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Acute ischemic stroke thrombi have an outer shell that impairs fibrinolysis.

Di Meglio L, Desilles JP, Ollivier V, Nomenjanahary MS, Di Meglio S, Deschildre C, Loyau S, Olivot JM, Blanc R, Piotin M, Bouton MC, Michel JB, Jandrot-Perrus M, Ho-Tin-Noé B, Mazighi M.

Neurology. 2019 Oct 29;93(18):e1686-e1698. doi: 10.1212/WNL.0000000000008395. Epub 2019 Sep 20. Erratum in: Neurology. 2019 Oct 29;93(18):819.


Critical role of neutrophil extracellular traps (NETs) in patients with Behcet's disease.

Le Joncour A, Martos R, Loyau S, Lelay N, Dossier A, Cazes A, Fouret P, Domont F, Papo T, Jandrot-Perrus M, Bouton MC, Cacoub P, Ajzenberg N, Saadoun D, Boulaftali Y.

Ann Rheum Dis. 2019 Sep;78(9):1274-1282. doi: 10.1136/annrheumdis-2018-214335. Epub 2019 May 30.


Platelet glycoprotein VI genetic quantitative and qualitative defects.

Jandrot-Perrus M, Hermans C, Mezzano D.

Platelets. 2019;30(6):708-713. doi: 10.1080/09537104.2019.1610166. Epub 2019 May 8. Review.


Safety and Tolerability, Pharmacokinetics, and Pharmacodynamics of ACT017, an Antiplatelet GPVI (Glycoprotein VI) Fab.

Voors-Pette C, Lebozec K, Dogterom P, Jullien L, Billiald P, Ferlan P, Renaud L, Favre-Bulle O, Avenard G, Machacek M, Plétan Y, Jandrot-Perrus M.

Arterioscler Thromb Vasc Biol. 2019 May;39(5):956-964. doi: 10.1161/ATVBAHA.118.312314.


First description of an IgM monoclonal antibody causing αII b β3 integrin activation and acquired Glanzmann thrombasthenia associated with macrothrombocytopenia.

Pillois X, Guy A, Choquet É, James C, Tuffigo M, Viallard JF, Garcia C, Bordet JC, Jandrot-Perrus M, Payrastre B, Fiore M.

J Thromb Haemost. 2019 May;17(5):795-802. doi: 10.1111/jth.14424. Epub 2019 Apr 19.


In vitro and in vivo evaluation of a dextran-graft-polybutylmethacrylate copolymer coated on CoCr metallic stent.

Delattre C, Velazquez D, Roques C, Pavon-Djavid G, Ollivier V, Lokajczyk A, Avramoglou T, Gueguen V, Louedec L, Caligiuri G, Jandrot-Perrus M, Boisson-Vidal C, Letourneur D, Meddahi-Pelle A.

Bioimpacts. 2019;9(1):25-36. doi: 10.15171/bi.2019.04. Epub 2018 Oct 2.


Microfluidic Modeling of Thrombolysis.

Loyau S, Ho-Tin-Noé B, Bourrienne MC, Boulaftali Y, Jandrot-Perrus M.

Arterioscler Thromb Vasc Biol. 2018 Nov;38(11):2626-2637. doi: 10.1161/ATVBAHA.118.311178.


Hematopoietic protease nexin-1 protects against lung injury by preventing thrombin signaling in mice.

François D, Arocas V, Venisse L, Aymonnier K, Idir L, Martos R, Gazit S, Couty L, Jandrot-Perrus M, Camerer E, Boulaftali Y, Bouton MC.

Blood Adv. 2018 Sep 25;2(18):2389-2399. doi: 10.1182/bloodadvances.2018018283.


A mutation of the human EPHB2 gene leads to a major platelet functional defect.

Berrou E, Soukaseum C, Favier R, Adam F, Elaib Z, Kauskot A, Bordet JC, Ballerini P, Loyau S, Feng M, Dias K, Muheidli A, Girault S, Nurden AT, Turro E, Ouwehand WH, Denis CV, Jandrot-Perrus M, Rosa JP, Nurden P, Bryckaert M.

Blood. 2018 Nov 8;132(19):2067-2077. doi: 10.1182/blood-2018-04-845644. Epub 2018 Sep 13.


Vascular endothelial cell expression of JAK2V617F is sufficient to promote a pro-thrombotic state due to increased P-selectin expression.

