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VISTA is a checkpoint regulator for naïve T cell quiescence and peripheral tolerance.

ElTanbouly MA, Zhao Y, Nowak E, Li J, Schaafsma E, Le Mercier I, Ceeraz S, Lines JL, Peng C, Carriere C, Huang X, Day M, Koehn B, Lee SW, Silva Morales M, Hogquist KA, Jameson SC, Mueller D, Rothstein J, Blazar BR, Cheng C, Noelle RJ.

Science. 2020 Jan 17;367(6475). pii: eaay0524. doi: 10.1126/science.aay0524.


Myeloid cells activate iNKT cells to produce IL-4 in the thymic medulla.

Wang H, Breed ER, Lee YJ, Qian LJ, Jameson SC, Hogquist KA.

Proc Natl Acad Sci U S A. 2019 Oct 29;116(44):22262-22268. doi: 10.1073/pnas.1910412116. Epub 2019 Oct 14.


NK Cell IL-10 Production Requires IL-15 and IL-10 Driven STAT3 Activation.

Clark SE, Burrack KS, Jameson SC, Hamilton SE, Lenz LL.

Front Immunol. 2019 Sep 4;10:2087. doi: 10.3389/fimmu.2019.02087. eCollection 2019.


Danger-associated extracellular ATP counters MDSC therapeutic efficacy in acute GVHD.

Koehn BH, Saha A, McDonald-Hyman C, Loschi M, Thangavelu G, Ma L, Zaiken M, Dysthe J, Krepps W, Panthera J, Hippen K, Jameson SC, Miller JS, Cooper MA, Farady CJ, Iwawaki T, Ting JP, Serody JS, Murphy WJ, Hill GR, Murray PJ, Bronte V, Munn DH, Zeiser R, Blazar BR.

Blood. 2019 Nov 7;134(19):1670-1682. doi: 10.1182/blood.2019001950.


Self-Regulation of Memory CD8 T Cell Metabolism through Extracellular ATP Signaling.

Wanhainen KM, Jameson SC, da Silva HB.

Immunometabolism. 2019;1(1). pii: e190009. doi: 10.20900/immunometab20190009. Epub 2019 Jul 23.


Microbial Exposure Enhances Immunity to Pathogens Recognized by TLR2 but Increases Susceptibility to Cytokine Storm through TLR4 Sensitization.

Huggins MA, Sjaastad FV, Pierson M, Kucaba TA, Swanson W, Staley C, Weingarden AR, Jensen IJ, Danahy DB, Badovinac VP, Jameson SC, Vezys V, Masopust D, Khoruts A, Griffith TS, Hamilton SE.

Cell Rep. 2019 Aug 13;28(7):1729-1743.e5. doi: 10.1016/j.celrep.2019.07.028.


The Functional Requirement for CD69 in Establishment of Resident Memory CD8+ T Cells Varies with Tissue Location.

Walsh DA, Borges da Silva H, Beura LK, Peng C, Hamilton SE, Masopust D, Jameson SC.

J Immunol. 2019 Aug 15;203(4):946-955. doi: 10.4049/jimmunol.1900052. Epub 2019 Jun 26.


ARTC2.2/P2RX7 Signaling during Cell Isolation Distorts Function and Quantification of Tissue-Resident CD8+ T Cell and Invariant NKT Subsets.

Borges da Silva H, Wang H, Qian LJ, Hogquist KA, Jameson SC.

J Immunol. 2019 Apr 1;202(7):2153-2163. doi: 10.4049/jimmunol.1801613. Epub 2019 Feb 18.


Embracing microbial exposure in mouse research.

Huggins MA, Jameson SC, Hamilton SE.

J Leukoc Biol. 2019 Jan;105(1):73-79. doi: 10.1002/JLB.4RI0718-273R. Epub 2018 Sep 27. Review.


The purinergic receptor P2RX7 directs metabolic fitness of long-lived memory CD8+ T cells.

Borges da Silva H, Beura LK, Wang H, Hanse EA, Gore R, Scott MC, Walsh DA, Block KE, Fonseca R, Yan Y, Hippen KL, Blazar BR, Masopust D, Kelekar A, Vulchanova L, Hogquist KA, Jameson SC.

Nature. 2018 Jul;559(7713):264-268. doi: 10.1038/s41586-018-0282-0. Epub 2018 Jul 4.


The virtuous self-tolerance of virtual memory T cells.

