Format

Send to

Choose Destination
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2017 Jun;161(2):174-178. doi: 10.5507/bp.2017.018. Epub 2017 May 16.

Possitive correlation between adipocyte fatty acid-binding protein and epicardial fat in patients with a family history of cardiovascular disesase.

Author information

1
Department of Sports Medicine, Faculty of Medicine and Dentistry, Palacky University Olomouc and University Hospital Olomouc, Czech Republic.
2
Department of Respiratory Medicine, Faculty of Medicine and Dentistry, Palacky University Olomouc and University Hospital Olomouc, Czech Republic.
3
Department of Medical Biophysics, Faculty of Medicine and Dentistry, Palacky University Olomouc, Czech Republic.
4
Department of Medical Chemistry and Biochemistry, Faculty of Medicine and Dentistry, Palacky University Olomouc, Czech Republic.
5
Department of Internal Medicine II - Gastroenterology and Hepatology, Faculty of Medicine and Dentistry, Palacky University Olomouc and University Hospital Olomouc, Czech Republic.
6
Faculty of Medicine, Saba University School of Medicine, Saba, Dutch Caribbean.
7
Department of Esthetic Surgery, University Hospital Olomouc, Czech Republic.
8
Department of Nuclear Medicine, University Hospital Olomouc, Czech Republic.

Abstract

BACKGROUND:

Adipocyte fatty acid-binding protein (A-FABP) is a promising link between metabolic syndrome and atherosclerosis. Epicardial fat (EPI) is an independent risk factor for cardiovascular disease (CVD).

OBJECTIVE:

The aim of this pilot study was to evaluate the correlation between EPI and A-FABP in asymptomatic patients with a family history of CVD.

METHODS:

59 subjects (39 males) (median = 54 years old) were enrolled in the study and their EPI thickness and A-FABP levels were assessed.

RESULTS:

EPI was found in 46 patients (77.9%). There were positive correlations between EPI and A-FABP (r=0.336; P=0.010), age (r=0.526; P<0.001), fibrinogen (r=0.304; P=0.023) and systolic blood pressure (r=0.279; P=0.034). A positive correlation was found between EPI and A-FABP in a subgroup of overweight and obese patients (0.389; P=0.041, 0.407; P=0.004) and in the subgroup of patients with excluded CVD (r=0.368; P=0.006).

CONCLUSIONS:

We found a positive correlation between EPI and A-FABP in a group of patients with a family history of CVD and in subgroups of overweight and obese patients.

KEYWORDS:

Adipocyte fatty acid bindig protein; echocardiography; epicardial fat; risk of cardiovascular disease

PMID:
28539672
DOI:
10.5507/bp.2017.018
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Palacky University Olomouc
Loading ...
Support Center