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Items: 1 to 50 of 259

1.

Trauma-Informed Care for Violently Injured Patients in the Emergency Department.

Fischer KR, Bakes KM, Corbin TJ, Fein JA, Harris EJ, James TL, Melzer-Lange MD.

Ann Emerg Med. 2019 Feb;73(2):193-202. doi: 10.1016/j.annemergmed.2018.10.018. Epub 2018 Nov 28. Review.

PMID:
30503381
2.

A Fragment-Based Ligand Screen Against Part of a Large Protein Machine: The ND1 Domains of the AAA+ ATPase p97/VCP.

Chimenti MS, Bulfer SL, Neitz RJ, Renslo AR, Jacobson MP, James TL, Arkin MR, Kelly MJ.

J Biomol Screen. 2015 Jul;20(6):788-800. doi: 10.1177/1087057115570550. Epub 2015 Feb 17.

PMID:
25690569
3.

Boston Violence Intervention Advocacy Program: a qualitative study of client experiences and perceived effect.

James TL, Bibi S, Langlois BK, Dugan E, Mitchell PM.

Acad Emerg Med. 2014 Jul;21(7):742-51. doi: 10.1111/acem.12409. Epub 2014 Jul 16.

4.

13C NMR metabolomic evaluation of immediate and delayed mild hypothermia in cerebrocortical slices after oxygen-glucose deprivation.

Liu J, Segal MR, Kelly MJ, Pelton JG, Kim M, James TL, Litt L.

Anesthesiology. 2013 Nov;119(5):1120-36. doi: 10.1097/ALN.0b013e31829c2d90.

5.

1H nuclear magnetic resonance brain metabolomics in neonatal mice after hypoxia-ischemia distinguished normothermic recovery from mild hypothermia recoveries.

Liu J, Sheldon RA, Segal MR, Kelly MJ, Pelton JG, Ferriero DM, James TL, Litt L.

Pediatr Res. 2013 Aug;74(2):170-9. doi: 10.1038/pr.2013.88. Epub 2013 May 24.

6.

Does activation of the anti proton, rather than concertedness, determine the stereochemistry of base-catalyzed 1,2-elimination reactions? Anti stereospecificity in E1cB eliminations of β-3-trifluoromethylphenoxy esters, thioesters, and ketones.

Mohrig JR, Beyer BG, Fleischhacker AS, Ruthenburg AJ, John SG, Snyder DA, Nyffeler PT, Noll RJ, Penner ND, Phillips LA, Hurley HL, Jacobs JS, Treitel C, James TL, Montgomery MP.

J Org Chem. 2012 Mar 16;77(6):2819-28. doi: 10.1021/jo300053w. Epub 2012 Feb 24.

PMID:
22321002
7.

Optimizing QSAR models for predicting ligand binding to the drug-metabolizing cytochrome P450 isoenzyme CYP2D6.

Saraceno M, Massarelli I, Imbriani M, James TL, Bianucci AM.

Chem Biol Drug Des. 2011 Aug;78(2):236-51. doi: 10.1111/j.1747-0285.2011.01137.x. Epub 2011 Jun 14.

PMID:
21575140
8.

Outcome-related metabolomic patterns from 1H/31P NMR after mild hypothermia treatments of oxygen-glucose deprivation in a neonatal brain slice model of asphyxia.

Liu J, Litt L, Segal MR, Kelly MJ, Yoshihara HA, James TL.

J Cereb Blood Flow Metab. 2011 Feb;31(2):547-59. doi: 10.1038/jcbfm.2010.125. Epub 2010 Aug 18.

9.
10.

Binding characteristics of small molecules that mimic nucleocapsid protein-induced maturation of stem-loop 1 of HIV-1 RNA.

Chung J, Ulyanov NB, Guilbert C, Mujeeb A, James TL.

Biochemistry. 2010 Aug 3;49(30):6341-51. doi: 10.1021/bi100660r.

11.

DOCK 6: combining techniques to model RNA-small molecule complexes.

Lang PT, Brozell SR, Mukherjee S, Pettersen EF, Meng EC, Thomas V, Rizzo RC, Case DA, James TL, Kuntz ID.

RNA. 2009 Jun;15(6):1219-30. doi: 10.1261/rna.1563609. Epub 2009 Apr 15.

12.

Perspectives on NMR in drug discovery: a technique comes of age.

Pellecchia M, Bertini I, Cowburn D, Dalvit C, Giralt E, Jahnke W, James TL, Homans SW, Kessler H, Luchinat C, Meyer B, Oschkinat H, Peng J, Schwalbe H, Siegal G.

Nat Rev Drug Discov. 2008 Sep;7(9):738-45. doi: 10.1038/nrd2606. Review.

13.

