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Items: 1 to 50 of 389

1.

Prophylactic vaccination protects against the development of oxycodone self-administration.

Nguyen JD, Hwang CS, Grant Y, Janda KD, Taffe MA.

Neuropharmacology. 2018 Jun 22;138:292-303. doi: 10.1016/j.neuropharm.2018.06.026. [Epub ahead of print]

PMID:
29936242
2.

Crystallography Coupled with Kinetic Analysis Provides Mechanistic Underpinnings of a Nicotine-Degrading Enzyme.

Tararina MA, Xue S, Smith LC, Muellers SN, Miranda PO, Janda KD, Allen KN.

Biochemistry. 2018 Jul 3;57(26):3741-3751. doi: 10.1021/acs.biochem.8b00384. Epub 2018 Jun 13.

PMID:
29812904
3.

Efficient Syntheses of Cocaine Vaccines and Their in Vivo Evaluation.

Kimishima A, Olson ME, Natori Y, Janda KD.

ACS Med Chem Lett. 2018 Apr 16;9(5):411-416. doi: 10.1021/acsmedchemlett.8b00051. eCollection 2018 May 10.

4.

Efficacious Vaccine against Heroin Contaminated with Fentanyl.

Hwang CS, Smith LC, Natori Y, Ellis B, Zhou B, Janda KD.

ACS Chem Neurosci. 2018 Jun 20;9(6):1269-1275. doi: 10.1021/acschemneuro.8b00079. Epub 2018 Mar 23.

5.

Enhancing Efficacy and Stability of an Antiheroin Vaccine: Examination of Antinociception, Opioid Binding Profile, and Lethality.

Hwang CS, Bremer PT, Wenthur CJ, Ho SO, Chiang S, Ellis B, Zhou B, Fujii G, Janda KD.

Mol Pharm. 2018 Mar 5;15(3):1062-1072. doi: 10.1021/acs.molpharmaceut.7b00933. Epub 2018 Feb 19.

6.

Mining a Kröhnke Pyridine Library for Anti-Arenavirus Activity.

Miranda PO, Cubitt B, Jacob NT, Janda KD, de la Torre JC.

ACS Infect Dis. 2018 May 11;4(5):815-824. doi: 10.1021/acsinfecdis.7b00236. Epub 2018 Mar 1.

PMID:
29405696
7.

Investigations into the efficacy of multi-component cocaine vaccines.

Kimishima A, Olson ME, Janda KD.

Bioorg Med Chem Lett. 2017 Dec 20. pii: S0960-894X(17)31217-9. doi: 10.1016/j.bmcl.2017.12.043. [Epub ahead of print]

PMID:
29317163
8.

An enzymatic advance in nicotine cessation therapy.

Xue S, Kallupi M, Zhou B, Smith LC, Miranda PO, George O, Janda KD.

Chem Commun (Camb). 2018 Feb 13;54(14):1686-1689. doi: 10.1039/c7cc09134f.

PMID:
29308799
9.

Vaccines to combat the opioid crisis: Vaccines that prevent opioids and other substances of abuse from entering the brain could effectively treat addiction and abuse.

Olson ME, Janda KD.

EMBO Rep. 2018 Jan;19(1):5-9. doi: 10.15252/embr.201745322. Epub 2017 Dec 13. No abstract available.

PMID:
29237715
10.

A Vision for Vaccines: Combating the Opioid Epidemic.

Hwang CS, Janda KD.

Biochemistry. 2017 Oct 24;56(42):5625-5627. doi: 10.1021/acs.biochem.7b00948. Epub 2017 Oct 10. Review. No abstract available.

PMID:
28994583
11.

Vaccine-driven pharmacodynamic dissection and mitigation of fenethylline psychoactivity.

Wenthur CJ, Zhou B, Janda KD.

Nature. 2017 Aug 24;548(7668):476-479. doi: 10.1038/nature23464. Epub 2017 Aug 16.

12.

Augmenting the efficacy of anti-cocaine catalytic antibodies through chimeric hapten design and combinatorial vaccination.

Wenthur CJ, Cai X, Ellis BA, Janda KD.

Bioorg Med Chem Lett. 2017 Aug 15;27(16):3666-3668. doi: 10.1016/j.bmcl.2017.07.014. Epub 2017 Jul 5.

PMID:
28709828
13.

A bioconjugate leveraging xenoreactive antibodies to alleviate cocaine-induced behavior.

Jacob NT, Anraku K, Kimishima A, Zhou B, Collins KC, Lockner JW, Ellis BA, Janda KD.