Guy A, Gourdou-Latyszenok V, Le Lay N, Peghaire C, Kilani B, Dias JV, Duplaa C, Renault MA, Denis C, Villeval JL, Boulaftali Y, Jandrot-Perrus M, Couffinhal T, James C.

Haematologica. 2019 Jan;104(1):70-81. doi: 10.3324/haematol.2018.195321. Epub 2018 Aug 31.


Evaluation of anticoagulant agents for the treatment of human metapneumovirus infection in mice.

Lê BV, Jandrot-Perrus M, Couture C, Checkmahomed L, Venable MC, Hamelin MÈ, Boivin G.

J Gen Virol. 2018 Oct;99(10):1367-1380. doi: 10.1099/jgv.0.001135. Epub 2018 Aug 10.


Carboxypeptidase U (CPU, carboxypeptidase B2, activated thrombin-activatable fibrinolysis inhibitor) inhibition stimulates the fibrinolytic rate in different in vitro models.

Leenaerts D, Loyau S, Mertens JC, Boisseau W, Michel JB, Lambeir AM, Jandrot-Perrus M, Hendriks D.

J Thromb Haemost. 2018 Oct;16(10):2057-2069. doi: 10.1111/jth.14249. Epub 2018 Aug 30.


Glycoprotein VI in securing vascular integrity in inflamed vessels.

Boulaftali Y, Mawhin MA, Jandrot-Perrus M, Ho-Tin-Noé B.

Res Pract Thromb Haemost. 2018 Apr 3;2(2):228-239. doi: 10.1002/rth2.12092. eCollection 2018 Apr.


Quality and cost assessment of a recombinant antibody fragment produced from mammalian, yeast and prokaryotic host cells: A case study prior to pharmaceutical development.

Lebozec K, Jandrot-Perrus M, Avenard G, Favre-Bulle O, Billiald P.

N Biotechnol. 2018 Sep 25;44:31-40. doi: 10.1016/j.nbt.2018.04.006. Epub 2018 Apr 22.


Downstream Microvascular Thrombosis in Cortical Venules Is an Early Response to Proximal Cerebral Arterial Occlusion.

Desilles JP, Syvannarath V, Di Meglio L, Ducroux C, Boisseau W, Louedec L, Jandrot-Perrus M, Michel JB, Mazighi M, Ho-Tin-Noé B.

J Am Heart Assoc. 2018 Mar 1;7(5). pii: e007804. doi: 10.1161/JAHA.117.007804.


Immobilized fibrinogen activates human platelets through glycoprotein VI.

Mangin PH, Onselaer MB, Receveur N, Le Lay N, Hardy AT, Wilson C, Sanchez X, Loyau S, Dupuis A, Babar AK, Miller JL, Philippou H, Hughes CE, Herr AB, Ariëns RA, Mezzano D, Jandrot-Perrus M, Gachet C, Watson SP.

Haematologica. 2018 May;103(5):898-907. doi: 10.3324/haematol.2017.182972. Epub 2018 Feb 22.


Long-term management of leukocyte adhesion deficiency type III without hematopoietic stem cell transplantation.

Saultier P, Szepetowski S, Canault M, Falaise C, Poggi M, Suchon P, Barlogis V, Michel G, Loyau S, Jandrot-Perrus M, Bordet JC, Alessi MC, Chambost H.

Haematologica. 2018 Jun;103(6):e264-e267. doi: 10.3324/haematol.2017.186304. Epub 2018 Feb 22. Review. No abstract available.


Platelets Drive Thrombus Propagation in a Hematocrit and Glycoprotein VI-Dependent Manner in an In Vitro Venous Thrombosis Model.

Lehmann M, Schoeman RM, Krohl PJ, Wallbank AM, Samaniuk JR, Jandrot-Perrus M, Neeves KB.

Arterioscler Thromb Vasc Biol. 2018 May;38(5):1052-1062. doi: 10.1161/ATVBAHA.118.310731. Epub 2018 Feb 22.


The contribution of platelet glycoprotein receptors to inflammatory bleeding prevention is stimulus and organ dependent.

Rayes J, Jadoui S, Lax S, Gros A, Wichaiyo S, Ollivier V, Denis CV, Ware J, Nieswandt B, Jandrot-Perrus M, Watson SP, Ho-Tin-Noé B.