Antioxidant effect of ethyl pyruvate in respiring neonatal cerebrocortical slices after H(2)O(2) stress.

Liu J, Segal M, Yoo S, Yang GY, Kelly M, James TL, Litt L.

Neurochem Int. 2009 Feb;54(2):106-10. doi: 10.1016/j.neuint.2008.10.009. Epub 2008 Nov 8.

PMID:
19041675
14.

Discovery of ligands for a novel target, the human telomerase RNA, based on flexible-target virtual screening and NMR.

Pinto IG, Guilbert C, Ulyanov NB, Stearns J, James TL.

J Med Chem. 2008 Nov 27;51(22):7205-15. doi: 10.1021/jm800825n.

15.

Structure of a construct of a human poly(C)-binding protein containing the first and second KH domains reveals insights into its regulatory mechanisms.

Du Z, Fenn S, Tjhen R, James TL.

J Biol Chem. 2008 Oct 17;283(42):28757-66. doi: 10.1074/jbc.M803046200. Epub 2008 Aug 13.

16.

Photoluminescent characterization of atomic diffusion in core-shell nanoparticles.

DiMaio J, Kokuoz B, James TL, Harkey T, Monofsky D, Ballato J.

Opt Express. 2008 Aug 4;16(16):11769-75.

PMID:
18679448
17.

A small molecule, Lys-Ala-7-amido-4-methylcoumarin, facilitates RNA dimer maturation of a stem-loop 1 transcript in vitro: structure-activity relationship of the activator.

Chung J, Mujeeb A, Jiang Y, Guilbert C, Pendke M, Wu Y, James TL.

Biochemistry. 2008 Aug 5;47(31):8148-56. doi: 10.1021/bi800230m. Epub 2008 Jul 11.

PMID:
18616287
18.

Docking to RNA via root-mean-square-deviation-driven energy minimization with flexible ligands and flexible targets.

Guilbert C, James TL.

J Chem Inf Model. 2008 Jun;48(6):1257-68. doi: 10.1021/ci8000327. Epub 2008 May 30.

19.

NMR determination of oligonucleotide structure.

James TL.

Curr Protoc Nucleic Acid Chem. 2001 May;Chapter 7:Unit 7.2. doi: 10.1002/0471142700.nc0702s00. Review.

PMID:
18428870
20.

Response to hepatitis A epidemic: emergency department collaboration with public health commission.

James TL, Aschkenasy M, Eliseo LJ, Olshaker J, Mehta SD.

J Emerg Med. 2009 May;36(4):412-6. doi: 10.1016/j.jemermed.2007.10.001. Epub 2008 Mar 24.

PMID:
18359602
21.

Structural and biochemical insights into the dicing mechanism of mouse Dicer: a conserved lysine is critical for dsRNA cleavage.

Du Z, Lee JK, Tjhen R, Stroud RM, James TL.

Proc Natl Acad Sci U S A. 2008 Feb 19;105(7):2391-6. doi: 10.1073/pnas.0711506105. Epub 2008 Feb 11.

22.

Exogenous ethyl pyruvate versus pyruvate during metabolic recovery after oxidative stress in neonatal rat cerebrocortical slices.

Zeng J, Liu J, Yang GY, Kelly MJ, James TL, Litt L.

Anesthesiology. 2007 Oct;107(4):630-40.

PMID:
17893460
23.

Pseudoknot structures with conserved base triples in telomerase RNAs of ciliates.

Ulyanov NB, Shefer K, James TL, Tzfati Y.

Nucleic Acids Res. 2007;35(18):6150-60. Epub 2007 Sep 7.

24.

Elimination of vertical streaking in polyacrylamide gel electrophoresis.

James TL, Milos NC.

Anal Biochem. 2007 Aug 1;367(1):134-6. Epub 2007 Apr 27. No abstract available.

PMID:
17540327
25.
26.

Resonance assignment of the first and second KH (hnRNP-K homology) domains of human poly(C)-binding protein-2 (PCBP2).

Du Z, Fenn S, James TL.

J Biomol NMR. 2007 Jun;38(2):197. Epub 2007 May 4. No abstract available.

PMID:
17479348
27.

Crystal structure of the third KH domain of human poly(C)-binding protein-2 in complex with a C-rich strand of human telomeric DNA at 1.6 A resolution.

Fenn S, Du Z, Lee JK, Tjhen R, Stroud RM, James TL.

Nucleic Acids Res. 2007;35(8):2651-60. Epub 2007 Apr 10.

28.

Nucleocapsid protein-mediated maturation of dimer initiation complex of full-length SL1 stemloop of HIV-1: sequence effects and mechanism of RNA refolding.

Mujeeb A, Ulyanov NB, Georgantis S, Smirnov I, Chung J, Parslow TG, James TL.