Chem Commun (Camb). 2017 Jul 18;53(58):8156-8159. doi: 10.1039/c7cc04055e.

14.

Conjugate Vaccine Immunotherapy for Substance Use Disorder.

Bremer PT, Janda KD.

Pharmacol Rev. 2017 Jul;69(3):298-315. doi: 10.1124/pr.117.013904. Review.

15.

Validation of onchocerciasis biomarker N-acetyltyramine-O-glucuronide (NATOG).

Globisch D, Eubanks LM, Shirey RJ, Pfarr KM, Wanji S, Debrah AY, Hoerauf A, Janda KD.

Bioorg Med Chem Lett. 2017 Aug 1;27(15):3436-3440. doi: 10.1016/j.bmcl.2017.05.082. Epub 2017 May 29.

16.

Development of a Clinically Viable Heroin Vaccine.

Bremer PT, Schlosburg JE, Banks ML, Steele FF, Zhou B, Poklis JL, Janda KD.

J Am Chem Soc. 2017 Jun 28;139(25):8601-8611. doi: 10.1021/jacs.7b03334. Epub 2017 Jun 20.

17.

Metal Ions Effectively Ablate the Action of Botulinum Neurotoxin A.

Bremer PT, Pellett S, Carolan JP, Tepp WH, Eubanks LM, Allen KN, Johnson EA, Janda KD.

J Am Chem Soc. 2017 May 31;139(21):7264-7272. doi: 10.1021/jacs.7b01084. Epub 2017 May 19.

18.

Effective active vaccination against methamphetamine in female rats.

Nguyen JD, Bremer PT, Hwang CS, Vandewater SA, Collins KC, Creehan KM, Janda KD, Taffe MA.

Drug Alcohol Depend. 2017 Jun 1;175:179-186. doi: 10.1016/j.drugalcdep.2017.03.005. Epub 2017 Apr 14.

19.

A synthetic small-molecule Isoxazole-9 protects against methamphetamine relapse.

Galinato MH, Lockner JW, Fannon-Pavlich MJ, Sobieraj JC, Staples MC, Somkuwar SS, Ghofranian A, Chaing S, Navarro AI, Joea A, Luikart BW, Janda KD, Heyser C, Koob GF, Mandyam CD.

Mol Psychiatry. 2018 Mar;23(3):629-638. doi: 10.1038/mp.2017.46. Epub 2017 Mar 28.

20.

The design and synthesis of an α-Gal trisaccharide epitope that provides a highly specific anti-Gal immune response.

Anraku K, Sato S, Jacob NT, Eubanks LM, Ellis BA, Janda KD.

Org Biomol Chem. 2017 Apr 5;15(14):2979-2992. doi: 10.1039/c7ob00448f.

21.

An Advance in Prescription Opioid Vaccines: Overdose Mortality Reduction and Extraordinary Alteration of Drug Half-Life.

Kimishima A, Wenthur CJ, Zhou B, Janda KD.

ACS Chem Biol. 2017 Jan 20;12(1):36-40. doi: 10.1021/acschembio.6b00977. Epub 2016 Nov 29.

PMID:
28103678
22.

Newly Designed Quinolinol Inhibitors Mitigate the Effects of Botulinum Neurotoxin A in Enzymatic, Cell-Based, and ex Vivo Assays.

Bremer PT, Adler M, Phung CH, Singh AK, Janda KD.

J Med Chem. 2017 Jan 12;60(1):338-348. doi: 10.1021/acs.jmedchem.6b01393. Epub 2017 Jan 3.

23.

Influencing Antibody-Mediated Attenuation of Methamphetamine CNS Distribution through Vaccine Linker Design.

Gooyit M, Miranda PO, Wenthur CJ, Ducime A, Janda KD.

ACS Chem Neurosci. 2017 Mar 15;8(3):468-472. doi: 10.1021/acschemneuro.6b00389. Epub 2016 Dec 16.

24.

Active vaccination attenuates the psychostimulant effects of α-PVP and MDPV in rats.

Nguyen JD, Bremer PT, Ducime A, Creehan KM, Kisby BR, Taffe MA, Janda KD.

Neuropharmacology. 2017 Apr;116:1-8. doi: 10.1016/j.neuropharm.2016.12.005. Epub 2016 Dec 9.

25.

Structural Analysis Provides Mechanistic Insight into Nicotine Oxidoreductase from Pseudomonas putida.

Tararina MA, Janda KD, Allen KN.

