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Items: 1 to 50 of 116


Ventral Tegmental Dopamine Neurons Participate in Reward Identity Predictions.

Keiflin R, Pribut HJ, Shah NB, Janak PH.

Curr Biol. 2019 Jan 7;29(1):93-103.e3. doi: 10.1016/j.cub.2018.11.050. Epub 2018 Dec 20.


Ventral pallidum encodes relative reward value earlier and more robustly than nucleus accumbens.

Ottenheimer D, Richard JM, Janak PH.

Nat Commun. 2018 Oct 19;9(1):4350. doi: 10.1038/s41467-018-06849-z.


Dopamine neurons create Pavlovian conditioned stimuli with circuit-defined motivational properties.

Saunders BT, Richard JM, Margolis EB, Janak PH.

Nat Neurosci. 2018 Aug;21(8):1072-1083. doi: 10.1038/s41593-018-0191-4. Epub 2018 Jul 23.


Stressing the other paraventricular nucleus.

Fraser KM, Janak PH.

Nat Neurosci. 2018 Jul;21(7):901-902. doi: 10.1038/s41593-018-0178-1. No abstract available.


Ventral pallidal encoding of reward-seeking behavior depends on the underlying associative structure.

Richard JM, Stout N, Acs D, Janak PH.

Elife. 2018 Mar 22;7. pii: e33107. doi: 10.7554/eLife.33107.


Error-Driven Learning: Dopamine Signals More Than Value-Based Errors.

Keiflin R, Janak PH.

Curr Biol. 2017 Dec 18;27(24):R1321-R1324. doi: 10.1016/j.cub.2017.10.043.


Inhibiting Mesolimbic Dopamine Neurons Reduces the Initiation and Maintenance of Instrumental Responding.

Fischbach-Weiss S, Reese RM, Janak PH.

Neuroscience. 2018 Feb 21;372:306-315. doi: 10.1016/j.neuroscience.2017.12.003. Epub 2017 Dec 15.


Lever Insertion as a Salient Stimulus Promoting Insensitivity to Outcome Devaluation.

Vandaele Y, Pribut HJ, Janak PH.

Front Integr Neurosci. 2017 Sep 27;11:23. doi: 10.3389/fnint.2017.00023. eCollection 2017.


Optogenetic activation of amygdala projections to nucleus accumbens can arrest conditioned and unconditioned alcohol consummatory behavior.

Millan EZ, Kim HA, Janak PH.

Neuroscience. 2017 Sep 30;360:106-117. doi: 10.1016/j.neuroscience.2017.07.044. Epub 2017 Jul 28.


Long-lasting contribution of dopamine in the nucleus accumbens core, but not dorsal lateral striatum, to sign-tracking.

Fraser KM, Janak PH.

Eur J Neurosci. 2017 Aug;46(4):2047-2055. doi: 10.1111/ejn.13642. Epub 2017 Aug 1.


Defining the place of habit in substance use disorders.

Vandaele Y, Janak PH.

Prog Neuropsychopharmacol Biol Psychiatry. 2018 Dec 20;87(Pt A):22-32. doi: 10.1016/j.pnpbp.2017.06.029. Epub 2017 Jun 27. Review.


Changes in the Influence of Alcohol-Paired Stimuli on Alcohol Seeking across Extended Training.

Corbit LH, Janak PH.

Front Psychiatry. 2016 Oct 10;7:169. eCollection 2016.


Ventral Pallidum Neurons Encode Incentive Value and Promote Cue-Elicited Instrumental Actions.

Richard JM, Ambroggi F, Janak PH, Fields HL.

Neuron. 2016 Jun 15;90(6):1165-1173. doi: 10.1016/j.neuron.2016.04.037. Epub 2016 May 26.


Habitual Alcohol Seeking: Neural Bases and Possible Relations to Alcohol Use Disorders.

Corbit LH, Janak PH.

Alcohol Clin Exp Res. 2016 Jul;40(7):1380-9. doi: 10.1111/acer.13094. Epub 2016 May 25. Review.


