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Items: 1 to 50 of 406

1.

TMEM16B regulates anxiety-related behavior and GABAergic neuronal signaling in the central lateral amygdala.

Li KX, He M, Ye W, Simms J, Gill M, Xiang X, Jan YN, Jan LY.

Elife. 2019 Sep 4;8. pii: e47106. doi: 10.7554/eLife.47106.

2.

Cryo-EM Studies of TMEM16F Calcium-Activated Ion Channel Suggest Features Important for Lipid Scrambling.

Feng S, Dang S, Han TW, Ye W, Jin P, Cheng T, Li J, Jan YN, Jan LY, Cheng Y.

Cell Rep. 2019 Jul 30;28(5):1385. doi: 10.1016/j.celrep.2019.07.052. No abstract available.

3.

TMEM16B Calcium-Activated Chloride Channels Regulate Action Potential Firing in Lateral Septum and Aggression in Male Mice.

Wang L, Simms J, Peters CJ, Tynan-La Fontaine M, Li K, Gill TM, Jan YN, Jan LY.

J Neurosci. 2019 Sep 4;39(36):7102-7117. doi: 10.1523/JNEUROSCI.3137-18.2019. Epub 2019 Jul 18.

PMID:
31320449
4.

Thermoregulation via Temperature-Dependent PGD2 Production in Mouse Preoptic Area.

Wang TA, Teo CF, Åkerblom M, Chen C, Tynan-La Fontaine M, Greiner VJ, Diaz A, McManus MT, Jan YN, Jan LY.

Neuron. 2019 Jul 17;103(2):349. doi: 10.1016/j.neuron.2019.06.026. No abstract available.

PMID:
31319050
5.

Dynamic change of electrostatic field in TMEM16F permeation pathway shifts its ion selectivity.

Ye W, Han TW, He M, Jan YN, Jan LY.

Elife. 2019 Jul 18;8. pii: e45187. doi: 10.7554/eLife.45187.

6.

Cryo-EM Studies of TMEM16F Calcium-Activated Ion Channel Suggest Features Important for Lipid Scrambling.

Feng S, Dang S, Han TW, Ye W, Jin P, Cheng T, Li J, Jan YN, Jan LY, Cheng Y.

Cell Rep. 2019 Jul 9;28(2):567-579.e4. doi: 10.1016/j.celrep.2019.06.023. Erratum in: Cell Rep. 2019 Jul 30;28(5):1385.

7.

The multifaceted role of TMEM16A in cancer.

Crottès D, Jan LY.

Cell Calcium. 2019 Sep;82:102050. doi: 10.1016/j.ceca.2019.06.004. Epub 2019 Jun 14. Review.

PMID:
31279157
8.

TMEM16A controls EGF-induced calcium signaling implicated in pancreatic cancer prognosis.

Crottès D, Lin YT, Peters CJ, Gilchrist JM, Wiita AP, Jan YN, Jan LY.

Proc Natl Acad Sci U S A. 2019 Jun 25;116(26):13026-13035. doi: 10.1073/pnas.1900703116. Epub 2019 Jun 10.

PMID:
31182586
9.

Thermoregulation via Temperature-Dependent PGD2 Production in Mouse Preoptic Area.

Wang TA, Teo CF, Åkerblom M, Chen C, Tynan-La Fontaine M, Greiner VJ, Diaz A, McManus MT, Jan YN, Jan LY.

Neuron. 2019 Jul 17;103(2):309-322.e7. doi: 10.1016/j.neuron.2019.04.035. Epub 2019 May 28. Erratum in: Neuron. 2019 Jul 17;103(2):349.

PMID:
31151773
10.

The Mechanosensitive Ion Channel Piezo Inhibits Axon Regeneration.

Song Y, Li D, Farrelly O, Miles L, Li F, Kim SE, Lo TY, Wang F, Li T, Thompson-Peer KL, Gong J, Murthy SE, Coste B, Yakubovich N, Patapoutian A, Xiang Y, Rompolas P, Jan LY, Jan YN.

