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Items: 1 to 50 of 245

1.

Transition of the prion protein from a structured cellular form (PrPC ) to the infectious scrapie agent (PrPSc ).

Baral PK, Yin J, Aguzzi A, James MNG.

Protein Sci. 2019 Dec;28(12):2055-2063. doi: 10.1002/pro.3735. Epub 2019 Oct 25. Review.

PMID:
31583788
2.

Structural characterization of POM6 Fab and mouse prion protein complex identifies key regions for prions conformational conversion.

Baral PK, Swayampakula M, Aguzzi A, James MNG.

FEBS J. 2018 May;285(9):1701-1714. doi: 10.1111/febs.14438. Epub 2018 Apr 14.

3.

Reduced Nonexercise Activity Attenuates Negative Energy Balance in Mice Engaged in Voluntary Exercise.

Lark DS, Kwan JR, McClatchey PM, James MN, James FD, Lighton JRB, Lantier L, Wasserman DH.

Diabetes. 2018 May;67(5):831-840. doi: 10.2337/db17-1293. Epub 2018 Mar 6.

4.

X-ray structural and molecular dynamical studies of the globular domains of cow, deer, elk and Syrian hamster prion proteins.

Baral PK, Swayampakula M, Aguzzi A, James MN.

J Struct Biol. 2015 Oct;192(1):37-47. doi: 10.1016/j.jsb.2015.08.014. Epub 2015 Aug 28.

PMID:
26320075
5.

Structural basis of prion inhibition by phenothiazine compounds.

Baral PK, Swayampakula M, Rout MK, Kav NN, Spyracopoulos L, Aguzzi A, James MN.

Structure. 2014 Feb 4;22(2):291-303. doi: 10.1016/j.str.2013.11.009. Epub 2013 Dec 26.

6.

The crystal structure of shiga toxin type 2 with bound disaccharide guides the design of a heterobifunctional toxin inhibitor.

Jacobson JM, Yin J, Kitov PI, Mulvey G, Griener TP, James MN, Armstrong G, Bundle DR.

J Biol Chem. 2014 Jan 10;289(2):885-94. doi: 10.1074/jbc.M113.518886. Epub 2013 Nov 13.

7.

Insights into mucopolysaccharidosis I from the structure and action of α-L-iduronidase.

Bie H, Yin J, He X, Kermode AR, Goddard-Borger ED, Withers SG, James MN.

Nat Chem Biol. 2013 Nov;9(11):739-45. doi: 10.1038/nchembio.1357. Epub 2013 Sep 11. Erratum in: Nat Chem Biol. 2013 Nov;9(11):746.

8.

Phosphorylation status of 72 kDa MMP-2 determines its structure and activity in response to peroxynitrite.

Jacob-Ferreira AL, Kondo MY, Baral PK, James MN, Holt A, Fan X, Schulz R.

PLoS One. 2013 Aug 27;8(8):e71794. doi: 10.1371/journal.pone.0071794. eCollection 2013.

9.

The toxicity of antiprion antibodies is mediated by the flexible tail of the prion protein.

Sonati T, Reimann RR, Falsig J, Baral PK, O'Connor T, Hornemann S, Yaganoglu S, Li B, Herrmann US, Wieland B, Swayampakula M, Rahman MH, Das D, Kav N, Riek R, Liberski PP, James MN, Aguzzi A.

Nature. 2013 Sep 5;501(7465):102-6. doi: 10.1038/nature12402. Epub 2013 Jul 31.

PMID:
23903654
10.

The crystal structure of an octapeptide repeat of the prion protein in complex with a Fab fragment of the POM2 antibody.

Swayampakula M, Baral PK, Aguzzi A, Kav NN, James MN.

Protein Sci. 2013 Jul;22(7):893-903. doi: 10.1002/pro.2270. Epub 2013 May 31.

11.

Structural studies on the folded domain of the human prion protein bound to the Fab fragment of the antibody POM1.

Baral PK, Wieland B, Swayampakula M, Polymenidou M, Rahman MH, Kav NN, Aguzzi A, James MN.

Acta Crystallogr D Biol Crystallogr. 2012 Nov;68(Pt 11):1501-12. doi: 10.1107/S0907444912037328. Epub 2012 Oct 18.

PMID:
23090399
12.

Molecular mechanisms underlying the interaction of protein phosphatase-1c with ASPP proteins.

Skene-Arnold TD, Luu HA, Uhrig RG, De Wever V, Nimick M, Maynes J, Fong A, James MN, Trinkle-Mulcahy L, Moorhead GB, Holmes CF.

Biochem J. 2013 Feb 1;449(3):649-59. doi: 10.1042/BJ20120506.

PMID:
23088536
13.

Expression, purification, crystallization and preliminary crystallographic analysis of the phosphoglycerate kinase from Acinetobacter baumannii.