Haematologica. 2018 Jun;103(6):e256-e258. doi: 10.3324/haematol.2017.182162. Epub 2018 Feb 1. No abstract available.


Amino-Fucoidan as a Vector for rtPA-Induced Fibrinolysis in Experimental Thrombotic Events.

Ghebouli R, Loyau S, Maire M, Saboural P, Collet JP, Jandrot-Perrus M, Letourneur D, Chaubet F, Michel JB.

Thromb Haemost. 2018 Jan;118(1):42-53. doi: 10.1160/TH17-02-0132. Epub 2018 Jan 5.


Protease-activated receptor 1 inhibition protects mice against thrombin-dependent respiratory syncytial virus and human metapneumovirus infections.

Lê VB, Riteau B, Alessi MC, Couture C, Jandrot-Perrus M, Rhéaume C, Hamelin MÈ, Boivin G.

Br J Pharmacol. 2018 Jan;175(2):388-403. doi: 10.1111/bph.14084. Epub 2017 Dec 10.


Design, development and characterization of ACT017, a humanized Fab that blocks platelet's glycoprotein VI function without causing bleeding risks.

Lebozec K, Jandrot-Perrus M, Avenard G, Favre-Bulle O, Billiald P.

MAbs. 2017 Aug/Sep;9(6):945-958. doi: 10.1080/19420862.2017.1336592. Epub 2017 Jun 9.


Exacerbation of Thromboinflammation by Hyperglycemia Precipitates Cerebral Infarct Growth and Hemorrhagic Transformation.

Desilles JP, Syvannarath V, Ollivier V, Journé C, Delbosc S, Ducroux C, Boisseau W, Louedec L, Di Meglio L, Loyau S, Jandrot-Perrus M, Potier L, Michel JB, Mazighi M, Ho-Tin-Noé B.

Stroke. 2017 Jul;48(7):1932-1940. doi: 10.1161/STROKEAHA.117.017080. Epub 2017 May 19.


Bioreactivity of stent material: Activation of platelets, coagulation, leukocytes and endothelial cell dysfunction in vitro.

Ollivier V, Roques C, Receveur N, Gratz M, Feldman L, Letourneur D, Gachet C, Mangin PH, Jandrot-Perrus M.

Platelets. 2017 Sep;28(6):529-539. doi: 10.1080/09537104.2016.1252836. Epub 2016 Dec 29.


Abacavir has no prothrombotic effect on platelets in vitro.

Diallo YL, Ollivier V, Joly V, Faille D, Catalano G, Jandrot-Perrus M, Rauch A, Yeni P, Ajzenberg N.

J Antimicrob Chemother. 2016 Dec;71(12):3506-3509. Epub 2016 Aug 11.


Alteplase Reduces Downstream Microvascular Thrombosis and Improves the Benefit of Large Artery Recanalization in Stroke.

Desilles JP, Loyau S, Syvannarath V, Gonzalez-Valcarcel J, Cantier M, Louedec L, Lapergue B, Amarenco P, Ajzenberg N, Jandrot-Perrus M, Michel JB, Ho-Tin-Noe B, Mazighi M.

Stroke. 2015 Nov;46(11):3241-8. doi: 10.1161/STROKEAHA.115.010721. Epub 2015 Oct 6.


Fibrillar cellular fibronectin supports efficient platelet aggregation and procoagulant activity.

Maurer E, Schaff M, Receveur N, Bourdon C, Mercier L, Nieswandt B, Dubois C, Jandrot-Perrus M, Goetz JG, Lanza F, Gachet C, Mangin PH.

Thromb Haemost. 2015 Nov 25;114(6):1175-88. doi: 10.1160/TH14-11-0958. Epub 2015 Aug 6.


Protease nexin-1 regulates retinal vascular development.

Selbonne S, Francois D, Raoul W, Boulaftali Y, Sennlaub F, Jandrot-Perrus M, Bouton MC, Arocas V.

Cell Mol Life Sci. 2015 Oct;72(20):3999-4011. doi: 10.1007/s00018-015-1972-5. Epub 2015 Jun 25.


Inhibition of Glycoprotein VI Clustering by Collagen as a Mechanism of Inhibiting Collagen-Induced Platelet Responses: The Example of Losartan.

Jiang P, Loyau S, Tchitchinadze M, Ropers J, Jondeau G, Jandrot-Perrus M.

PLoS One. 2015 Jun 8;10(6):e0128744. doi: 10.1371/journal.pone.0128744. eCollection 2015.