Neuron. 2019 Apr 17;102(2):373-389.e6. doi: 10.1016/j.neuron.2019.01.050. Epub 2019 Feb 25.

11.

Glial ensheathment of the somatodendritic compartment regulates sensory neuron structure and activity.

Yadav S, Younger SH, Zhang L, Thompson-Peer KL, Li T, Jan LY, Jan YN.

Proc Natl Acad Sci U S A. 2019 Mar 12;116(11):5126-5134. doi: 10.1073/pnas.1814456116. Epub 2019 Feb 25.

12.

Chemically induced vesiculation as a platform for studying TMEM16F activity.

Han TW, Ye W, Bethel NP, Zubia M, Kim A, Li KH, Burlingame AL, Grabe M, Jan YN, Jan LY.

Proc Natl Acad Sci U S A. 2019 Jan 22;116(4):1309-1318. doi: 10.1073/pnas.1817498116. Epub 2019 Jan 8.

13.

Activation of orexin system facilitates anesthesia emergence and pain control.

Zhou W, Cheung K, Kyu S, Wang L, Guan Z, Kurien PA, Bickler PE, Jan LY.

Proc Natl Acad Sci U S A. 2018 Nov 6;115(45):E10740-E10747. doi: 10.1073/pnas.1808622115. Epub 2018 Oct 22.

14.

Influences: Cold Spring Harbor summer courses and Drosophila melanogaster neurogenetics.

Jan LY, Jan YN.

J Gen Physiol. 2018 Jun 4;150(6):773-775. doi: 10.1085/jgp.201812063. Epub 2018 May 16. No abstract available.

15.

Dendrite regeneration of adult Drosophila sensory neurons diminishes with aging and is inhibited by epidermal-derived matrix metalloproteinase 2.

DeVault L, Li T, Izabel S, Thompson-Peer KL, Jan LY, Jan YN.

Genes Dev. 2018 Mar 1;32(5-6):402-414. doi: 10.1101/gad.308270.117. Epub 2018 Mar 21.

16.

The Sixth Transmembrane Segment Is a Major Gating Component of the TMEM16A Calcium-Activated Chloride Channel.

Peters CJ, Gilchrist JM, Tien J, Bethel NP, Qi L, Chen T, Wang L, Jan YN, Grabe M, Jan LY.

Neuron. 2018 Mar 7;97(5):1063-1077.e4. doi: 10.1016/j.neuron.2018.01.048. Epub 2018 Feb 22.

17.

Force-activated ion channels in close-up.

Jan YN, Jan LY.

Nature. 2018 Feb 22;554(7693):469-470. doi: 10.1038/d41586-018-01631-z. No abstract available.

PMID:
29469134
18.

Phosphatidylinositol-(4, 5)-bisphosphate regulates calcium gating of small-conductance cation channel TMEM16F.

Ye W, Han TW, Nassar LM, Zubia M, Jan YN, Jan LY.

Proc Natl Acad Sci U S A. 2018 Feb 13;115(7):E1667-E1674. doi: 10.1073/pnas.1718728115. Epub 2018 Jan 30.

19.

Cryo-EM structures of the TMEM16A calcium-activated chloride channel.

Dang S, Feng S, Tien J, Peters CJ, Bulkley D, Lolicato M, Zhao J, Zuberbühler K, Ye W, Qi L, Chen T, Craik CS, Jan YN, Minor DL Jr, Cheng Y, Jan LY.

Nature. 2017 Dec 21;552(7685):426-429. doi: 10.1038/nature25024. Epub 2017 Dec 13.

20.

Cytoplasmic Cl- couples membrane remodeling to epithelial morphogenesis.

He M, Ye W, Wang WJ, Sison ES, Jan YN, Jan LY.