Baretta K, Garen C, Yin J, James MN.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Jul 1;68(Pt 7):790-2. doi: 10.1107/S1744309112020222. Epub 2012 Jun 27.

14.

Structure-activity characterization of sulfide:quinone oxidoreductase variants.

Cherney MM, Zhang Y, James MN, Weiner JH.

J Struct Biol. 2012 Jun;178(3):319-28. doi: 10.1016/j.jsb.2012.04.007. Epub 2012 Apr 19.

PMID:
22542586
15.

Expression, purification and preliminary crystallographic analysis of Rv2247, the β subunit of acyl-CoA carboxylase (ACCD6) from Mycobacterium tuberculosis.

Niu C, Yin J, Cherney MM, James MN.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Dec 1;67(Pt 12):1637-40. doi: 10.1107/S1744309111038413. Epub 2011 Nov 30.

16.

Crystallization and preliminary X-ray diffraction analysis of prion protein bound to the Fab fragment of the POM1 antibody.

Baral PK, Wieland B, Swayampakula M, Polymenidou M, Aguzzi A, Kav NN, James MN.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Oct 1;67(Pt 10):1211-3. doi: 10.1107/S1744309111026273. Epub 2011 Sep 24.

17.

The structures of Thermoplasma volcanium phosphoribosyl pyrophosphate synthetase bound to ribose-5-phosphate and ATP analogs.

Cherney MM, Cherney LT, Garen CR, James MN.

J Mol Biol. 2011 Nov 4;413(4):844-56. doi: 10.1016/j.jmb.2011.09.007. Epub 2011 Sep 21.

PMID:
21963988
18.

Expression, purification and preliminary crystallographic analysis of O-acetylhomoserine sulfhydrylase from Mycobacterium tuberculosis.

Yin J, Garen CR, Bateman K, Yu M, Lyon EZ, Habel J, Kim H, Hung LW, Kim CY, James MN.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Aug 1;67(Pt 8):959-63. doi: 10.1107/S1744309111017611. Epub 2011 Jul 27.

19.

Expression, purification and preliminary crystallographic analysis of Rv3002c, the regulatory subunit of acetolactate synthase (IlvH) from Mycobacterium tuberculosis.

Yin J, Garen G, Garen C, James MN.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Aug 1;67(Pt 8):933-6. doi: 10.1107/S1744309111021105. Epub 2011 Jul 20.

20.

The structure of LL-diaminopimelate aminotransferase from Chlamydia trachomatis: implications for its broad substrate specificity.

Watanabe N, Clay MD, van Belkum MJ, Fan C, Vederas JC, James MN.

J Mol Biol. 2011 Aug 19;411(3):649-60. doi: 10.1016/j.jmb.2011.06.023. Epub 2011 Jun 21.

PMID:
21722650
21.

Site-directed mutagenesis of histidine 69 and glutamic acid 148 alters the ribonuclease activity of pea ABR17 (PR10.4).

Krishnaswamy S, Baral PK, James MN, Kav NN.

Plant Physiol Biochem. 2011 Sep;49(9):958-62. doi: 10.1016/j.plaphy.2010.10.010. Epub 2011 May 4.

PMID:
21600779
22.

Structural insights for the substrate recognition mechanism of LL-diaminopimelate aminotransferase.

Watanabe N, James MN.

Biochim Biophys Acta. 2011 Nov;1814(11):1528-33. doi: 10.1016/j.bbapap.2011.03.008. Epub 2011 Mar 22. Review.

PMID:
21435399
23.

Plant protein proteinase inhibitors: structure and mechanism of inhibition.

Bateman KS, James MN.

Curr Protein Pept Sci. 2011 Aug;12(5):340-7. Review.

PMID:
21418022
24.

Crystal structure of β-hexosaminidase B in complex with pyrimethamine, a potential pharmacological chaperone.

Bateman KS, Cherney MM, Mahuran DJ, Tropak M, James MN.

J Med Chem. 2011 Mar 10;54(5):1421-9. doi: 10.1021/jm101443u. Epub 2011 Jan 25.

25.

The TB Structural Genomics Consortium: a decade of progress.

Chim N, Habel JE, Johnston JM, Krieger I, Miallau L, Sankaranarayanan R, Morse RP, Bruning J, Swanson S, Kim H, Kim CY, Li H, Bulloch EM, Payne RJ, Manos-Turvey A, Hung LW, Baker EN, Lott JS, James MN, Terwilliger TC, Eisenberg DS, Sacchettini JC, Goulding CW.

Tuberculosis (Edinb). 2011 Mar;91(2):155-72. doi: 10.1016/j.tube.2010.11.009. Epub 2011 Jan 17. Review.

26.