Nucleus accumbens core and shell are differentially involved in general and outcome-specific forms of Pavlovian-instrumental transfer with alcohol and sucrose rewards.

Corbit LH, Fischbach SC, Janak PH.

Eur J Neurosci. 2016 May;43(9):1229-36. doi: 10.1111/ejn.13235. Epub 2016 Mar 31.


Long-range orbitofrontal and amygdala axons show divergent patterns of maturation in the frontal cortex across adolescence.

Johnson CM, Loucks FA, Peckler H, Thomas AW, Janak PH, Wilbrecht L.

Dev Cogn Neurosci. 2016 Apr;18:113-20. doi: 10.1016/j.dcn.2016.01.005. Epub 2016 Feb 4.


A Transgenic Rat for Investigating the Anatomy and Function of Corticotrophin Releasing Factor Circuits.

Pomrenze MB, Millan EZ, Hopf FW, Keiflin R, Maiya R, Blasio A, Dadgar J, Kharazia V, De Guglielmo G, Crawford E, Janak PH, George O, Rice KC, Messing RO.

Front Neurosci. 2015 Dec 24;9:487. doi: 10.3389/fnins.2015.00487. eCollection 2015.


Dopamine Prediction Errors in Reward Learning and Addiction: From Theory to Neural Circuitry.

Keiflin R, Janak PH.

Neuron. 2015 Oct 21;88(2):247-63. doi: 10.1016/j.neuron.2015.08.037. Review.


Optogenetics: 10 years after ChR2 in neurons--views from the community.

Adamantidis A, Arber S, Bains JS, Bamberg E, Bonci A, Buzsáki G, Cardin JA, Costa RM, Dan Y, Goda Y, Graybiel AM, Häusser M, Hegemann P, Huguenard JR, Insel TR, Janak PH, Johnston D, Josselyn SA, Koch C, Kreitzer AC, Lüscher C, Malenka RC, Miesenböck G, Nagel G, Roska B, Schnitzer MJ, Shenoy KV, Soltesz I, Sternson SM, Tsien RW, Tsien RY, Turrigiano GG, Tye KM, Wilson RI.

Nat Neurosci. 2015 Sep;18(9):1202-12. doi: 10.1038/nn.4106. Review. No abstract available.


Contemporary approaches to neural circuit manipulation and mapping: focus on reward and addiction.

Saunders BT, Richard JM, Janak PH.

Philos Trans R Soc Lond B Biol Sci. 2015 Sep 19;370(1677):20140210. doi: 10.1098/rstb.2014.0210. Review.


Alcohol-Seeking Triggered by Discrete Pavlovian Cues is Invigorated by Alcohol Contexts and Mediated by Glutamate Signaling in the Basolateral Amygdala.

Sciascia JM, Reese RM, Janak PH, Chaudhri N.

Neuropsychopharmacology. 2015 Nov;40(12):2801-12. doi: 10.1038/npp.2015.130. Epub 2015 May 8.


Nucleus Accumbens and Posterior Amygdala Mediate Cue-Triggered Alcohol Seeking and Suppress Behavior During the Omission of Alcohol-Predictive Cues.

Millan EZ, Reese RM, Grossman CD, Chaudhri N, Janak PH.

Neuropsychopharmacology. 2015 Oct;40(11):2555-65. doi: 10.1038/npp.2015.102. Epub 2015 Apr 15.


From circuits to behaviour in the amygdala.

Janak PH, Tye KM.

Nature. 2015 Jan 15;517(7534):284-92. doi: 10.1038/nature14188. Review.


Habitual responding for alcohol depends upon both AMPA and D2 receptor signaling in the dorsolateral striatum.

Corbit LH, Nie H, Janak PH.

Front Behav Neurosci. 2014 Sep 2;8:301. doi: 10.3389/fnbeh.2014.00301. eCollection 2014.


Positive reinforcement mediated by midbrain dopamine neurons requires D1 and D2 receptor activation in the nucleus accumbens.