Truckenbrod EN, Jameson SC.

EMBO J. 2018 Jul 13;37(14). pii: e99883. doi: 10.15252/embj.201899883. Epub 2018 Jun 26. No abstract available.


Interleukin-15 Complex Treatment Protects Mice from Cerebral Malaria by Inducing Interleukin-10-Producing Natural Killer Cells.

Burrack KS, Huggins MA, Taras E, Dougherty P, Henzler CM, Yang R, Alter S, Jeng EK, Wong HC, Felices M, Cichocki F, Miller JS, Hart GT, Johnson AJ, Jameson SC, Hamilton SE.

Immunity. 2018 Apr 17;48(4):760-772.e4. doi: 10.1016/j.immuni.2018.03.012. Epub 2018 Apr 3.


Understanding Subset Diversity in T Cell Memory.

Jameson SC, Masopust D.

Immunity. 2018 Feb 20;48(2):214-226. doi: 10.1016/j.immuni.2018.02.010. Review.


Is a Human CD8 T-Cell Vaccine Possible, and if So, What Would It Take? CD8 T-Cell Vaccines: To B or Not to B?

Beura LK, Jameson SC, Masopust D.

Cold Spring Harb Perspect Biol. 2018 Sep 4;10(9). pii: a028910. doi: 10.1101/cshperspect.a028910. Review.


Hemodynamic Forces Sculpt Developing Heart Valves through a KLF2-WNT9B Paracrine Signaling Axis.

Goddard LM, Duchemin AL, Ramalingan H, Wu B, Chen M, Bamezai S, Yang J, Li L, Morley MP, Wang T, Scherrer-Crosbie M, Frank DB, Engleka KA, Jameson SC, Morrisey EE, Carroll TJ, Zhou B, Vermot J, Kahn ML.

Dev Cell. 2017 Nov 6;43(3):274-289.e5. doi: 10.1016/j.devcel.2017.09.023. Epub 2017 Oct 19.


Retrieving short-term memories of flu.

Borges da Silva H, Jameson SC.

Sci Immunol. 2017 Jan 6;2(7). pii: eaam5330. doi: 10.1126/sciimmunol.aam5330. Epub 2017 Jan 6. Review.


Corrigendum: Spontaneous partial loss of the OT-I transgene.

Pritchard GH, Cross EW, Strobel M, Jameson SC, Kedl RM, Hogquist KA, Hunter CA.

Nat Immunol. 2017 Jul 19;18(8):951. doi: 10.1038/ni0817-951b. No abstract available.


Of Mice, Dirty Mice, and Men: Using Mice To Understand Human Immunology.

Masopust D, Sivula CP, Jameson SC.

J Immunol. 2017 Jul 15;199(2):383-388. doi: 10.4049/jimmunol.1700453. Review.


CD8αα intraepithelial lymphocytes arise from two main thymic precursors.

Ruscher R, Kummer RL, Lee YJ, Jameson SC, Hogquist KA.

Nat Immunol. 2017 Jul;18(7):771-779. doi: 10.1038/ni.3751. Epub 2017 May 22.


What Is the Predictive Value of Animal Models for Vaccine Efficacy in Humans? Reevaluating the Potential of Mouse Models for the Human Immune System.

Jameson SC, Masopust D.

Cold Spring Harb Perspect Biol. 2018 Apr 2;10(4). pii: a029132. doi: 10.1101/cshperspect.a029132. Review.


Lineage-Specific Effector Signatures of Invariant NKT Cells Are Shared amongst γδ T, Innate Lymphoid, and Th Cells.

Lee YJ, Starrett GJ, Lee ST, Yang R, Henzler CM, Jameson SC, Hogquist KA.

J Immunol. 2016 Aug 15;197(4):1460-70. doi: 10.4049/jimmunol.1600643. Epub 2016 Jul 6.


IL-4 sensitivity shapes the peripheral CD8+ T cell pool and response to infection.

Renkema KR, Lee JY, Lee YJ, Hamilton SE, Hogquist KA, Jameson SC.

J Exp Med. 2016 Jun 27;213(7):1319-29. doi: 10.1084/jem.20151359. Epub 2016 Jun 13.


Sequential Infection with Common Pathogens Promotes Human-like Immune Gene Expression and Altered Vaccine Response.

Reese TA, Bi K, Kambal A, Filali-Mouhim A, Beura LK, Bürger MC, Pulendran B, Sekaly RP, Jameson SC, Masopust D, Haining WN, Virgin HW.

