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TMEM203 is a binding partner and regulator of STING-mediated inflammatory signaling in macrophages.

Li Y, James SJ, Wyllie DH, Wynne C, Czibula A, Bukhari A, Pye K, Bte Mustafah SM, Fajka-Boja R, Szabo E, Angyal A, Hegedus Z, Kovacs L, Hill AVS, Jefferies CA, Wilson HL, Yongliang Z, Kiss-Toth E.

Proc Natl Acad Sci U S A. 2019 Aug 13;116(33):16479-16488. doi: 10.1073/pnas.1901090116. Epub 2019 Jul 25.


Maternal metabolic profile predicts high or low risk of an autism pregnancy outcome.

Hollowood K, Melnyk S, Pavliv O, Evans T, Sides A, Schmidt RJ, Hertz-Picciotto I, Elms W, Guerrero E, Kruger U, Hahn J, James SJ.

Res Autism Spectr Disord. 2018 Dec;56:72-82. doi: 10.1016/j.rasd.2018.09.003. Epub 2018 Sep 19.


LIMPRINT in Australia.

Gordon SJ, Murray SG, Sutton T, Coulombe MM, James SJ, Van Zanten M, Lawson JK, Moffatt C.

Lymphat Res Biol. 2019 Apr;17(2):173-177. doi: 10.1089/lrb.2018.0087.


Comparison of Three Clinical Trial Treatments for Autism Spectrum Disorder Through Multivariate Analysis of Changes in Metabolic Profiles and Adaptive Behavior.

Vargason T, Kruger U, Roth E, Delhey LM, Tippett M, Rose S, Bennuri SC, Slattery JC, Melnyk S, James SJ, Frye RE, Hahn J.

Front Cell Neurosci. 2018 Dec 19;12:503. doi: 10.3389/fncel.2018.00503. eCollection 2018.


Multivariate techniques enable a biochemical classification of children with autism spectrum disorder versus typically-developing peers: A comparison and validation study.

Howsmon DP, Vargason T, Rubin RA, Delhey L, Tippett M, Rose S, Bennuri SC, Slattery JC, Melnyk S, James SJ, Frye RE, Hahn J.

Bioeng Transl Med. 2018 Jun 19;3(2):156-165. doi: 10.1002/btm2.10095. eCollection 2018 May.


Comparison of Treatment for Metabolic Disorders Associated with Autism:Reanalysis of Three Clinical Trials.

Delhey LM, Tippett M, Rose S, Bennuri SC, Slattery JC, Melnyk S, James SJ, Frye RE.

Front Neurosci. 2018 Feb 12;12:19. doi: 10.3389/fnins.2018.00019. eCollection 2018.


Epigenetically mediated inhibition of S-adenosylhomocysteine hydrolase and the associated dysregulation of 1-carbon metabolism in nonalcoholic steatohepatitis and hepatocellular carcinoma.

Pogribny IP, Dreval K, Kindrat I, Melnyk S, Jimenez L, de Conti A, Tryndyak V, Pogribna M, Ortega JF, James SJ, Rusyn I, Beland FA.

FASEB J. 2018 Mar;32(3):1591-1601. doi: 10.1096/fj.201700866R. Epub 2018 Jan 3.


Dual-Specificity Phosphatase 12 Targets p38 MAP Kinase to Regulate Macrophage Response to Intracellular Bacterial Infection.

Cho SSL, Han J, James SJ, Png CW, Weerasooriya M, Alonso S, Zhang Y.

Front Immunol. 2017 Oct 9;8:1259. doi: 10.3389/fimmu.2017.01259. eCollection 2017.


Time Well Spent: Patient Industry and Occupation Data Collection in Emergency Departments.

Taylor JA, Widman SA, James SJ, Green-McKenzie J, McGuire C, Harris EJ.

J Occup Environ Med. 2017 Aug;59(8):742-745. doi: 10.1097/JOM.0000000000001088.


One-carbon metabolism and ionizing radiation: a multifaceted interaction.

Miousse IR, Tobacyk J, Melnyk S, James SJ, Cheema AK, Boerma M, Hauer-Jensen M, Koturbash I.

Biomol Concepts. 2017 May 24;8(2):83-92. doi: 10.1515/bmc-2017-0003. Review.


Severity of anxiety- but not depression- is associated with oxidative stress in Major Depressive Disorder.

Steenkamp LR, Hough CM, Reus VI, Jain FA, Epel ES, James SJ, Morford AE, Mellon SH, Wolkowitz OM, Lindqvist D.

J Affect Disord. 2017 Sep;219:193-200. doi: 10.1016/j.jad.2017.04.042. Epub 2017 May 6.


