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In situ 10-cell RNA sequencing in tissue and tumor biopsy samples.

Singh S, Wang L, Schaff DL, Sutcliffe MD, Koeppel AF, Kim J, Onengut-Gumuscu S, Park KS, Zong H, Janes KA.

Sci Rep. 2019 Mar 20;9(1):4836. doi: 10.1038/s41598-019-41235-9.


CIRCOAST: a statistical hypothesis test for cellular colocalization with network structures.

Corliss BA, Ray HC, Patrie JT, Mansour J, Kesting S, Park JH, Rohde G, Yates PA, Janes KA, Peirce SM.

Bioinformatics. 2019 Feb 15;35(4):720-721. doi: 10.1093/bioinformatics/bty797. No abstract available.


CIRCOAST: a statistical hypothesis test for cellular colocalization with network structures.

Corliss BA, Ray HC, Patrie JT, Mansour J, Kesting S, Park JH, Rohde G, Yates PA, Janes KA, Peirce SM.

Bioinformatics. 2019 Feb 1;35(3):506-514. doi: 10.1093/bioinformatics/bty638. Erratum in: Bioinformatics. 2019 Feb 15;35(4):720-721.


Dysregulation of sphingolipid metabolism contributes to bortezomib-induced neuropathic pain.

Stockstill K, Doyle TM, Yan X, Chen Z, Janes K, Little JW, Braden K, Lauro F, Giancotti LA, Harada CM, Yadav R, Xiao WH, Lionberger JM, Neumann WL, Bennett GJ, Weng HR, Spiegel S, Salvemini D.

J Exp Med. 2018 May 7;215(5):1301-1313. doi: 10.1084/jem.20170584. Epub 2018 Apr 27.


Automated brightfield morphometry of 3D organoid populations by OrganoSeg.

Borten MA, Bajikar SS, Sasaki N, Clevers H, Janes KA.

Sci Rep. 2018 Mar 28;8(1):5319. doi: 10.1038/s41598-017-18815-8.


Chemotherapy-induced pain is promoted by enhanced spinal adenosine kinase levels through astrocyte-dependent mechanisms.

Wahlman C, Doyle TM, Little JW, Luongo L, Janes K, Chen Z, Esposito E, Tosh DK, Cuzzocrea S, Jacobson KA, Salvemini D.

Pain. 2018 Jun;159(6):1025-1034. doi: 10.1097/j.pain.0000000000001177.


Tumor-Suppressor Inactivation of GDF11 Occurs by Precursor Sequestration in Triple-Negative Breast Cancer.

Bajikar SS, Wang CC, Borten MA, Pereira EJ, Atkins KA, Janes KA.

Dev Cell. 2017 Nov 20;43(4):418-435.e13. doi: 10.1016/j.devcel.2017.10.027.


Corrigendum to: "Small Molecule Inhibitor of CBFβ-RUNX Binding for RUNX Transcription Factor Driven Cancers" [EBioMedicine 8 (2016) 117-131].

Illendula A, Gilmour J, Grembecka J, Tirumala VSS, Boulton A, Kuntimaddi A, Schmidt C, Wang L, Pulikkan JA, Zong H, Parlak M, Kuscu C, Pickin A, Zhou Y, Gao Y, Mishra L, Adli M, Castilla LH, Rajewski RA, Janes KA, Guzman ML, Bonifer C, Bushweller JH.

EBioMedicine. 2017 Nov;25:188. doi: 10.1016/j.ebiom.2017.10.029. Epub 2017 Oct 31. No abstract available.


An engineering design approach to systems biology.

Janes KA, Chandran PL, Ford RM, Lazzara MJ, Papin JA, Peirce SM, Saucerman JJ, Lauffenburger DA.

Integr Biol (Camb). 2017 Jul 17;9(7):574-583. doi: 10.1039/c7ib00014f. Review.


Profiling Subcellular Protein Phosphatase Responses to Coxsackievirus B3 Infection of Cardiomyocytes.

Shah M, Smolko CM, Kinicki S, Chapman ZD, Brautigan DL, Janes KA.

Mol Cell Proteomics. 2017 Apr;16(4 suppl 1):S244-S262. doi: 10.1074/mcp.O116.063487. Epub 2017 Feb 7.