Structure-activity analysis of cathepsin K/chondroitin 4-sulfate interactions.

Cherney MM, Lecaille F, Kienitz M, Nallaseth FS, Li Z, James MN, Brömme D.

J Biol Chem. 2011 Mar 18;286(11):8988-98. doi: 10.1074/jbc.M110.126706. Epub 2010 Dec 30.

27.

Studies on the catalytic mechanism of a glutamic peptidase.

Kondo MY, Okamoto DN, Santos JA, Juliano MA, Oda K, Pillai B, James MN, Juliano L, Gouvea IE.

J Biol Chem. 2010 Jul 9;285(28):21437-45. doi: 10.1074/jbc.M110.122432. Epub 2010 May 4.

28.

Crystal structure of the intermediate complex of the arginine repressor from Mycobacterium tuberculosis bound with its DNA operator reveals detailed mechanism of arginine repression.

Cherney LT, Cherney MM, Garen CR, James MN.

J Mol Biol. 2010 Jun 4;399(2):240-54. doi: 10.1016/j.jmb.2010.03.065. Epub 2010 Apr 9.

PMID:
20382162
29.

Crystal structure of sulfide:quinone oxidoreductase from Acidithiobacillus ferrooxidans: insights into sulfidotrophic respiration and detoxification.

Cherney MM, Zhang Y, Solomonson M, Weiner JH, James MN.

J Mol Biol. 2010 Apr 30;398(2):292-305. doi: 10.1016/j.jmb.2010.03.018. Epub 2010 Mar 19.

PMID:
20303979
30.

The molecular structure of ornithine acetyltransferase from Mycobacterium tuberculosis bound to ornithine, a competitive inhibitor.

Sankaranarayanan R, Cherney MM, Garen C, Garen G, Niu C, Yuan M, James MN.

J Mol Biol. 2010 Apr 9;397(4):979-90. doi: 10.1016/j.jmb.2010.02.018. Epub 2010 Feb 22.

PMID:
20184895
31.

Regulatory RNA elements. Preface.

James MN, Yin J.

Biochim Biophys Acta. 2009 Sep-Oct;1789(9-10):493-4. doi: 10.1016/j.bbagrm.2009.10.003. No abstract available.

PMID:
19892311
32.

Preliminary X-ray crystallographic analysis of sulfide:quinone oxidoreductase from Acidithiobacillus ferrooxidans.

Zhang Y, Cherney MM, Solomonson M, Liu J, James MN, Weiner JH.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Aug 1;65(Pt 8):839-42. doi: 10.1107/S1744309109027535. Epub 2009 Jul 30.

33.

The structure of the arginine repressor from Mycobacterium tuberculosis bound with its DNA operator and Co-repressor, L-arginine.

Cherney LT, Cherney MM, Garen CR, James MN.

J Mol Biol. 2009 Apr 24;388(1):85-97. doi: 10.1016/j.jmb.2009.02.053. Epub 2009 Mar 2.

PMID:
19265706
34.

Preliminary X-ray crystallographic analysis of ornithine acetyltransferase (Rv1653) from Mycobacterium tuberculosis.

Sankaranarayanan R, Garen CR, Cherney MM, Yuan M, Lee C, James MN.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Feb 1;65(Pt 2):173-6. doi: 10.1107/S1744309109000360. Epub 2009 Jan 31.

35.

The POM monoclonals: a comprehensive set of antibodies to non-overlapping prion protein epitopes.

Polymenidou M, Moos R, Scott M, Sigurdson C, Shi YZ, Yajima B, Hafner-Bratkovic I, Jerala R, Hornemann S, Wuthrich K, Bellon A, Vey M, Garen G, James MN, Kav N, Aguzzi A.

PLoS One. 2008;3(12):e3872. doi: 10.1371/journal.pone.0003872. Epub 2008 Dec 8.

36.

Crystal structure of diaminopimelate epimerase from Arabidopsis thaliana, an amino acid racemase critical for L-lysine biosynthesis.

Pillai B, Moorthie VA, van Belkum MJ, Marcus SL, Cherney MM, Diaper CM, Vederas JC, James MN.

J Mol Biol. 2009 Jan 16;385(2):580-94. doi: 10.1016/j.jmb.2008.10.072. Epub 2008 Nov 5.

PMID:
19013471
37.

Crystal structure of the arginine repressor protein in complex with the DNA operator from Mycobacterium tuberculosis.

Cherney LT, Cherney MM, Garen CR, Lu GJ, James MN.

J Mol Biol. 2008 Dec 31;384(5):1330-40. doi: 10.1016/j.jmb.2008.10.015. Epub 2008 Oct 15.

PMID:
18952097
38.

Mechanism of substrate recognition and PLP-induced conformational changes in LL-diaminopimelate aminotransferase from Arabidopsis thaliana.

