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Items: 8

1.

Quantification of unbound concentration of ticagrelor in plasma as a proof of mechanism biomarker of the reversal agent, MEDI2452.

Sandinge AS, Janefeldt A, Pehrsson S, Nylander S.

PLoS One. 2018 Jul 26;13(7):e0201202. doi: 10.1371/journal.pone.0201202. eCollection 2018.

2.

The brain-penetrant clinical ATM inhibitor AZD1390 radiosensitizes and improves survival of preclinical brain tumor models.

Durant ST, Zheng L, Wang Y, Chen K, Zhang L, Zhang T, Yang Z, Riches L, Trinidad AG, Fok JHL, Hunt T, Pike KG, Wilson J, Smith A, Colclough N, Reddy VP, Sykes A, Janefeldt A, Johnström P, Varnäs K, Takano A, Ling S, Orme J, Stott J, Roberts C, Barrett I, Jones G, Roudier M, Pierce A, Allen J, Kahn J, Sule A, Karlin J, Cronin A, Chapman M, Valerie K, Illingworth R, Pass M.

Sci Adv. 2018 Jun 20;4(6):eaat1719. doi: 10.1126/sciadv.aat1719. eCollection 2018 Jun.

3.

Hemostatic effects of the ticagrelor antidote MEDI2452 in pigs treated with ticagrelor on a background of aspirin.

Pehrsson S, Johansson KJ, Janefeldt A, Sandinge AS, Maqbool S, Goodman J, Sanchez J, Almquist J, Gennemark P, Nylander S.

J Thromb Haemost. 2017 Jun;15(6):1213-1222. doi: 10.1111/jth.13680. Epub 2017 May 11.

PMID:
28322016
4.

Unraveling the pharmacokinetic interaction of ticagrelor and MEDI2452 (Ticagrelor antidote) by mathematical modeling.

Almquist J, Penney M, Pehrsson S, Sandinge AS, Janefeldt A, Maqbool S, Madalli S, Goodman J, Nylander S, Gennemark P.

CPT Pharmacometrics Syst Pharmacol. 2016 Jun;5(6):313-23. doi: 10.1002/psp4.12089. Epub 2016 Jun 16.

5.

Determination of Human Hepatocyte Intrinsic Clearance for Slowly Metabolized Compounds: Comparison of a Primary Hepatocyte/Stromal Cell Co-culture with Plated Primary Hepatocytes and HepaRG.

Bonn B, Svanberg P, Janefeldt A, Hultman Ia, Grime K.

Drug Metab Dispos. 2016 Apr;44(4):527-33. doi: 10.1124/dmd.115.067769. Epub 2016 Feb 5.

6.

Structural and functional characterization of a specific antidote for ticagrelor.

Buchanan A, Newton P, Pehrsson S, Inghardt T, Antonsson T, Svensson P, Sjögren T, Öster L, Janefeldt A, Sandinge AS, Keyes F, Austin M, Spooner J, Gennemark P, Penney M, Howells G, Vaughan T, Nylander S.

Blood. 2015 May 28;125(22):3484-90. doi: 10.1182/blood-2015-01-622928. Epub 2015 Mar 18.

7.

HepaRG cells as human-relevant in vitro model to study the effects of inflammatory stimuli on cytochrome P450 isoenzymes.

Rubin K, Janefeldt A, Andersson L, Berke Z, Grime K, Andersson TB.

Drug Metab Dispos. 2015 Jan;43(1):119-25. doi: 10.1124/dmd.114.059246. Epub 2014 Nov 4.

8.

Stapled Vasoactive Intestinal Peptide (VIP) Derivatives Improve VPAC2 Agonism and Glucose-Dependent Insulin Secretion.

Giordanetto F, Revell JD, Knerr L, Hostettler M, Paunovic A, Priest C, Janefeldt A, Gill A.

ACS Med Chem Lett. 2013 Oct 16;4(12):1163-8. doi: 10.1021/ml400257h. eCollection 2013 Dec 12.

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