliott MJ, Birchall MA.

Am J Transplant. 2015 Oct;15(10):2750-7. doi: 10.1111/ajt.13318. Epub 2015 Jun 2.

50.

Smoking is associated with pessimistic and avoidant beliefs about cancer: results from the International Cancer Benchmarking Partnership.

Quaife SL, McEwen A, Janes SM, Wardle J.

Br J Cancer. 2015 May 26;112(11):1799-804. doi: 10.1038/bjc.2015.148. Epub 2015 May 7.

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