Use of the Fascial Distortion Model to Evaluate a Limp in a Child.

James SJ, Hudnall J.

J Am Osteopath Assoc. 2017 Jun 1;117(6):399-402. doi: 10.7556/jaoa.2017.079.


Classification and adaptive behavior prediction of children with autism spectrum disorder based upon multivariate data analysis of markers of oxidative stress and DNA methylation.

Howsmon DP, Kruger U, Melnyk S, James SJ, Hahn J.

PLoS Comput Biol. 2017 Mar 16;13(3):e1005385. doi: 10.1371/journal.pcbi.1005385. eCollection 2017 Mar.


Mathematical modeling of the methionine cycle and transsulfuration pathway in individuals with autism spectrum disorder.

Vargason T, Howsmon DP, Melnyk S, James SJ, Hahn J.

J Theor Biol. 2017 Mar 7;416:28-37. doi: 10.1016/j.jtbi.2016.12.021. Epub 2016 Dec 29.


Oxidative stress, inflammation and treatment response in major depression.

Lindqvist D, Dhabhar FS, James SJ, Hough CM, Jain FA, Bersani FS, Reus VI, Verhoeven JE, Epel ES, Mahan L, Rosser R, Wolkowitz OM, Mellon SH.

Psychoneuroendocrinology. 2017 Feb;76:197-205. doi: 10.1016/j.psyneuen.2016.11.031. Epub 2016 Nov 30.


Mitochondrial and redox abnormalities in autism lymphoblastoid cells: a sibling control study.

Rose S, Bennuri SC, Wynne R, Melnyk S, James SJ, Frye RE.

FASEB J. 2017 Mar;31(3):904-909. doi: 10.1096/fj.201601004R. Epub 2016 Nov 18.


Science journals: The worlds of H. G. Wells.

James SJ.

Nature. 2016 Sep 8;537(7619):162-4. doi: 10.1038/537162a. No abstract available.


Randomized, Placebo-Controlled Trial of Methyl B12 for Children with Autism.

Hendren RL, James SJ, Widjaja F, Lawton B, Rosenblatt A, Bent S.

J Child Adolesc Psychopharmacol. 2016 Nov;26(9):774-783. Epub 2016 Feb 18.


Dietary Supplementation in Children with Autism Spectrum Disorders: Common, Insufficient, and Excessive.

Stewart PA, Hyman SL, Schmidt BL, Macklin EA, Reynolds A, Johnson CR, James SJ, Manning-Courtney P.

J Acad Nutr Diet. 2015 Aug;115(8):1237-48. doi: 10.1016/j.jand.2015.03.026. Epub 2015 Jun 4.


Casein kinase II controls TBK1/IRF3 activation in IFN response against viral infection.

Du M, Liu J, Chen X, Xie Y, Yuan C, Xiang Y, Sun B, Lan K, Chen M, James SJ, Zhang Y, Zhong J, Xiao H.

J Immunol. 2015 May 1;194(9):4477-88. doi: 10.4049/jimmunol.1402777. Epub 2015 Mar 25.


MAPK Phosphatase 5 Expression Induced by Influenza and Other RNA Virus Infection Negatively Regulates IRF3 Activation and Type I Interferon Response.

James SJ, Jiao H, Teh HY, Takahashi H, Png CW, Phoon MC, Suzuki Y, Sawasaki T, Xiao H, Chow VTK, Yamamoto N, Reynolds JM, Flavell RA, Dong C, Zhang Y.

Cell Rep. 2015 Mar 17;10(10):1722-1734. doi: 10.1016/j.celrep.2015.02.030. Epub 2015 Mar 12.


DUSP10 regulates intestinal epithelial cell growth and colorectal tumorigenesis.

Png CW, Weerasooriya M, Guo J, James SJ, Poh HM, Osato M, Flavell RA, Dong C, Yang H, Zhang Y.

Oncogene. 2016 Jan 14;35(2):206-17. doi: 10.1038/onc.2015.74. Epub 2015 Mar 16.


Oxidative stress induces mitochondrial dysfunction in a subset of autistic lymphoblastoid cell lines.

Rose S, Frye RE, Slattery J, Wynne R, Tippett M, Melnyk S, James SJ.

Transl Psychiatry. 2015 Mar 10;5:e526. doi: 10.1038/tp.2015.29. No abstract available.


Increased susceptibility to ethylmercury-induced mitochondrial dysfunction in a subset of autism lymphoblastoid cell lines.

Rose S, Wynne R, Frye RE, Melnyk S, James SJ.

J Toxicol. 2015;2015:573701. doi: 10.1155/2015/573701. Epub 2015 Jan 21.