Computational Models of Reactive Oxygen Species as Metabolic Byproducts and Signal-Transduction Modulators.

Pereira EJ, Smolko CM, Janes KA.

Front Pharmacol. 2016 Nov 29;7:457. eCollection 2016. Review.


Results from 10 Years of a CBT Pain Self-Management Outpatient Program for Complex Chronic Conditions.

Boschen KA, Robinson E, Campbell KA, Muir S, Oey E, Janes K, Fashler SR, Katz J.

Pain Res Manag. 2016;2016:4678083. Epub 2016 Nov 6.


Small Molecule Inhibitor of CBFβ-RUNX Binding for RUNX Transcription Factor Driven Cancers.

Illendula A, Gilmour J, Grembecka J, Tirumala VSS, Boulton A, Kuntimaddi A, Schmidt C, Wang L, Pulikkan JA, Zong H, Parlak M, Kuscu C, Pickin A, Zhou Y, Gao Y, Mishra L, Adli M, Castilla LH, Rajewski RA, Janes KA, Guzman ML, Bonifer C, Bushweller JH.

EBioMedicine. 2016 Jun;8:117-131. doi: 10.1016/j.ebiom.2016.04.032. Epub 2016 Apr 29. Erratum in: EBioMedicine. 2017 Nov;25:188.


TNF-insulin crosstalk at the transcription factor GATA6 is revealed by a model that links signaling and transcriptomic data tensors.

Chitforoushzadeh Z, Ye Z, Sheng Z, LaRue S, Fry RC, Lauffenburger DA, Janes KA.

Sci Signal. 2016 Jun 7;9(431):ra59. doi: 10.1126/scisignal.aad3373.


Science Signaling Podcast for 7 June 2016: Modeling signal integration.

Janes KA, VanHook AM.

Sci Signal. 2016 Jun 7;9(431):pc13. doi: 10.1126/scisignal.aag1902.


Single-cell states versus single-cell atlases - two classes of heterogeneity that differ in meaning and method.

Janes KA.

Curr Opin Biotechnol. 2016 Jun;39:120-125. doi: 10.1016/j.copbio.2016.03.015. Epub 2016 Apr 1. Review.


Network Architecture Predisposes an Enzyme to Either Pharmacologic or Genetic Targeting.

Jensen KJ, Moyer CB, Janes KA.

Cell Syst. 2016 Feb 24;2(2):112-121.


Identification of A3 adenosine receptor agonists as novel non-narcotic analgesics.

Janes K, Symons-Liguori AM, Jacobson KA, Salvemini D.

Br J Pharmacol. 2016 Apr;173(8):1253-67. doi: 10.1111/bph.13446. Epub 2016 Mar 6. Review.


Cell-to-Cell Transcript Variability: Seeing Signal in the Noise.

Janes KA.

Cell. 2015 Dec 17;163(7):1566-8. doi: 10.1016/j.cell.2015.12.010.


An analysis of critical factors for quantitative immunoblotting.

Janes KA.

Sci Signal. 2015 Apr 7;8(371):rs2. doi: 10.1126/scisignal.2005966.


Endogenous adenosine A3 receptor activation selectively alleviates persistent pain states.

Little JW, Ford A, Symons-Liguori AM, Chen Z, Janes K, Doyle T, Xie J, Luongo L, Tosh DK, Maione S, Bannister K, Dickenson AH, Vanderah TW, Porreca F, Jacobson KA, Salvemini D.

Brain. 2015 Jan;138(Pt 1):28-35. doi: 10.1093/brain/awu330. Epub 2014 Nov 19.


A3 adenosine receptor agonist prevents the development of paclitaxel-induced neuropathic pain by modulating spinal glial-restricted redox-dependent signaling pathways.

Janes K, Esposito E, Doyle T, Cuzzocrea S, Tosh DK, Jacobson KA, Salvemini D.

Pain. 2014 Dec;155(12):2560-7. doi: 10.1016/j.pain.2014.09.016. Epub 2014 Sep 19.


Spinal neuroimmune activation is independent of T-cell infiltration and attenuated by A3 adenosine receptor agonists in a model of oxaliplatin-induced peripheral neuropathy.