Biochemistry. 2016 Dec 6;55(48):6595-6598. Epub 2016 Nov 18.

PMID:
27933790
26.

Efficacy of an adenovirus-based anti-cocaine vaccine to reduce cocaine self-administration and reacqusition using a choice procedure in rhesus macaques.

Evans SM, Foltin RW, Hicks MJ, Rosenberg JB, De BP, Janda KD, Kaminsky SM, Crystal RG.

Pharmacol Biochem Behav. 2016 Nov - Dec;150-151:76-86. doi: 10.1016/j.pbb.2016.09.008. Epub 2016 Sep 30.

27.

Picolinic acids as β-exosite inhibitors of botulinum neurotoxin A light chain.

Bremer PT, Xue S, Janda KD.

Chem Commun (Camb). 2016 Oct 13;52(84):12521-12524.

28.

Cocaine Vaccine Development: Evaluation of Carrier and Adjuvant Combinations That Activate Multiple Toll-Like Receptors.

Kimishima A, Wenthur CJ, Eubanks LM, Sato S, Janda KD.

Mol Pharm. 2016 Nov 7;13(11):3884-3890. Epub 2016 Oct 18.

PMID:
27717287
29.

Reprofiled anthelmintics abate hypervirulent stationary-phase Clostridium difficile.

Gooyit M, Janda KD.

Sci Rep. 2016 Sep 16;6:33642. doi: 10.1038/srep33642.

30.

Modulation of the Surface-Layer Protein of Clostridium difficile through Cwp84 Inhibition.

Gooyit MD, Janda KD.

ACS Infect Dis. 2016 Jul 8;2(7):465-70. doi: 10.1021/acsinfecdis.6b00061. Epub 2016 May 31.

PMID:
27626098
31.

Studies towards the improvement of an anti-cocaine monoclonal antibody for treatment of acute overdose.

Zhou B, Eubanks LM, Jacob NT, Ellis B, Roberts AJ, Janda KD.

Bioorg Med Chem Lett. 2016 Oct 15;26(20):5078-5081. doi: 10.1016/j.bmcl.2016.08.081. Epub 2016 Aug 25.

32.

Dissecting AI-2-mediated quorum sensing through C5-analogue synthesis and biochemical analysis.

Collins KC, Tsuchikama K, Lowery CA, Zhu J, Janda KD.

Tetrahedron. 2015 Jun;72(25):3593-3598.

33.

Cellular Protection of SNAP-25 against Botulinum Neurotoxin/A: Inhibition of Thioredoxin Reductase through a Suicide Substrate Mechanism.

Seki H, Xue S, Pellett S, Šilhár P, Johnson EA, Janda KD.

J Am Chem Soc. 2016 May 4;138(17):5568-75. doi: 10.1021/jacs.5b12929. Epub 2016 Apr 20.

34.

Methamphetamine Vaccines: Improvement through Hapten Design.

Collins KC, Schlosburg JE, Bremer PT, Janda KD.

J Med Chem. 2016 Apr 28;59(8):3878-85. doi: 10.1021/acs.jmedchem.6b00084. Epub 2016 Apr 19.

35.

Investigations of Enantiopure Nicotine Haptens Using an Adjuvanting Carrier in Anti-Nicotine Vaccine Development.

Jacob NT, Lockner JW, Schlosburg JE, Ellis BA, Eubanks LM, Janda KD.

J Med Chem. 2016 Mar 24;59(6):2523-9. doi: 10.1021/acs.jmedchem.5b01676. Epub 2016 Mar 7.

PMID:
26918428
36.

Lycopodium clavatum exine microcapsules enable safe oral delivery of 3,4-diaminopyridine for treatment of botulinum neurotoxin A intoxication.

Harris TL, Wenthur CJ, Diego-Taboada A, Mackenzie G, Corbitt TS, Janda KD.

Chem Commun (Camb). 2016 Mar 18;52(22):4187-90. doi: 10.1039/c6cc00615a.

PMID:
26906286
37.

Glycation Reactivity of a Quorum-Sensing Signaling Molecule.

Tsuchikama K, Gooyit M, Harris TL, Zhu J, Globisch D, Kaufmann GF, Janda KD.

Angew Chem Int Ed Engl. 2016 Mar 14;55(12):4002-6. doi: 10.1002/anie.201511911. Epub 2016 Feb 17.

38.

Combatting Synthetic Designer Opioids: A Conjugate Vaccine Ablates Lethal Doses of Fentanyl Class Drugs.

Bremer PT, Kimishima A, Schlosburg JE, Zhou B, Collins KC, Janda KD.