Single platelets seal neutrophil-induced vascular breaches via GPVI during immune-complex-mediated inflammation in mice.

Gros A, Syvannarath V, Lamrani L, Ollivier V, Loyau S, Goerge T, Nieswandt B, Jandrot-Perrus M, Ho-Tin-Noé B.

Blood. 2015 Aug 20;126(8):1017-26. doi: 10.1182/blood-2014-12-617159. Epub 2015 Jun 2.


Platelet glycoprotein VI binds to polymerized fibrin and promotes thrombin generation.

Mammadova-Bach E, Ollivier V, Loyau S, Schaff M, Dumont B, Favier R, Freyburger G, Latger-Cannard V, Nieswandt B, Gachet C, Mangin PH, Jandrot-Perrus M.

Blood. 2015 Jul 30;126(5):683-91. doi: 10.1182/blood-2015-02-629717. Epub 2015 May 14.


Platelet activation and aggregation promote lung inflammation and influenza virus pathogenesis.

Lê VB, Schneider JG, Boergeling Y, Berri F, Ducatez M, Guerin JL, Adrian I, Errazuriz-Cerda E, Frasquilho S, Antunes L, Lina B, Bordet JC, Jandrot-Perrus M, Ludwig S, Riteau B.

Am J Respir Crit Care Med. 2015 Apr 1;191(7):804-19. doi: 10.1164/rccm.201406-1031OC.


Phosphorothioate backbone modifications of nucleotide-based drugs are potent platelet activators.

Flierl U, Nero TL, Lim B, Arthur JF, Yao Y, Jung SM, Gitz E, Pollitt AY, Zaldivia MT, Jandrot-Perrus M, Schäfer A, Nieswandt B, Andrews RK, Parker MW, Gardiner EE, Peter K.

J Exp Med. 2015 Feb 9;212(2):129-37. doi: 10.1084/jem.20140391. Epub 2015 Feb 2.


Increased expression of protease nexin-1 in fibroblasts during idiopathic pulmonary fibrosis regulates thrombin activity and fibronectin expression.

François D, Venisse L, Marchal-Somme J, Jandrot-Perrus M, Crestani B, Arocas V, Bouton MC.

Lab Invest. 2014 Nov;94(11):1237-46. doi: 10.1038/labinvest.2014.111. Epub 2014 Sep 8.


Collagen can selectively trigger a platelet secretory phenotype via glycoprotein VI.

Ollivier V, Syvannarath V, Gros A, Butt A, Loyau S, Jandrot-Perrus M, Ho-Tin-Noé B.

PLoS One. 2014 Aug 12;9(8):e104712. doi: 10.1371/journal.pone.0104712. eCollection 2014.


Hemostatic disorders in a JAK2V617F-driven mouse model of myeloproliferative neoplasm.

Lamrani L, Lacout C, Ollivier V, Denis CV, Gardiner E, Ho Tin Noe B, Vainchenker W, Villeval JL, Jandrot-Perrus M.

Blood. 2014 Aug 14;124(7):1136-45. doi: 10.1182/blood-2013-10-530832. Epub 2014 Jun 20.


New advances in treating thrombotic diseases: GPVI as a platelet drug target.

Jiang P, Jandrot-Perrus M.

Drug Discov Today. 2014 Sep;19(9):1471-5. doi: 10.1016/j.drudis.2014.06.005. Epub 2014 Jun 12. Review.


Switch from protective to adverse inflammation during influenza: viral determinants and hemostasis are caught as culprits.

Berri F, Lê VB, Jandrot-Perrus M, Lina B, Riteau B.

Cell Mol Life Sci. 2014 Mar;71(5):885-98. doi: 10.1007/s00018-013-1479-x. Epub 2013 Oct 4. Review.


Smad2-dependent protease nexin-1 overexpression differentiates chronic aneurysms from acute dissections of human ascending aorta.

Gomez D, Kessler K, Borges LF, Richard B, Touat Z, Ollivier V, Mansilla S, Bouton MC, Alkoder S, Nataf P, Jandrot-Perrus M, Jondeau G, Vranckx R, Michel JB.

Arterioscler Thromb Vasc Biol. 2013 Sep;33(9):2222-32. doi: 10.1161/ATVBAHA.113.301327. Epub 2013 Jun 27.