Steinberg EE, Boivin JR, Saunders BT, Witten IB, Deisseroth K, Janak PH.

PLoS One. 2014 Apr 14;9(4):e94771. doi: 10.1371/journal.pone.0094771. eCollection 2014.


Pavlovian-conditioned alcohol-seeking behavior in rats is invigorated by the interaction between discrete and contextual alcohol cues: implications for relapse.

Remedios J, Woods C, Tardif C, Janak PH, Chaudhri N.

Brain Behav. 2014 Mar;4(2):278-89. doi: 10.1002/brb3.216. Epub 2014 Feb 6.


Nucleus accumbens plasticity underlies multifaceted behavioral changes associated with addiction.

Saunders BT, Janak PH.

Biol Psychiatry. 2014 Jan 15;75(2):92-3. doi: 10.1016/j.biopsych.2013.11.003. No abstract available.


The orbitofrontal cortex as part of a hierarchical neural system mediating choice between two good options.

Keiflin R, Reese RM, Woods CA, Janak PH.

J Neurosci. 2013 Oct 2;33(40):15989-98. doi: 10.1523/JNEUROSCI.0026-13.2013.


Disruption of alcohol-related memories by mTORC1 inhibition prevents relapse.

Barak S, Liu F, Ben Hamida S, Yowell QV, Neasta J, Kharazia V, Janak PH, Ron D.

Nat Neurosci. 2013 Aug;16(8):1111-7. doi: 10.1038/nn.3439. Epub 2013 Jun 23.


Unilateral inactivation of the basolateral amygdala attenuates context-induced renewal of Pavlovian-conditioned alcohol-seeking.

Chaudhri N, Woods CA, Sahuque LL, Gill TM, Janak PH.

Eur J Neurosci. 2013 Sep;38(5):2751-61. doi: 10.1111/ejn.12278. Epub 2013 Jun 12.


A causal link between prediction errors, dopamine neurons and learning.

Steinberg EE, Keiflin R, Boivin JR, Witten IB, Deisseroth K, Janak PH.

Nat Neurosci. 2013 Jul;16(7):966-73. doi: 10.1038/nn.3413. Epub 2013 May 26.


Safety encoding in the basal amygdala.

Sangha S, Chadick JZ, Janak PH.

J Neurosci. 2013 Feb 27;33(9):3744-51. doi: 10.1523/JNEUROSCI.3302-12.2013.


BDNF-mediated regulation of ethanol consumption requires the activation of the MAP kinase pathway and protein synthesis.

Jeanblanc J, Logrip ML, Janak PH, Ron D.

Eur J Neurosci. 2013 Feb;37(4):607-12. doi: 10.1111/ejn.12067. Epub 2012 Nov 28.


The small G protein H-Ras in the mesolimbic system is a molecular gateway to alcohol-seeking and excessive drinking behaviors.

Ben Hamida S, Neasta J, Lasek AW, Kharazia V, Zou M, Carnicella S, Janak PH, Ron D.

J Neurosci. 2012 Nov 7;32(45):15849-58. doi: 10.1523/JNEUROSCI.2846-12.2012.


Establishing causality for dopamine in neural function and behavior with optogenetics.

Steinberg EE, Janak PH.

Brain Res. 2013 May 20;1511:46-64. doi: 10.1016/j.brainres.2012.09.036. Epub 2012 Sep 29. Review.


Responses to ethanol in C57BL/6 versus C57BL/6 × 129 hybrid mice.

Lim JP, Zou ME, Janak PH, Messing RO.

Brain Behav. 2012 Jan;2(1):22-31. doi: 10.1002/brb3.29.


Habitual alcohol seeking: time course and the contribution of subregions of the dorsal striatum.

Corbit LH, Nie H, Janak PH.

Biol Psychiatry. 2012 Sep 1;72(5):389-95. doi: 10.1016/j.biopsych.2012.02.024. Epub 2012 Mar 20.