Proc Natl Acad Sci U S A. 2017 Dec 26;114(52):E11161-E11169. doi: 10.1073/pnas.1714448115. Epub 2017 Dec 11.

21.

Phospholipid Homeostasis Regulates Dendrite Morphogenesis in Drosophila Sensory Neurons.

Meltzer S, Bagley JA, Perez GL, O'Brien CE, DeVault L, Guo Y, Jan LY, Jan YN.

Cell Rep. 2017 Oct 24;21(4):859-866. doi: 10.1016/j.celrep.2017.09.089.

22.

Inferior Olivary TMEM16B Mediates Cerebellar Motor Learning.

Zhang Y, Zhang Z, Xiao S, Tien J, Le S, Le T, Jan LY, Yang H.

Neuron. 2017 Aug 30;95(5):1103-1111.e4. doi: 10.1016/j.neuron.2017.08.010.

23.

Composition and Control of a Deg/ENaC Channel during Presynaptic Homeostatic Plasticity.

Orr BO, Gorczyca D, Younger MA, Jan LY, Jan YN, Davis GW.

Cell Rep. 2017 Aug 22;20(8):1855-1866. doi: 10.1016/j.celrep.2017.07.074.

24.

Electron cryo-microscopy structure of the mechanotransduction channel NOMPC.

Jin P, Bulkley D, Guo Y, Zhang W, Guo Z, Huynh W, Wu S, Meltzer S, Cheng T, Jan LY, Jan YN, Cheng Y.

Nature. 2017 Jul 6;547(7661):118-122. doi: 10.1038/nature22981. Epub 2017 Jun 26.

25.

Age-dependent diastolic heart failure in an in vivo Drosophila model.

Klassen MP, Peters CJ, Zhou S, Williams HH, Jan LY, Jan YN.

Elife. 2017 Mar 22;6. pii: e20851. doi: 10.7554/eLife.20851.

26.

TAOK2 Kinase Mediates PSD95 Stability and Dendritic Spine Maturation through Septin7 Phosphorylation.

Yadav S, Oses-Prieto JA, Peters CJ, Zhou J, Pleasure SJ, Burlingame AL, Jan LY, Jan YN.

Neuron. 2017 Jan 18;93(2):379-393. doi: 10.1016/j.neuron.2016.12.006. Epub 2017 Jan 5.

27.

A Defensive Kicking Behavior in Response to Mechanical Stimuli Mediated by Drosophila Wing Margin Bristles.

Li J, Zhang W, Guo Z, Wu S, Jan LY, Jan YN.

J Neurosci. 2016 Nov 2;36(44):11275-11282.

28.

In vivo dendrite regeneration after injury is different from dendrite development.

Thompson-Peer KL, DeVault L, Li T, Jan LY, Jan YN.

Genes Dev. 2016 Aug 1;30(15):1776-89. doi: 10.1101/gad.282848.116.

29.

N-linked glycosylation of Kv1.2 voltage-gated potassium channel facilitates cell surface expression and enhances the stability of internalized channels.

Thayer DA, Yang SB, Jan YN, Jan LY.

J Physiol. 2016 Nov 15;594(22):6701-6713. doi: 10.1113/JP272394. Epub 2016 Aug 2.

30.

Transmembrane channel-like (tmc) gene regulates Drosophila larval locomotion.

Guo Y, Wang Y, Zhang W, Meltzer S, Zanini D, Yu Y, Li J, Cheng T, Guo Z, Wang Q, Jacobs JS, Sharma Y, Eberl DF, Göpfert MC, Jan LY, Jan YN, Wang Z.

Proc Natl Acad Sci U S A. 2016 Jun 28;113(26):7243-8. doi: 10.1073/pnas.1606537113. Epub 2016 Jun 13.

31.

Phosphorylation of β-Tubulin by the Down Syndrome Kinase, Minibrain/DYRK1a, Regulates Microtubule Dynamics and Dendrite Morphogenesis.