Cerebellar oxidative DNA damage and altered DNA methylation in the BTBR T+tf/J mouse model of autism and similarities with human post mortem cerebellum.

Shpyleva S, Ivanovsky S, de Conti A, Melnyk S, Tryndyak V, Beland FA, James SJ, Pogribny IP.

PLoS One. 2014 Nov 25;9(11):e113712. doi: 10.1371/journal.pone.0113712. eCollection 2014.


Elevated 5-hydroxymethylcytosine in the Engrailed-2 (EN-2) promoter is associated with increased gene expression and decreased MeCP2 binding in autism cerebellum.

James SJ, Shpyleva S, Melnyk S, Pavliv O, Pogribny IP.

Transl Psychiatry. 2014 Oct 7;4:e460. doi: 10.1038/tp.2014.87.


Highly interlocked anion-bridged supramolecular networks from interrupted imidazole-urea gels.

James SJ, Perrin A, Jones CD, Yufit DS, Steed JW.

Chem Commun (Camb). 2014 Nov 4;50(85):12851-4. doi: 10.1039/c4cc05789a.


Effect of methionine-deficient and methionine-supplemented diets on the hepatic one-carbon and lipid metabolism in mice.

Aissa AF, Tryndyak V, de Conti A, Melnyk S, Gomes TD, Bianchi ML, James SJ, Beland FA, Antunes LM, Pogribny IP.

Mol Nutr Food Res. 2014 Jul;58(7):1502-12. doi: 10.1002/mnfr.201300726. Epub 2014 May 15.


Metabolic pathology of autism in relation to redox metabolism.

Frye RE, James SJ.

Biomark Med. 2014;8(3):321-30. doi: 10.2217/bmm.13.158. Review.


Oxidative stress induces mitochondrial dysfunction in a subset of autistic lymphoblastoid cell lines.

Rose S, Frye RE, Slattery J, Wynne R, Tippett M, Melnyk S, James SJ.

Transl Psychiatry. 2014 Apr 1;4:e377. doi: 10.1038/tp.2014.15. Erratum in: Transl Psychiatry. 2015;5:e526.


Baseline bone mineral density and boneturnover in pre-operative hip and knee arthroplasty patients.

James SJ, Mirza SB, Culliford DJ, Taylor PA, Carr AJ, Arden NK.

Bone Joint Res. 2014 Jan 17;3(1):14-9. doi: 10.1302/2046-3758.31.2000218. Print 2014.


Autism and Folate-dependent One-carbon Metabolism: Serendipity and Critical Branch-point Decisions in Science.

James SJ.

Glob Adv Health Med. 2013 Nov;2(6):48-51. doi: 10.7453/gahmj.2013.088.


Oxidative stress induces mitochondrial dysfunction in a subset of autism lymphoblastoid cell lines in a well-matched case control cohort.

Rose S, Frye RE, Slattery J, Wynne R, Tippett M, Pavliv O, Melnyk S, James SJ.

PLoS One. 2014 Jan 8;9(1):e85436. doi: 10.1371/journal.pone.0085436. eCollection 2014.


Dietary intake and plasma levels of choline and betaine in children with autism spectrum disorders.

Hamlin JC, Pauly M, Melnyk S, Pavliv O, Starrett W, Crook TA, James SJ.

Autism Res Treat. 2013;2013:578429. doi: 10.1155/2013/578429. Epub 2013 Dec 16.


Effectiveness of methylcobalamin and folinic Acid treatment on adaptive behavior in children with autistic disorder is related to glutathione redox status.

Frye RE, Melnyk S, Fuchs G, Reid T, Jernigan S, Pavliv O, Hubanks A, Gaylor DW, Walters L, James SJ.

Autism Res Treat. 2013;2013:609705. doi: 10.1155/2013/609705. Epub 2013 Oct 12.


Redox metabolism abnormalities in autistic children associated with mitochondrial disease.

Frye RE, Delatorre R, Taylor H, Slattery J, Melnyk S, Chowdhury N, James SJ.

Transl Psychiatry. 2013 Jun 18;3:e273. doi: 10.1038/tp.2013.51.


Metabolic effects of sapropterin treatment in autism spectrum disorder: a preliminary study.

Frye RE, DeLatorre R, Taylor HB, Slattery J, Melnyk S, Chowdhury N, James SJ.

Transl Psychiatry. 2013 Mar 5;3:e237. doi: 10.1038/tp.2013.14.


Strain-dependent dysregulation of one-carbon metabolism in male mice is associated with choline- and folate-deficient diet-induced liver injury.

