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Items: 1 to 50 of 407

1.

Consequence of Hapten Stereochemistry: An Efficacious Methamphetamine Vaccine.

Olson ME, Sugane T, Zhou B, Janda KD.

J Am Chem Soc. 2019 Sep 11;141(36):14089-14092. doi: 10.1021/jacs.9b07294. Epub 2019 Sep 3.

PMID:
31479256
2.

Vaccine blunts fentanyl potency in male rhesus monkeys.

Tenney RD, Blake S, Bremer PT, Zhou B, Hwang CS, Poklis JL, Janda KD, Banks ML.

Neuropharmacology. 2019 Nov 1;158:107730. doi: 10.1016/j.neuropharm.2019.107730. Epub 2019 Jul 29.

PMID:
31369740
3.

Strategies to Counteract Botulinum Neurotoxin A: Nature's Deadliest Biomolecule.

Lin L, Olson ME, Eubanks LM, Janda KD.

Acc Chem Res. 2019 Aug 20;52(8):2322-2331. doi: 10.1021/acs.accounts.9b00261. Epub 2019 Jul 19.

PMID:
31322847
4.

Monoclonal Antibodies for Combating Synthetic Opioid Intoxication.

Smith LC, Bremer PT, Hwang CS, Zhou B, Ellis B, Hixon MS, Janda KD.

J Am Chem Soc. 2019 Jul 3;141(26):10489-10503. doi: 10.1021/jacs.9b04872. Epub 2019 Jun 25.

5.

Heroin vaccine: Using titer, affinity, and antinociception as metrics when examining sex and strain differences.

Hwang CS, Smith LC, Wenthur CJ, Ellis B, Zhou B, Janda KD.

Vaccine. 2019 Jul 9;37(30):4155-4163. doi: 10.1016/j.vaccine.2019.05.061. Epub 2019 Jun 5.

PMID:
31176539
6.

A chemically contiguous hapten approach for a heroin-fentanyl vaccine.

Natori Y, Hwang CS, Lin L, Smith LC, Zhou B, Janda KD.

Beilstein J Org Chem. 2019 May 3;15:1020-1031. doi: 10.3762/bjoc.15.100. eCollection 2019.

7.

Conjugate vaccine produces long-lasting attenuation of fentanyl vs. food choice and blocks expression of opioid withdrawal-induced increases in fentanyl choice in rats.

Townsend EA, Blake S, Faunce KE, Hwang CS, Natori Y, Zhou B, Bremer PT, Janda KD, Banks ML.

Neuropsychopharmacology. 2019 Sep;44(10):1681-1689. doi: 10.1038/s41386-019-0385-9. Epub 2019 May 2.

PMID:
31043682
8.

Δ9-tetrahydrocannabinol attenuates oxycodone self-administration under extended access conditions.

Nguyen JD, Grant Y, Creehan KM, Hwang CS, Vandewater SA, Janda KD, Cole M, Taffe MA.

Neuropharmacology. 2019 Jun;151:127-135. doi: 10.1016/j.neuropharm.2019.04.010. Epub 2019 Apr 11.

PMID:
30980837
9.

Myc and Loss of p53 Cooperate to Drive Formation of Choroid Plexus Carcinoma.

Wang J, Merino DM, Light N, Murphy BL, Wang YD, Guo X, Hodges AP, Chau LQ, Liu KW, Dhall G, Asgharzadeh S, Kiehna EN, Shirey RJ, Janda KD, Taylor MD, Malkin D, Ellison DW, VandenBerg SR, Eberhart CG, Sears RC, Roussel MF, Gilbertson RJ, Wechsler-Reya RJ.

Cancer Res. 2019 May 1;79(9):2208-2219. doi: 10.1158/0008-5472.CAN-18-2565. Epub 2019 Mar 18.

PMID:
30885981
10.

Ghrelin Receptor Influence on Cocaine Reward is Not Directly Dependent on Peripheral Acyl-Ghrelin.

Wenthur CJ, Gautam R, Zhou B, Vendruscolo LF, Leggio L, Janda KD.

Sci Rep. 2019 Feb 12;9(1):1841. doi: 10.1038/s41598-019-38549-z.

11.

Chemical Interventions for the Opioid Crisis: Key Advances and Remaining Challenges.

Olson ME, Eubanks LM, Janda KD.

J Am Chem Soc. 2019 Feb 6;141(5):1798-1806. doi: 10.1021/jacs.8b09756. Epub 2018 Dec 11.

PMID:
30532973
12.