Ori-McKenney KM, McKenney RJ, Huang HH, Li T, Meltzer S, Jan LY, Vale RD, Wiita AP, Jan YN.

Neuron. 2016 May 4;90(3):551-63. doi: 10.1016/j.neuron.2016.03.027. Epub 2016 Apr 21.

32.

Epidermis-Derived Semaphorin Promotes Dendrite Self-Avoidance by Regulating Dendrite-Substrate Adhesion in Drosophila Sensory Neurons.

Meltzer S, Yadav S, Lee J, Soba P, Younger SH, Jin P, Zhang W, Parrish J, Jan LY, Jan YN.

Neuron. 2016 Feb 17;89(4):741-55. doi: 10.1016/j.neuron.2016.01.020. Epub 2016 Feb 4.

33.

Neutrophil-derived microvesicles enter cartilage and protect the joint in inflammatory arthritis.

Headland SE, Jones HR, Norling LV, Kim A, Souza PR, Corsiero E, Gil CD, Nerviani A, Dell'Accio F, Pitzalis C, Oliani SM, Jan LY, Perretti M.

Sci Transl Med. 2015 Nov 25;7(315):315ra190. doi: 10.1126/scitranslmed.aac5608.

34.

Dorsal Horn Parvalbumin Neurons Are Gate-Keepers of Touch-Evoked Pain after Nerve Injury.

Petitjean H, Pawlowski SA, Fraine SL, Sharif B, Hamad D, Fatima T, Berg J, Brown CM, Jan LY, Ribeiro-da-Silva A, Braz JM, Basbaum AI, Sharif-Naeini R.

Cell Rep. 2015 Nov 10;13(6):1246-1257. doi: 10.1016/j.celrep.2015.09.080. Epub 2015 Oct 29.

35.

Ankyrin Repeats Convey Force to Gate the NOMPC Mechanotransduction Channel.

Zhang W, Cheng LE, Kittelmann M, Li J, Petkovic M, Cheng T, Jin P, Guo Z, Göpfert MC, Jan LY, Jan YN.

Cell. 2015 Sep 10;162(6):1391-403. doi: 10.1016/j.cell.2015.08.024.

36.

EAG2 potassium channel with evolutionarily conserved function as a brain tumor target.

Huang X, He Y, Dubuc AM, Hashizume R, Zhang W, Reimand J, Yang H, Wang TA, Stehbens SJ, Younger S, Barshow S, Zhu S, Cooper MK, Peacock J, Ramaswamy V, Garzia L, Wu X, Remke M, Forester CM, Kim CC, Weiss WA, James CD, Shuman MA, Bader GD, Mueller S, Taylor MD, Jan YN, Jan LY.

Nat Neurosci. 2015 Sep;18(9):1236-46. doi: 10.1038/nn.4088. Epub 2015 Aug 10.

37.

Regulation of axon regeneration by the RNA repair and splicing pathway.

Song Y, Sretavan D, Salegio EA, Berg J, Huang X, Cheng T, Xiong X, Meltzer S, Han C, Nguyen TT, Bresnahan JC, Beattie MS, Jan LY, Jan YN.

Nat Neurosci. 2015 Jun;18(6):817-25. doi: 10.1038/nn.4019. Epub 2015 May 11.

38.

The Ret receptor regulates sensory neuron dendrite growth and integrin mediated adhesion.

Soba P, Han C, Zheng Y, Perea D, Miguel-Aliaga I, Jan LY, Jan YN.

Elife. 2015 Mar 12;4. doi: 10.7554/eLife.05491.

39.

Four basic residues critical for the ion selectivity and pore blocker sensitivity of TMEM16A calcium-activated chloride channels.

Peters CJ, Yu H, Tien J, Jan YN, Li M, Jan LY.

Proc Natl Acad Sci U S A. 2015 Mar 17;112(11):3547-52. doi: 10.1073/pnas.1502291112. Epub 2015 Mar 2.