Pogribny IP, Kutanzi K, Melnyk S, de Conti A, Tryndyak V, Montgomery B, Pogribna M, Muskhelishvili L, Latendresse JR, James SJ, Beland FA, Rusyn I.

FASEB J. 2013 Jun;27(6):2233-43. doi: 10.1096/fj.12-227116. Epub 2013 Feb 25.


Complex epigenetic regulation of engrailed-2 (EN-2) homeobox gene in the autism cerebellum.

James SJ, Shpyleva S, Melnyk S, Pavliv O, Pogribny IP.

Transl Psychiatry. 2013 Feb 19;3:e232. doi: 10.1038/tp.2013.8.


Vitamin B-6 restriction impairs fatty acid synthesis in cultured human hepatoma (HepG2) cells.

Zhao M, Ralat MA, da Silva V, Garrett TJ, Melnyk S, James SJ, Gregory JF 3rd.

Am J Physiol Endocrinol Metab. 2013 Feb 15;304(4):E342-51. doi: 10.1152/ajpendo.00359.2012. Epub 2012 Dec 4.


Iron status in children with autism spectrum disorder.

Reynolds A, Krebs NF, Stewart PA, Austin H, Johnson SL, Withrow N, Molloy C, James SJ, Johnson C, Clemons T, Schmidt B, Hyman SL.

Pediatrics. 2012 Nov;130 Suppl 2:S154-9. doi: 10.1542/peds.2012-0900M.


Nutrient intake from food in children with autism.

Hyman SL, Stewart PA, Schmidt B, Cain U, Lemcke N, Foley JT, Peck R, Clemons T, Reynolds A, Johnson C, Handen B, James SJ, Courtney PM, Molloy C, Ng PK.

Pediatrics. 2012 Nov;130 Suppl 2:S145-53. doi: 10.1542/peds.2012-0900L.


Associations between maternal genotypes and metabolites implicated in congenital heart defects.

Chowdhury S, Hobbs CA, MacLeod SL, Cleves MA, Melnyk S, James SJ, Hu P, Erickson SW.

Mol Genet Metab. 2012 Nov;107(3):596-604. doi: 10.1016/j.ymgme.2012.09.022. Epub 2012 Sep 27.


Intracellular and extracellular redox status and free radical generation in primary immune cells from children with autism.

Rose S, Melnyk S, Trusty TA, Pavliv O, Seidel L, Li J, Nick T, James SJ.

Autism Res Treat. 2012;2012:986519. doi: 10.1155/2012/986519. Epub 2011 Nov 24.


Evidence of oxidative damage and inflammation associated with low glutathione redox status in the autism brain.

Rose S, Melnyk S, Pavliv O, Bai S, Nick TG, Frye RE, James SJ.

Transl Psychiatry. 2012 Jul 10;2:e134. doi: 10.1038/tp.2012.61.


Postnatal exposure to trichloroethylene alters glutathione redox homeostasis, methylation potential, and neurotrophin expression in the mouse hippocampus.

Blossom SJ, Melnyk S, Cooney CA, Gilbert KM, James SJ.

Neurotoxicology. 2012 Dec;33(6):1518-1527. doi: 10.1016/j.neuro.2012.02.017. Epub 2012 Mar 7.


Cerebral folate receptor autoantibodies in autism spectrum disorder.

Frye RE, Sequeira JM, Quadros EV, James SJ, Rossignol DA.

Mol Psychiatry. 2013 Mar;18(3):369-81. doi: 10.1038/mp.2011.175. Epub 2012 Jan 10.


Role of epigenetic and miR-22 and miR-29b alterations in the downregulation of Mat1a and Mthfr genes in early preneoplastic livers in rats induced by 2-acetylaminofluorene.

Koturbash I, Melnyk S, James SJ, Beland FA, Pogribny IP.

Mol Carcinog. 2013 Apr;52(4):318-27. doi: 10.1002/mc.21861. Epub 2011 Dec 27.


Molecular alterations in hepatocarcinogenesis induced by dietary methyl deficiency.

Pogribny IP, James SJ, Beland FA.

Mol Nutr Food Res. 2012 Jan;56(1):116-25. doi: 10.1002/mnfr.201100524. Epub 2011 Nov 17. Review.


Mathematical modeling predicts the effect of folate deficiency and excess on cancer-related biomarkers.

Neuhouser ML, Nijhout HF, Gregory JF 3rd, Reed MC, James SJ, Liu A, Shane B, Ulrich CM.

Cancer Epidemiol Biomarkers Prev. 2011 Sep;20(9):1912-7. doi: 10.1158/1055-9965.EPI-10-1352. Epub 2011 Jul 13.

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