Heat shock proteins: A dual carrier-adjuvant for an anti-drug vaccine against heroin.

Hwang CS, Ellis B, Zhou B, Janda KD.

Bioorg Med Chem. 2019 Jan 1;27(1):125-132. doi: 10.1016/j.bmc.2018.11.027. Epub 2018 Nov 20.

PMID:
30497790
13.

Lateral Flow Assessment and Unanticipated Toxicity of Kratom.

Smith LC, Lin L, Hwang CS, Zhou B, Kubitz DM, Wang H, Janda KD.

Chem Res Toxicol. 2019 Jan 22;32(1):113-121. doi: 10.1021/acs.chemrestox.8b00218. Epub 2018 Nov 16.

14.

An enzymatic approach reverses nicotine dependence, decreases compulsive-like intake, and prevents relapse.

Kallupi M, Xue S, Zhou B, Janda KD, George O.

Sci Adv. 2018 Oct 17;4(10):eaat4751. doi: 10.1126/sciadv.aat4751. eCollection 2018 Oct.

15.

Immunopharmacotherapies for Treating Opioid Use Disorder.

Banks ML, Olson ME, Janda KD.

Trends Pharmacol Sci. 2018 Nov;39(11):908-911. doi: 10.1016/j.tips.2018.08.001. Review.

16.

Improved Admixture Vaccine of Fentanyl and Heroin Hapten Immunoconjugates: Antinociceptive Evaluation of Fentanyl-Contaminated Heroin.

Hwang CS, Smith LC, Natori Y, Ellis B, Zhou B, Janda KD.

ACS Omega. 2018 Sep 30;3(9):11537-11543. doi: 10.1021/acsomega.8b01478. Epub 2018 Sep 20.

17.

Noninvasive Urine Biomarker Lateral Flow Immunoassay for Monitoring Active Onchocerciasis.

Shirey RJ, Globisch D, Eubanks LM, Hixon MS, Janda KD.

ACS Infect Dis. 2018 Oct 12;4(10):1423-1431. doi: 10.1021/acsinfecdis.8b00163. Epub 2018 Sep 21.

18.

Synthetic molecules for disruption of the MYC protein-protein interface.

Jacob NT, Miranda PO, Shirey RJ, Gautam R, Zhou B, de Orbe Izquierdo ME, Hixon MS, Hart JR, Ueno L, Vogt PK, Janda KD.

Bioorg Med Chem. 2018 Aug 7;26(14):4234-4239. doi: 10.1016/j.bmc.2018.07.019. Epub 2018 Jul 11.

19.

Introduction.

Disney MD, Janda KD.

Bioorg Med Chem Lett. 2018 Sep 1;28(16):2661-2662. doi: 10.1016/j.bmcl.2018.07.013. Epub 2018 Jul 10. No abstract available.

PMID:
30029841
20.

Prophylactic vaccination protects against the development of oxycodone self-administration.

Nguyen JD, Hwang CS, Grant Y, Janda KD, Taffe MA.

Neuropharmacology. 2018 Aug;138:292-303. doi: 10.1016/j.neuropharm.2018.06.026. Epub 2018 Jun 22.

21.

Crystallography Coupled with Kinetic Analysis Provides Mechanistic Underpinnings of a Nicotine-Degrading Enzyme.

Tararina MA, Xue S, Smith LC, Muellers SN, Miranda PO, Janda KD, Allen KN.

Biochemistry. 2018 Jul 3;57(26):3741-3751. doi: 10.1021/acs.biochem.8b00384. Epub 2018 Jun 13.

22.

Efficient Syntheses of Cocaine Vaccines and Their in Vivo Evaluation.

Kimishima A, Olson ME, Natori Y, Janda KD.

ACS Med Chem Lett. 2018 Apr 16;9(5):411-416. doi: 10.1021/acsmedchemlett.8b00051. eCollection 2018 May 10.

23.

Efficacious Vaccine against Heroin Contaminated with Fentanyl.

Hwang CS, Smith LC, Natori Y, Ellis B, Zhou B, Janda KD.

ACS Chem Neurosci. 2018 Jun 20;9(6):1269-1275. doi: 10.1021/acschemneuro.8b00079. Epub 2018 Mar 23.

24.

Enhancing Efficacy and Stability of an Antiheroin Vaccine: Examination of Antinociception, Opioid Binding Profile, and Lethality.

Hwang CS, Bremer PT, Wenthur CJ, Ho SO, Chiang S, Ellis B, Zhou B, Fujii G, Janda KD.