Cell Host Microbe. 2016 May 11;19(5):713-9. doi: 10.1016/j.chom.2016.04.003. Epub 2016 Apr 20.


Normalizing the environment recapitulates adult human immune traits in laboratory mice.

Beura LK, Hamilton SE, Bi K, Schenkel JM, Odumade OA, Casey KA, Thompson EA, Fraser KA, Rosato PC, Filali-Mouhim A, Sekaly RP, Jenkins MK, Vezys V, Haining WN, Jameson SC, Masopust D.

Nature. 2016 Apr 28;532(7600):512-6. doi: 10.1038/nature17655. Epub 2016 Apr 20.


Spontaneous partial loss of the OT-I transgene.

Pritchard GH, Cross EW, Strobel M, Jameson SC, Kedl RM, Hogquist KA, Hunter CA.

Nat Immunol. 2016 May;17(5):471. doi: 10.1038/ni.3411. No abstract available. Erratum in: Nat Immunol. 2017 Jul 19;18(8):951.


Late stages of T cell maturation in the thymus involve NF-κB and tonic type I interferon signaling.

Xing Y, Wang X, Jameson SC, Hogquist KA.

Nat Immunol. 2016 May;17(5):565-73. doi: 10.1038/ni.3419. Epub 2016 Apr 4.


Effective effector generation of CD8+ T cells and NK cells: A need for T-bet and ZEB-too.

Hamilton SE, Jameson SC.

J Exp Med. 2015 Nov 16;212(12):1990. doi: 10.1084/jem.21212insight3. No abstract available.


Tissue-Specific Distribution of iNKT Cells Impacts Their Cytokine Response.

Lee YJ, Wang H, Starrett GJ, Phuong V, Jameson SC, Hogquist KA.

Immunity. 2015 Sep 15;43(3):566-78. doi: 10.1016/j.immuni.2015.06.025. Epub 2015 Sep 8.


TCR affinity for thymoproteasome-dependent positively selecting peptides conditions antigen responsiveness in CD8(+) T cells.

Takada K, Van Laethem F, Xing Y, Akane K, Suzuki H, Murata S, Tanaka K, Jameson SC, Singer A, Takahama Y.

Nat Immunol. 2015 Oct;16(10):1069-76. doi: 10.1038/ni.3237. Epub 2015 Aug 24.


Innate memory T cells.

Jameson SC, Lee YJ, Hogquist KA.

Adv Immunol. 2015;126:173-213. doi: 10.1016/ Epub 2015 Feb 7. Review.


The transcription factor KLF2 restrains CD4⁺ T follicular helper cell differentiation.

Lee JY, Skon CN, Lee YJ, Oh S, Taylor JJ, Malhotra D, Jenkins MK, Rosenfeld MG, Hogquist KA, Jameson SC.

Immunity. 2015 Feb 17;42(2):252-264. doi: 10.1016/j.immuni.2015.01.013.


The TCR's sensitivity to self peptide-MHC dictates the ability of naive CD8(+) T cells to respond to foreign antigens.

Fulton RB, Hamilton SE, Xing Y, Best JA, Goldrath AW, Hogquist KA, Jameson SC.

Nat Immunol. 2015 Jan;16(1):107-17. doi: 10.1038/ni.3043. Epub 2014 Nov 24.


The self-obsession of T cells: how TCR signaling thresholds affect fate 'decisions' and effector function.

Hogquist KA, Jameson SC.

Nat Immunol. 2014 Sep;15(9):815-23. doi: 10.1038/ni.2938. Review.


An uncommon tail about the common γ-chain.

Jameson SC, Renkema KR.

Immunity. 2014 Jun 19;40(6):859-60. doi: 10.1016/j.immuni.2014.05.008.


Antigen-specific culture of memory-like CD8 T cells for adoptive immunotherapy.

Litterman AJ, Zellmer DM, LaRue RS, Jameson SC, Largaespada DA.

Cancer Immunol Res. 2014 Sep;2(9):839-45. doi: 10.1158/2326-6066.CIR-14-0038. Epub 2014 May 22.


Cutting edge: The signals for the generation of T cell memory are qualitatively different depending on TCR ligand strength.

Knudson KM, Hamilton SE, Daniels MA, Jameson SC, Teixeiro E.

J Immunol. 2013 Dec 15;191(12):5797-801. doi: 10.4049/jimmunol.1300905. Epub 2013 Nov 15.