Microinjection of glycine into the ventral tegmental area selectively decreases ethanol consumption.

Li J, Nie H, Bian W, Dave V, Janak PH, Ye JH.

J Pharmacol Exp Ther. 2012 Apr;341(1):196-204. doi: 10.1124/jpet.111.190058. Epub 2012 Jan 11.


Similar neural activity during fear and disgust in the rat basolateral amygdala.

Shabel SJ, Schairer W, Donahue RJ, Powell V, Janak PH.

PLoS One. 2011;6(12):e27797. doi: 10.1371/journal.pone.0027797. Epub 2011 Dec 14.


Recombinase-driver rat lines: tools, techniques, and optogenetic application to dopamine-mediated reinforcement.

Witten IB, Steinberg EE, Lee SY, Davidson TJ, Zalocusky KA, Brodsky M, Yizhar O, Cho SL, Gong S, Ramakrishnan C, Stuber GD, Tye KM, Janak PH, Deisseroth K.

Neuron. 2011 Dec 8;72(5):721-33. doi: 10.1016/j.neuron.2011.10.028.


Compound stimulus presentation and the norepinephrine reuptake inhibitor atomoxetine enhance long-term extinction of cocaine-seeking behavior.

Janak PH, Bowers MS, Corbit LH.

Neuropsychopharmacology. 2012 Mar;37(4):975-85. doi: 10.1038/npp.2011.281. Epub 2011 Nov 16.


Alpha4 subunit-containing GABAA receptors in the accumbens shell contribute to the reinforcing effects of alcohol.

Rewal M, Donahue R, Gill TM, Nie H, Ron D, Janak PH.

Addict Biol. 2012 Mar;17(2):309-21. doi: 10.1111/j.1369-1600.2011.00333.x. Epub 2011 Apr 20.


Extrasynaptic delta-containing GABAA receptors in the nucleus accumbens dorsomedial shell contribute to alcohol intake.

Nie H, Rewal M, Gill TM, Ron D, Janak PH.

Proc Natl Acad Sci U S A. 2011 Mar 15;108(11):4459-64. doi: 10.1073/pnas.1016156108. Epub 2011 Feb 22.


Deepened extinction following compound stimulus presentation: noradrenergic modulation.

Janak PH, Corbit LH.

Learn Mem. 2010 Dec 14;18(1):1-10. doi: 10.1101/lm.1923211. Print 2011 Jan.


Posterior dorsomedial striatum is critical for both selective instrumental and Pavlovian reward learning.

Corbit LH, Janak PH.

Eur J Neurosci. 2010 Apr;31(7):1312-21. doi: 10.1111/j.1460-9568.2010.07153.x. Epub 2010 Mar 19.


Dissociable roles of the medial prefrontal cortex and nucleus accumbens core in goal-directed actions for differential reward magnitude.

Gill TM, Castaneda PJ, Janak PH.

Cereb Cortex. 2010 Dec;20(12):2884-99. doi: 10.1093/cercor/bhq036. Epub 2010 Mar 22.


Methylphenidate facilitates learning-induced amygdala plasticity.

Tye KM, Tye LD, Cone JJ, Hekkelman EF, Janak PH, Bonci A.

Nat Neurosci. 2010 Apr;13(4):475-81. doi: 10.1038/nn.2506. Epub 2010 Mar 7.


Altered glutamatergic neurotransmission in the striatum regulates ethanol sensitivity and intake in mice lacking ENT1.

Chen J, Nam HW, Lee MR, Hinton DJ, Choi S, Kim T, Kawamura T, Janak PH, Choi DS.

Behav Brain Res. 2010 Apr 2;208(2):636-42. doi: 10.1016/j.bbr.2010.01.011. Epub 2010 Jan 18.


Amygdala neural encoding of the absence of reward during extinction.

Tye KM, Cone JJ, Schairer WW, Janak PH.

J Neurosci. 2010 Jan 6;30(1):116-25. doi: 10.1523/JNEUROSCI.4240-09.2010.

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