Mol Pharm. 2018 Mar 5;15(3):1062-1072. doi: 10.1021/acs.molpharmaceut.7b00933. Epub 2018 Feb 19.

25.

Mining a Kröhnke Pyridine Library for Anti-Arenavirus Activity.

Miranda PO, Cubitt B, Jacob NT, Janda KD, de la Torre JC.

ACS Infect Dis. 2018 May 11;4(5):815-824. doi: 10.1021/acsinfecdis.7b00236. Epub 2018 Mar 1.

PMID:
29405696
26.

Investigations into the efficacy of multi-component cocaine vaccines.

Kimishima A, Olson ME, Janda KD.

Bioorg Med Chem Lett. 2018 Sep 1;28(16):2779-2783. doi: 10.1016/j.bmcl.2017.12.043. Epub 2017 Dec 20.

27.

An enzymatic advance in nicotine cessation therapy.

Xue S, Kallupi M, Zhou B, Smith LC, Miranda PO, George O, Janda KD.

Chem Commun (Camb). 2018 Feb 13;54(14):1686-1689. doi: 10.1039/c7cc09134f.

28.

Vaccines to combat the opioid crisis: Vaccines that prevent opioids and other substances of abuse from entering the brain could effectively treat addiction and abuse.

Olson ME, Janda KD.

EMBO Rep. 2018 Jan;19(1):5-9. doi: 10.15252/embr.201745322. Epub 2017 Dec 13. No abstract available.

29.

A Vision for Vaccines: Combating the Opioid Epidemic.

Hwang CS, Janda KD.

Biochemistry. 2017 Oct 24;56(42):5625-5627. doi: 10.1021/acs.biochem.7b00948. Epub 2017 Oct 10. Review. No abstract available.

PMID:
28994583
30.

Vaccine-driven pharmacodynamic dissection and mitigation of fenethylline psychoactivity.

Wenthur CJ, Zhou B, Janda KD.

Nature. 2017 Aug 24;548(7668):476-479. doi: 10.1038/nature23464. Epub 2017 Aug 16.

31.

Augmenting the efficacy of anti-cocaine catalytic antibodies through chimeric hapten design and combinatorial vaccination.

Wenthur CJ, Cai X, Ellis BA, Janda KD.

Bioorg Med Chem Lett. 2017 Aug 15;27(16):3666-3668. doi: 10.1016/j.bmcl.2017.07.014. Epub 2017 Jul 5.

32.

A bioconjugate leveraging xenoreactive antibodies to alleviate cocaine-induced behavior.

Jacob NT, Anraku K, Kimishima A, Zhou B, Collins KC, Lockner JW, Ellis BA, Janda KD.

Chem Commun (Camb). 2017 Jul 18;53(58):8156-8159. doi: 10.1039/c7cc04055e.

33.

Conjugate Vaccine Immunotherapy for Substance Use Disorder.

Bremer PT, Janda KD.

Pharmacol Rev. 2017 Jul;69(3):298-315. doi: 10.1124/pr.117.013904. Review.

34.

Validation of onchocerciasis biomarker N-acetyltyramine-O-glucuronide (NATOG).

Globisch D, Eubanks LM, Shirey RJ, Pfarr KM, Wanji S, Debrah AY, Hoerauf A, Janda KD.

Bioorg Med Chem Lett. 2017 Aug 1;27(15):3436-3440. doi: 10.1016/j.bmcl.2017.05.082. Epub 2017 May 29.

35.

Development of a Clinically Viable Heroin Vaccine.

Bremer PT, Schlosburg JE, Banks ML, Steele FF, Zhou B, Poklis JL, Janda KD.

J Am Chem Soc. 2017 Jun 28;139(25):8601-8611. doi: 10.1021/jacs.7b03334. Epub 2017 Jun 20.

36.

Metal Ions Effectively Ablate the Action of Botulinum Neurotoxin A.

Bremer PT, Pellett S, Carolan JP, Tepp WH, Eubanks LM, Allen KN, Johnson EA, Janda KD.

J Am Chem Soc. 2017 May 31;139(21):7264-7272. doi: 10.1021/jacs.7b01084. Epub 2017 May 19.

37.

Effective active vaccination against methamphetamine in female rats.

Nguyen JD, Bremer PT, Hwang CS, Vandewater SA, Collins KC, Creehan KM, Janda KD, Taffe MA.

Drug Alcohol Depend. 2017 Jun 1;175:179-186. doi: 10.1016/j.drugalcdep.2017.03.005. Epub 2017 Apr 14.

38.

A synthetic small-molecule Isoxazole-9 protects against methamphetamine relapse.