Watanabe N, Clay MD, van Belkum MJ, Cherney MM, Vederas JC, James MN.

J Mol Biol. 2008 Dec 31;384(5):1314-29. doi: 10.1016/j.jmb.2008.10.022. Epub 2008 Oct 15.

PMID:
18952095
39.

Expression, purification and preliminary crystallographic analysis of N-acetylglucosamine-1-phosphate uridylyltransferase from Mycobacterium tuberculosis.

Yin J, Garen CR, Cherney MM, Cherney LT, James MN.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Sep 1;64(Pt 9):805-8. doi: 10.1107/S1744309108024500. Epub 2008 Aug 9.

40.

Structure of the C-terminal domain of the arginine repressor protein from Mycobacterium tuberculosis.

Cherney LT, Cherney MM, Garen CR, Lu GJ, James MN.

Acta Crystallogr D Biol Crystallogr. 2008 Sep;64(Pt 9):950-6. doi: 10.1107/S0907444908021513. Epub 2008 Aug 13.

41.

The crystal and molecular structures of a cathepsin K:chondroitin sulfate complex.

Li Z, Kienetz M, Cherney MM, James MN, Brömme D.

J Mol Biol. 2008 Oct 31;383(1):78-91. doi: 10.1016/j.jmb.2008.07.038. Epub 2008 Jul 22.

PMID:
18692071
42.

Crystal structure of Mycobacterium tuberculosis Rv0760c at 1.50 A resolution, a structural homolog of Delta(5)-3-ketosteroid isomerase.

Cherney MM, Garen CR, James MN.

Biochim Biophys Acta. 2008 Nov;1784(11):1625-32. doi: 10.1016/j.bbapap.2008.05.012. Epub 2008 Jun 6.

PMID:
18589008
43.

The molecular structure of epoxide hydrolase B from Mycobacterium tuberculosis and its complex with a urea-based inhibitor.

Biswal BK, Morisseau C, Garen G, Cherney MM, Garen C, Niu C, Hammock BD, James MN.

J Mol Biol. 2008 Sep 12;381(4):897-912. doi: 10.1016/j.jmb.2008.06.030. Epub 2008 Jun 17.

44.

Expression, purification, crystallization and preliminary X-ray analysis of Rv3117, a probable thiosulfate sulfurtransferase (CysA3) from Mycobacterium tuberculosis.

Witholt SJ, Sankaranarayanan R, Garen CR, Cherney MM, Cherney LT, James MN.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Jun 1;64(Pt 6):541-4. doi: 10.1107/S1744309108014449. Epub 2008 May 24.

45.

Heteroaromatic ester inhibitors of hepatitis A virus 3C proteinase: Evaluation of mode of action.

Huitema C, Zhang J, Yin J, James MN, Vederas JC, Eltis LD.

Bioorg Med Chem. 2008 May 15;16(10):5761-77. doi: 10.1016/j.bmc.2008.03.059. Epub 2008 Mar 27.

PMID:
18407505
46.

Aryl methylene ketones and fluorinated methylene ketones as reversible inhibitors for severe acute respiratory syndrome (SARS) 3C-like proteinase.

Zhang J, Huitema C, Niu C, Yin J, James MN, Eltis LD, Vederas JC.

Bioorg Chem. 2008 Oct;36(5):229-40. doi: 10.1016/j.bioorg.2008.01.001. Epub 2008 Mar 4.

PMID:
18295820
47.

1.2A-resolution crystal structures reveal the second tetrahedral intermediates of streptogrisin B (SGPB).

Lee TW, James MN.

Biochim Biophys Acta. 2008 Feb;1784(2):319-34. Epub 2007 Nov 29.

PMID:
18157955
48.

The crystal structures of ornithine carbamoyltransferase from Mycobacterium tuberculosis and its ternary complex with carbamoyl phosphate and L-norvaline reveal the enzyme's catalytic mechanism.

Sankaranarayanan R, Cherney MM, Cherney LT, Garen CR, Moradian F, James MN.

J Mol Biol. 2008 Jan 25;375(4):1052-63. Epub 2007 Nov 19.

PMID:
18062991
49.

X-ray crystal structure of Mycobacterium tuberculosis haloalkane dehalogenase Rv2579.

Mazumdar PA, Hulecki JC, Cherney MM, Garen CR, James MN.

Biochim Biophys Acta. 2008 Feb;1784(2):351-62. Epub 2007 Nov 13.

PMID:
18062934
50.

Expression, purification and preliminary X-ray analysis of the C-terminal domain of an arginine repressor protein from Mycobacterium tuberculosis.

Lu GJ, Garen CR, Cherney MM, Cherney LT, Lee C, James MN.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Nov 1;63(Pt 11):936-9. Epub 2007 Oct 24.

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