Transcriptional downregulation of S1pr1 is required for the establishment of resident memory CD8+ T cells.

Skon CN, Lee JY, Anderson KG, Masopust D, Hogquist KA, Jameson SC.

Nat Immunol. 2013 Dec;14(12):1285-93. doi: 10.1038/ni.2745. Epub 2013 Oct 27.


Steady-state production of IL-4 modulates immunity in mouse strains and is determined by lineage diversity of iNKT cells.

Lee YJ, Holzapfel KL, Zhu J, Jameson SC, Hogquist KA.

Nat Immunol. 2013 Nov;14(11):1146-54. doi: 10.1038/ni.2731. Epub 2013 Oct 6. Erratum in: Nat Immunol. 2014 Mar;15(3):305.


Virtual memory CD8 T cells display unique functional properties.

Lee JY, Hamilton SE, Akue AD, Hogquist KA, Jameson SC.

Proc Natl Acad Sci U S A. 2013 Aug 13;110(33):13498-503. doi: 10.1073/pnas.1307572110. Epub 2013 Jul 29.


Preexisting high frequencies of memory CD8+ T cells favor rapid memory differentiation and preservation of proliferative potential upon boosting.

Fraser KA, Schenkel JM, Jameson SC, Vezys V, Masopust D.

Immunity. 2013 Jul 25;39(1):171-83. doi: 10.1016/j.immuni.2013.07.003.


Effector-like CD8⁺ T cells in the memory population mediate potent protective immunity.

Olson JA, McDonald-Hyman C, Jameson SC, Hamilton SE.

Immunity. 2013 Jun 27;38(6):1250-60. doi: 10.1016/j.immuni.2013.05.009. Epub 2013 Jun 6.


T Cell Memory: without Prompting.

Jameson SC.

J Immunol. 2013 May 1;190(9):4443-4. doi: 10.4049/jimmunol.1300671. No abstract available.


Thymoproteasome subunit-β5T generates peptide-MHC complexes specialized for positive selection.

Xing Y, Jameson SC, Hogquist KA.

Proc Natl Acad Sci U S A. 2013 Apr 23;110(17):6979-84. doi: 10.1073/pnas.1222244110. Epub 2013 Apr 8.


Murine thymic selection quantified using a unique method to capture deleted T cells.

Stritesky GL, Xing Y, Erickson JR, Kalekar LA, Wang X, Mueller DL, Jameson SC, Hogquist KA.

Proc Natl Acad Sci U S A. 2013 Mar 19;110(12):4679-84. doi: 10.1073/pnas.1217532110. Epub 2013 Mar 4.


Kruppel-like factor 2 protects against ischemic stroke by regulating endothelial blood brain barrier function.

Shi H, Sheng B, Zhang F, Wu C, Zhang R, Zhu J, Xu K, Kuang Y, Jameson SC, Lin Z, Wang Y, Chen J, Jain MK, Atkins GB.

Am J Physiol Heart Circ Physiol. 2013 Mar 15;304(6):H796-805. doi: 10.1152/ajpheart.00712.2012. Epub 2013 Jan 18.


CD8 T cell memory: it takes all kinds.

Hamilton SE, Jameson SC.

Front Immunol. 2012 Nov 27;3:353. doi: 10.3389/fimmu.2012.00353. eCollection 2012.


Cutting edge: Krűppel-like factor 2 is required for phenotypic maintenance but not development of B1 B cells.

Hart GT, Peery SL, Hamilton SE, Jameson SC.

J Immunol. 2012 Oct 1;189(7):3293-7. Epub 2012 Aug 31.


TGF-β sensitivity restrains CD8+ T cell homeostatic proliferation by enforcing sensitivity to IL-7 and IL-15.

Johnson LD, Jameson SC.

PLoS One. 2012;7(8):e42268. doi: 10.1371/journal.pone.0042268. Epub 2012 Aug 6.


CD8 T cell quiescence revisited.

Hamilton SE, Jameson SC.

Trends Immunol. 2012 May;33(5):224-30. doi: 10.1016/ Epub 2012 Feb 21. Review.


Pillars article: T cell receptor antagonist peptides induce positive selection. Cell. 1994. 76: 17-27.

Hogquist KA, Jameson SC, Heath WR, Howard JL, Bevan MJ, Carbone FR.

J Immunol. 2012 Mar 1;188(5):2046-56. No abstract available.

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