Janes K, Wahlman C, Little JW, Doyle T, Tosh DK, Jacobson KA, Salvemini D.

Brain Behav Immun. 2015 Feb;44:91-9. doi: 10.1016/j.bbi.2014.08.010. Epub 2014 Sep 8.


Bringing systems biology to cancer, immunology and infectious disease.

Janes KA, Wang CC.

Genome Biol. 2014 Jul 31;15(7):407. doi: 10.1186/s13059-014-0407-1.


Non-genetic heterogeneity caused by differential single-cell adhesion.

Wang CC, Janes KA.

Cell Cycle. 2014;13(14):2149-50. doi: 10.4161/cc.29660. Epub 2014 Jun 23. No abstract available.


The development and maintenance of paclitaxel-induced neuropathic pain require activation of the sphingosine 1-phosphate receptor subtype 1.

Janes K, Little JW, Li C, Bryant L, Chen C, Chen Z, Kamocki K, Doyle T, Snider A, Esposito E, Cuzzocrea S, Bieberich E, Obeid L, Petrache I, Nicol G, Neumann WL, Salvemini D.

J Biol Chem. 2014 Jul 25;289(30):21082-97.


A time- and matrix-dependent TGFBR3-JUND-KRT5 regulatory circuit in single breast epithelial cells and basal-like premalignancies.

Wang CC, Bajikar SS, Jamal L, Atkins KA, Janes KA.

Nat Cell Biol. 2014 Apr;16(4):345-56. doi: 10.1038/ncb2930. Epub 2014 Mar 23.


Parameterizing cell-to-cell regulatory heterogeneities via stochastic transcriptional profiles.

Bajikar SS, Fuchs C, Roller A, Theis FJ, Janes KA.

Proc Natl Acad Sci U S A. 2014 Feb 4;111(5):E626-35. doi: 10.1073/pnas.1311647111. Epub 2014 Jan 21.


Simultaneous profiling of 194 distinct receptor transcripts in human cells.

Kang BH, Jensen KJ, Hatch JA, Janes KA.

Sci Signal. 2013 Aug 6;6(287):rs13. doi: 10.1126/scisignal.2003624.


Bioenergetic deficits in peripheral nerve sensory axons during chemotherapy-induced neuropathic pain resulting from peroxynitrite-mediated post-translational nitration of mitochondrial superoxide dismutase.

Janes K, Doyle T, Bryant L, Esposito E, Cuzzocrea S, Ryerse J, Bennett GJ, Salvemini D.

Pain. 2013 Nov;154(11):2432-40. doi: 10.1016/j.pain.2013.07.032. Epub 2013 Jul 25.


The same frequency of planets inside and outside open clusters of stars.

Meibom S, Torres G, Fressin F, Latham DW, Rowe JF, Ciardi DR, Bryson ST, Rogers LA, Henze CE, Janes K, Barnes SA, Marcy GW, Isaacson H, Fischer DA, Howell SB, Horch EP, Jenkins JM, Schuler SC, Crepp J.

Nature. 2013 Jul 4;499(7456):55-8. doi: 10.1038/nature12279. Epub 2013 Jun 26.


Models of signalling networks - what cell biologists can gain from them and give to them.

Janes KA, Lauffenburger DA.

J Cell Sci. 2013 May 1;126(Pt 9):1913-21. doi: 10.1242/jcs.112045. Review.


An ERK-p38 subnetwork coordinates host cell apoptosis and necrosis during coxsackievirus B3 infection.

Jensen KJ, Garmaroudi FS, Zhang J, Lin J, Boroomand S, Zhang M, Luo Z, Yang D, Luo H, McManus BM, Janes KA.

Cell Host Microbe. 2013 Jan 16;13(1):67-76. doi: 10.1016/j.chom.2012.11.009. Epub 2013 Jan 16.


Stochastic profiling of transcriptional regulatory heterogeneities in tissues, tumors and cultured cells.

Wang L, Janes KA.

Nat Protoc. 2013 Feb;8(2):282-301. doi: 10.1038/nprot.2012.158. Epub 2013 Jan 10.


A high-throughput assay for phosphoprotein-specific phosphatase activity in cellular extracts.