Nucleic Acids Res. 2007;35(6):2026-34. Epub 2007 Mar 6.

29.

Synthesis and testing of a focused phenothiazine library for binding to HIV-1 TAR RNA.

Mayer M, Lang PT, Gerber S, Madrid PB, Pinto IG, Guy RK, James TL.

Chem Biol. 2006 Sep;13(9):993-1000.

30.

Pyruvate improves recovery after PARP-1-associated energy failure induced by oxidative stress in neonatal rat cerebrocortical slices.

Zeng J, Yang GY, Ying W, Kelly M, Hirai K, James TL, Swanson RA, Litt L.

J Cereb Blood Flow Metab. 2007 Feb;27(2):304-15. Epub 2006 May 24.

PMID:
16736046
31.

NMR structure of the full-length linear dimer of stem-loop-1 RNA in the HIV-1 dimer initiation site.

Ulyanov NB, Mujeeb A, Du Z, Tonelli M, Parslow TG, James TL.

J Biol Chem. 2006 Jun 9;281(23):16168-77. Epub 2006 Apr 6.

32.

Physician variability in history taking when evaluating patients presenting with chest pain in the emergency department.

James TL, Feldman J, Mehta SD.

Acad Emerg Med. 2006 Feb;13(2):147-52. Epub 2006 Jan 25.

33.

Crystal structure of the first KH domain of human poly(C)-binding protein-2 in complex with a C-rich strand of human telomeric DNA at 1.7 A.

Du Z, Lee JK, Tjhen R, Li S, Pan H, Stroud RM, James TL.

J Biol Chem. 2005 Nov 18;280(46):38823-30. Epub 2005 Sep 25.

34.
35.
36.
37.

Using 31P NMR spectroscopy at 14.1 Tesla to investigate PARP-1 associated energy failure and metabolic rescue in cerebrocortical slices.

Zeng J, Hirai K, Yang GY, Ying W, Swanson RA, Kelly M, Mayer M, James TL, Litt L.

J Bioenerg Biomembr. 2004 Aug;36(4):415-9.

PMID:
15377881
38.
40.

PI3K inhibition in neonatal rat brain slices during and after hypoxia reduces phospho-Akt and increases cytosolic cytochrome c and apoptosis.

Hirai K, Hayashi T, Chan PH, Zeng J, Yang GY, Basus VJ, James TL, Litt L.

Brain Res Mol Brain Res. 2004 Apr 29;124(1):51-61.

PMID:
15093685
41.

Slow conformational dynamics in the hamster prion protein.

Kuwata K, Kamatari YO, Akasaka K, James TL.

Biochemistry. 2004 Apr 20;43(15):4439-46.

PMID:
15078089
42.

NMR-based characterization of phenothiazines as a RNA binding scaffold.

Mayer M, James TL.

J Am Chem Soc. 2004 Apr 7;126(13):4453-60.

PMID:
15053636
43.

Akt phosphorylation and cell survival after hypoxia-induced cytochrome c release in superfused respiring neonatal rat cerebrocortical slices.

Hirai K, Hayashi T, Chan PH, Basus VJ, James TL, Litt L.

Acta Neurochir Suppl. 2003;86:227-30.

PMID:
14753441
45.

NMR-detected hydrogen exchange and molecular dynamics simulations provide structural insight into fibril formation of prion protein fragment 106-126.

Kuwata K, Matumoto T, Cheng H, Nagayama K, James TL, Roder H.

Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):14790-5. Epub 2003 Dec 1.

46.

Dynamic NMR structures of [Rp]- and [Sp]-phosphorothioated DNA-RNA hybrids: is flexibility required for RNase H recognition?

Tonelli M, Ulyanov NB, Billeci TM, Karwowski B, Guga P, Stec WJ, James TL.

Biophys J. 2003 Oct;85(4):2525-38.

47.

Extending the family of UNCG-like tetraloop motifs: NMR structure of a CACG tetraloop from coxsackievirus B3.

Du Z, Yu J, Andino R, James TL.

Biochemistry. 2003 Apr 22;42(15):4373-83.

PMID:
12693932
48.

Temperature control of respiring rat brain slices during high field NMR spectroscopy.

Litt L, Hirai K, Basus VJ, James TL.

Brain Res Brain Res Protoc. 2003 Feb;10(3):191-8.

PMID:
12565690
49.

A molecular switch underlies a human telomerase disease.

Comolli LR, Smirnov I, Xu L, Blackburn EH, James TL.

Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16998-7003. Epub 2002 Dec 13.

50.

Cytochrome c associated apoptosis during ATP recovery after hypoxia in neonatal rat cerebrocortical slices.

Hirai K, Sugawara T, Chan PH, Basus VJ, James TL, Litt L.

J Neurochem. 2002 Oct;83(2):309-19.

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