Galinato MH, Lockner JW, Fannon-Pavlich MJ, Sobieraj JC, Staples MC, Somkuwar SS, Ghofranian A, Chaing S, Navarro AI, Joea A, Luikart BW, Janda KD, Heyser C, Koob GF, Mandyam CD.

Mol Psychiatry. 2018 Mar;23(3):629-638. doi: 10.1038/mp.2017.46. Epub 2017 Mar 28.

39.

The design and synthesis of an α-Gal trisaccharide epitope that provides a highly specific anti-Gal immune response.

Anraku K, Sato S, Jacob NT, Eubanks LM, Ellis BA, Janda KD.

Org Biomol Chem. 2017 Apr 5;15(14):2979-2992. doi: 10.1039/c7ob00448f.

40.

An Advance in Prescription Opioid Vaccines: Overdose Mortality Reduction and Extraordinary Alteration of Drug Half-Life.

Kimishima A, Wenthur CJ, Zhou B, Janda KD.

ACS Chem Biol. 2017 Jan 20;12(1):36-40. doi: 10.1021/acschembio.6b00977. Epub 2016 Nov 29.

41.

Newly Designed Quinolinol Inhibitors Mitigate the Effects of Botulinum Neurotoxin A in Enzymatic, Cell-Based, and ex Vivo Assays.

Bremer PT, Adler M, Phung CH, Singh AK, Janda KD.

J Med Chem. 2017 Jan 12;60(1):338-348. doi: 10.1021/acs.jmedchem.6b01393. Epub 2017 Jan 3.

42.

Influencing Antibody-Mediated Attenuation of Methamphetamine CNS Distribution through Vaccine Linker Design.

Gooyit M, Miranda PO, Wenthur CJ, Ducime A, Janda KD.

ACS Chem Neurosci. 2017 Mar 15;8(3):468-472. doi: 10.1021/acschemneuro.6b00389. Epub 2016 Dec 16.

43.

Active vaccination attenuates the psychostimulant effects of α-PVP and MDPV in rats.

Nguyen JD, Bremer PT, Ducime A, Creehan KM, Kisby BR, Taffe MA, Janda KD.

Neuropharmacology. 2017 Apr;116:1-8. doi: 10.1016/j.neuropharm.2016.12.005. Epub 2016 Dec 9.

44.

Structural Analysis Provides Mechanistic Insight into Nicotine Oxidoreductase from Pseudomonas putida.

Tararina MA, Janda KD, Allen KN.

Biochemistry. 2016 Dec 6;55(48):6595-6598. Epub 2016 Nov 18.

45.

Efficacy of an adenovirus-based anti-cocaine vaccine to reduce cocaine self-administration and reacqusition using a choice procedure in rhesus macaques.

Evans SM, Foltin RW, Hicks MJ, Rosenberg JB, De BP, Janda KD, Kaminsky SM, Crystal RG.

Pharmacol Biochem Behav. 2016 Nov - Dec;150-151:76-86. doi: 10.1016/j.pbb.2016.09.008. Epub 2016 Sep 30.

46.

Picolinic acids as β-exosite inhibitors of botulinum neurotoxin A light chain.

Bremer PT, Xue S, Janda KD.

Chem Commun (Camb). 2016 Oct 13;52(84):12521-12524.

47.

Cocaine Vaccine Development: Evaluation of Carrier and Adjuvant Combinations That Activate Multiple Toll-Like Receptors.

Kimishima A, Wenthur CJ, Eubanks LM, Sato S, Janda KD.

Mol Pharm. 2016 Nov 7;13(11):3884-3890. Epub 2016 Oct 18.

48.

Reprofiled anthelmintics abate hypervirulent stationary-phase Clostridium difficile.

Gooyit M, Janda KD.

Sci Rep. 2016 Sep 16;6:33642. doi: 10.1038/srep33642.

49.

Modulation of the Surface-Layer Protein of Clostridium difficile through Cwp84 Inhibition.

Gooyit MD, Janda KD.

ACS Infect Dis. 2016 Jul 8;2(7):465-70. doi: 10.1021/acsinfecdis.6b00061. Epub 2016 May 31.

PMID:
27626098
50.

Studies towards the improvement of an anti-cocaine monoclonal antibody for treatment of acute overdose.

Zhou B, Eubanks LM, Jacob NT, Ellis B, Roberts AJ, Janda KD.

Bioorg Med Chem Lett. 2016 Oct 15;26(20):5078-5081. doi: 10.1016/j.bmcl.2016.08.081. Epub 2016 Aug 25.

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