Endothelial protease nexin-1 is a novel regulator of A disintegrin and metalloproteinase 17 maturation and endothelial protein C receptor shedding via furin inhibition.

Boulaftali Y, François D, Venisse L, Jandrot-Perrus M, Arocas V, Bouton MC.

Arterioscler Thromb Vasc Biol. 2013 Jul;33(7):1647-54. doi: 10.1161/ATVBAHA.113.301494. Epub 2013 May 9.


Heterogeneity of platelet functional alterations in patients with filamin A mutations.

Berrou E, Adam F, Lebret M, Fergelot P, Kauskot A, Coupry I, Jandrot-Perrus M, Nurden A, Favier R, Rosa JP, Goizet C, Nurden P, Bryckaert M.

Arterioscler Thromb Vasc Biol. 2013 Jan;33(1):e11-8. doi: 10.1161/ATVBAHA.112.300603. Epub 2012 Nov 1.


The future of glycoprotein VI as an antithrombotic target.

Zahid M, Mangin P, Loyau S, Hechler B, Billiald P, Gachet C, Jandrot-Perrus M.

J Thromb Haemost. 2012 Dec;10(12):2418-27. doi: 10.1111/jth.12009. Review.


The mouse dorsal skinfold chamber as a model for the study of thrombolysis by intravital microscopy.

Boulaftali Y, Lamrani L, Rouzaud MC, Loyau S, Jandrot-Perrus M, Bouton MC, Ho-Tin-Noé B.

Thromb Haemost. 2012 May;107(5):962-71. doi: 10.1160/TH11-10-0705. Epub 2012 Mar 8.


Activation state of platelets in experimental severe hemophilia A.

Teyssandier M, Delignat S, Rayes J, Bryckaert M, Jandrot-Perrus M, Kaveri SV, Lacroix-Desmazes S.

Haematologica. 2012 Jul;97(7):1115-6. doi: 10.3324/haematol.2012.065235. Epub 2012 Mar 14. No abstract available.


In vitro and in vivo antiangiogenic properties of the serpin protease nexin-1.

Selbonne S, Azibani F, Iatmanen S, Boulaftali Y, Richard B, Jandrot-Perrus M, Bouton MC, Arocas V.

Mol Cell Biol. 2012 Apr;32(8):1496-505. doi: 10.1128/MCB.06554-11. Epub 2012 Feb 13.


A humanized glycoprotein VI (GPVI) mouse model to assess the antithrombotic efficacies of anti-GPVI agents.

Mangin PH, Tang C, Bourdon C, Loyau S, Freund M, Hechler B, Gachet C, Jandrot-Perrus M.

J Pharmacol Exp Ther. 2012 Apr;341(1):156-63. doi: 10.1124/jpet.111.189050. Epub 2012 Jan 11.


Emerging role of serpinE2/protease nexin-1 in hemostasis and vascular biology.

Bouton MC, Boulaftali Y, Richard B, Arocas V, Michel JB, Jandrot-Perrus M.

Blood. 2012 Mar 15;119(11):2452-7. doi: 10.1182/blood-2011-10-387464. Epub 2012 Jan 10. Review.


Platelet glycoprotein VI dimerization, an active process inducing receptor competence, is an indicator of platelet reactivity.

Loyau S, Dumont B, Ollivier V, Boulaftali Y, Feldman L, Ajzenberg N, Jandrot-Perrus M.

Arterioscler Thromb Vasc Biol. 2012 Mar;32(3):778-85. doi: 10.1161/ATVBAHA.111.241067. Epub 2011 Dec 8.


Radiolabeled fucoidan as a p-selectin targeting agent for in vivo imaging of platelet-rich thrombus and endothelial activation.

Rouzet F, Bachelet-Violette L, Alsac JM, Suzuki M, Meulemans A, Louedec L, Petiet A, Jandrot-Perrus M, Chaubet F, Michel JB, Le Guludec D, Letourneur D.

J Nucl Med. 2011 Sep;52(9):1433-40. doi: 10.2967/jnumed.110.085852. Epub 2011 Aug 17.


Design and reshaping of an scFv directed against human platelet glycoprotein VI with diagnostic potential.

Zahid M, Loyau S, Bouabdelli M, Aubrey N, Jandrot-Perrus M, Billiald P.

Anal Biochem. 2011 Oct 15;417(2):274-82. doi: 10.1016/j.ab.2011.06.036. Epub 2011 Jul 2.


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