Angew Chem Int Ed Engl. 2016 Mar 7;55(11):3772-5. doi: 10.1002/anie.201511654. Epub 2016 Feb 16.

39.

MINCR is not a MYC-induced lncRNA.

Hart JR, Weinberg MS, Morris KV, Roberts TC, Janda KD, Garner AL, Vogt PK.

Proc Natl Acad Sci U S A. 2016 Feb 2;113(5):E496-7. doi: 10.1073/pnas.1519903113. Epub 2016 Jan 25. No abstract available.

40.

Litomosoides sigmodontis: a jird urine metabolome study.

Globisch D, Specht S, Pfarr KM, Eubanks LM, Hoerauf A, Janda KD.

Bioorg Med Chem Lett. 2015 Dec 15;25(24):5804-7. doi: 10.1016/j.bmcl.2015.10.037. Epub 2015 Oct 23.

PMID:
26573416
41.

A New Strategy for Smoking Cessation: Characterization of a Bacterial Enzyme for the Degradation of Nicotine.

Xue S, Schlosburg JE, Janda KD.

J Am Chem Soc. 2015 Aug 19;137(32):10136-9. doi: 10.1021/jacs.5b06605. Epub 2015 Aug 6.

PMID:
26237398
42.

Effects of active anti-methamphetamine vaccination on intravenous self-administration in rats.

Miller ML, Aarde SM, Moreno AY, Creehan KM, Janda KD, Taffe MA.

Drug Alcohol Depend. 2015 Aug 1;153:29-36. doi: 10.1016/j.drugalcdep.2015.06.014. Epub 2015 Jun 19.

43.

Onchocerca volvulus Molting Inhibitors Identified through Scaffold Hopping.

Gooyit M, Harris TL, Tricoche N, Javor S, Lustigman S, Janda KD.

ACS Infect Dis. 2015 May 8;1(5):198-202. doi: 10.1021/acsinfecdis.5b00017. Epub 2015 Mar 18.

PMID:
27622649
44.

Disarming Pseudomonas aeruginosa virulence factor LasB by leveraging a Caenorhabditis elegans infection model.

Zhu J, Cai X, Harris TL, Gooyit M, Wood M, Lardy M, Janda KD.

Chem Biol. 2015 Apr 23;22(4):483-491. doi: 10.1016/j.chembiol.2015.03.012. Epub 2015 Apr 16.

45.

Exploiting the Polypharmacology of ß-Carbolines to Disrupt O. volvulus Molting.

Gooyit M, Tricoche N, Javor S, Lustigman S, Janda KD.

ACS Med Chem Lett. 2015 Jan 20;6(3):339-43. doi: 10.1021/ml500516r. eCollection 2015 Mar 12.

46.

Toward the discovery of dual inhibitors for botulinum neurotoxin A: concomitant targeting of endocytosis and light chain protease activity.

Seki H, Xue S, Hixon MS, Pellett S, Remes M, Johnson EA, Janda KD.

Chem Commun (Camb). 2015 Apr 11;51(28):6226-9. doi: 10.1039/c5cc00677e.

PMID:
25759983
47.

Flagellin as carrier and adjuvant in cocaine vaccine development.

Lockner JW, Eubanks LM, Choi JL, Lively JM, Schlosburg JE, Collins KC, Globisch D, Rosenfeld-Gunn RJ, Wilson IA, Janda KD.

Mol Pharm. 2015 Feb 2;12(2):653-62. doi: 10.1021/mp500520r. Epub 2015 Jan 7.

48.

A conjugate vaccine using enantiopure hapten imparts superior nicotine-binding capacity.

Lockner JW, Lively JM, Collins KC, Vendruscolo JC, Azar MR, Janda KD.

J Med Chem. 2015 Jan 22;58(2):1005-11. doi: 10.1021/jm501625j. Epub 2014 Dec 17.

PMID:
25493909
49.

In vivo quantification and perturbation of Myc-Max interactions and the impact on oncogenic potential.

Raffeiner P, Röck R, Schraffl A, Hartl M, Hart JR, Janda KD, Vogt PK, Stefan E, Bister K.

Oncotarget. 2014 Oct 15;5(19):8869-78.

50.

Probing BoNT/A protease exosites: implications for inhibitor design and light chain longevity.

Xue S, Javor S, Hixon MS, Janda KD.

Biochemistry. 2014 Nov 4;53(43):6820-4. doi: 10.1021/bi500950x. Epub 2014 Oct 21.

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