Bose AK, Janes KA.

Mol Cell Proteomics. 2013 Mar;12(3):797-806. doi: 10.1074/mcp.O112.024059. Epub 2012 Dec 11.


Modeling the latent dimensions of multivariate signaling datasets.

Jensen KJ, Janes KA.

Phys Biol. 2012 Aug;9(4):045004. doi: 10.1088/1478-3975/9/4/045004. Epub 2012 Aug 7.


Multiscale models of cell signaling.

Bajikar SS, Janes KA.

Ann Biomed Eng. 2012 Nov;40(11):2319-27. doi: 10.1007/s10439-012-0560-1. Epub 2012 Apr 3. Review.


Controlling murine and rat chronic pain through A3 adenosine receptor activation.

Chen Z, Janes K, Chen C, Doyle T, Bryant L, Tosh DK, Jacobson KA, Salvemini D.

FASEB J. 2012 May;26(5):1855-65. doi: 10.1096/fj.11-201541. Epub 2012 Feb 17.


Anti-superoxide and anti-peroxynitrite strategies in pain suppression.

Janes K, Neumann WL, Salvemini D.

Biochim Biophys Acta. 2012 May;1822(5):815-21. doi: 10.1016/j.bbadis.2011.12.008. Epub 2011 Dec 19.


RUNX1 and its understudied role in breast cancer.

Janes KA.

Cell Cycle. 2011 Oct 15;10(20):3461-5. doi: 10.4161/cc.10.20.18029. Epub 2011 Oct 15.


Normal morphogenesis of epithelial tissues and progression of epithelial tumors.

Wang CC, Jamal L, Janes KA.

Wiley Interdiscip Rev Syst Biol Med. 2012 Jan-Feb;4(1):51-78. doi: 10.1002/wsbm.159. Epub 2011 Sep 2. Review.


Intersection of FOXO- and RUNX1-mediated gene expression programs in single breast epithelial cells during morphogenesis and tumor progression.

Wang L, Brugge JS, Janes KA.

Proc Natl Acad Sci U S A. 2011 Oct 4;108(40):E803-12. doi: 10.1073/pnas.1103423108. Epub 2011 Aug 22.


Courage, collaboration, complexity and chemotherapy safety: the view from the sharp end.

Green E, White R, Janes K, Fields A, Easty A.

Can Oncol Nurs J. 2011 Spring;21(2):81-90. English, French.


Pairwise network mechanisms in the host signaling response to coxsackievirus B3 infection.

Garmaroudi FS, Marchant D, Si X, Khalili A, Bashashati A, Wong BW, Tabet A, Ng RT, Murphy K, Luo H, Janes KA, McManus BM.

Proc Natl Acad Sci U S A. 2010 Sep 28;107(39):17053-8. doi: 10.1073/pnas.1006478107. Epub 2010 Sep 10.


Paring down signaling complexity.

Janes KA.

Nat Biotechnol. 2010 Jul;28(7):681-2. doi: 10.1038/nbt0710-681. No abstract available.


Identifying single-cell molecular programs by stochastic profiling.

Janes KA, Wang CC, Holmberg KJ, Cabral K, Brugge JS.

Nat Methods. 2010 Apr;7(4):311-7. doi: 10.1038/nmeth.1442. Epub 2010 Mar 14.


Cytokine-induced signaling networks prioritize dynamic range over signal strength.

Janes KA, Reinhardt HC, Yaffe MB.

Cell. 2008 Oct 17;135(2):343-54. doi: 10.1016/j.cell.2008.08.034.


When microarrays Met epidermal-cell migration.

Janes KA.

Mol Syst Biol. 2008;4:200. doi: 10.1038/msb.2008.41. Epub 2008 Jul 1. No abstract available.


Common effector processing mediates cell-specific responses to stimuli.

Miller-Jensen K, Janes KA, Brugge JS, Lauffenburger DA.

Nature. 2007 Aug 2;448(7153):604-8. Epub 2007 Jul 18.


Data-driven modelling of signal-transduction networks.

Janes KA, Yaffe MB.

Nat Rev Mol Cell Biol. 2006 Nov;7(11):820-8. Review.


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