40.

Protein mutated in paroxysmal dyskinesia interacts with the active zone protein RIM and suppresses synaptic vesicle exocytosis.

Shen Y, Ge WP, Li Y, Hirano A, Lee HY, Rohlmann A, Missler M, Tsien RW, Jan LY, Fu YH, Ptáček LJ.

Proc Natl Acad Sci U S A. 2015 Mar 10;112(10):2935-41. doi: 10.1073/pnas.1501364112. Epub 2015 Feb 17.

41.

MST3 kinase phosphorylates TAO1/2 to enable Myosin Va function in promoting spine synapse development.

Ultanir SK, Yadav S, Hertz NT, Oses-Prieto JA, Claxton S, Burlingame AL, Shokat KM, Jan LY, Jan YN.

Neuron. 2014 Dec 3;84(5):968-82. doi: 10.1016/j.neuron.2014.10.025. Epub 2014 Nov 13.

42.

Identification of Ppk26, a DEG/ENaC Channel Functioning with Ppk1 in a Mutually Dependent Manner to Guide Locomotion Behavior in Drosophila.

Gorczyca DA, Younger S, Meltzer S, Kim SE, Cheng L, Song W, Lee HY, Jan LY, Jan YN.

Cell Rep. 2014 Nov 20;9(4):1446-58. doi: 10.1016/j.celrep.2014.10.034. Epub 2014 Nov 6.

43.
44.

Common variants associated with general and MMR vaccine-related febrile seizures.

Feenstra B, Pasternak B, Geller F, Carstensen L, Wang T, Huang F, Eitson JL, Hollegaard MV, Svanström H, Vestergaard M, Hougaard DM, Schoggins JW, Jan LY, Melbye M, Hviid A.

Nat Genet. 2014 Dec;46(12):1274-82. doi: 10.1038/ng.3129. Epub 2014 Oct 26.

45.

Double-bromo and extraterminal (BET) domain proteins regulate dendrite morphology and mechanosensory function.

Bagley JA, Yan Z, Zhang W, Wildonger J, Jan LY, Jan YN.

Genes Dev. 2014 Sep 1;28(17):1940-56. doi: 10.1101/gad.239962.114.

46.

Targeting potassium channels in cancer.

Huang X, Jan LY.

J Cell Biol. 2014 Jul 21;206(2):151-62. doi: 10.1083/jcb.201404136. Review.

47.

A comprehensive search for calcium binding sites critical for TMEM16A calcium-activated chloride channel activity.

Tien J, Peters CJ, Wong XM, Cheng T, Jan YN, Jan LY, Yang H.

Elife. 2014 Jun 30;3. doi: 10.7554/eLife.02772.

48.

Cardiac BIN1 folds T-tubule membrane, controlling ion flux and limiting arrhythmia.

Hong T, Yang H, Zhang SS, Cho HC, Kalashnikova M, Sun B, Zhang H, Bhargava A, Grabe M, Olgin J, Gorelik J, Marbán E, Jan LY, Shaw RM.

Nat Med. 2014 Jun;20(6):624-32. doi: 10.1038/nm.3543. Epub 2014 May 18.

49.

An improved monomeric infrared fluorescent protein for neuronal and tumour brain imaging.

Yu D, Gustafson WC, Han C, Lafaye C, Noirclerc-Savoye M, Ge WP, Thayer DA, Huang H, Kornberg TB, Royant A, Jan LY, Jan YN, Weiss WA, Shu X.

Nat Commun. 2014 May 15;5:3626. doi: 10.1038/ncomms4626.

50.

Krüppel mediates the selective rebalancing of ion channel expression.

Parrish JZ, Kim CC, Tang L, Bergquist S, Wang T, Derisi JL, Jan LY, Jan YN, Davis GW.

Neuron. 2014 May 7;82(3):537-44. doi: 10.1016/j.neuron.2014.03.015.

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